Kodi kukumbukira kwanu ndi mayendedwe anu akuchepa pang'onopang'ono? Tiyeni tiphunzire za izi (Corticobasal Degeneration)!

Kodi nthawi zina mumaiwala zinthu? Kapena mumavutika kusuntha manja ndi miyendo yanu? Kodi mumanyodola mawu anu mukamalankhula? Ngati zinthuzi zikuoneka kuti zikuchulukirachulukira, mwina ndikofunikira kuti mudziwe vuto lomwe tikukamba lero lotchedwa `(Corticobasal Degeneration)`. Musadandaule, tiyeni tikambirane izi mosavuta.

Kodi `(Corticobasal Degeneration)` ndi chiyani?

Mwachidule, `(Corticobasal Degeneration)` ndi matenda amitsempha omwe amakhudza ubongo wathu. Anthu ena amatchanso `(Corticobasal Syndrome).` Chomwe chimachitika pamenepa ndichakuti maselo ena muubongo wathu amawonongeka ndikuwonongeka pang'onopang'ono. Monga momwe zida zina zimawonongeka pakapita nthawi. Chifukwa cha izi, luso lathu lolankhula, kumeza chakudya, kusuntha matupi athu, ndi kukumbukira zinthu zimatha kuchepa pang'onopang'ono. Chomvetsa chisoni n'chakuti zizindikirozi zimawonjezeka pang'onopang'ono pakapita nthawi.

Mawu akuti "corticobasal" m'dzina lake amatanthauza magawo awiri a ubongo omwe amawonongeka kwambiri ndi matendawa:

• Cerebral cortex: Iyi ndi gawo lakunja kwa minofu ya mitsempha muubongo wathu. Gawoli ndi lofunika kwambiri pa kukumbukira kwathu, kuphunzira, mayendedwe athu odzifunira, komanso momwe timamvera.
• Basal ganglia: Iyi ndi gulu la maselo amitsempha omwe ali mkati mwa ubongo. Ndi ofunikira pakuphunzira ndi kugwira ntchito kwa ziwalo.

Mawu oti "kuchepa kwa ntchito" amatanthauza "kuchepa kwa ntchito" kapena "kuchepa kwa ntchito." Chifukwa chake chomwe chimachitika mu matendawa ndichakuti ntchito ya ziwalo ziwirizi za ubongo imachepa pang'onopang'ono.

Matendawa, ``Corticobasal Degeneration``, amatha kufupikitsa moyo wa munthu ndikuyambitsa mavuto omwe angawononge moyo wake. Pamene zizindikiro zikufalikira m'thupi lonse, zimakhala zovuta kuti munthu azitha kugwira ntchito payekha.

Kodi zizindikiro za `(Corticobasal Degeneration)` ndi ziti?

Zizindikiro za matendawa zimatha kusiyana malinga ndi munthu, koma mphamvu zomwe zingakhudzidwe ndi izi:

• Mavuto oyenda (`Apraxia`): Izi zikutanthauza kuti zinthu monga kukanikiza batani kapena kugwira supuni kuti mudye zimakhala zovuta. Ngakhale ubongo umatumiza mauthenga m'manja, sangathe kuchita bwino.
• Kulephera kukumbukira: Zimakhala zovuta kukumbukira zinthu zatsopano, ndipo zinthu zakale zimaiwalika pang'onopang'ono.
• Kulephera kuwona bwino: Anthu ena angakhalenso ndi mavuto a masomphenya.
• Mavuto olankhula (`Aphasia`): Kuvutika kupeza mawu, kusamvetsetsa zomwe mukufuna kunena, ndipo nthawi zina kutaya mawu kwathunthu.
• Kuvuta kumeza: Mungamve ngati mukugwira mphuno mukameza chakudya ndi chakumwa.

Kuwonjezera apo, zizindikiro zina monga izi zingawonekere:

• Kugwedezeka kwa minofu, kugwedezeka, kuuma kwa minofu, kapena kunjenjemera.
• Kuvuta kuchita ntchito zazing'ono komanso zofewa (monga kutseka shati, kulemba ndi cholembera).
• Matenda a dzanja lachilendo: Kulephera kulamulira mkono umodzi kapena mwendo umodzi momwe mukufunira (`Alien hand syndrome`). Tangoganizirani kuti mkono wanu umodzi ukuchita zinthu zomwe simukufuna kuti uchite, ndipo mukumva ngati simungathe kuzilamulira.
• Kumva dzanzi mbali imodzi ya thupi.
• Kuyenda pang'onopang'ono kwambiri (`Bradykinesia`) kapena kulephera kusuntha miyendo (`Akinesia`).
• Kuchepa kwa ntchito ya ubongo, ndiko kuti, kuchepa kwa nzeru (Dementia).
• Kuvuta kuyenda popanda thandizo.
• Kusintha kwa maganizo ndi khalidwe (kusowa chidwi, mkwiyo wadzidzidzi, kusasamala).

Matendawa sakhudza aliyense mofanana. Nthawi zambiri amakula pang'onopang'ono. Nthawi zina zizindikiro zimayamba m'dzanja limodzi, kenako zimafalikira ku dzanja lina ndi miyendo. Mungayambe kumva ngati mukupunthwa mukuyenda, kenako mungalephere kuyenda popanda thandizo. Mungayambe kunyoza mawu anu mukamalankhula, ndipo pakapita nthawi, simungathe kulankhula chiganizo chimodzi chomveka bwino.

Pamene matendawa akukhudza mbali zambiri za ubongo, zizindikiro zake zimakula pang'onopang'ono. Izi zimachitika pang'onopang'ono.

Kodi zizindikiro za `(Corticobasal Degeneration)` zimayamba liti?

Zizindikiro nthawi zambiri zimayamba pakati pa zaka 50 ndi 70. Anthu ambiri amakhala ndi zizindikiro zawo ali ndi zaka 64. Ngakhale kuti sizingayambe msanga ali ndi zaka 40, palibe malipoti oti matendawa amayamba ali aang'ono.

Kodi zifukwa za `(Corticobasal Degeneration)` ndi ziti?

Chifukwa chachikulu cha izi ndi chakuti maselo ndi minofu ya ubongo imasweka pang'onopang'ono ndi kufa. Nthawi zambiri, kuwonongeka kumeneku kumayambira m'malo omwe tidakambirana kale otchedwa cerebral cortex ndi basal ganglia. Pamene matendawa akupita patsogolo, amathanso kukhudza mbali zina za ubongo.

Ofufuza amakhulupirira kuti puloteni yotchedwa "Tau" imagwira ntchito pa matendawa. Puloteni iyi nthawi zambiri imapezeka m'maselo a muubongo. Koma pa matendawa, puloteni iyi imalumikizana mosazolowereka ndikupanga ma clumps. Ma clumps awa amatchedwa "neurofibrillar tangles." Ma clumps awa amachititsa kuti maselo a muubongo azifooka ndikufa. Zotsatira zake, pamakhala mavuto okhudza kuyenda, kulankhula, ndi kukumbukira.

Chifukwa chenicheni chomwe puloteni ya Tau imagwirira pamodzi sichinadziwikebe. Zapezeka kuti anthu ambiri omwe ali ndi Corticobasal Degeneration ali ndi mtundu wa majini (mutation) wotchedwa H1 haplotype pa chromosome 17. Kusintha kwa majini kumeneku kungayambitse puloteni ya Tau kupangidwa mopitirira muyeso ndikuzungulira pamodzi, kapena mwina gulu la methyl limalumikizidwa ku jini ya Tau, zomwe zimakhudza ntchito yake.

Koma ofufuza akudziwa kuti jini iyi si yokhayo yomwe imayambitsa izi. Chifukwa anthu ambiri mwa anthu ambiri ali ndi jini iyi, samakhala ndi zizindikiro za ``Corticobasal Degeneration``. Choncho kafukufuku akupitilirabe kuti apeze chomwe chimayambitsa vutoli.

Kodi `(Corticobasal Degeneration)` ndi cholowa?

Akatswiri azachipatala sakudziwabe chifukwa chake anthu ena amadwala Corticobasal Degeneration. N'zosowa kwambiri kuti anthu a m'banja limodzi adwale matendawa. Izi zikutanthauza kuti n'zovuta kunena kuti ndi matenda obadwa nawo.

Kodi mavuto omwe angakhalepo ndi ati?

Pamene matendawa akupita patsogolo, chiopsezo chokhala ndi mavuto oopsa monga:

• Matenda a bakiteriya
• Magazi oundana ndi ma pulmonary embolisms
• Ngozi zakuthupi (monga kugwa)
• Chibayo
• Sepsis (matenda oopsa omwe amayamba chifukwa cha majeremusi omwe amalowa m'magazi)

Kodi madokotala amazindikira bwanji matendawa? ('Kuzindikira`)

Chinthu chapadera chodziwira `(Corticobasal Degeneration)` ndichakuti chingatsimikizidwe motsimikizika pongofufuza ubongo pambuyo pa imfa. Pokhapokha dokotala kapena katswiri wa matenda angadziwe molondola kukula kwa kuwonongeka kwa ubongo.

Komabe, pa moyo wanu wonse, dokotala wanu angatchule vutoli kuti "Corticobasal Syndrome" kutengera zizindikiro zanu.

Kuti adziwe ngati muli ndi matenda, dokotala wanu ayamba kaye wakuyezetsa thupi. Adzayang'ana mosamala zizindikiro zanu.

Popeza matenda ambiri ali ndi zizindikiro zofanana, dokotala wanu angachite mayeso osiyanasiyana kuti adziwe chomwe chimayambitsa matendawa. Izi zingaphatikizepo:

• Kuyezetsa magazi
• Mayeso ojambulira ubongo (`Ma scan ojambulira`) - mwachitsanzo `(MRI)` kapena `(CT scan`)
• Kuyesa kwa ubongo kuti muone momwe ubongo umagwirira ntchito komanso kukumbukira

Kuphatikiza apo, dokotala angalamulenso kuti ayesedwe ndi mankhwala a nyukiliya monga `(FDG-PET (Fluorodeoxyglucose Positron Emission Tomography))` ndi `(DAT (Dopamine Transporter))`. Nthawi zina, `kujambula khungu` kungathandizenso kupeza matenda.

Kodi mankhwala a `(Corticobasal Degeneration)` ndi ati?

Dokotala wanu angapereke mankhwala osiyanasiyana kuti athetse zizindikiro zosiyanasiyana za matendawa.

Kumbukirani, pakadali pano palibe mankhwala a matendawa kapena mankhwala oletsa kupitirira kwa zizindikiro. Komabe, pali zinthu zomwe zingathandize kuchepetsa kusasangalala komwe kumachitika chifukwa cha zizindikirozo.

Mankhwala a zizindikiro zokhudzana ndi minofu angaphatikizepo:

• Kuyenda pang'onopang'ono kapena kuuma kwa minofu: `(Levodopa)`
• Kwa kupweteka kwa minofu: Clonazepam (Benzodiazepines)
• Kulimbitsa minofu kapena kuwongolera kayendedwe kake: `(Poizoni wa Botulinum)` (jakisoni wa Botox)
• Pakulimba kwa minofu: `(Cyclobenzaprine)`, `(Levetiracetam)` kapena `(Baclofen)`

Ngati muli ndi vuto la kukumbukira, dokotala wanu angakulembeni mankhwala amodzi mwa awa otchedwa ``Cholinesterase inhibitors'':

• `(Donepezil)`
• `(Rivastigmine)`
• `(Galantamine)`

Mankhwala ena sagwira ntchito mofanana pa zizindikiro za aliyense, kotero dokotala wanu angayese mitundu yosiyanasiyana kuti apeze yomwe ikukuthandizani.

Komanso, monga mankhwala ena onse, palinso zotsatirapo zina. Dokotala wanu adzakulankhulani za izi. Adzakuyang'anani nthawi zonse kuti atsimikizire kuti mankhwalawo akugwira ntchito bwino komanso ngati pali mavuto. Ngati mukukumana ndi zotsatirapo zina, muyenera kuuza dokotala wanu nthawi yomweyo.

Chofunika kwambiri n’chakuti pakadali pano palibe mankhwala oletsa kupitirira kwa zizindikirozi kapena kuchiritsa matendawa kotheratu.

Kodi mungatani kuti muthane ndi zizindikiro?

Ngati muli ndi zizindikiro za "Corticobasal Syndrome," njira zotsatirazi zingathandize kuzithetsa:

• Chithandizo cha ntchito: Izi zingakuthandizeni kuphunzira njira zatsopano zogwirira ntchito za tsiku ndi tsiku ndikukhalabe odziyimira pawokha kwa nthawi yayitali. Ngati pakufunika, mutha kuphunziranso momwe mungagwiritsire ntchito zida zothandizira kuyenda.
• Kuchiza thupi: Izi zimathandiza kuti thupi liziyenda bwino komanso kuchepetsa kusasangalala komwe kumachitika chifukwa cha zizindikiro zokhudzana ndi minofu. Kuchita masewera olimbitsa thupi kungathandize kulimbitsa minofu ndikukhalabe ndi kusinthasintha.
• Chithandizo cha kulankhula: Izi zimathandiza pamavuto olankhula ndi kumeza. Zingathandize pa zinthu monga momwe mungafotokozere malingaliro, momwe mungatchulire mawu, komanso momwe mungamezere chakudya mosamala.

Dokotala wanu adzagwira nanu ntchito kuti apeze njira zabwino kwambiri zothanirana ndi zizindikiro zanu. Njirazi zitha kusiyana malinga ndi munthu, ndipo zingafunike kusinthidwa malinga ndi momwe matenda anu amasinthira pakapita nthawi.

Kodi muyenera kupita kwa dokotala liti?

Ngati inu kapena wokondedwa wanu muli ndi zizindikiro izi za `(Corticobasal Degeneration)`, pitani kwa dokotala nthawi yomweyo:

• Ngati mukuvutika kuyenda kapena kulamulira miyendo yanu.
• Ngati mukukumana ndi mavuto okumbukira kapena zizindikiro za matenda a dementia.
• Ngati mukuvutika kulankhula, kumeza, kapena kupuma.
• Ngati pali kugwedezeka.

Kodi chiyembekezo cha `(Corticobasal Degeneration)` ndi chiyani?

Kunena zoona, chiyembekezo cha Corticobasal Degeneration sichili chabwino kwenikweni. Ndi matenda opitirira muyeso, zomwe zikutanthauza kuti zizindikiro zimakula pakapita nthawi.Koma izi zimachitika pang'onopang'ono, pakapita zaka zambiri. Dokotala wanu adzakupatsani mankhwala oti akuthandizeni kuthana ndi zizindikiro zanu. Ngakhale kuti mankhwala amenewa angachepetse kuopsa kwa zizindikiro zanu, sangalepheretse kuti zisakule kwambiri. Zizindikiro zanu zikamakula, zimakhala zovuta kwambiri kuzithetsa nokha.

Popeza matendawa akupita pang'onopang'ono, mumakhala ndi nthawi yokonzekera tsogolo lanu. Simuyenera kuchita izi nthawi yomweyo mukapeza matenda. Muyenera kutenga nthawi yoganizira zomwe zili zabwino kwa inu. Muyenera kugwira ntchito ndi madokotala anu ndi anthu omwe mumawadalira kuti akonze zomwe mukufuna komanso chisamaliro chomwe mukufuna.

Kodi munthu amene ali ndi vuto la `(Corticobasal Degeneration)` amakhala ndi moyo wautali bwanji?

Pa avareji, anthu ambiri amakhala ndi moyo zaka pafupifupi zisanu ndi chimodzi mpaka zisanu ndi zitatu pambuyo poti zizindikiro zoyamba za Corticobasal Degeneration zaonekera. Komabe, izi sizili zofanana kwa aliyense, ndipo anthu ena amakhala ndi moyo wautali kwambiri. Mkhalidwe wanu sungakhale wogwirizana ndi ziwerengerozi, kotero munthu wabwino kwambiri woti mulankhule naye za izi ndi dokotala wanu.

Ndi matenda ena ati omwe ali ndi zizindikiro zofanana?

Zizindikiro zina za `(Corticobasal Degeneration)` zitha kukhala zofanana ndi zizindikiro za matenda ena, monga:

• Khansa ya muubongo (`Khansa ya muubongo / chotupa cha muubongo`)
• `(Frontotemporal dementia)`
• Matenda a Alzheimer
• `(Kufooka kwa dongosolo lazinthu zambiri)`
• Matenda a Parkinson
• `(Progressive supranuclear palsy)`
• Stroke

Choncho, ndikofunikira kwambiri kuonana ndi dokotala nthawi yomweyo ngati mukukumana ndi zizindikiro zilizonse, chifukwa chithandizo choyambirira chingapulumutse moyo, makamaka pazochitika monga kufooka kwa ziwalo.

Zingakhale zovuta kuthana ndi malingaliro omwe amabwera ndi matenda monga `(Corticobasal Degeneration)`. Mutha kukhala ndi mantha komanso nkhawa za tsogolo. Zizindikiro zikamakula pakapita nthawi, mungadabwe momwe mungagwiritsire ntchito bwino mphindi iliyonse. Zingakhale zovuta kuthana ndi zonsezi nthawi imodzi. Mungafunenso kulankhula ndi katswiri wa zamaganizo kuti akuthandizeni panthawi yovutayi.

Kumbukirani kuti simuli nokha pa zonsezi. Ngati mukufuna thandizo, musazengereze kulankhulana ndi gulu lanu lachipatala.

Pomaliza, zinthu zoti muzikumbukira

Chabwino, nazi zina mwa zinthu zomwe takambirana zokhudza `(Corticobasal Degeneration)` zomwe ndikuganiza kuti zidzakhala zofunika kwa inu:

• Imeneyi ndi vuto lomwe limakhudza ubongo ndipo zizindikiro zimawonjezeka pang'onopang'ono pakapita nthawi.
• Choyambitsa chenicheni cha izi sichinapezekebe, koma akuganiziridwa kuti chikugwirizana ndi puloteni yotchedwa `(Tau)`.
• Pakadali pano palibe mankhwala ochiritsira matendawa kwathunthu.
• Komabe, pali mankhwala ochiritsira zizindikiro ndikupangitsa moyo kukhala wosavuta.(Monga mankhwala, physiotherapy, occupational therapy, speak therapy).
• Ndikofunikira kufunafuna upangiri wa dokotala mwachangu.
• Konzani zamtsogolo ndipo pezani chithandizo chomwe mukufuna.
• Simuli nokha. Ndikofunikanso kukhala olimba m'maganizo. Pezani thandizo kwa madokotala, abale, ndi anzanu.

Ndikukhulupirira kuti izi zikuthandizani. Ngati muli ndi mafunso aliwonse, musazengereze kulankhula ndi dokotala wanu.

Kuchepa kwa Corticobasal, Matenda a Ubongo, Matenda a Mitsempha, Matenda Oyenda, Kulephera Kukumbukira, Matenda Olankhula, Mapuloteni a Tau, CBS, Kufooka kwa Ubongo, Apraxia, Aphasia, Dementia