Kodi mukudziwa za khansa ya m'mawere ya HER2-Negative? Tiyeni tikambirane!

Mwina mwamvapo zambiri zokhudza khansa ya m'mawere. Koma kodi mukudziwadi kuti khansa yamtunduwu imatchedwa 'HER2-negative'? Imachita mosiyana pang'ono ndi mitundu ina ya khansa ya m'mawere, ndipo chithandizo chake chingakhale chosiyana. Musadandaule, lero tikambirana za 'HER2-Negative Breast Cancer' m'njira yosavuta yomwe mungamvetse, chabwino?

Kodi khansa ya m'mawere ya HER2-Negative ndi chiyani?

Mwachidule, `khansa ya m'mawere ya HER2-negative` imatanthauza kuti maselo a khansa m'mawere mwanu alibe puloteni yapadera yochuluka kapena yochepa kwambiri yotchedwa `human epidermal growth factor 2 (HER2). Kodi mukudziwa kuti khansa ya m'mawere nthawi zambiri imayamba chifukwa cha mahomoni (makamaka estrogen ndi progesterone) kapena chifukwa cha puloteni iyi ya `HER2`? Mwachitsanzo, mu khansa ya m'mawere ya `HER2-positive`, puloteni ya `HER2` imapezeka pamwamba pa maselo, zomwe zimapangitsa kuti maselo a khansa agawikane mwachangu ndikupanga zotupa.

Koma pa milandu ya `HER2-negative`, khansa siikula chifukwa chakuti pali mapuloteni ambiri a `HER2`. Izi zikutanthauza kuti pali zinthu zina zomwe zimakhudzidwa.

Dokotala wanu akamakupezani ndi khansa ya m'mawere, adzafufuza momwe mulili ndi `HER2` (monga zabwino kapena zoipa). Izi ndi makhalidwe apadera a maselo a khansa, omwe timawatcha `biomarkers` , ndipo akamvetsetsa bwino, madokotala amatha kusankha chithandizo choyenera komanso chogwira ntchito kwa inu. Mwamva?

Kodi mitundu ikuluikulu ya khansa ya m'mawere ya HER2-negative ndi iti?

Khansa zambiri za m'mawere zomwe zapezeka pakadali pano ndi za mtundu wa `HER2-negative`. Pali mitundu iwiri ikuluikulu ya khansa iyi, tiyeni tiwone zomwe zili:

1. Khansa ya m'mawere ya HER2-positive ndi HER2-negative (HR+/HER2-) :

Uwu ndi mtundu wofala kwambiri wa khansa ya m'mawere, womwe umapanga pafupifupi 70 peresenti (70%) ya khansa zonse za m'mawere. Pankhaniyi, maselo a khansa ali ndi ma receptors omwe amakhudzidwa ndi estrogen hormone (ER+), progesterone hormone (PR+), kapena zonse ziwiri. Mwachidule, mahomoni awa akamangirira ku ma receptors awa, maselo a khansa amayamba kukula. Komabe, mitundu iyi ya khansa siili ndi mapuloteni ambiri a HER2. Ndicho chifukwa chake amatchedwa HR+/HER2-.

2. Khansa ya m'mawere ya HER2-negative receptor ndi HER2-negative (HR-/HER2-) :

Mtundu uwu umapanga pafupifupi 11 peresenti (11%) ya khansa yonse ya m'mawere. Maselo a khansa awa alibe ma receptor a estrogen kapena progesterone. Komanso, monga tanenera kale, puloteni ya `HER2` siili yokwera. Izi zikutanthauza kuti mahomoni kapena puloteni ya `HER2` sizimathandizira kukula kwa khansa iyi . Dzina lina la izi ndi `Triple-Negative Breast Cancer` . Izi zili choncho chifukwa estrogen receptor, progesterone receptor, ndi `HER2` protein zonse ndi `negative` pankhaniyi.

Kodi zizindikiro za khansa ya m'mawere ya HER2-negative ndi ziti?

Ndipotu, zizindikiro za khansa ya m'mawere ya HER2-negative zimafanana kwambiri ndi za khansa ina iliyonse ya m'mawere. Muyenera kudziwa izi:

• Ngati muwona kusintha kwachilendo mu kukula kapena mawonekedwe a bere limodzi kapena onse awiri.
• Ngati muwona chotupa chatsopano, chotupa, kapena kulimba m'bere lanu kapena m'khwapa, makamaka ngati chotupacho sichisintha ndi nthawi yanu ya mwezi uliwonse.
• Kusintha kwa khungu la bere kapena nipple. Mwachitsanzo:
• Kutuluka kwa zinyalala pakhungu, ngati khungu la lalanje
• Khungu limakwinya, limatuluka
• Khungu lokhala ndi mamba
• Kuyabwa kosalekeza
• Kusintha kwa mtundu wa khungu (lofiira, lofiirira, lofiirira, kapena lakuda kwambiri).
• Kutuluka kwa nyini . Izi zitha kukhala zofiira ngati magazi, madzi oyera, kapena mtundu woyera ngati mkaka (ngati simuli ndi pakati kapena mukuyamwitsa).
• Kusinthasintha kwa nipple (ngati sikunalipo kale).

Ndikofunikira kudziwa kuti khansa ya m'mawere si nthawi zonse imayambitsa kusintha koonekeratu m'mawonekedwe anu . Komanso, kusinthaku kungawonekerenso m'matenda abwinobwino (monga ma cysts, fibroadenoma). Ichi ndichifukwa chake ndikofunikira kwambiri kuyang'anira mabere anu nthawi zonse ndikupeza mayeso a khansa ya m'mawere oyenera msinkhu wanu . Ngati muli ndi nkhawa iliyonse yokhudza kusintha, onetsetsani kuti mwawonana ndi dokotala kuti mudziwe ngati ndi chizindikiro cha khansa kapena vuto lina.

Kodi n’chiyani chimayambitsa khansa ya m’mawere ya HER2-negative?

Mwachidule, khansa ya m'mawere ya HER2-negative imayamba chifukwa cha kusintha kwa majini, kapena DNA, m'maselo a m'mawere, otchedwa mutations , zomwe zimapangitsa maselo amenewo kukhala maselo a khansa. Kenako maselo a khansa awa amagawikana ndikuchulukana mwachangu popanda kulamulira, ndikupanga zotupa.

Zinthu Zoopsa

Akatswiri sakudziwabe chomwe chimayambitsa kusintha kwa majini kumeneku mu khansa ya m'mawere ya HER2-negative. Komabe, apeza zinthu zingapo zomwe zingawonjezere chiopsezo chotenga khansa ya m'mawere. Izi zikuphatikizapo:

• Kusintha kwa majini kobadwa nako : Palibe kusintha kwa majini komwe kumakhudzana ndi khansa ya m'mawere yokhudzana ndi HER2. Komabe, ngati wina alandira kusintha kwa majini monga BRCA1 kapena BRCA2, ali pachiwopsezo chachikulu chotenga khansa ya m'mawere (ndi khansa zina) nthawi zambiri.
• Inu kapena wina m'banja mwanu mudadwalapo khansa ya m'mawere.: Ngati mudadwalapo khansa ya m'mawere kale, muli ndi chiopsezo choti ibwererenso. Komanso, ngati achibale anu a m'magazi (makamaka amayi anu, abambo anu, abale anu, ana anu) adakhalapo ndi khansa ya m'mawere, mulinso ndi chiopsezo chachikulu pang'ono.
• Kukumana ndi mahomoni a estrogen kapena progesterone kwa nthawi yayitali : Ngati munayamba kusamba muli aang'ono (monga musanafike zaka 12), kapena ngati munayamba kusamba mochedwa (monga mutatha zaka 55), thupi lanu lakhala likukumana ndi mahomoni ogonana awa kwa nthawi yayitali. Izi zitha kukhalanso chifukwa choopsa. Mankhwala ena olowa m'malo mwa mahomoni amathanso kuwonjezera chiopsezo chanu ngati mutatenga nthawi yayitali.
• Kugwiritsa ntchito mowa : Kafukufuku wapeza kuti kumwa zakumwa zoledzeretsa zoposa chimodzi patsiku kumawonjezera chiopsezo cha khansa ya m'mawere.

Kuonjezera apo, zinthu monga kukalamba, kunenepa kwambiri, komanso kusachita masewera olimbitsa thupi zingawonjezere chiopsezo cha khansa ya m'mawere.

Kodi khansa ya m'mawere ya HER2-negative imapezeka bwanji?

Madokotala nthawi zambiri amazindikira khansa ya m'mawere ya HER2-negative kudzera mu biopsy ya m'mawere . Izi zimaphatikizapo kutenga chidutswa chaching'ono cha minofu kuchokera ku chotupa kapena malo okayikitsa ndikuchitumiza ku labu. Kumeneko, katswiri wa matenda amafufuza chitsanzocho pansi pa maikulosikopu kuti aone ngati pali maselo a khansa.

Ngati maselo a khansa atsimikizika, mayeso apadera amachitidwa kuti awone kuchuluka kwa mapuloteni a `HER2` omwe alipo pamwamba pa maselo a khansawo, kapena makope angati a jini ya `HER2` omwe alipo.

• Ngati muli ndi puloteni kapena jini ya `HER2` yokwanira (yochepa), muli ndi khansa ya m'mawere ya `HER2-negative`.

Mayeso awiri akuluakulu a labotale omwe amachitika pachifukwa ichi ndi awa:

1. Immunohistochemistry (IHC) : Mayesowa amagwiritsa ntchito ma antibodies ndi utoto wapadera kuti azindikire mapuloteni a HER2 pamwamba pa maselo a khansa. Ngati zotsatira za IHC ndi 0 kapena 1+, khansa imaonedwa kuti ndi HER2-negative. Ngati zotsatira zake ndi 2+ (nthawi zina zimatchedwa "equivocal" kapena "borderline"), mayeso otchedwa FISH amachitidwanso kuti atsimikizire momwe HER2 ilili.

2. Kusakaniza kwa Fluorescence in situ (NSOMBA) : Kuyesaku kumayang'ana kuchuluka kwa makope a jini ya HER2, yomwe imapanga puloteni ya HER2, omwe amapezeka m'maselo a khansa. Izi zimagwiritsa ntchito maikulosikopu yapadera ndi zizindikiro za fluorescent (zotulutsa kuwala). Ngati zotsatira za mayeso a IHC sizikudziwika, monga 2+, mayeso a NSOMBA amatha kutsimikizira motsimikiza kuti HER2 ili ndi vuto (loipa kapena labwino).

Kuwonjezera pa mayeso a `HER2` awa, katswiri wa matenda adzayang'ananso chitsanzo cha biopsy ndikuyang'ana kupezeka kwa estrogen receptors (ETU) ndi progesterone receptors (PR) mu khansa.

Mungafunikenso kuchitidwa njira zojambulira zithunzi monga mammogram, ultrasound, CT scan, kapena MRI scan kuti mudziwe siteji ya khansa yanu (ndiko kuti, kuona kukula kwa chotupacho komanso ngati chafalikira ku ma lymph nodes kapena mbali zina zakutali za thupi).

Dokotala wanu adzaphatikiza zonsezi (mkhalidwe wa HER2, mkhalidwe wa HR, gawo la khansa, ndi makhalidwe a khansa) kuti apange dongosolo loyenera kwambiri la chithandizo kwa inu.

Kodi mankhwala a khansa ya m'mawere ya HER2-negative ndi ati?

Chithandizo chabwino kwambiri cha khansa ya m'mawere ya HER2-negative chingasiyane malinga ndi munthu aliyense. Zimatengera zinthu zambiri, kuphatikizapo gawo la khansa yanu, kaya ndi hormone receptor-positive kapena negative (HR+/HER2- kapena HR-/HER2-), komanso thanzi lanu lonse.

Kawirikawiri, mankhwala angaphatikizepo:

• Opaleshoni ya khansa ya m'mawere : Kuchotsa chotupa cha khansa komanso minofu yathanzi yozungulira. Imeneyi ingakhale opaleshoni ya lumpectomy, yomwe imachotsa gawo la bere, kapena opaleshoni ya mastectomy, yomwe imachotsa bere lonse.
• Chithandizo cha radiation : Radiation yamphamvu kwambiri imagwiritsidwa ntchito kuwononga maselo aliwonse a khansa omwe angakhalepo pambuyo pa opaleshoni, kapena kuchepetsa chotupacho musanachite opaleshoni.

Kuwonjezera pa mankhwala oyambira awa, palinso mankhwala ena enieni kutengera mtundu wa khansa:

Chithandizo cha khansa ya m'mawere ya HR+/HER2- (yomwe ili ndi receptor-positive, HER2-negative)

Popeza khansa yamtunduwu imadalira mahomoni, njira zimenezi ndizofunikira kwambiri kuwonjezera pa opaleshoni ndi/kapena chithandizo cha radiation:

• Chithandizo cha mahomoni : Mankhwalawa amagwira ntchito pochepetsa kuchuluka kwa mahomoni otchedwa estrogen kapena progesterone omwe amathandiza khansa kukula, kapena poletsa mahomoni amenewo kuti asamamatire ku maselo a khansa. Mwachitsanzo:
• Mankhwala oletsa kutupa (monga Anastrozole, Letrozole, Exemestane)
• Ma agonist a gonadotropin-releasing hormone (GnRH) (amaletsa mazira kupanga mahomoni)
• `Ma modulators osankha a estrogen receptor (SERMs)` (monga Tamoxifen, Raloxifene)

Nthawi zina, mungafunike opaleshoni (oophorectomy) kuti muchotse mazira anu, omwe amapanga estrogen. Chithandizo cha mahomoni chingaperekedwe chokha kapena kuphatikiza ndi chithandizo cholunjika kwa zaka zingapo.

• Chithandizo Cholunjika : Mankhwalawa amayang'ana zofooka zinazake m'maselo a khansa ndipo amawaukira kuti aletse kukula ndi kufalikira kwa maselo a khansa. Pa khansa ya HR+/HER2, mankhwala otchedwa CDK4/6 inhibitors (monga Palbociclib, Ribociclib, Abemaciclib) amagwiritsidwa ntchito limodzi ndi mankhwala a mahomoni. Izi zimaletsa enzyme yomwe imayang'anira kugawikana kwa maselo a khansa.
• Chemotherapy: Kwa khansa zina za m'mawere za HR+/HER2, makamaka ngati khansayo yafalikira kapena yamphamvu, madokotala angalimbikitse chemotherapy pamodzi ndi mankhwala a mahomoni ndi/kapena chithandizo cholunjika.

Chithandizo cha khansa ya m'mawere ya HR-/HER2- (triple-negative)

Popeza khansa ya m'mawere yokhala ndi ma triple-negative siidalira mahomoni, chithandizo cha mahomoni sichigwira ntchito. Kuwonjezera pa opaleshoni ndi/kapena chithandizo cha radiation, mankhwala otsatirawa amagwiritsidwa ntchito kwambiri:

• Chemotherapy : Chemotherapy ndi mankhwala ofunikira kwambiri a khansa ya triple-negative. Madokotala amagwiritsa ntchito mitundu yosiyanasiyana ya mankhwala a chemotherapy. Angapereke mankhwala amodzi kapena kuphatikiza mankhwala angapo.
• Chithandizo cha Immunotherapy : Ichi ndi chithandizo chatsopano. Chimagwira ntchito polimbikitsa chitetezo cha mthupi lanu kuti chizindikire ndikuwononga maselo a khansa. Pembrolizumab (Keytruda®) ndi mankhwala ochiritsira matenda omwe amavomerezedwa ndi Food and Drug Administration (FDA) ndipo amaperekedwa pamodzi ndi chemotherapy pa mitundu ina ya khansa ya m'mawere yopanda katatu.
• Chithandizo Cholunjika : Pa khansa ya triple-negative yokhala ndi kusintha kwa majini a BRCA, mankhwala olunjika otchedwa PARP inhibitors (monga Olaparib, Talazoparib) amagwiritsidwa ntchito. Komanso, pa matenda ofalikira, mitundu yatsopano ya mankhwala olunjika (monga ma antibodies-drug conjugates) tsopano ikupezeka.

Kodi zotsatirapo zake ndi ziti?

Ngakhale kuti mankhwala a khansa amatha kulimbana bwino ndi khansa, mankhwala onse, kuphatikizapo chemotherapy, radiation therapy, hormone therapy, target therapy, ndi immunotherapy, angayambitse zotsatira zina zoyipa. Izi zitha kukhala zakanthawi kapena nthawi yayitali. Mwachitsanzo, kutopa, nseru, kusanza, kutayika tsitsi, kusowa chilakolako cha chakudya, zilonda pakamwa, kusintha kwa khungu, kutsegula m'mimba kapena kudzimbidwa, komanso kuchepa kwa maselo amagazi.

Onetsetsani kuti mwalankhula ndi dokotala wanu za zotsatirapo zake, nthawi yomwe zidzakhalire, komanso momwe mungathanirane nazo. Angakutumizireninso kwa akatswiri odziwa za chisamaliro cha khansa . Chisamaliro cha khansa sikuti chimangokhudza magawo omaliza a khansa, komanso chimakuthandizani kukhala ndi moyo wabwino mwa kuwongolera zizindikiro ndi zotsatirapo zake panthawi yonse ya chithandizo.

Kodi chiŵerengero cha mankhwala a khansa ya m'mawere ya HER2-negative ndi chiyani?

Mu khansa zonse za m'mawere za HER2-negative, kuchuluka kwa kupulumuka kumakhala kwakukulu kwambiri pamene khansayo ili m'mawere okha ndipo sinafalikire (gawo lapafupi) kuposa pamene khansayo yafalikira ku ziwalo zakutali m'thupi (monga chiwindi, mapapo, ubongo, mafupa) (khansa yofalikira kapena gawo lakutali).Chiŵerengero cha kupulumuka kwa khansa zomwe zafalikira ku ma lymph nodes apafupi koma sizinafalikire ku ziwalo zakutali (gawo lachigawo) chili pakati.

Komabe, ndikofunikira kukumbukira kuti mwayi wanu wochira, kapena kuti matenda anu adzathe bwanji, zimadalira zinthu zomwe zimadalira matenda anu. Izi zikuphatikizapo momwe khansa yafalikira (gawo), kaya khansa ili ndi mahomoni olandirira (HR+/HER2- kapena HR-/HER2-), momwe maselo a khansa alili amphamvu (kalasi), zaka zanu, thanzi lanu lonse, komanso momwe mumayankhira chithandizo. Izi ndi zinthu zomwe dokotala wanu angakuuzeni ndikukufotokozerani zomwe mungayembekezere. Ziwerengero ndi zapakati chabe, ndipo sizidzakhala zofanana kwa aliyense.

Kodi ndimadzisamalira bwanji? (Kudzisamalira)

Kaya ndinu munthu amene ali ndi khansa ya m'mawere ya HER2-negative yomwe ili pamlingo woyambirira kapena amene ali ndi khansa yoopsa, ndikofunikira kutenga nthawi yodzisamalira. Izi zidzakuthandizani mwakuthupi komanso m'maganizo. Nazi zina zomwe mungachite:

• Pumulani mukafunika kupuma : Ndi zachilendo kumva kutopa komanso kutopa, chifukwa cha mankhwala a khansa komanso khansa. Mukatopa, pumulani pang'ono ndikupumula. Mvetserani thupi lanu.
• Idyani zakudya zabwino komanso zopatsa thanzi : Mankhwala ena a khansa angakhudze chilakolako chanu cha chakudya komanso kukoma kwanu. Koma yesani kudya zakudya zopatsa thanzi kuti mupeze michere yomwe thupi lanu limafunikira. Phatikizani zipatso, ndiwo zamasamba, ulusi, ndi zakudya zokhala ndi mapuloteni ambiri. Ngati simukudziwa zakudya zomwe mungadye ndi zomwe simukudya, funsani katswiri wa zakudya kuti akupatseni upangiri.
• Kuchita masewera olimbitsa thupi (koma musapitirire) : Ndikofunikira kuchita masewera olimbitsa thupi nthawi zonse pamlingo woyenera kwa inu, monga momwe dokotala wanu akulangizira. Ngakhale kuyenda pang'ono kapena yoga kungakhale bwino. Kungakuthandizeni kukhala ndi mphamvu, kusintha momwe mukumvera, komanso kuchepetsa zotsatirapo zake. Komabe, funsani dokotala wanu mtundu wa masewera olimbitsa thupi oyenera kwa inu komanso kuchuluka kwa zomwe muyenera kuchita, kutengera matenda anu ndi chithandizo chanu.
• Kuwongolera kupsinjika maganizo : Ndizachibadwa kumva kupsinjika maganizo, kuda nkhawa, komanso kuchita mantha ndi matenda ngati awa. Pezani njira zothanirana ndi vutoli zomwe zingakuthandizeni. Ngakhale kuti kuchita masewera olimbitsa thupi osinkhasinkha ndi kupuma kumathandiza kwa ena, ena angakonde kuchita zinthu zolenga monga kuwerenga buku, kumvetsera nyimbo, kujambula, kapena kulima dimba. Patulani nthawi tsiku lililonse kuti muchite chilichonse chomwe chimakuthandizani kukhala bata komanso kumasuka.
• Pezani chithandizo chamaganizo: Ndikofunikira kukambirana za momwe mukumvera ndi achibale anu komanso anzanu apamtima. Zingakhalenso zolimbikitsa kwambiri kulumikizana ndi ena omwe akudwala khansa ndikugawana zomwe akumana nazo. Funsani dokotala wanu za magulu othandizira kapena mapulogalamu opulumutsa khansa.

Ndiyenera kupita kwa dokotala liti?

Ndikofunikira kwambiri kuti nthawi zonse muzilankhulana ndi dokotala wanu, panthawi ya chithandizo komanso pambuyo pake.

• Ngati mukupeza zizindikiro zatsopano (monga kupweteka kosalekeza, chotupa chatsopano, kupuma movutikira, kuchepa thupi kosadziŵika), kapena ngati zizindikiro zanu zikuoneka kuti zikuipiraipira , pitani kwa dokotala nthawi yomweyo .
• Pambuyo pa chithandizo, dokotala wanu adzakonza nthawi yokumana ndi dokotala nthawi ndi nthawi . Onetsetsani kuti mwasunga nthawi yokumana ndi dokotala. Izi ndi zowunikira ngati matenda anu abwereranso, kuthana ndi zotsatirapo zoyipa za chithandizo kwa nthawi yayitali, komanso kuwona thanzi lanu lonse. Nthawi yokumana ndi dokotala ndi yofunika kwambiri pazaka zisanu zoyambirira mutalandira chithandizo . Apa ndi pamene khansa imabweranso nthawi zambiri.

Ndi mafunso ati omwe ndiyenera kufunsa dokotala wanga?

Mukamalankhula ndi dokotala wanu, musaope kufunsa mafunso aliwonse omwe muli nawo, ngakhale atakhala ang'onoang'ono bwanji. Nazi mafunso ena omwe mungafunse kuti akuthandizeni:

• Kodi cholandirira changa cha mahomoni a khansa chili ndi ubwino kapena kuipa?
• Kodi mtundu ndi gawo lanji la khansa yanga?
• Kodi mukundilangiza chithandizo chanji? Chifukwa chiyani?
• Kodi zotsatirapo zake za nthawi yochepa komanso yayitali ndi ziti zomwe mungayembekezere kuchokera ku mankhwalawa? Kodi tingatani kuti tichepetse zotsatira zake?
• Kodi chithandizo chimatenga nthawi yayitali bwanji?
• Kodi mungandiuze chiyani za matenda anga?
• Kodi ndingapitirize ntchito zanga za tsiku ndi tsiku (ntchito, ntchito zapakhomo) panthawi ya chithandizo?
• Kodi pali zinthu zina zapadera zomwe ndiyenera kusamala nazo pankhani ya zakudya ndi masewera olimbitsa thupi?
• Kodi ndingatani kuti ndichepetse chiopsezo chobwereranso kwa khansa?
• Ngati ndikufuna thandizo kapena uphungu, kodi ndingapeze munthu woti andithandize?

Ndi bwino kulemba mafunso awa ndikuwafunsa, kuti musaiwale chilichonse.

Kodi ndi bwino kukhala ndi HER2-positive kapena negative?

Funso limene anthu ambiri amafunsa ndi ili. Koma n'kovuta kupereka yankho losavuta pa funsoli, chifukwa zoona zake n'zakuti 'zimadalira' .

Mwachitsanzo, khansa ya m'mawere ya HER2-positive imakonda kukula mofulumira komanso kukhala yamphamvu kwambiri kuposa khansa ya HER2-negative. Komabe, pali ubwino wa izi. Pali njira zinazake zochiritsira zomwe zingagwiritsidwe ntchito polimbana ndi mapuloteni a HER2, mwachitsanzo, Herceptin, Perjeta, ndipo ndi zothandiza kwambiri pa khansa ya HER2-positive. Mankhwalawa sagwira ntchito pa khansa ya HER2-negative, chifukwa khansa imeneyo ilibe mapuloteni ambiri a HER2 oti iwagwiritse ntchito.

Kumbali inayi, ngati khansa ya `HER2-negative` ili ndi `HR+` (hormone receptor-positive), kutanthauza mtundu wa `HR+/HER2-`, ndiye kuti pali mankhwala othandiza kwambiri a mahomoni ndi mankhwala ochizira monga `CDK4/6 inhibitors`. Ndipotu, khansa ya m'mawere ya `HR+/HER2-` imaonedwa kuti ndi yabwino kwambiri pakati pa mitundu ya khansa ya m'mawere yomwe ilipo.

Koma ngati khansa ili ndi `HER2-negative` (HR-) (hormone receptor-negative), kutanthauza kuti, katatu-negative, nthawi zambiri imakhala yoopsa kwambiri kuposa mitundu ina, ndipo chithandizo chingakhale chovuta pang'ono. Koma tsopano pali mankhwala a chemotherapy, immunotherapy, ndi njira zatsopano zothandizira zimenezo.

Chifukwa chake, sizingatheke kunena kuti chimodzi ndi "chabwino" kapena "choipa" kuposa china. Chofunika kwambiri ndi kuzindikira molondola mtundu wa khansa yanu ndikupeza chithandizo choyenera kwambiri.

Pomaliza, ndiyenera kukuuzani... (Uthenga Wopita Nawo Kunyumba)

Mukapezeka ndi khansa ya m'mawere ya `HER2-negative`, ndi zachilendo kukhala ndi mantha komanso nkhawa. Koma kumbukirani, si mapeto a dziko. Sayansi ndi ukadaulo wazachipatala zapita patsogolo kwambiri masiku ano, ndipo pali njira zambiri zochizira khansa yamtunduwu.

Chofunika kwambiri ndi ichi:

• Kudziwitsidwa bwino za vutoli.
• Nthawi zonse dziwani kusintha kwa thupi lanu, makamaka mabere anu.
• Ngati muli ndi kukayikira kulikonse, pitani kwa dokotala nthawi yake ndipo mupite kuchipatala.
• Kambiranani momasuka komanso moona mtima ndi dokotala wanu, funsani mafunso anu onse, ndipo mumvetse bwino njira zochiritsira.

Kumbukirani, simuli nokha paulendowu. Pali madokotala aluso, anamwino, banja lanu, ndi anzanu apamtima omwe alipo kuti akuthandizeni ndikukuthandizani. Khalani ndi malingaliro abwino, tsatirani malangizo a madokotala anu ndendende, ndipo pezani chithandizo chomwe mukufuna, ndipo mudzatha kuthana ndi vutoli bwino ndikuchira. Khalani olimba mtima!

Khansa ya m'mawere , HER2-negative, zizindikiro za khansa, chithandizo cha khansa, thanzi la amayi, chithandizo cha mahomoni, katatu-negative