Tiyeni tiphunzire za mtundu watsopano wa mankhwala ochepetsa cholesterol (PCSK9 Inhibitors)?

Kodi dokotala wanu wakuuzani kuti muli ndi cholesterol yambiri? Ngati ndi choncho, mwina munayamba kumwa statin. Nthawi zambiri imeneyi ndi njira yoyamba yochizira. Koma nthawi zina mankhwala okhawo sakwanira. Kapena anthu ena sangapirire zotsatirapo za mankhwalawo. Ndicho chifukwa chake madokotala tsopano akulankhula za gulu latsopano la mankhwala omwe 'amasintha kwambiri'. Mankhwalawa amatchedwa PCSK9 Inhibitors. Tiyeni tikambirane za iwo mwachidule lero.

Mwachidule, kodi ma PCSK9 Inhibitors amenewa ndi chiyani?

Awa ndi mankhwala atsopano omwe angathe kuchepetsa bwino cholesterol 'yoipa', kapena LDL cholesterol , m'magazi mwathu. Pakadali pano pali mitundu iwiri ikuluikulu ya mankhwala ovomerezeka padziko lonse lapansi. Mankhwalawa ndi `alirocumab (Praluent)` ndi `evolocumab (Repatha)`.

Kafukufuku wasonyeza kuti mankhwala awa, otchedwa PCSK9 inhibitors, ndi othandiza kwambiri. Nthawi zina, amathanso kupewa matenda a mtima ndi sitiroko . Mankhwalawa amatha kumwedwa okha, kapena kuphatikiza ndi mankhwala a statin omwe mwamwa kale. Koma chinthu chimodzi choyenera kukumbukira ndichakuti ndi okwera mtengo kwambiri kuposa mankhwala ena a cholesterol.

Chabwino, tsopano tiyeni tiwone momwe mankhwalawa amagwirira ntchito mkati mwa thupi.

Kuti timvetse izi, tiyeni tiganizire nkhani yaying'ono. Chiwalo chachikulu chomwe chimayang'anira cholesterol m'thupi lathu ndi chiwindi.

Koma pali puloteni ina yotchedwa PCSK9 yomwe matupi athu amapanga. Ntchito yake ndi kupeza ndikuwononga "zotsukira" zabwinozo. Kenako, chifukwa palibe wochotsa cholesterol, imasonkhana m'magazi ndikuyikidwa m'makoma a mitsempha.

Apa ndi pomwe sipika yathu, mankhwala oletsa PCSK9, amathandiza. Chomwe mankhwalawa amachita ndikutenga puloteni yoyipa ya PCSK9 ndikuyiletsa kugwira ntchito. Zili ngati kugwira mwana wopusa ndikumuyika pampando. Kenako "oyeretsa" athu amatha kugwira ntchito yawo popanda choletsa chilichonse. Zotsatira zake? Mlingo wa cholesterol ya LDL m'magazi umachepa mwachangu.

Kodi izi zimasiyana bwanji ndi 'statins'?

Ma Statins ndi ma PCSK9 inhibitors ndi mitundu iwiri ya mankhwala omwe amachepetsa cholesterol, koma amagwira ntchito m'njira ziwiri zosiyana. Tebulo ili likuthandizani kumvetsetsa izi.

Ndiye ndani akufuna kumwa mankhwalawa?

Funso ili ndi lofunika chifukwa si aliyense amene ali ndi cholesterol yambiri amene amafunikira mankhwalawa. Dokotala wanu choyamba adzayesa kuwongolera cholesterol yanu ndi ma statins. Koma dokotala wanu angaganizire zoletsa PCSK9 pazochitika zotsatirazi:

• Matenda a cholesterol yambiri m'majini: Anthu ena ali ndi vuto la chibadwa lotchedwa ``Familial Hypercholesterolemia.'' Anthu awa ali ndi vuto pa momwe thupi lawo limalamulira cholesterol. Ngakhale atakhala ndi mlingo waukulu wa ma statin, zimakhala zovuta kwambiri kuti anthuwa achepetse cholesterol ya LDL kufika pamlingo wabwinobwino.
• Kwa anthu omwe ali pachiwopsezo chachikulu cha matenda a mtima kapena sitiroko: Ngati muli kale ndi matenda a mtima, ndipo kuchuluka kwa cholesterol m'magazi anu sikukulamulidwa mokwanira ndi mankhwala monga ma statins, dokotala wanu angaganizire za mankhwalawa.
• Kwa iwo omwe sangalolere 'ma statin': Pafupifupi 10%-20% ya anthu omwe amamwa ma statin amakumana ndi zotsatirapo zoyipa monga kupweteka kwa minofu, kufooka, komanso kupweteka kwa thupi . Kwa anthu amenewo, iyi ikhoza kukhala njira yabwino.

Kodi dokotala amapereka liti mankhwala awa?

Dokotala sangapereke mankhwala awa nthawi imodzi. Pali njira yochitira izi.

1. Choyamba, sinthani moyo wanu: Dokotala choyamba akunena kuti muzichita masewera olimbitsa thupi bwino ndikudya zakudya zopatsa thanzi zomwe zili ndi mafuta ochepa, shuga, ndi ufa .

2. Kenako, 'Statin': Ngati kusintha kwa moyo sikukwanira, statin imayamba. Ngati cholesterol siitsika, mlingo umawonjezeka pang'onopang'ono.

3. Pomaliza: Ngati cholesterol yanu siikulamulidwa ngakhale mutapatsidwa mlingo waukulu wa ma statins, kapena ngati zotsatira zake zili zoopsa, ndiye kuti dokotala wanu angaganizire za PCSK9 inhibitor. Chisankhochi chingapangidwe poyesa, monga coronary calcium score, kuti awone chiopsezo chanu cha matenda a mtima.

Kodi mankhwalawa amagwiritsidwa ntchito bwanji ndipo zotsatira zake ndi ziti?

Imabwera ngati jakisoni wopangidwa pansi pa khungu womwe mumapereka pansi pa khungu milungu iwiri kapena inayi iliyonse . Mutha kuupeza pakhungu la m'mimba mwanu, pamwamba pa ntchafu, kapena pamwamba pa mkono. Dokotala wanu kapena namwino wophunzitsidwa bwino adzakuwonetsani momwe mungaperekere moyenera. Nthawi zambiri sizikhala zopweteka komanso zosavuta.

Ponena za zotsatirapo zake, zomwe zimapezeka kwambiri zimakhala zazing'ono.

• Kupweteka kwa msana
• Zizindikiro zonga chimfine (kuyabwa pakhosi, kutulutsa ntchofu)
• Kufiira, kuvulala, kapena kupweteka pang'ono pamalo omwe adabayidwa jakisoni

Pomaliza, pankhani ya mtengo wa mankhwala awa, si monga mankhwala wamba, ndipo ndi okwera mtengo kwambiri . Chifukwa chake, chithandizochi sichingakhale chotsika mtengo kwa aliyense. Ndi bwino kukambirana momasuka ndi dokotala wanu za izi ndikukambirana ngati mukuchifuna, ngati chili choyenera kwa inu, komanso mtengo wake.