Umuti wa Amvuttra uvura indwara idakunze kugaragara itera imitsi kugabanuka (hatATTR Polyneuropathy)

Ese wumva gusa ibinure cyangwa ubabara mu biganza no mu birenge? Cyangwa ufite intege nke z'imitsi no kugenda bigoranye? Hari igihe ibi bimenyetso bishobora guterwa n'indwara idasanzwe tutaramenya. Uyu munsi, tugiye kuvuga kuri imwe muri izo ndwara n'uburyo bushya bwo kuyivura.

HATTR ni iki? Amvuttra ikora ite?

Mu magambo make, hATTR (Hereditary Transthyretin-Mediated Amyloidosis) ni indwara ivuka mu ruragi. Iri mu itsinda ry'indwara zitwa amyloidosis. Muri izi ndwara, poroteyine zimwe na zimwe mu mubiri wacu zihindura imiterere yazo, zikiyongera mu buryo budasanzwe, kandi zigashyirwa mu ngingo zitandukanye.

Mu ndwara ya hATTR, poroteyine yitwa Transthyretin (TTR) ishyirwa muri ubu buryo. TTR mu by'ukuri ni poroteyine nziza ikorerwa mu mwijima wacu kandi igafasha gutwara imisemburo ya tiroyide na vitamine A mu mubiri wose. Ariko, umuntu urwaye hATTR agira impinduka nto mu ngirabuzimafatizo ya TTR, ni ukuvuga impinduka. Kubera iyo mpamvu, poroteyine ya TTR ikorwa iba ifite imiterere itari yo. Iyi poroteyine idakora neza irakusanya ikajya ahantu nko mu mitsi, mu mutima, no mu gifu nk'aho ari imiyoboro yitwa amyloid .

Iyo izi myanda zirundanyije hafi y’imitsi, zirangirika. Ibi twita polyneuropathy . Ni bwo ibimenyetso byavuzwe haruguru, nko kubyimba, kugira ibisebe, kubabara no kugorwa no kugenda, bibaho.

Umuti wa Amvuttra ukora mu kugabanya ingano y'iyi poroteyine ya TTR idasanzwe ikorwa n'umwijima. Ibi bigabanya ukwiyongera kw'uturemangingo twa amyloid mu mubiri, bigafasha mu kugenzura ibimenyetso no gukumira cyangwa gutinza indwara gukomeza kwiyongera.

Muganga wawe azagusaba kandi guhindura imirire yawe n'imyitozo ngororamubiri, hamwe no kuvura ibimenyetso byawe. Kugeza vuba aha, uburyo bwonyine bwo kuvura iyi ndwara bwari ukurwanya ibimenyetso, ndetse byaba ngombwa, no gutera umwijima cyangwa umutima. Ariko imiti igezweho nka Amvuttra ubu ikwemerera kugenzura iyi ndwara ugabanya poroteyine ya TTR, ari nayo mpamvu nyamukuru y’iyi ndwara.

Ukoresha uyu muti ute?

Amvuttra ni urushinge ruterwa munsi y'uruhu . Rutangwa n'inzobere mu by'ubuzima, nka muganga cyangwa umuforomo wabyigiye. Ubusanzwe rutangwa inshuro enye mu mwaka (buri mezi atatu) . Ushobora gutegura kwakira uru rukingo kwa muganga wawe, kwa muganga, cyangwa ndetse no mu rugo.

Ni gute ubu buvuzi bwakozweho ubushakashatsi?

Kimwe n'ubundi muti mushya uwo ari wo wose, Amvuttra yageragejwe mu igeragezwa ry'ubuvuzi kugira ngo hamenyekane imikorere n'umutekano wayo. Muri iri gerageza, itsinda ry'abarwayi bahawe Amvuttra ryagereranyijwe n'itsinda ry'abarwayi bahawe placebo , ubuvuzi bw'impimbano butari burimo ikintu gikora. Uku ni ko dushobora kumenya niba umuti ukora koko.

Ubushakashatsi bwakorewe ku barwayi barwaye indwara ya hATTR ndetse n’indwara ya polyneuropathy yavuyemo. Ubukene bwabo mu mitsi, imbaraga z’imitsi, n’ubushobozi bwo gukora imirimo ya buri munsi byapimwe hakoreshejwe uburyo bwihariye bwo gutanga amanota.

Nk’uko ibyavuye mu bushakashatsi byagaragaje, abarwayi bahawe Amvuttra barushijeho kunoza imikorere y’imitsi n’ubuzima bwabo. Nubwo amanota yabo mu mitsi yagabanutse n’ibimenyetso byarushijeho kwiyongera, abahawe placebo bagaragaje kwiyongera kw’ibimenyetso.

Ni ryari nzatangira kumva ingaruka z'umuti?

Iyi si umuti wihuse. Uko umuti utangira gukora buhoro buhoro mu mubiri wawe, ushobora kubona ibimenyetso byawe bigabanuka cyangwa bikagenda neza mu mezi make . Intego y'igihe kirekire y'ubu buvuzi ni ukugenzura uko indwara ikomeza. Kubwibyo, ni ngombwa cyane gukurikirana ibimenyetso byawe.

Bwira muganga wawe kwitondera ibi bintu:

• Ubushobozi bwo kugenda nta bufasha
• Gucika intege no gucika intege mu maguru
• Imitekerereze y'umubiri
• Kugenzura umuvuduko w'amaraso uhagaze

Nubwo waba utabonye impinduka ako kanya, ntucikwe no kubona inkingo zawe ku gihe. Muganga wawe ashobora kandi gukora ibizamini bitandukanye by'amaraso, gupima, cyangwa gusuzuma umubiri kugira ngo arebe uko ugenda.

Ingaruka mbi n'uburyo bwo kuzirwanya?

Ingaruka mbi zikunze kugaragara kuri Amvuttra ni izi:

• Ububabare mu maboko cyangwa amaguru
• Ububabare bw'ingingo
• Guhumeka bigoranye

Byongeye kandi, Amvuttra ishobora kugabanya urugero rwa Vitamine A. Kubwibyo, muganga wawe azagupima amaraso kugira ngo arebe urugero rwa Vitamine A mbere no mu gihe cyo kuvurwa. Niba ubonye impinduka mu byo ubona, cyane cyane ibibazo byo kureba nijoro , bimenyeshe muganga wawe ako kanya.

Izi si zo ngaruka mbi zishobora kubaho gusa. Niba ufite ibimenyetso bishya bigutera kumva umerewe nabi, bwira muganga wawe ako kanya.

Ese hari ibibazo bishobora kubaho ku yindi miti?

Ntabwo Amvuttra izwiho kugira ingaruka zikomeye ku bindi biribwa, ibinyobwa, cyangwa imiti. Ariko, ni byiza kubwira muganga wawe imiti yose, vitamine, ibikomoka ku bimera, n'inyongeramusaruro ufata.