Tiyeni tiphunzire za Aldosterone, yomwe imakhudza kuthamanga kwa magazi mwachinsinsi.

Vuto lomwe anthu ambiri ku Sri Lanka ali nalo ndi kuthamanga kwa magazi. Kwa ena, zimakhala zovuta kwambiri kuwongolera izi ngakhale atamwa mankhwala. Koma pali wina m'thupi mwathu amene sitilankhula kwambiri za iye, koma mwachinsinsi amakhudza kuthamanga kwa magazi. Ndicho chimene tikambirana lero. Dzina lake ndi Aldosterone.

Mwachidule, kodi aldosterone iyi ndi ndani?

Aldosterone ndi homoni m'thupi lathu. Mahomoni ali ngati a positi m'thupi lathu. Amatumiza mauthenga ku chiwalo chilichonse, kuwauza kuti achite izi, asiye zimenezo.

Choncho mahomoni awa otchedwa aldosterone amapangidwa ndi tiziwalo tiwiri tating'onoting'ono ta triangular tomwe tili ngati chivundikiro pamwamba pa impso zathu. Timatcha izi kuti tiziwalo ta adrenal. Tiwaloti ndi gawo la dongosolo lathu la endocrine.

Ntchito yaikulu ya homoni iyi ndikusunga kuthamanga kwa magazi athu pamlingo woyenera . Imachita izi poyang'anira kuchuluka kwa mchere m'magazi mwathu wotchedwa sodium (ndiye mchere) ndi potaziyamu. Sodium ndi potaziyamu izi ndi mitundu iwiri ya ma electrolyte . Ndi omwe amasunga kuchuluka kwa madzi m'thupi moyenera komanso amathandiza mitsempha ndi minofu kugwira ntchito bwino.

Kodi aldosterone imachepetsa bwanji kuthamanga kwa magazi?

Iyi ndi njira yosangalatsa kwambiri. Aldosterone imakhudza kwambiri kuthamanga kwa magazi m'njira zotsatirazi:

1. Kusunga Sodium: Aldosterone imauza impso zathu ndi m'matumbo kuti "ziwonjezere sodium (mchere) wambiri m'magazi ndikuwonjezera kuchuluka kwa potaziyamu yomwe imatuluka mu mkodzo."

2. Kusunga madzi: Sodium ikawonjezedwa m'magazi, madzi amasungidwanso m'thupi. Zili ngati madzi amakopeka ndi mchere.

3. Kuchuluka kwa magazi: Tikasunga madzi m'thupi lathu, kuchuluka kwa magazi athu kumawonjezeka. Monga momwe kudzaza madzi ambiri paipi yamadzi kumawonjezera kuthamanga kwa magazi, kuchuluka kwa magazi kukawonjezeka, kuthamanga kwa magazi nako kumawonjezeka.

Mwanjira imeneyi, kuthamanga kwa magazi athu kukatsika, aldosterone imalowa m'magazi ndipo imathandiza kuti magazi athu abwererenso pamlingo wabwino. Homoni iyi imathandizanso kuwongolera pH (monga acid-base balance) ndi kuchuluka kwa ma electrolyte m'magazi.

Kodi kuchuluka kwa aldosterone kumeneku kumayendetsedwa bwanji? - Njira yodabwitsa!

Aldosterone sigwira ntchito yokha. Ndi gawo la gulu lomwe limagwira ntchito limodzi. Timatcha dongosololi kuti Renin-Angiotensin-Aldosterone System (RAAS) . Lili ngati mpikisano wobwerezabwereza.

Ganizirani motere.

• Gawo loyamba: Kuthamanga kwa magazi (BP) kwanu kumatsika. Impso zathu zimazindikira izi. Kenako impso zimatulutsa enzyme yotchedwa renin m'magazi.
• Gawo lachiwiri: Renin iyi imaphwanya puloteni yotchedwa angiotensinogen, yomwe imapangidwa ndi chiwindi chathu, kukhala chidutswa chotchedwa angiotensin I. Koma ikadali yopanda mphamvu, zomwe zikutanthauza kuti ilibe mphamvu zambiri.
• Gawo Lachitatu: Tsopano, pamene angiotensin I iyi ikuyenda m'magazi, imasweka ndi angiotensin-converting enzyme (ACE) yochokera m'mapapu athu, ndikupanga hormone yamphamvu kwambiri yotchedwa angiotensin II . Uyu ndiye ngwazi yeniyeni.
• Gawo Lachinayi: Angiotensin II iyi imachita zinthu ziwiri zazikulu.

1. Zimapangitsa kuti mitsempha yamagazi (arterioles) ichepetse. Izi zimapangitsa kuti kuthamanga kwa magazi kukwere nthawi yomweyo.

2. Imapita ku ma adrenal glands ndikuwauza kuti, "Zadzidzidzi! Imatulutsa aldosterone mwachangu!"

• Gawo lomaliza: Tsopano aldosterone imabwera ndikuuza impso kuti zisunge mchere (sodium) ndi madzi ndikutulutsa potaziyamu pang'ono. Izi zimawonjezera kuchuluka kwa magazi ndikubwezeretsa kuthamanga kwa magazi kukhala kwabwinobwino.

Ndondomeko yonseyi ikatha, ndipo kuthamanga kwa magazi kubwerera mwakale, dongosololi limazimitsa lokha. Iyi ndi njira yovuta kwambiri, koma yowongolera bwino kwambiri.

Kodi kuchuluka kwa aldosterone kumayesedwa bwanji?

Ngati dokotala wanu akuvutika kulamulira kuthamanga kwa magazi anu, kapena ngati muli ndi kusintha kwa potaziyamu m'magazi mwanu, angaganize kuti aldosterone ndi yofanana ndi aldosterone. Chiyeso chachikulu cha izi ndi mayeso a aldosterone:renin ratio .

Popeza aldosterone ndi renin zimagwira ntchito limodzi, kuyeza milingo ya zonsezi kungathandize kudziwa komwe vutolo lili. Izi nthawi zambiri zimachitika potenga magazi ochepa kuchokera mumtsempha womwe uli m'dzanja lanu.

Kuphatikiza apo, kuchuluka kwa aldosterone kumatha kuyezedwa padera m'magazi kapena mkodzo womwe wasonkhanitsidwa mkati mwa maola 24.

Kodi chimachitika ndi chiyani ngati kuchuluka kwa aldosterone m'magazi kukukwera?

Ngati kuchuluka kwa aldosterone m'thupi kuli kokwera kuposa kwachibadwa, timatcha hyperaldosteronism . Chifukwa chachikulu cha izi ndi vuto lotchedwa primary aldosteronism . IziAmatchedwanso kuti Conn's syndrome.

Vutoli nthawi zambiri limayamba chifukwa cha chotupa chaching'ono, chosakhala khansa (chosaopsa) chomwe chimayamba mu adrenal gland. Chotupachi chimapangitsa kuti chiberekero chipange aldosterone yochuluka. Izi zimapangitsa kuti sodium (mchere) ichuluke m'magazi, potaziyamu ichepe, komanso kusalinganika kwa ma electrolyte.

Kodi chimachitika ndi chiyani ngati kuchuluka kwa aldosterone m'magazi kumatsika?

Komanso, pamene mulingo wa aldosterone m'thupi uli wochepa kuposa wabwinobwino, timautcha hypoaldosteronism . Izi zimachitika pamene hormone ya aldosterone imapangidwa pang'ono kwambiri kapena ntchito yake imasokonekera. Izi zingayambitse kuchuluka kwa sodium (mchere) m'magazi, kuchuluka kwa potaziyamu, komanso vuto lotchedwa metabolic acidosis (kuwonjezeka kwa acidity m'magazi) .

Kodi zifukwa zake ndi ziti?

• Matenda a Addison:Imeneyi ndi matenda osowa kwambiri omwe amayambitsa matenda a autoimmune. Izi zikutanthauza kuti chitetezo cha thupi chimadziukira chokha ndikuwononga ma adrenal glands. Izi zimachepetsa kupanga mahomoni onse awiri, aldosterone ndi cortisol.
• Congenital Adrenal Hyperplasia (CAH): Ichi ndi matenda a majini omwe amapezeka pobadwa. Amayambitsa kusowa kwa ma enzyme ena ofunikira kuti apange mahomoni m'ziphuphu za adrenal.
• Matenda ena: Matendawa angachitike kwa anthu omwe ali ndi matenda a shuga, matenda a impso, komanso omwe akudwala kwambiri.
• Mankhwala ena: Matendawa amathanso kuyambitsidwa ndi mankhwala ochepetsa ululu (NSAIDs) , mankhwala ochepetsa magazi monga heparin, ndi mankhwala ena a mtima.

Ngati muli ndi zizindikiro izi, ndikofunikira kwambiri kupanga nthawi yoti mukakumane ndi dokotala wanu ndikukambirana za izi.