Kodi Felty Syndrome ndi chiyani? Izi ndizofunikira kwa inu omwe muli ndi nyamakazi!

Mungakhalenso ndi ululu wa mafupa, kutupa, komanso kuuma pang'ono m'miyendo yanu m'mawa, sichoncho? Nthawi zambiri, izi zimatha kuyambitsidwa ndi nyamakazi. Koma kodi mumadziwa kuti pali vuto lina lomwe lingabwere ndi vuto la nyamakazi ili, koma silikudziwika bwino, koma ndikofunikira kudziwa za izi? Imeneyo ndi Felty Syndrome. Tiyeni tikambirane za izi mwatsatanetsatane lero.

Kodi kwenikweni Felty Syndrome ndi chiyani?

Mwachidule, Felty Syndrome ndi kuphatikiza kwa matenda atatu omwe amachitika pamodzi. Awa ndi:

• Matenda a Nyamakazi - Kutupa kwa mafupa komwe ambiri a inu mumakudziwa.
• Neutropenia - Ichi ndi kuchepa kwa chiwerengero cha ma neutrophils, mtundu wa maselo oyera a magazi m'magazi.
• Splenomegaly - Izi zikutanthauza kuti ndulu, yomwe ndi chiwalo m'thupi, imakula kuposa momwe imakhalira.

Nthawi zambiri imayamba ndi nyamakazi ya m'mafupa (RA). Matenda ena awiriwa amapezeka ngati mavuto a RA. Madokotala amatcha izi 'mawonekedwe akunja kwa mafupa'. Izi zikutanthauza kuti, nyamakazi siimalumikizana ndi mafupa okha, koma imakhudza mafupa omwe ali kunja kwa mafupawo. Izi zimachitika chifukwa cha kutupa komwe kumayambitsa nyamakazi. Ngakhale kuti nthawi zambiri mitundu iyi ya zotsatira zimachitika kunja kwa mafupa omwe ali ndi RA, Felty Syndrome ndi vuto losowa kwambiri.

Kodi izi zikukukhudzani bwanji?

Matenda a Felty amayamba ndi Matenda a Nyamakazi. Kenako mumakhala ndi ululu waukulu komanso kutupa m'mafupa anu. Kenako, matenda monga Neutropenia ndi Splenomegaly akachitika, amakhudza chitetezo chamthupi chanu. Neutropenia ndi kuchepa kwa mtundu wa maselo oyera amagazi otchedwa neutrophils. Ma neutrophils awa ndi mtundu wofunikira kwambiri wa maselo omwe amateteza thupi lathu ku matenda. Chifukwa chake akachepa, mwayi wopeza matenda umawonjezeka. Kukulirakulira kwa ndulu kungakhalenso chifukwa china chochepetsera ma neutrophils.

Kodi vutoli ndi lofala bwanji?

Matenda a Felty amapezeka mwa anthu pafupifupi 2% omwe ali ndi nyamakazi. Monga RA, matenda a Felty amapezeka kwambiri mwa akazi katatu kuposa amuna. Chochititsa chidwi n'chakuti, pafupifupi anthu onse omwe ali ndi RA omwe ali ndi matenda a Felty ndi 'seropositive'. Izi zikutanthauza kuti mayeso amatsimikizira kuti ali ndi chinthu chotchedwa rheumatoid factor antibodies m'magazi mwawo. Anthu omwe ali ndi 'seronegative', kutanthauza anthu omwe alibe ma antibodies amenewo, nthawi zambiri samakhala ndi matenda a Felty.

Kodi zizindikiro za izi ndi ziti?

Kawirikawiri, zizindikiro zoyamba kuwoneka ndi za nyamakazi. Izi zikuphatikizapo:

• Kupweteka kwa mafupa
• Kutupa kwa mafupa
• Kuuma kwa mafupa, makamaka m'mawa

Anthu ena angakumane ndi zizindikiro zina kuwonjezera pa RA m'mafupa awo. Mwachitsanzo:

• Ziphuphu zomwe zimapangika pansi pa khungu pafupi ndi malo olumikizirana mafupa (izi zimatchedwa rheumatoid nodules)
• Kutupa kwa ma lymph nodes m'malo monga khosi ndi m'khwapa
• Chiwindi chikhoza kutupa ndipo chingakhale chopweteka chikakhudza.
• Maso ndi pakamwa pouma (izi zimatchedwa matenda a Sjogren)
• Maso ofiira, otupa (izi zimatchedwa episcleritis)
• Zilonda za pakhungu, makamaka pa miyendo
• Zizindikiro za kutuluka magazi pansi pa khungu
• Kuvuta kupuma chifukwa cha kutupa kwa mapapo
• Kupweteka pachifuwa chifukwa cha kutupa kuzungulira mtima
• Malungo
• Kutopa ndi ulesi
• Kutaya chilakolako cha chakudya kapena kuchepa thupi kosaneneka

Kuwonjezera pa izi, Felty Syndrome ilinso ndi zizindikiro zina. Nthawi zina zizindikirozi zimatha kuwonekera zizindikiro za RA zisanayambe.

• Matenda obwerezabwereza komanso okhalitsa. Zitsanzo zake ndi chimfine, kupweteka m'mimba, ndi matenda a pakhungu.
• Kutupa kwa ndulu. Kungamveke m'dzanja ndipo kungakhale kopweteka.
• Kusintha kwa mtundu wa khungu (monga mawanga).

Koma chodabwitsa n'chakuti, nthawi zina munthu angazindikire kuti ali ndi Felty Syndrome popanda zizindikiro zilizonse. Kuyezetsa magazi ndi ma scan kungasonyeze kuti muli ndi matenda onse atatu musanamve zizindikiro zilizonse.

Kodi nthawi zambiri izi zimayamba pa msinkhu wanji?

Matenda a Felty nthawi zambiri amakula mwa anthu okalamba, azaka zapakati pa 50 ndi 70. Kwa anthu ambiri, matenda a Felty amaonekera atakhala ndi zizindikiro za nyamakazi kwa zaka pafupifupi 10 mpaka 15.

Nchifukwa chiyani Felty Syndrome imachitika?

Matenda a nyamakazi ndi 'matenda odziteteza okha'. Izi zikutanthauza kuti chitetezo chathu chamthupi chimaukira ziwalo za thupi lathu ngati kuti ndi mdani. Asayansi ambiri amakhulupirira kuti Felty Syndrome ndi vuto lalikulu la RA. Mu matenda odziteteza okha awa, matupi athu amapanga 'ma antibodies' motsutsana ndi mapuloteni ena. Ma antibodies amenewa amapita ndikugwira mapuloteniwo ndikuwadziwitsa kuti awonongeke. Umu ndi momwe kutupa kumakulirakulira.

Ma antibodies amenewa sangakhalepo nthawi zonse mu RA. Komabe, mwa anthu omwe ali ndi Felty Syndrome, ma antibodies amenewa amapezekadi. Kupezeka kwa ma antibodies amenewa ndi chifukwa chomwe RA imakulirakulira komanso zotsatira zina kunja kwa mafupa (extra-articular manifestations) zimawonjezeka. RA yokhala ndi ma antibodies imatchedwa 'seropositive RA'. Kafukufuku akuwonetsa kuti seropositive RA ndi Felty Syndrome zonse zimagwirizanitsidwa ndi 'ma genetic factors' ena. Izi zikutanthauza kuti zimatha kuperekedwa kudzera m'mibadwomibadwo mpaka pamlingo wina.

Kodi nyamakazi ya rheumatoid (RA) imayambitsa bwanji neutropenia ndi splenomegaly?

Momwe Neutropenia Imachitikira

Neutropenia ndi kuchepa kwa chiwerengero cha maselo oyera amagazi otchedwa neutrophils. Pali zifukwa ziwiri zazikulu zomwe zimapangitsa izi. Choyamba ndi chakuti mafupa anu sakupanga ma neutrophils okwanira. Kapena, ma neutrophils m'thupi lanu akuwonongeka. Mu Felty Syndrome, zonsezi zimatha kuchitika. Njira yodziyimira payokha yomwe yatchulidwa kale ikhoza kusokoneza kupanga ma neutrophils mu mafupa, ndipo ma neutrophils omwe apangidwa kale amatha kuwonongeka. Komanso, ndulu yokulirapo ndi chifukwa china chochepetsera ma neutrophils.

Momwe Splenomegaly Imachitikira

Ntchito ya ndulu yanu ndikusefa maselo akale amagazi osafunikira m'magazi anu. Koma ndulu yanu ikakula kwambiri (splenomegaly), imayamba kugwira ntchito mopitirira muyeso ndipo imayamba kuchotsa maselo ambiri abwino amagazi. Matenda a nyamakazi nthawi zina angayambitse ndulu kukula. Chifukwa chenicheni sichinadziwikebe. ndulu imathanso kukula popanda neutropenia. Komanso, nthawi zambiri, Felty Syndrome imatha kuchitika popanda ndulu kukula.

Kodi mavuto oopsa a Felty Syndrome ndi ati?

Popeza Felty Syndrome imafooketsa chitetezo chamthupi chanu, muli pachiwopsezo chachikulu chotenga matenda obwera pafupipafupi komanso oopsa . Ngakhale mutakhala ndi matenda ang'onoang'ono omwe amachiritsidwa mosavuta, vutoli likhoza kukhala lalikulu kwambiri moti limatha kukhala lopitirira ndipo nthawi zina likhoza kupha. Matenda oyambitsidwa ndi mabakiteriya osalamulirika angayambitse matenda oopsa otchedwa sepsis. Anthu omwe ali ndi Felty Syndrome nawonso ali pachiwopsezo chachikulu chotenga mitundu ina ya khansa, monga lymphoma.

Koma musachite mantha mukamva izi. Zoopsazi zilipo, koma zitha kuthetsedwa ndi chithandizo choyenera komanso chisamaliro choyenera.

Kodi mungazindikire bwanji izi?

Madokotala amazindikira matenda a Felty Syndrome akapeza kuti matenda a nyamakazi, neutropenia, ndi splenomegaly zonse zilipo. (Nthawi zambiri, matendawa amatha kudziwika popanda ndulu yokulirapo.)

Mayeso omwe amachitidwa nthawi zambiri ndi awa:

• Kuyezetsa magazi: Kuyezetsa magazi kwathunthu, makamaka kuti muwone kuchuluka kwa ma neutrophils.
• X-ray ya mafupa: Yang'anani nyamakazi.
• Kujambula kwa spleen: Mwachitsanzo, ultrasound kapena CT scan.
• Kufufuza za m'mafupa:Izi zimathandiza kuonetsetsa kuti palibe matenda ena.

Kodi chithandizo cha izi ndi chiyani?

Pali zolinga zitatu zazikulu pochiza Felty Syndrome:

• Kuwongolera vuto lalikulu la Matenda a Nyamakazi.
• Ngati neutropenia ndi yoopsa, perekani chithandizo mwachindunji.
• Kupewa matenda ndi kuwachiza ngati achitika.

Matenda a Felty amatha kukhala chifukwa cha nyamakazi ya m'mafupa (RA) yomwe sinachiritsidwe kapena yosalamuliridwa bwino. Kwa anthu ambiri, neutropenia imakula pamene RA yawo ikukulirakulira. Chifukwa chake, madokotala amayesa kaye kusankha mankhwala othandiza oletsa nyamakazi (DMARDs) ochiza RA. Amayesanso kupewa mankhwala oletsa chitetezo chamthupi momwe angathere.

Pali mitundu ingapo ya DMARD yomwe ingagwiritsidwe ntchito pa Felty Syndrome:

• Methotrexate ndi folic acid (kuchepetsa zotsatira zoyipa za methotrexate)
• Abatacept
• Rituximab
• Leflunomide

Koma ngati neutropenia yanu siikuchira ndi ma DMARD awa, kapena ngati neutropenia yanu ndi yoopsa kwambiri, kapena ngati muli kale ndi matenda, dokotala wanu adzayesa njira zina zochiritsira kuti awonjezere kuchuluka kwa neutrophils yanu. Izi zingaphatikizepo:

• Katemera wotchedwa G-CSF (granulocyte colony-stimulating factor).
• Mankhwala a corticosteroid a nthawi yochepa.
• 'Splenectomy' - Izi zikutanthauza kuchotsa ndulu yomwe ikugwira ntchito mopitirira muyeso.

Komanso, madokotala adzachitapo kanthu kuti akutetezeni ku matenda, makamaka ngati chithandizo chanu chikukhudza chitetezo chanu cha mthupi. Angakulangizeni zinthu monga:

• Kumwa mankhwala opha tizilombo toyambitsa matenda osiyanasiyana.
• Kulandira katemera wofunikira.
• Samalani kwambiri thanzi la pakamwa ndi mano anu.

Ngati munthu amene ali ndi matenda a Felty Syndrome atenga matenda, madokotala amaona kuti ndi ofunika kwambiri. Ngati izi zitakuchitikirani , muyenera kupeza chithandizo nthawi yomweyo . Dokotala wanu adzakupatsani mankhwala amphamvu.

Kodi nthawi ya moyo ndi yotani yokhala ndi Felty Syndrome?

Palibe ziwerengero zomwe zilipo pakali pano zokhudza nthawi yomwe anthu omwe ali ndi Felty Syndrome amakhala ndi moyo. Komabe, kawirikawiri, njira zochiritsira zasintha kwambiri m'zaka zaposachedwa. Chifukwa chake pali mwayi waukulu kuti chithandizo chilichonse chikhale chopambana kwa inu. Chiwopsezo chachikulu cha imfa mu Felty Syndrome chikadali chifukwa cha matenda oopsa . Chifukwa chake, kutenga njira zodzitetezera ku matenda kungapangitse kusiyana kwakukulu pa thanzi lanu la nthawi yayitali.

Felty Syndrome ndi vuto losowa kwambiri komanso lomwe nthawi zambiri silimaganiziridwa la nyamakazi (RA). Ngati mwakhala ndi RA yosalamulirika kwa nthawi yayitali, kapena ngati mankhwala anu asiya kugwira ntchito monga kale, mutha kudwala Felty Syndrome. Anthu ena amadwala popanda zizindikiro zilizonse. Zingakhale zosokoneza pang'ono kudziwa kuti matenda omwe amakhudza mafupa anu amathanso kukhudza maselo anu amagazi.

Ngati muli kale ndi RA, komanso zizindikiro zina, zingakhale zovuta kupeza matenda atsopano. Koma Felty Syndrome siimayambitsa zizindikiro zatsopano zambiri, ndipo sizingafunike chithandizo china chilichonse. Chofunika kwambiri ndikuzindikira zoopsa zake. Mwa kugwira ntchito ndi dokotala wanu kuti muchiritse RA yanu ndikupewa matenda, mutha kuthana ndi Felty Syndrome.

Pomaliza, zinthu zoti muzikumbukira

Matenda a Felty ndi matenda omwe angachitike mwa anthu ena omwe ali ndi nyamakazi ya m'magazi (RA). Amadziwika ndi kuchepa kwa maselo oyera amagazi otchedwa neutrophils m'magazi anu (neutropenia) ndi ndulu yokulirapo (splenomegaly).

• Chiopsezo chachikulu ndi matenda opatsirana pafupipafupi, choncho ndikofunikira kwambiri kudziteteza ku matenda.
• Ngakhale izi zingawoneke zoopsa pang'ono, vutoli lingathe kuthetsedwa bwino ndi chithandizo choyenera chamankhwala ndi upangiri .
• Ngati muli ndi RA, yang'anirani zizindikiro zina izi. Ngati muli ndi nkhawa iliyonse , onetsetsani kuti mwalankhula ndi dokotala wanu. Adzakuthandizani.

Matenda a Felty, Matenda a Nyamakazi, Neutropenia, Splenomegaly, Matenda a Nyamakazi, Kutupa kwa Mafupa, Ma Neutrophils, Spleen, Chitetezo cha Mthupi