Reka twige ku misemburo ikura mu mubiri w'umuntu (HGH) mu magambo yoroheje.

Ese wumva umwana wawe adakura neza nk'uko bikwiye? Cyangwa uhora wumva unaniwe kandi unaniwe? Ahari impamvu y'ibi ni ikintu gito mu mubiri wawe. Imwe muri iyo misemburo ni ingenzi ku mikurire y'umubiri wacu n'ibindi byinshi yitwa imisemburo ikura mu mubiri . Mu magambo make tuyita HGH (Human Growth Hormone) . Hari n'iyitwa somatotropin . None rero uyu munsi, reka tuvuge kuri iyi HGH mu buryo burambuye, mu buryo bworoshye.

HGH ni iki? Ikorwa ite mu mubiri wacu?

Muri make, HGH ni imisemburo karemano umubiri wacu ukora. Ikorwa n'agahu gato kari munsi y'ubwonko bwacu, kangana n'igufwa rito. Tuyita agahu k'ubwonko . Iyi misemburo ya HGH igira ingaruka ku bice byinshi by'umubiri wacu. Ni ingenzi cyane mu mikurire y'abana . HGH ifasha cyane mu bintu nko gutuma umwana wawe aba muremure no gutuma amagufwa ye akomera.

Ariko, iyo tumaze gukura, ni ukuvuga nyuma yuko ibice by'igufwa (epiphyses) bifunze, HGH ntikitugira barebare. Ariko si byo gusa HGH ikora. Ndetse na nyuma yo gukura, HGH ifasha kubungabunga imiterere isanzwe y'umubiri wacu no gutuma metabolisme yacu ikora neza. Iyi metabolisme ni yo ihindura ibiryo turya mo ingufu. HGH inafasha mu gutuma isukari (glucose) mu maraso yacu iguma ku rugero runaka.

Imisemburo ni imiti iri mu mibiri yacu. Ikora nk'intumwa. Inyura mu maraso ikabwira ingingo zacu, imitsi, n'izindi ngingo icyo gukora n'igihe cyo kubikora. Hari imisemburo irenga 50 mu mibiri yacu!

Ingirabuzimafatizo ya pituitary navuze mbere iherereye mu nsi y'ubwonko, munsi ya hypothalamus . Iyi hypothalamus igenzura ibintu byinshi nko umuvuduko w'amaraso yacu, umuvuduko w'umutima, ubushyuhe bw'umubiri, n'igogora. Rero, iyi hypothalamus ni yo ibwira ingirabuzimafatizo ya pituitary kurekura HGH. Imisemburo ifasha muri ibyo yitwa GHRH (hormone ikura imisemburo) . Nanone, indi misemburo (somatostatin) ituruka muri hypothalamus kugira ngo ihagarike irekurwa rya HGH. Uku ni ko HGH igenzurwa.

Hari igihe abaganga bakoresha HGH ya sintetike kugira ngo bavure indwara zimwe na zimwe. Ariko ibuka ko utagomba gukoresha HGH ya sintetike udafite uruhushya rwa muganga.

Ni ibihe bintu bigira ingaruka ku gusohora HGH?

Ubusanzwe imisemburo yacu ya pituitary isohora HGH mu rugero ruto umunsi wose, yitwa pulses . Ibi bigenzurwa ahanini n'imisemburo ibiri iva muri hypothalamus yitwa GHRH na somatostatin.

Si ibyo gusa, ahubwo hari n'indi misemburo irimo. Urugero,Insulin-like growth factor 1 (IGF-1) igabanya ikorwa rya HGH, mu gihe imisemburo nka thyroxine , glucocorticoids , na ghrelin yongera irekurwa rya HGH.

IGF-1, irekurwa n'umwijima wacu, ni umusaruro ukomeye w'ibikorwa bya HGH. Iyi IGF-1 ni yo igenzura umusaruro urenze urugero wa HGH. Ni ukuvuga ko HGH ituma IGF-1 ikorwa, naho IGF-1 ikorwa ikongera ikagabanya umusaruro wa HGH. Ni nk'uruziga.

Ku muntu muzima, irekurwa rya HGH ribuzwa n’isukari nyinshi mu maraso (hyperglycemia) . Byongeye kandi, irekurwa rya HGH riterwa n’ibintu nko gusinzira, imihangayiko, imyitozo ngororamubiri, irekurwa ry’isukari mu maraso (hypoglycemia) , na aside amine .

Ni iyihe mirimo y'ingenzi ya hormone ya HGH?

HGH ifite imirimo ibiri y'ingenzi:

1. Gukangura imikurire (cyane cyane mu bana)

2. Kugira ingaruka ku mikorere y'umubiri (uburyo duhindura ibiryo turya mo ingufu)

HGH n'imikurire

HGH ifasha buri ngingo n'ingingo zose mu mubiri wacu gukura. Ariko izwi cyane mu gufasha gukurura ...

Ariko, nk'uko nabivuze mbere, HGH ntiyongera uburebure nyuma y'uko ibice by'igufwa ry'umwana (epiphyses) bifunze. Ahubwo, HGH ifasha mu kubungabunga imiterere y'umubiri mu buzima bwe bwose.

HGH na metabolism

Metabolism ni inzira y'ibinyabutabire ihindura ibiryo turya mo ingufu. Buri selile mu mubiri wacu ikenera ingufu kugira ngo ikore neza.

HGH igira ingaruka ku mikorere y'umubiri ahanini binyuze mu kongera umusaruro wa IGF-1, ibi bikaba bihindura uburyo igira ingaruka ku turemangingo tw'umubiri wacu. IGF-1 ni imisemburo ifite imiterere isa na insuline . Insulini ni imisemburo y'ingenzi ikorwa na pancreas yacu igabanya urugero rw'isukari mu maraso (glucose) . IGF-1 ifite kandi ubushobozi bwo kugabanya isukari mu maraso.

Ubusanzwe, imibiri yacu igenzura neza urugero rwa glucose mu maraso yacu. Isukari yo mu maraso, cyangwa isukari, ni yo isukari nyamukuru mu maraso yacu. Tuyikura mu biribwa bya karubohidrati turya. Iyi sukari ni yo itanga ingufu ku ngingo zacu, imitsi, n'imitsi.

Insulini ni yo misemburo nyamukuru igabanya isukari mu maraso iyo iri hejuru. Kandi imisemburo ya glukagoni yongera isukari mu maraso iyo iri hasi. Ariko, HGH ikunze kongera isukari mu maraso iyo iri hasi. Ariko,Iyo ingano ya HGH mu mubiri wawe yiyongereye cyane, ishobora kubangamira imikorere ya insuline bigatuma urugero rw'isukari mu maraso rwiyongera.

Ese koko HGH igutera kuba muremure?

Yego, HGH ishobora kongera uburebure bw'abana. Ariko ibyo biba mbere yuko ibice by'imikurire mu magufwa yabo byifatanya. HGH ntishobora gutuma uba muremure nyuma yuko ibice by'imikurire byifatanya. Ahubwo, iyo umaze kugera ku burebure ntarengwa, HGH ifasha kubungabunga imiterere n'imikorere y'umubiri wawe.

Ni izihe ngero zisanzwe za HGH?

Nkuko nabivuze mbere, agahu k'ubwonko gasohora HGH mu buryo butunguranye umunsi wose. Izi ngero ziratandukanye bitewe n'igihe cy'umunsi, imyaka, n'igitsina. Kubwibyo, ikizamini kimwe cy'amaraso cyo gupima HGH ntabwo ari ingirakamaro cyane mu gusuzuma indwara. Ahubwo, abaganga bareba ingano ya HGH binyuze mu bipimo byihariye (ibizamini byo gukangura cyangwa gufunga).

Igipimo gisanzwe cya HGH ni iki gikurikira:

• Abagabo bakuze: 0.4 kugeza 10 nanogramu kuri mililitiro (ng / mL)
• Abagore bakuru: nanogarama 1 kugeza kuri 14 kuri mililitiro (ng/mL)
• Abana: nanogramu 10 kugeza kuri 50 kuri mililitiro (ng / mL)

Ariko ibuka ko izi ndangagaciro zishobora gutandukana gato bitewe na laboratwari. Rero zigereranye n'urugero rusanzwe rwa raporo yawe ya laboratwari. Niba ufite impungenge, menya neza ko wavuganye na muganga wawe.

Bigenda bite iyo urugero rwa HGH rugabanutse? (Kubura imisemburo yo gukura)

Iyo urugero rwa HGH ruri hasi ugereranije n'ibisanzwe, turwita ibura ry'imisemburo ikura . Ibi akenshi biterwa n'ikibazo cyangwa kwangirika kw'agace ka pituitary. Ibi bishobora gutera indwara yitwa hypopituitarism . Ibi bivuze ko imisemburo imwe cyangwa myinshi ikorwa n'agace ka pituitary igabanuka. HGH nayo ni imisemburo ishobora kugira ingaruka muri ubu buryo.

Uku kubura kwa HGH bigira ingaruka ku bantu bakuru n'abana mu buryo butandukanye.

Iyo urugero rwa HGH rugabanutse ku bantu bakuru:

Iyo urugero rwa HGH ku muntu mukuru rugabanutse, ibibazo bikurikira bishobora kubaho:

• Kugabanuka kw'ibyishimo no kunyurwa mu buzima.
• Ubwiyongere bw'ibinure mu mubiri.
• Ingaruka zo kurwara indwara z'umutima ziyongera.
• Gucika intege k'umutima, imitsi n'amagufwa.

Ku bantu bakuru, iyi ndwara ishobora guterwa na adenoma ya pituitary (iyi si kanseri, ahubwo ni ikibyimba) cyangwa kwangirika kwa pituitary gland/hypothalamus.

Niba abana bafite HGH nke:

Iyo urugero rwa HGH rw'umwana rugabanutse, imikurire ye izagabanuka. Ikimenyetso nyamukuru ni ukwiyongera buhoro k'uburebure nyuma y'imyaka itatu y'amavuko y'umwana. Ni ukuvuga munsi ya santimetero 1.4 ku mwaka. Urugero, niba umwana wawe asa n'aho ari mugufi cyane ugereranyije n'abandi bana mu ishuri, ugomba kugira impungenge.

Byongeye kandi, umwana ufite ikibazo cyo kubura HGH ashobora no kugira ibimenyetso nk'ibi bikurikira:

• Isura isa n'aho ari nto cyane ugereranyije n'imyaka yayo.
• Kudakura neza k'umusatsi.
• Gutinda mu bugimbi.

Abana bashobora kuvukana iyi ndwara. Hari igihe impamvu iba itazwi (idiopathic), ishobora kuba ari genetiki, cyangwa ishobora guterwa no kwangirika kw'agace ka pituitary mu gihe cyo gutwita cyangwa igihe cyo kuvuka. Hari igihe ishobora no guterwa no kwangirika kw'agace ka pituitary cyangwa hypothalamus mu myaka y'ubukure.

Bigenda bite iyo urugero rwa HGH rwiyongereye?

Indwara nyamukuru ijyana no kwiyongera kwa HGH mu rugero rusanzwe ni acromegaly . Ibi kandi bigira ingaruka ku bantu bakuru n'abana mu buryo butandukanye. Ni indwara idakunze kugaragara cyane.

Acromegaly mu bantu bakuru

Abantu bakuru barwaye acromegaly bakunze kugira amaboko n'ibirenge binini cyangwa bibyimba ndetse n'isura yabo ihinduka .

Bashobora kandi kugira amagufwa manini n'ingingo nini z'imbere. Bashobora kurwara indwara nka hypertension , diyabete yo mu bwoko bwa 2, n'indwara z'umutima. Abantu barenga 99% barwaye acromegaly baterwa n'ibibyimba bitari kanseri mu gasabo k'ubwonko kitwa pituitary adenomas . Ibi bibyimba bishobora gutanga HGH nyinshi. Acromegaly ikunze kugaragara nyuma y'imyaka yo hagati, nyuma yo gukura. Kubwibyo, abantu bakuru bafite acromegaly ntibaba barebire. Ahubwo, amagufwa yabo ashobora kubyimba.

Acromegaly (Gigantism) mu bana

Ni gake cyane abana bashobora kugira HGH nyinshi mbere yuko bagera ku burebure bwabo bwose. Ibi bishobora gutera gukura cyane kw'amagufwa maremare, bigatera abana barebire cyane. Iyi ndwara yitwa juvenile acromegaly . Hari igihe yitwa gigantism . Iyo itavuwe, aba bana bashobora gukura bakagera kuri metero ebyiri cyangwa ebyiri z'uburebure. Bashobora kandi kugira ibimenyetso nko gucika intege, gutinda mu bwana, no kuribwa umutwe.

Ibi kandi akenshi biterwa no kurwara kwa pituitary.

Ni gute urugero rwa HGH rupimwa?

Niba wowe cyangwa umwana wawe mufite ibimenyetso bigaragaza ko afite ibibazo bifitanye isano na HGH, muganga wawe ashobora gutegeka ko bapima amaraso menshi kugira ngo barebe urugero rwa HGH mu mubiri wawe.

Nkuko nabivuze mbere, agahu k'ubwonko gasohora HGH mu maraso umunsi wose ndetse nijoro rimwe na rimwe. Kubwibyo, biragoye gusobanukirwa neza ikibazo ufata amaraso hanyuma ugasuzuma HGH rimwe gusa.

Kubwibyo, abaganga bakunze gukoresha uburyo bwitwa ibizamini byo gukangura imisemburo yo gukura no gupima kugira ngo bamenye indwara ziterwa no kubura HGH cyangwa kurenga urugero.

Byongeye kandi, ikizamini cy'amaraso gishobora gukorwa kugira ngo harebwe urugero rwa IGF-1 (insuline-like growth factor 1) .

Ni gute HGH ikoreshwa nk'umuti?

Ikigo gishinzwe ibiribwa n'imiti muri Leta Zunze Ubumwe za Amerika (FDA) cyemeje HGH y’ubukorano kugira ngo ivure indwara zimwe na zimwe. Iyi HGH y’ubukorano iboneka gusa iyo muganga aguhaye imiti, kandi itangwa nk'urushinge.

HGH ihabwa abana ku ndwara zikurikira:

• Kubura imisemburo ikura.
• Indwara zitera kuba ngufi, nk'indwara zidakira z'impyiko , Turner syndrome , na Prader-Willi syndrome .

HGH ihabwa abantu bakuru ku ndwara zikurikira:

• Kubura imisemburo ikura.
• Kubura imitsi bitewe na virusi itera SIDA .
• Indwara y'amara magufi .

Icy'ingenzi cyane: Ntukigere ukoresha HGH y'ubukorano keretse muganga wawe yayigundikiye.

Ingaruka mbi za HGH y’ubukorano ni izihe?

Ingaruka zimwe na zimwe zishobora kubaho iyo ukoresheje HGH y’ubukorano nk'ubuvuzi. Izi ni:

• Indwara ya Carpal tunnel syndrome (imitsi ipfutse mu kuboko).
• Ubudahangarwa bwa insuline cyangwa diyabete yo mu bwoko bwa 2 bwiyongera.
• Kubyimba amaboko n'ibirenge (edema) .
• Kubabara ingingo n'imitsi.
• Kwaguka kw'imitsi y'amabere ku bagabo (gynecomastia) .
• Ubwiyongere bw'ibyago byo kurwara ubwoko bumwe na bumwe bwa kanseri.

Abashakashatsi ntibaramenya bihagije ingaruka z'igihe kirekire zo gukoresha imiti ya HGH mu buryo bwa sintetike.

Ni ryari nkwiye kujya kwa muganga ku bijyanye n'urugero rwa HGH?

Niba wowe cyangwa umwana wawe mufite ibimenyetso bijyanye no kubura HGH cyangwa kurenga urugero (urugero: gukura buhoro, gukomera kw'ingingo), menya neza ko mwagiye kwa muganga.

Niba usanzwe uvurwa ikibazo kidasanzwe mu rugero rwa HGH, ni ngombwa cyane kubonana na muganga wawe buri gihe kugira ngo umenye neza ko ubuvuzi bwawe bukora neza.

HGH ni imisemburo ikomeye ikenewe cyane mu mikorere myinshi y'ingenzi mu mubiri wacu. Hari igihe ingirabuzimafatizo yacu ya pituitary ishobora kuyikora cyane cyangwa nke cyane. Niba wowe cyangwa umwana wawe mufite kimwe muri ibi bimenyetso, ni byiza kuvugana na muganga. Barahari kugira ngo bagufashe.

Ubutumwa bwa nyuma bwo kujyana mu rugo

None se, twaganiriye cyane kuri HGH uyu munsi, si byo se? Reka dusubiremo muri make:

• HGH ni imisemburo ifite akamaro kanini mu mikurire yacu, cyane cyane mu bwana, no mu mikorere y'umubiri wacu.
• Ibi bikorwa n'agahu k'ubwonko ka pituitary.
• Iyo urugero rwa HGH rugabanutse, abana bashobora kugabanuka mu mikurire, kandi abantu bakuru nabo bashobora kugira ibibazo bitandukanye by'ubuzima.
• Iyo urugero rwa HGH rwiyongereye, indwara nka acromegaly zishobora kubaho.Ku bana, ibi bishobora kugaragara nk'ubugigantism, bivuze gukura mu burebure budasanzwe.
• Niba ukeka ko wowe cyangwa umwana wawe mushobora kuba mufite ikibazo cya HGH, ntutindiganye gushaka inama kwa muganga.
• Ntukigere ukoresha HGH y’ubukorano udafite urupapuro rwa muganga.

Wibuke ko ibi byose bigamije kukwigisha. Niba ufite ikibazo cy'ubuzima, umuganga wawe ni we wenyine ushobora kuguha igisubizo cyiza. Komeza ugire ubuzima bwiza!

Imisemburo y'imikurire y'umuntu , HGH, Indwara y'ubwonko, Imikurire y'umwana, Kwiyongera k'uburebure, Ihinduka ry'imisemburo, Kudahuza kw'imisemburo