Tiyeni tiphunzire zambiri za Triptans pochiza mutu waching'alang'ala.

Kodi mudayamba mwadwalapo mutu womwe umamveka ngati mutu wanu watsala pang'ono kuphulika, womwe umapweteka mbali imodzi yokha? Kodi mumamvanso ngati mukufuna kusanza, simungathe kuyang'ana kuwala, ndikukwiya mukamva phokoso? Izi ndi zomwe timatcha mutu waching'alang'ala. Izi si mutu wamba wamba. Izi ndi matenda okhudzana ndi ubongo. Kwa anthu ena, ululuwu ndi wosapiririka. Chinthu chokha chomwe angachite ndikukhala m'chipinda chamdima, chete ndikudikirira kuti ululuwo uthe. Chifukwa chake ngati mukuvutikanso ndi izi, ndikofunikira kwambiri kuti mudziwe za mtundu wa mankhwala otchedwa `Triptans`.

Kodi Triptans ndi chiyani?

Mwachidule, `Triptans` ndi mtundu wapadera wa mankhwala omwe amaperekedwa pochiza mutu waching'alang'ala. Uwu ndiye mzere woyamba wa chithandizo cha mutu waching'alang'ala. Mankhwalawa sangalepheretse mutu waching'alang'ala kuchitika (kupatulapo pazochitika zingapo zapadera), koma amatha kuwaletsa akangochitika.

Mankhwalawa, otchedwa `Triptans`, adapezeka m'zaka za m'ma 1980 ndipo adasintha kwambiri chithandizo cha mutu waching'alang'ala. `Sumatriptan` inali mankhwala oyamba kuvomerezedwa pachifukwa ichi. `Triptan` ina ingapo idayambitsidwa pambuyo pake.

Kodi ma triptan amagwira ntchito bwanji?

Kuti timvetse izi, choyamba tiyenera kuyang'ana momwe timamvera ululu. Mitsempha m'thupi lathu siimva ululu mwachindunji. M'malo mwake, imatumiza zizindikiro ku ubongo wathu kuti pali china chake m'thupi, monga kuvulala kapena matenda. Ubongo umamasulira zizindikiro zimenezo kukhala zomwe timazitcha "ululu."

Asayansi sakudziwabe 100% momwe mutu umachitikira, koma amakhulupirira kuti pali zinthu zitatu zazikulu zomwe zimapangitsa kuti mutu ukhale wopweteka kwambiri:

1. Kugwira ntchito kwa mitsempha ya m'mitsempha: Pa nthawi ya mutu waching'alang'ala, maselo ena a mitsempha (ma neuron) muubongo amayamba kugwira ntchito mosayenera. Ichi ndi chomwe chimayambitsa ululu ndi zizindikiro zina.

2. Kuyenda kwa magazi kumasintha: Mutu waukulu ukayamba, mitsempha ya magazi muubongo imachepa ndikukulirakulira, zomwe zimasintha kuyenda kwa magazi.

3. Kutupa: Mankhwala ena otupa muubongo amaganiziridwanso kuti amayambitsa mutu waching'alang'ala.

Tsopano tiyeni tiwone momwe `Triptans` imakhudzira machitidwe awa. Ubongo wathu uli ndi `Neurotransmitter` yotchedwa `Serotonin`, mthenga wa mankhwala womwe umanyamula mauthenga pakati pa mitsempha. Mankhwala `Triptans` amagwira ntchito mofanana ndi `Serotonin` iyi. Amalumikizana ndi mitundu itatu yapadera ya `receptor` mu ubongo. Ganizirani za `receptor` izi ngati makiyi a loko, ndipo `Triptans` ali ngati makiyi omwe amawakwanira.

• Ma receptor a 5HT1B: Awa amalamulira kufalikira kwa mitsempha yamagazi muubongo. Ma triptan amayatsa ma receptor awa ndipo amathandiza kuchepetsa mitsempha yamagazi yomwe yakula mosafunikira panthawi ya mutu waching'alang'ala.
• Ma receptor a 5HT1D ndi 5HT1F: Izi zimachepetsa ntchito ya mitsempha yomwe imanyamula zizindikiro za ululu kupita ku ubongo. Izi zikutanthauza kuti, zimaletsa zizindikiro za ululu kufika ku ubongo.

Umu ndi momwe ma triptan amawongolera kupweteka kwa mutu waching'alang'ala ndi zizindikiro zina.

Kodi pali mitundu iti ya ma triptan?

Pali mitundu isanu ndi iwiri ya ma triptan omwe akugwiritsidwa ntchito panopa. Mankhwala onsewa amatha ndi dzina lakuti "-triptan", zomwe zimapangitsa kuti azidziwika mosavuta. Dokotala wanu adzasankha mtundu wa triptan womwe ndi wabwino kwa inu.

Kodi ubwino wa ma triptan ndi wotani?

Ma Triptans ndi othandiza kwambiri kwa anthu omwe ali ndi mutu waching'alang'ala pazifukwa zingapo.

• Zotsatirapo zochepa: Poyerekeza ndi mankhwala a mutu waching'alang'ala omwe adagwiritsidwa ntchito kale, zotsatirapo za Triptans ndizochepa kwambiri, ndipo sizowopsa kwambiri.
• Sizoledzeretsa: Anthu akhoza kukhala oledzeretsa pogwiritsa ntchito mankhwala ochepetsa ululu, makamaka opioid. Komabe, ma triptan saledzeretsa.
• Otetezeka: Kawirikawiri, Triptans ndi gulu la mankhwala otetezeka kwambiri.
• Amapezeka m'njira zosiyanasiyana: Monga mukuonera, mankhwalawa sapezeka ngati piritsi lokha, komanso ngati mankhwala opopera m'mphuno ndi jakisoni. Mankhwala opopera kapena jakisoni angagwiritsidwe ntchito kwa munthu amene akuvutika kumeza mapiritsi kapena kusanza.

Zotsatirapo ndi zinthu zomwe muyenera kudziwa ndi ma triptan

Monga mankhwala ena aliwonse, Triptans ingayambitse zotsatirapo zina zazing'ono. Komabe, si aliyense amene amalandira mankhwalawa, ndipo ngati atero, nthawi zambiri sizikhala zoopsa.

• Chizungulire
• Kugona kapena kutopa
• Kutsuka
• Kusanza
• Kupweteka kwa khosi
• Kutuluka thukuta
• Kusanza m'miyendo
• Kumva kufooka
• Kawirikawiri, mungamve kupweteka pachifuwa kapena kupsinjika.

Ndani sayenera kumwa ma triptan?

Ma Triptans si oyenera anthu omwe ali ndi matenda enaake.

• Matenda a mtima kapena mavuto a kayendedwe ka magazi: Ngati mwakhalapo kapena muli pachiwopsezo cha matenda a mtima, kuthamanga kwa magazi kosalamulirika (kuthamanga kwa magazi kosalamulirika), sitiroko, kapena kuukira kwa ischemic kwa nthawi yochepa (TIA), dokotala wanu sangakulangizeni mankhwalawa.
• Mavuto ndi mankhwala ena (Kuyanjana kwa mankhwala):Mankhwala a Triptans amatha kuyanjana ndi mankhwala ena omwe mukumwa, makamaka omwe ali ndi ergotamine, omwe amagwiritsidwa ntchito pochiza mutu waching'alang'ala. Choncho onetsetsani kuti mwauza dokotala wanu za mankhwala onse omwe mukumwa, ngakhale mavitamini .**
• Amayi oyembekezera kapena oyamwitsa: Ngati muli ndi pakati, mukufuna kutenga pakati, kapena kuyamwitsa, muyenera kulankhula ndi dokotala wanu za kugwiritsa ntchito ma triptan.

Kodi muyenera kupita kwa dokotala liti?

Ngati zotsatirapo zoyipa za triptan zikusokoneza zochita zanu za tsiku ndi tsiku, kapena ngati mukuona kuti mankhwala anu sakugwira ntchito bwino monga kale, lankhulani ndi dokotala wanu.

Nthawi yoti mupeze chithandizo chamankhwala chadzidzidzi:

Triptans sizimayambitsa mavuto aakulu nthawi zambiri. Komabe, ngati mukukumana ndi zizindikiro zotsatirazi zomwe zikufanana ndi matenda a mtima kapena sitiroko, pitani kuchipatala mwamsanga.

• Kupweteka kwambiri pachifuwa kapena kukanika
• Kugunda kwa mtima kosakhazikika (kofulumira, pang'onopang'ono)
• Kuvuta kupuma
• Kusanza, kufooka, kapena kufooka mbali imodzi ya thupi.

Anthu ena omwe ali ndi mutu waching'alang'ala angakumane ndi zizindikiro zofanana ndi sitiroko. Komabe, sitingathe kudziwa kunyumba ngati ndi chizindikiro cha mutu waching'alang'ala kapena sitiroko. Chifukwa chake , ngati mukukayikira, chinthu chabwino kwambiri chomwe mungachite ndikupempha upangiri wa dokotala nthawi yomweyo.