Kodi Somatostatin ndi chiyani? Tiyeni tiphunzire za mahomoni odabwitsa awa m'thupi lathu!

Lero tikambirana za mankhwala achilendo komanso ofunika kwambiri omwe ali m'thupi mwathu. Dzina lake ndi somatostatin. Mwina simunamvepo za dzinali kale. Koma kodi mukudziwa, limathandiza kulamulira zinthu zambiri m'thupi mwathu, monga munthu wobisika amene amagwiritsa ntchito mankhwala. Tiyeni tiwone tanthauzo la somatostatin, momwe imagwirira ntchito, komanso kufunika kwake pa thanzi lathu.

Kodi Somatostatin ndi chiyani kwenikweni?

Mwachidule, somatostatin ndi mahomoni opangidwa m'thupi lathu. Tsopano mwina mukudabwa kuti 'mahomoni' ndi chiyani. N'zosavuta kwambiri. Mahomoni ndi mankhwala omwe amanyamula mauthenga pakati pa ziwalo zosiyanasiyana za thupi lathu. Ali ngati 'anthu otumiza mauthenga' m'thupi lathu. Mauthengawa amauza ziwalo zathu, khungu, ndi minofu kuti zichite zinazake kapena kusiya kuchita zinazake.

Choncho, homoni yapadera iyi yotchedwa somatostatin imaletsa kupanga mahomoni ena, imalamulira ntchito zina m'thupi lathu (m'mimba (GI), komanso imalamulira kugawikana kwa maselo mwachangu (makamaka maselo a khansa). Zili ngati wapolisi woyendetsa magalimoto, chinthu chikakula kwambiri, amapereka chizindikiro, "Chabwino, chabwino, siyani tsopano."

Kodi somatostatin iyi imapangidwa kuti?

Tsopano tiyeni tiwone komwe hormone yodabwitsa iyi ya somatostatin imapangidwira m'thupi lathu. Imapezeka m'malo angapo:

• Njira ya m'mimba (GI): Iyi ndi njira yayitali yolumikizira ziwalo yomwe imayenda kuchokera pakamwa kupita ku anus yomwe imatithandiza kugaya chakudya chomwe timadya. Apa ndi pomwe matumbo anu ali.
• Pancreas: Uwu ndi gland womwe umapezeka m'mimba mwathu. Gland ndi chiwalo chomwe chimapanga mankhwala enaake. Pancreas imapanga ma enzyme omwe amathandiza kugaya chakudya, komanso mahomoni ofunikira monga insulin ndi glucagon .
• Hypothalamus: Izi zili mu ubongo wathu. Zili ngati 'malo olamulira' a thupi lathu. Zimathandiza kusunga homeostasis (monga kusunga malo okhazikika amkati). Zimapatsanso mphamvu pituitary gland, yomwe ili pansi pa hypothalamus, kuti itulutse mahomoni ena.
• Dongosolo Lapakati Lamitsempha (CNS): Izi zikuphatikizapo ubongo wathu ndi msana. Ndi kudzera mu dongosolo la mitsempha limeneli momwe mauthenga amatumizidwa kuchokera muubongo kupita ku thupi lonse.

Mayina ena a somatostatin

Somatostatin imadziwikanso ndi mayina ena angapo. Ngati dokotala wanu atchula limodzi mwa mayina awa, mwina akunena chinthu chomwecho:

• SS, SST kapena SOM
• Homoni yoletsa kukula kwa mahomoni (GHIH)
• Somatotropin release -inhibiting factor (SRIF)
• Homoni yoletsa kutulutsidwa kwa Somatotropin (SRIH)

Kodi somatostatin imagwiritsidwanso ntchito ngati mankhwala?

Inde, nthawi zina, madokotala amagwiritsa ntchito somatostatin yopangidwa ngati mankhwala pochiza matenda ena. Mwachitsanzo:

• Matenda ena a m'mimba
• Acromegaly ndi vuto losowa kwambiri lomwe thupi limapanga mahomoni ochulukirapo.
• Mitundu ina ya khansa yotchedwa neuroendocrine tumors (NETs) .
• Matenda ena a dongosolo la endocrine (monga dongosolo la glandular lomwe limapanga mahomoni).

Kodi ntchito zazikulu za hormone ya somatostatin ndi ziti?

Chabwino, tsopano tiyeni tiwone ntchito yaikulu ya hormone iyi ya somatostatin.

Mwachidule, ntchito yake yaikulu ndikuletsa kupanga mahomoni ena opangidwa ndi dongosolo lathu la endocrine ndikuwongolera kutulutsidwa kwa zinthu zina zochokera mu dongosolo la exocrine.

'Endocrine system' imatanthauza dongosolo lomwe limatulutsa mahomoni kuchokera ku tiziwalo tomwe tili m'thupi lathu kupita mwachindunji m'magazi. Zitsanzo zikuphatikizapo chithokomiro, chithokomiro cha pituitary, ndi tiziwalo ta adrenal . 'Exocrine system' imatanthauza dongosolo lomwe limatulutsa zinthu zopangidwa ndi tiziwaloto kudzera mu duct. Zitsanzo zikuphatikizapo ma glands a malovu ndi ma glands a thukuta .

Kotero, monga momwe zimakhalira kuzimitsa pompo yamadzi, somatostatin imaletsa kwakanthawi kuyenda kwa mahomoni ndi kutulutsa kwamadzi komwe thupi lathu silikufuna. Tangoganizani, ngati mungosiya pompo yamadzi yotseguka, madzi amawonongeka, sichoncho? Mofananamo, ngati thupi lipanga mahomoni ochulukirapo kuposa momwe limafunikira, mavuto angabuke. Somatostatin imalamulira zimenezo.

Chinanso n'chakuti somatostatin imathandizanso kuletsa maselo kugawikana mofulumira kwambiri, monga maselo a khansa.

Imagwiranso ntchito ngati cholumikizira mitsempha mu dongosolo lathu la mitsempha (CNS). Cholumikizira mitsempha ndi chotumizira mankhwala chomwe selo imodzi ya mitsempha (neuron) imatulutsa kuti ikhudze selo lina.

Momwe somatostatin imakhudzira ziwalo zosiyanasiyana za thupi lathu

Tsopano tiyeni tiwone momwe somatostatin imakhudzira gawo lililonse la thupi lathu:

• Mu hypothalamus: Somatostatin imaletsa kutulutsidwa kwa mahomoni opangidwa ndi pituitary gland yathu, monga kukula kwa mahomoni , thyroid-stimulating hormone (TSH) , ndi prolactin .
• Mu kapamba: Apa, insulin ,Zimaletsa kutulutsidwa kwa mahomoni a kapamba monga glucagon ndi gastrin , komanso zimaletsa kutulutsidwa kwa ma enzyme a kapamba omwe amathandiza kugaya chakudya.
• Mu dongosolo la kugaya chakudya (GI tract): Zimachepetsa kutulutsa kwa madzi m'mimba, komwe kumalimbikitsidwa tikamadya. Zimalepheretsanso kutulutsa mahomoni ochepetsa kugaya chakudya monga secretin ndi gastrin .
• Mu dongosolo la mitsempha yapakati (CNS): Apa, zimathandiza kusintha momwe mauthenga amafalitsidwira kudzera mu mitsempha (neurotransmission) ndi momwe zokumbukira zimapangidwira.

Kodi n’chifukwa chiyani somatostatin imatulutsidwa?

Chabwino, tsopano mwina mukudabwa kuti, 'Kodi somatostatin iyi imatulutsidwa bwanji? N’chiyani chimayambitsa?' Kunena zoona, asayansi sakumvetsabe bwino momwe matupi athu amalamulira kutulutsidwa kwa somatostatin iyi, komanso minofu yomwe imayambitsa kutulutsidwa kwake. Mpaka pano, zapezeka kuti pali mitundu yosiyanasiyana ya maselo ndi mapuloteni omwe amakhudzidwa.

Kafukufuku wina wasonyeza kuti shuga , yomwe ndi gwero lalikulu la mphamvu m'thupi lathu, sikuti imangolamulira kutulutsa kwa somatostatin, komanso imathandizira kupanga kwake. Mu kafukufukuyu, asayansi adawona kuti shuga m'magazi akakhala otsika, insulin imalimbikitsa kutulutsa kwa somatostatin (kutanthauza, imaletsa kupanga kwa insulin), ndipo shuga m'magazi akakhala okwera , glucagon imalimbikitsa kutulutsa kwa somatostatin (kutanthauza, imaletsa kupanga kwa glucagon).

Mwa kuyankhula kwina, popeza insulin imachepetsa shuga m'magazi, shuga m'magazi mwanu akachepa, somatostatin imatulutsidwa kuti isatsike, kuti ilepheretse kutulutsa insulin. N'zodabwitsa momwe zinthu zimalamuliridwira m'thupi lathu, sichoncho?

Mavuto ndi Mikhalidwe Yokhudzana ndi Somatostatin

Kawirikawiri, mavuto akuluakulu ndi somatostatin ndi osowa. Koma vuto lalikulu lomwe limachitika ndi mtundu wosowa kwambiri wa khansa wotchedwa somatostatinoma . Ichi ndi chotupa chomwe chimayamba mu dongosolo la endocrine. Chotupachi chimakula mu kapamba kapena m'mimba (GI tract). Izi zimapangitsa kuti somatostatin ipangidwe mopitirira muyeso.

Matendawa, otchedwa somatostatinoma, angachitike mwachisawawa, kapena angagwirizane ndi matenda enaake a majini . Ena mwa matenda amenewa ndi awa:

• Matenda a Multiple Endocrine Neoplasia (mtundu 1 wa MEN):Imeneyi ndi vuto losowa kwambiri, la majini lomwe limapezeka m'matenda osiyanasiyana a endocrine system.
• Matenda a Neurofibromatosis amtundu 1 (NF1): Ichinso ndi matenda obadwa nawo. Amayambitsa mawanga a café-au-lait ndi zotupa zosaopsa pakhungu.
• Matenda a Von Hippel-Lindau: Uwu ndi matenda obadwa nawo osowa. Ungayambitse zotupa zosavulaza kapena zoyipa mu ubongo, msana, maso, impso, kapamba, ndi adrenal glands.

Pamene somatostatin ipangidwa mopitirira muyeso, kupanga mahomoni ena ambiri a endocrine kumachepa kwambiri. Zizindikiro za izi zitha kukhala zofanana ndi zizindikiro za matenda ena ambiri. Chifukwa chake, nthawi zina zimakhala zovuta kuzindikira molondola vuto lotchedwa somatostatinoma.

Chofunika kwambiri ndichakuti mavuto amenewa okhudzana ndi somatostatin ndi osowa kwambiri , zomwe zikutanthauza kuti anthu ambiri alibe chodetsa nkhawa nacho.

Komanso, pakhala malipoti ochepa kwambiri okhudza kuchuluka kwa somatostatin m'thupi la munthu komwe sikuli bwino.

Ndi mayeso ati omwe amayesa kuchuluka kwa somatostatin?

Popeza mavuto okhudzana ndi somatostatin ndi osowa kwambiri, madokotala nthawi zambiri samayesa kuchuluka kwa somatostatin kwa aliyense. Komabe, ngati pali kukayikira kwa chotupa chosowa chomwe chimapanga somatostatin yambiri yotchedwa somatostatinoma, monga tafotokozera kale, mayeso a magazi otchedwa somatostatin-like-immunoreactivity (SLI) amagwiritsidwa ntchito kuti adziwe.

Kodi ndiyenera kupita liti kwa dokotala za kuchuluka kwa somatostatin m'magazi anga?

Nthawi zambiri simuyenera kuda nkhawa ndi kuchuluka kwa somatostatin m'thupi lanu, chifukwa pali mavuto ochepa okhudzana ndi izi.

Komabe, ngati wachibale wapafupi (kholo kapena m'bale) wapezeka ndi vuto monga multiple endocrine neoplasia type 1 (MEN type 1), neurofibromatosis type 1 (NF1), kapena matenda a Von Hippel-Lindau, ndikofunikira kuuza dokotala wanu. Popeza izi ndi matenda obadwa nawo, mungakhalenso pachiwopsezo chotenga somatostatinoma. Dokotala wanu akhoza kuchita mayeso kuti aone ngati muli ndi vutoli.

Zinthu zofunika kwambiri kukumbukira (Uthenga Wopita Nawo Kunyumba)

Chabwino, nazi zinthu zofunika kwambiri zomwe muyenera kukumbukira kuchokera pa zomwe takambirana lero:

• Somatostatin ndi hormone ya 'master' yomwe imagwira ntchito yofunika kwambiri m'thupi lathu, kulamulira mahomoni ena.
• Imayang'anira makamaka zinthu monga kupanga mahomoni ena, kugwira ntchito kwa dongosolo logaya chakudya, komanso kugawikana kwa maselo mwachangu.
• Mavuto ndi somatostatin nthawi zambiri amakhala osowa kwambiri.Vuto lalikulu ndi chotupa chosowa chotchedwa somatostatinoma.
• Ngati wina m'banja mwanu ali ndi matenda a majini monga matenda a MEN type 1, NF1, kapena Von Hippel-Lindau , lankhulani ndi dokotala wanu za vutoli.
• Musachite mantha ndi izi pachabe. Ndikofunikira kudziwa machitidwe odabwitsa awa m'thupi lathu.

Kotero, somatostatin ndi chinthu chopanda phokoso, koma chofunikira kwambiri, m'thupi lathu. Bola ngati ikugwira ntchito yake bwino, palibe choopa!

Somatostatin , Somatostatin, Hormone, Pancreas, Hypothalamus, Digestive System, Somatostatinoma, Somatostatinoma, GHIH, Endocrine System, Khansa