Kodi khansa yanu ya m'mawere ndi HER2-Negative? Tiyeni tikambirane izi mwachidule! (HER2-Negative Breast Cancer)

Ndikudziwa kuti n'zovuta kufotokoza m'mawu zomwe mumamva dokotala wanu akakuuzani kuti muli ndi khansa ya m'mawere. N'zachibadwa kukhala ndi mafunso ndi mantha ambiri omwe akubwera m'maganizo mwanu. Koma chimodzi mwazinthu zofunika kwambiri zomwe zingakuthandizeni paulendo wovutawu ndikumvetsetsa mtundu weniweni wa khansa yanu. Kudziwa gawo la khansa, mtundu wake, kukula kwake, ndi mapuloteni ena omwe ali m'maselo anu a khansa ndikofunikira kwambiri posankha chithandizo.

Mwachidule, kodi HER2-Negative ndi chiyani?

Tiyeni timvetse izi motere. Maselo m'thupi lathu ali ngati nyumba zazing'ono. Nyumbazi zili ndi 'ma antenna' apadera omwe amalandira mauthenga ochokera kunja. Mu zamankhwala, timatcha ma receptor awa. Ndi kuchokera ku ma antenna awa komwe selo limalandira mauthenga monga 'kukula' ndi 'kugawa'.

HER2 (Human Epidermal Growth Factor Receptor 2) ndi imodzi mwa antenna yapadera. HER2 imathandiza kuwongolera kukula kwa maselo athanzi. Komabe, maselo a khansa nthawi zina amapanga antenna ya HER2 yambiri, kuposa masiku onse. Kenako khansa imalandira uthenga wokhazikika woiuza kuti 'ikule', ndipo khansa imayamba kufalikira mwachangu kwambiri. Timatcha vutoli kuti HER2-Positive .

Choncho, ngati dokotala wanu akunena kuti khansa yanu ya m'mawere ndi HER2-negative , zikutanthauza kuti maselo anu a khansa alibe antenna yowonjezera ya HER2. Mwachidule, khansa yanu ilibe chinthu chachikulu chomwe chimapangitsa kuti ikule mofulumira.

Kodi mungadziwe bwanji momwe khansa yanu ilili ndi HER2?

Zizindikiro za khansa ya HER2-negative ndi HER2-positive zimafanana. Dokotala wanu sangakuuzeni mtundu wa khansa yomwe muli nayo pongokuyang'anirani. Iye adzafunika kutenga chitsanzo cha khansa yanu (biopsy) ndikuyesa. Kuyesa kumeneku kudzatsimikizira kuchuluka kwa mapuloteni a HER2 omwe ali m'maselo a khansa.

Tiyenera kuyang'ana zambiri osati HER2 yokha!

HER2 si chinthu chokhacho chomwe chimakhudza kukula kwa khansa. Pali mitundu ina iwiri ya ma receptor ( ma hormone receptors - HR) m'thupi lathu omwe amakhudzidwa ndi mahomoni.

• Zolandirira Estrogen (ER)
• Zolandirira Progesterone (PR)

Ngati ma receptor awa alipo pa maselo a khansa, mahomoni a estrogen ndi progesterone angathandize khansa kukula. Madokotala amakambirana za ma receptor onsewa pamodzi. Izi zikutanthauza kuti khansa yanu ya HER2-negative ikhoza kugawidwa m'mitundu iwiri:

1. Khansa ya HR-Positive / HER2-Negative: Izi zikutanthauza kuti khansa siikhudzidwa ndi HER2, koma imakhudzidwa ndi mahomoni. Iyi ndi khansa ya m'mawere yofala kwambiri .

2. HR-Negative / HER2-Negative: Izi zikutanthauza kuti khansayo siikhudzidwa ndi HER2 kapena mahomoni. Chifukwa ma receptor onse atatuwa (HER2, ER, PR) akusowa, mtundu uwu umatchedwanso Triple Negative .

Kudziwa zonsezi kudzakuthandizani inu ndi dokotala wanu kudziwa bwino momwe khansa yanu imakhudzira thupi lanu, zomwe zingakuthandizeni kusankha njira yoyenera komanso yothandiza kwambiri yothandizira khansa yanu.

Kodi mankhwala a khansa ya HER2-negative ndi ati?

Popeza khansa yanu ili ndi HER2-negative, simudzapatsidwa chithandizo cholunjika, chomwe chimayang'ana puloteni ya HER2. Izi zili choncho chifukwa mankhwalawo amafunika kukhala ndi antenna ya HER2 pa maselo a khansa kuti agwire ntchito. M'malo mwake, mankhwala ena adzasankhidwa kutengera gawo la khansa yanu komanso ngati imakhudzidwa ndi mahomoni.

• Opaleshoni ndi radiation: Ngati khansa yapezeka msanga, opaleshoni ikhoza kuichotsa kwathunthu. Chithandizo cha radiation chingalimbikitsenso opaleshoni isanayambe kapena itatha.

• Chithandizo cha Endocrine/ Hormone : Chithandizochi n'chofunika kwambiri ngati khansa yanu ili ndi HR-Positive/HER2-Negative. Chimagwira ntchito pochepetsa kuchuluka kwa mahomoni monga estrogen m'thupi. Pamene mahomoniwo atha, maselo a khansa amataya uthenga woti akule, ndipo khansayo ikhoza kuchepa kapena kusiya kukula.

• Chemotherapy: Chemotherapy nthawi zina ingaperekedwe pamodzi ndi mankhwala a mahomoni a khansa ya HR-positive / HER2-negative. Izi zimadalira zinthu monga siteji ndi giredi ya khansa, zaka zanu, ndi thanzi lanu lonse. Nthawi zina zotsatira zoyipa za chemotherapy zimatha kuposa zabwino zake, choncho ndikofunikira kulankhula ndi dokotala wanu za zomwe zili zabwino kwa inu.

• Chithandizo cha Immunotherapy: Ngati khansa yanu ili ndi triple negative ndipo yapita patsogolo, ndipo ili ndi puloteni ina yotchedwa PD-L1, chithandizochi chingakhale njira ina. Chimagwira ntchito polimbikitsa chitetezo cha mthupi lanu kuti chigonjetse khansa.

Chiyembekezo ndi Kuneneratu Zamtsogolo

Chofunika kwambiri pa khansa ya m'mawere ndikupeza khansayo isanafalikire ku ziwalo zina za thupi. Ngati khansa yanu ya HER2-negative ili m'bere, kuchuluka kwa moyo wa zaka 5 kumakhala kwakukulu kwambiri. Izi ndi zoona makamaka ngati khansa yanu ili ndi HR-positive.

Khansa zitatu zopanda khansa zimakhala zovuta kuzichiza chifukwa sizimayankha chithandizo cha mahomoni kapena mankhwala ochizira a HER2. Zingakhalenso zankhanza kwambiri.

Pansipa pali kuchuluka kwa zaka 5 zomwe munthu angapulumuke kutengera gawo la khansa. Izi ndi avareji chabe, kumbukirani kuti mkhalidwe wanu ukhoza kukhala wosiyana.

Musachite mantha ndi ziwerengerozi. Izi ndi ziwerengero chabe kuchokera kwa anthu masauzande ambiri. Kawonedwe kanu ka munthu payekha kamadalira zinthu zambiri, kuphatikizapo momwe thupi lanu limayankhira chithandizo ndi thanzi lanu lonse. Chifukwa chake, lankhulani ndi dokotala wanu za matenda anu ndi mayeso ena aliwonse omwe mungafunike.