Kodi munayamba mwakhalapo ndi nseru ndi kusanza kwambiri mutachita opaleshoni kapena panthawi ina yaikulu? Kapena munakhalapo ndi nseru ndi kusanza kosalekeza panthawi ya mimba? Zingakhale zosasangalatsa kwambiri moti zingatipangitse kukhala ndi moyo wosasangalatsa. Komabe, pali gulu la mankhwala othandiza kwambiri omwe madokotala amagwiritsa ntchito poletsa nseru ndi kusanza kwamtunduwu. Ndicho chimene tikambirana lero.
Mwachidule, kodi mdani wa serotonin uyu ndi chiyani?
Ili ndi dzina lomwe gulu la mankhwala limapatsidwa. Mwachidule, awa ndi mankhwala omwe amaperekedwa kuti apewe ndi kuchiza nseru ndi kusanza. M'mawu azachipatala, awa amatchedwa `antiemetics`. Ngakhale dokotala wanu sanatchule dzinali mwachindunji, mwina munapatsidwa mankhwala mu gulu ili.
Mayina ena angapo amagwiritsidwa ntchito pa gulu ili la mankhwala:
- Otsutsa a Serotonin-receptor
- Otsutsana ndi ma receptor a 5HT3
- Zoletsa za Serotonin
Ngakhale mayina awa angamveke ngati ovuta pang'ono, onse amatanthauza chinthu chimodzi. Izi zikutanthauza kuti, mankhwala awa amaletsa kugwira ntchito kwa mankhwala enaake m'thupi mwathu otchedwa serotonin . Tiyeni tiwone mwatsatanetsatane.
Pali mitundu ingapo ya mankhwala m'gululi omwe amagwiritsidwa ntchito kwambiri ku Sri Lanka ndi padziko lonse lapansi:
- Ondansetron - Iyi ndi yodziwika kwambiri. Imabwera pansi pa dzina la kampani ya Zofran®.
- Granisetron - imapezeka pansi pa dzina la Kytril®.
- Palonosetron - imapezeka pansi pa dzina la kampani ya Aloxi®.
- Dolasetron - Ngakhale poyamba inkadziwika kuti Anzemet®, tsopano yachotsedwa kugwiritsidwa ntchito m'maiko ngati United States.
Mankhwalawa amapezeka m'mapiritsi ndi m'njira ya jakisoni.
Kodi mankhwalawa amagwiritsidwa ntchito pa chiyani kwenikweni?
Mankhwalawa amavomerezedwa makamaka kuti apewe nseru ndi kusanza m'mikhalidwe ina.
- Mankhwala a khansa (Chemotherapy): Izi ndizofunikira kwambiri poletsa nseru yoopsa yomwe anthu ambiri amakumana nayo akalandira mankhwala a chemotherapy.
- Chithandizo cha khansa pogwiritsa ntchito radiation: Chithandizo cha khansa pogwiritsa ntchito radiation chingayambitsenso nseru.
- Pambuyo pa Anesthesia: Anthu ambiri amasanza ndi nseru akachira pambuyo pochita opaleshoni. Mankhwalawa amaperekedwa kuti apewe izi.
Izi zimaperekedwa ndi madokotala monga momwe ziyenera kukhalira kwa akuluakulu ndi ana.
Nthawi zina madokotala amagwiritsa ntchito mankhwalawa pa matenda ena. Izi zimatchedwa kugwiritsa ntchito "osati chizindikiro". Izi zikutanthauza kuti, amawalembera chifukwa madokotala amadziwa kuti ndi othandiza pa matenda amenewo, ngakhale kuti sakuvomerezedwa pa matenda amenewo.
Zitsanzo zotsatirazi za kugwiritsa ntchito mankhwalawa popanda chizindikiro:
- Kuchiza (osati kungoletsa) nseru ndi kusanza pambuyo pa opaleshoni.
- Kuletsa nseru ndi kusanza kwambiri (kusanza m'mawa) panthawi ya mimba zomwe zimakhala zovuta kuziletsa ndi mankhwala ena.
Kodi mankhwalawa amagwira ntchito bwanji m'thupi lathu?
Kuti timvetse izi, choyamba tiyeni timvetse tanthauzo la 'serotonin'.
Serotonin ndi neurotransmitter m'thupi lathu. Ili ngati 'mthenga'. Mthenga uyu amalamulira zinthu zambiri, kuphatikizapo momwe timamvera, kugona, ndi kugaya chakudya. 90% ya serotonin m'thupi lathu imapezeka m'maselo a dongosolo lathu logaya chakudya (matumbo).
Tangoganizirani, tikalandira mankhwala monga chemotherapy, maselo m'matumbo mwathu amawonongeka. Kenako, maselo amenewo mwadzidzidzi amatulutsa serotonin yambiri m'magazi. Serotonin yochulukirapoyi imatumiza uthenga ku ubongo kuti, "Pali cholakwika apa!" Uthenga umenewo ndi umene umatipangitsa kumva 'nseru' .
Kuti mauthenga a serotonin awa afike ku ubongo, amafunika kumangirira ku 'ma receptor' enaake m'matumbo ndi muubongo mwathu. Izi zili ngati 'mabowo a makiyi' omwe kiyi imalowa. Serotonin ndiye kiyi, ndipo cholandirira ndiye bowo la makiyi. Kiyi ikalowetsedwa bwino, chitseko chimatseguka (monga uthenga wa nseru umatumizidwa).
Mankhwala a `Serotonin Antagonist` amagwira ntchito popita ku ma keybool awa (5-HT3 receptors) ndikutseka. Zili ngati kuyika kiyi yabodza mu keybool. Kenako kiyi yeniyeni (serotonin) singalowe. Uthengawo supita ku ubongo. Zotsatira zake? Kuseweretsa nseru ndi kusanza kumasiya.
Zotsatirapo zoyipa ndi zoopsa za mankhwala
Mankhwalawa nthawi zambiri amakhala otetezeka kwambiri. Komabe, monga mankhwala ena aliwonse, ali ndi zotsatirapo zina komanso zinthu zingapo zofunika kuzidziwa.
Zotsatira zoyipa zofala
- Mutu
- Kutopa
- Kudzimbidwa
Izi nthawi zambiri sizimakhala zoopsa, koma ngati zikukuvutitsani, lankhulani ndi dokotala wanu.
Zoopsa zomwe muyenera kuzidziwa bwino
| Mkhalidwe wa chiopsezo | Zoyenera kudziwa |
|---|---|
| Matenda a mtima | Ngati muli ndi vuto la mtima monga Long QT syndrome , Ventricular arrhythmia , kapena matenda ena a mtima, onetsetsani kuti mwadziwitsa dokotala musanamwe mankhwalawa. Anthu ena angasinthe kugunda kwa mtima wawo chifukwa cha mankhwalawa. |
| Matenda a Serotonin | Uwu ndiye vuto loopsa kwambiri komanso lofulumira. Mukamwedwa limodzi ndi mankhwala ena omwe amawonjezera kuchuluka kwa serotonin (monga SSRIs, SNRIs ya kuvutika maganizo), kuchuluka kwa serotonin m'thupi kumatha kukwera kwambiri. Ndikofunikira kwambiri kuuza dokotala wanu za mankhwala onse omwe mukumwa. |
| Mimba | Ngakhale kuti mankhwalawa alibe chiopsezo chachikulu cha zilema zobadwa nazo, pali kuwonjezeka pang'ono kwa zilema za mtima ndi cleft palate. Chifukwa chake, ayenera kugwiritsidwa ntchito panthawi yapakati pokhapokha ngati dokotala akuwalangiza ngati ubwino wake ukuposa zoopsa zake. |
Zambiri Zokhudza Serotonin Syndrome
Uwu ndi matenda oopsa omwe angayambitse imfa. Dziwani bwino zizindikiro zotsatirazi. Ngati mukukumana ndi chimodzi kapena zingapo mwa izi, pitani ku Dipatimenti Yothandiza Anthu Odwala Mwadzidzidzi (ETU) ya chipatala nthawi yomweyo.
- Kusakhazikika, nkhawa
- Kusanza ndi kusanza
- Kutsegula m'mimba
- Kukula kwa maso
- Kugwedezeka kwa thupi
- Kugwedezeka kwa minofu, kuuma
- Kutuluka thukuta, kumva kuzizira
- Kusokonezeka, kutaya chidziwitso
- Kugunda kwa mtima
- Kuthamanga kwa magazi
- Kutentha kwa thupi kokwera (kupitirira 101.3°F / 38.5°C)
- Kugwidwa ndi khunyu
- Kutaya chidziwitso
Ndiyenera kukaonananso ndi dokotala liti?
Ngati mukumwa mankhwalawa kwa nthawi yayitali, ndikofunikira kuti muzilankhulana ndi dokotala nthawi zonse. Onetsetsani kuti mwalankhula ndi dokotala wanu pazochitika izi:
- Ngati zotsatirapo zake zikuyamba kukuvutitsani.
- Ngati nseru ndi kusanza kwanu sizikuchepa kapena zikuipiraipira.
- Ngati mukuganiza zosiya kumwa mankhwala (musasiye kumwa mankhwala popanda kufunsa dokotala wanu).
Kusanza ndi chinthu chosasangalatsa kwambiri. Koma nkhani yabwino ndi yakuti pali mankhwala othandiza kwambiri omwe alipo masiku ano kuti athetse mavuto otere. Ngati muli ndi vutoli, lankhulani ndi dokotala wanu momasuka ndipo pezani chithandizo chomwe chili choyenera kwa inu.
Uthenga Wopita Nawo Kunyumba
- Serotonin Antagonist ndi mankhwala othandiza kwambiri omwe amaletsa nseru ndi kusanza komwe kumachitika chifukwa cha chithandizo cha khansa, chithandizo cha radiation, ndi opaleshoni.
- Izi zimagwira ntchito poletsa ntchito ya serotonin m'thupi.
- Ngati muli ndi vuto la mtima kapena mukumwa mankhwala ena (makamaka mankhwala oletsa kuvutika maganizo), onetsetsani kuti mwadziwitsa dokotala wanu musanamwe mankhwalawa.
- Dziwani zizindikiro za Serotonin Syndrome (nkhawa, thukuta kwambiri, kuuma kwa minofu, kugunda kwa mtima mofulumira) ndipo pitani ku Dipatimenti Yothandiza Anthu Odwala Zadzidzidzi (ETU) kuchipatala nthawi yomweyo ngati mukukayikira vuto lotere.
- Nthawi zonse pezani ndikugwiritsa ntchito mankhwalawa pokhapokha mutalangizidwa ndi dokotala.
💬 Comments (0)
Palibe ndemanga zomwe zatumizidwa pano. Onjezani ndemanga yanu pano koyamba.
Onjezani ndemanga yanu