Acetylcholine (ACh) ni iki? Reka turebe neza icyo ikora ku mibiri yacu!

Ese wigeze wumva ibya acetylcholine , cyangwa (ACh)? Ahari muganga wawe yarabikubwiye, cyangwa wasomye ahantu runaka. Ni ikintu gito ariko gifite akamaro cyane mu mubiri wacu. Ni nk'umukozi muto w'iposita utwara ubutumwa mu mubiri wacu. Rero, uyu munsi turaganira kuri acetylcholine mu buryo bworoshye ushobora kumva.

Asetilikolini ni iki mu by'ukuri?

Mu magambo make, acetylcholine ni icyuma gitera imikorere y'ubwonko . Tekereza kuri ibi, ubwonko bwawe bukeneye kohereza ubutumwa buke bw'amashanyarazi kugira ngo bukoreshe ukuboko kwawe, gutekereza, kwibuka ikintu runaka, ibi bintu byose. Acetylcholine ni ubutumwa bw'ibinyabutabire bufasha gutwara ubwo butumwa binyuze mu turemangingo tw'imitsi .

Ibi kandi byitwa "neurotransmitter" " excitatory " . Uzi icyo ari cyo? "Bikangura" ingirabuzimafatizo z'imitsi, ni ukuvuga, bikayitera imbaraga, bigatuma "yohereza" ubutumwa vuba. Ni nko gukomanga ku rugi rw'umuntu usinziriye ukavuga uti "Dore, fata iyi baruwa."

Izina acetylcholine rikomoka ku bintu bibiri biyigize. Kimwe ni itsinda rya acetyl . Ibi bikomoka ku kintu cyitwa acetyl coenzyme A, gikozwe mu isukari ya glucose. Ikindi ni intungamubiri yitwa choline . Choline iboneka mu buryo busanzwe mu muhondo w'igi, soya, umwijima, imboga, n'ibinyamisogwe. Choline nayo ikorerwa mu mwijima wacu.

Asetilikolini igira uruhare mu mirimo myinshi y'ingenzi mu mubiri wacu, cyane cyane imitsi ikora ku bushake.Ibi bigira uruhare runini mu bikorwa byacu byo gutekereza, nko kwimura amaguru n'amaboko no kugenda. Bikangura uturemangingo tw'imitsi mu mitsi yacu, bigatuma ducika intege. Si ibyo gusa, ahubwo ni ingenzi cyane ku turemangingo tw'imitsi mu bwonko bwacu, no ku bikorwa nko kwibuka, gutekereza no kwiga.

Asetilikolini (ACh) ikora ite?

Asetilikolini ibikwa ku mpera z'uturemangingo tw'imitsi, kugeza igihe ubutumwa bukenewe koherezwa. Iyo "ikimenyetso" kigeze cyo kohereza ubutumwa, iyi asetilikolini yabitswe irarekurwa. Iyo imaze kurekurwa, ijya mu cyuho gito kiri hagati y'uturemangingo tubiri tw'imitsi. Iki cyuho cyitwa synaptic cleft .

Nyuma yo kwambuka urwego rwa synaptic, hari ubwoko bubiri bwa receptors acetylcholine ishobora kwihambiraho. Ubwo bwoko ni:

• Receptors za Nikotine
• Receivers za Muscarinic

Nyuma yo gufatana n'izi receptor, ubutumwa bwa shimi bujya mu ngirabuzimafatizo y'imitsi ikurikira. Nyuma yo koherezwa ubutumwa, acetylcholine iguma mu gice cya synaptic ntabwo ipfa ubusa. Indi enzyme yitwa acetylcholinesterase iraza igaca iyi acetylcholine mu bice byayo, choline na acetate. Hanyuma ibi bice byavunitse bikongera kwinjizwamo, bigasubirwamo, bigakoreshwa mu gutwara ubundi butumwa bwa shimi. Sisitemu ikora neza cyane!

Ni iki kibera acetylcholine (ACh)?

Asetilikoline ifite akamaro kenshi ku mibiri yacu. Reka turebe iby'ingenzi.

Ubwo bwoko bwombi bwa receptor bufite uruhare mu kwibuka kwacu. Ni ukuvuga ko ari ingenzi mu kwibuka igihe kirekire, kwibuka igihe gito, kurema kwibuka, guhuza no kubigarura. Mu bwonko, acetylcholine igira uruhare mu bindi bintu. Itera imbaraga, gushishikazwa/kwita ku bintu, kwiga, no gusinzira REM (icyiciro cy'ibitotsi durotamo).

Ni ibihe bintu bibaho iyo urugero rwa acetylcholine (ACh) rugabanutse?

Kubura acetylcholine mu rugero ruto, cyangwa kubura, bishobora gutera indwara nyinshi. Izingenzi muri zo ni izi zikurikira:

• Indwara ya Alzheimer : Abantu barwaye indwara ya Alzheimer ntibaba bafite acetylcholine ihagije mu bwonko bwabo. Kubera iyo mpamvu, gutakaza kwibuka ni ikimenyetso gikomeye.
• Lambert-Eaton myasthenic syndrome : Iyi ndwara iterwa no kugabanuka kw'irekurwa rya acetylcholine mu turemangingo tw'imitsi.
• Myasthenia gravis : Iyi ni indwara iterwa n’ubwiyongere bw’umubiri ituma imitsi y’amagufwa icika intege vuba nyuma yo kuyikoresha kenshi.

Ni iyihe miti yibasira acetylcholine (ACh)?

Imiti ibuza kolinesterase ni ubwoko bw'imiti ikora binyuze mu guhagarika enzyme isenya acetylcholine no kongera imikorere ya acetylcholine receptors. Ikoreshwa mu kuvura indwara ya Alzheimer na myasthenia gravis. Donepezil (Aricept®), Rivastigmine (Exelon®), na Galantamine (Razadyne®) ni imwe muri iyo miti.

Ni ibihe biribwa birimo choline, ifasha mu gukora acetylcholine (ACh)?

Choline, intungamubiri ihinduka acetylcholine, iboneka mu biribwa byinshi. Urugero:

• Umwijima w'inyama z'inka
• Amagi (cyane cyane umuhondo)
• Igice cyo hejuru cy'inyama z'inka
• Soya zokeje, ibishyimbo by'impyiko byo mu macupa
• Igituza cy'inkoko cyokejwe
• Ifi y'ifi ya cod `(Cod)`
• Quinoa itetse
• Ibihumyo bya shiitake bitetse, broccoli itetse na Brussels sprouts
• Amata (1%) `(Amata (1%)`, yogurt ya vanilla idafite amavuta `(yogurt ya vanilla idafite amavuta)`

Gerageza kongeramo ibi biribwa mu ndyo yawe. Indyo yuzuye ni ingenzi cyane kugira ngo ugire ubuzima bwiza.