Ese nawe wumva amaguru yawe arimo gucika intege? Iyi ishobora kuba ari Lambert-Eaton Myasthenic Syndrome (LEMS)!

Ese hari igihe wumva amaguru yawe afite intege nke, ugorwa no kubyuka ku ntebe, wumva unaniwe iyo uzamuka ingazi? Cyangwa wumva unaniwe ufite ibimenyetso nk'amaso aremereye, umunwa wumye, no kubona ibintu bibiri? Ibi bishobora kuba atari umunaniro gusa. Uyu munsi turaganira ku ndwara ushobora kuba utari warigeze wumva, ariko ikwiye kumenyekana cyane, Lambert-Eaton Myasthenic Syndrome, cyangwa ``(LEMS)`` nk'uko tubyita mu magambo ahinnye.

Lambert-Eaton Myasthenic Syndrome (LEMS) ni iki?

Mu magambo make, Lambert-Eaton Myasthenic Syndrome (LEMS) ni indwara iterwa n’ubwiyongere bw’umubiri. Noneho ushobora kwibaza icyo indwara iterwa n’ubwiyongere bw’umubiri ari cyo. Imibiri yacu ifite ubudahangarwa bw’umubiri. Ibi nibyo biturinda mu kurwanya mikorobe zitera indwara ziturutse hanze. Ni nk'ingabo zo mu gihugu cyacu. Ariko rimwe na rimwe ubu budahangarwa bw’umubiri buragenda nabi. Hanyuma bugatangira kwibasira uturemangingo twacu tuzima. Ibyo ni ko biba muri LEMS.

Muri iyi '(LEMS)', ubudahangarwa bwacu bw'umubiri bwibasira isano iri hagati y'imitsi yacu n'imitsi . Mu by'ukuri, iyi sano yitwa 'ihuriro ry'imitsi y'ubwonko'. Iyo iri huriro ryangiritse, ubutumwa buva mu mitsi bujya mu mitsi buragabanuka. Ni bwo imitsi icika intege .

Ubu burwayi bukunze gutangirira mu bibero byawe byo hejuru , ariko bushobora gukwirakwira buhoro buhoro mu maboko yawe, mu guhumeka, mu kumira no mu mitsi ivuga.

Ni nde ufite amahirwe menshi yo guteza imbere iyi `(LEMS)`?

Hari amatsinda abiri y'ingenzi agize `(LEMS)`.

1. Bifitanye isano na kanseri: Abantu bagera kuri 60% barwaye LEMS bafite ubwoko runaka bwa kanseri. Ubwoko bukunze kugaragara cyane ni kanseri y’ibihaha ifite utunyangingo duto . Igitangaje ni uko rimwe na rimwe ibimenyetso bya LEMS bishobora kugaragara amezi cyangwa imyaka mbere yuko kanseri itangira. Abenshi muri aba bantu barengeje imyaka 60, ni abagabo, kandi banywaga itabi.

2. Nta kanseri: Abandi 40% by'abantu barwaye LEMS nta kanseri basanze. Aba bantu bakunze kuyisanga bafite imyaka hafi 35 ndetse banayisanga bafite imyaka hafi 60.

LEMS ni indwara idakunze kugaragara mu bana bato.

Ese kanseri y'ibihaha (LEMS) ni yo yonyine ifitanye isano n'ibi?

Oya. Kanseri y'ibihaha y'uturemangingo duto ni yo kanseri ikunze kugaragara cyane, ariko izindi kanseri zishobora no kujyana na LEMS. Ingero zirimo kanseri ya prostate, thymoma, n'indwara za lymphoproliferative. Kubera ko ibimenyetso bya LEMS bishobora kugaragara mbere yuko ibimenyetso bya kanseri bigaragara, ni ngombwa kugira ibizamini bikwiye kugira ngo urebe niba urwaye kanseri niba muganga wawe agusuzumye.

Ese LEMS iterwa n'impinduka mu ngirabuzimafatizo?

Abahanga mu bya siyansi bemeza ko indwara ziterwa n’ubwiyongere bw’umubiri muri rusange zishobora kuba zifite aho zihuriye n’uturemangingo. Kubera ko LEMS nayo ari indwara iterwa n’ubwiyongere bw’umubiri, birashoboka ko nayo ifite ingaruka ku ngirabuzimafatizo, ariko ibi ntibirasobanuka neza.

Ni gute `(LEMS)` ikunze kugaragara?

LEMS ni indwara idakunze kugaragara cyane . Bivugwa ko iyi ndwara yibasira abantu bagera kuri miliyoni 2.8 ku isi. Muri Leta Zunze Ubumwe za Amerika, hari abantu bagera kuri 400 banduye LEMS. Nubwo nta mibare nyayo igaragaza umubare w'abantu mu gihugu cyacu, biragaragara ko iyi ari indwara idakunze kugaragara.

Ni ibihe bimenyetso bya `(LEMS)`?

Reka turebe ibimenyetso bya `(LEMS)` kimwe kimwe. Ibi bimenyetso byose ntabwo bibaho icyarimwe kuri buri wese, bimwe bishobora kugaragara mbere y'igihe, ibindi bishobora kugaragara nyuma y'igihe.

• Intege nke z'imitsi n'umunaniro: cyane cyane mu maguru yo hejuru.
• Kugorwa no kugenda: Kugorwa no kuzamuka ingazi cyangwa kuva ku ntebe.
• Kubabara imitsi cyangwa kuyikomera.
• Kumva ufite ibinya mu maguru.
• Ijisho rinanutse (ptosis): Ibi bishobora kugaragara nk'ibitotsi.
• Kubona ibintu bibiri icyarimwe (diplopia).
• Kuma k'umunwa n'amaso (xerostomia): kugabanuka kw'amacandwe, kugabanuka kw'amarira mu maso.
• Kwihagarika impatwe.
• Kugabanuka kw'ibyuya.
• Kugabanya ibiro.
• Kugorwa no kunyara.
• Kudakora neza kw'imibonano mpuzabitsina ku bagabo.
• Kugorwa no kuvuga (dysarthria) no kugorwa no kumira (dysphagia): Ibi akenshi ni ibimenyetso bikunze kugaragara nyuma y’indwara.
• Guhumeka nabi (kubura umwuka) no kubura umwuka: Iki kandi ni ikimenyetso kidasanzwe kandi gikomeye gishobora kugaragara mu mpera z'indwara.

Icy'ingenzi: Niba ufite kimwe cyangwa byinshi muri ibi bimenyetso, ntugatekereze ko ari LEMS. Ariko, niba ibi bimenyetso bikomeje, ni byiza gushaka inama kwa muganga.

Ubusanzwe LEMS igaragara ite kandi itera imbere gute?

Ubusanzwe LEMS ibanza kugira ingaruka ku mitsi yo mu bibero . Hanyuma ishobora kugira ingaruka ku mitsi yo mu bitugu, ku mitsi y'amaboko n'amaguru, ku mitsi ifasha mu kuvuga no kumira, ndetse no ku mitsi y'amaso.

Mu ntangiriro z'iyi ndwara, ushobora kugira ingorane zo kubyuka ku ntebe, kuzamuka ingazi cyangwa imisozi, cyangwa gukora akazi gasaba gukoresha amaguru yawe.

Ibimenyetso bikunze kwiyongera buhoro buhoro, mu gihe cy'ibyumweru bike cyangwa amezi . Ariko, niba ufite LEMS urwaye kanseri, ibimenyetso bishobora kwiyongera vuba.

Ni iki gitera LEMS?

Nkuko twabiganiriyeho mbere, LEMS ni indwara iterwa n’ubwiyongere bw’umubiri . Ibi bivuze ko ubwirinzi bw’umubiri wawe (antibodies) bwibasira ingirabuzima fatizo zawe. Muri LEMS, izi antibodies zitera aho uturemangingo tw’imitsi n’imitsi bihurira, aho imitsi ihurira. By’umwihariko, zitera imiyoboro ya kalisiyumu iri aho. Iyi miyoboro ya kalisiyumu ni ingenzi kugira ngo ubutumwa bw’imitsi buhererekanywa.

Tekereza nk'umurongo w'udupira tw'intambara. Iki gitero gitera urukurikirane rw'ibintu:

1. Utunyangingo tw’umubiri dufata imiyoboro ya kalisiyumu ku mpera z’uturemangingo tw’imitsi hanyuma tukayifunga.

2. Iyo imiyoboro ya kalisiyumu igabanutse, ingano ya acetylcholine, umusemburo w’imitsi, irekurwa iragabanuka. Iyi acetylcholine ni shimi y’ingenzi ku mikorere y’imitsi.

3. Iyo acetylcholine idasohotse bihagije, "ubutumwa" bujya ku mitsi ntibugera neza. Icyo gihe imitsi yawe ntishobora gukora neza.

4. Ingaruka zabyo ni uko imitsi idakora neza, bigatuma umuntu agira intege nke.

Dore uko abantu barwaye kanseri y’ibihaha ifite uturemangingo duto barwara LEMS: Iyo ufite kanseri mu mubiri wawe, uturemangingo dufasha abantu "kujya mu ntambara." Ariko aho kwibasira uturemangingo twa kanseri (cyane cyane imiyoboro ya kalisiyumu iri hejuru y’uturemangingo twa kanseri), utwo turemangingo dutera mu buryo butari bwo imiyoboro ya kalisiyumu iri ku mpera z’uturemangingo tw’imitsi. Hanyuma ibintu bimwe bibaho.

Abahanga mu bya siyansi bemeza ko impamvu ya LEMS ku bantu badafite kanseri y'ibihaha ari uko ubudahangarwa bw'umubiri bukora nabi. Ariko ntibiramenyekana neza impamvu ibi bibaho.

Ni gute wamenya `(LEMS)`?

Intambwe ya mbere mu gusuzuma LEMS ni uko muganga wawe agusuzuma neza. Ibi bikunze kuba bikubiyemo inzobere mu ndwara z'imitsi, cyangwa umuganga w’inzobere mu kuvura indwara z’imitsi n’imitsi. Igice kimwe cy’iyi gahunda kikubiyemo kubaza ibimenyetso byawe, amateka y’ubuzima bwawe, n’imiti iyo ari yo yose ufata. Hakorwa isuzuma ryimbitse ry’imitsi kugira ngo harebwe imiterere y’intege nke n’ibimenyetso bihuye na LEMS.

Intambwe ikurikiraho ni ibizamini. Ibizamini bya `(LEMS)` birimo:

• Ikizamini cy'amaraso: Ibi bishobora kugenzura niba ufite anti-calcium channel antibodies mu maraso yawe. Abantu bagera kuri 85% bafite LEMS bafite izi anti-antibodies mu maraso yabo.
• Electromyography (EMG): Iki kizamini kireba uburyo imitsi n'imitsi yawe bikora neza. Muri LEMS, ikizamini cya EMG gifite ibimenyetso byihariye, bityo gishobora gufasha kwemeza indwara.
• Gupima X-ray y'ibihaha `(X-ray)` cyangwa CT scan `(CT scan)` cyangwa MRI scan `(MRI)` (yo mu gituza): Kubera ko indwara yitwa `(LEMS)` ishobora kugaragara ku bantu bafite kanseri y'ibihaha mu turemangingo duto, ibi bizamini bireba ibimenyetso bya kanseri y'ibihaha.

Ibimenyetso bya LEMS bishobora gutangira amezi kugeza ku myaka itandatu mbere yuko kanseri itangira. Kubwibyo, nyuma yuko LEMS imenyekanye, ugomba gupimwa kanseri buri mezi atatu kugeza kuri atandatu byibuze mu gihe cy'imyaka ibiri. Muganga wawe azakugira inama yo gupimwa ikwiranye nawe.

LEMS ivurwa ite?

Hari uburyo butandukanye bwo kuvura LEMS.

• Kuvura kanseri y’ibanze: Niba LEMS ifitanye isano na kanseri, nka kanseri y’uturemangingo duto tw’ibihaha, kuvura iyo kanseri bishobora no kugabanya ibimenyetso bya LEMS. Uburyo bwo kuvura kanseri bushobora kuba burimo imiti ivura kanseri, imiti ivura imirasire, cyangwa kubagwa. Ibi biterwa n’ubwoko bwa kanseri n’ibyo muganga wawe agusaba.
• Uburyo bwihariye bwo kuvura (LEMS): Muri ubu buryo harimo imiti igabanya ibimenyetso n'imiti igenzura ubudahangarwa bw'umubiri.

Kuvura ibimenyetso

• Amifampridine (Firdapse®), Guanidine: Iyi miti yongera imbaraga z'imitsi. Yongera irekurwa rya acetylcholine y'imitsi mu ihuriro ry'imitsi, ikarushaho kunoza ibimenyetso ku mitsi.
• Pyridostigmine (Pyridostigmine - Mestinon®): Pyridostigmine ikora mu gukumira gusenyuka kwa acetylcholine mu ihuriro ry'imitsi. Ibi kandi byongera uburyo acetylcholine ikora kandi bikongera imbaraga z'imitsi. Pyridostigmine rimwe na rimwe itangwa hamwe na amifampridine kugira ngo inoze imikorere y'imitsi no kuvura ibimenyetso bya LEMS nko kuma mu kanwa, amaso yumye, kuribwa mu nda, kudakora neza mu mibonano mpuzabitsina, no kugabanuka kw'ibyuya. Ariko, gukoresha pyridostigmine kuri LEMS ni ikoreshwa ritari iry'ikimenyetso, bivuze ko Ikigo gishinzwe ibiribwa n'imiti muri Amerika (FDA) kitaremeje uyu muti kuri iyi ndwara.

Uburyo bwo kuvura ubudahangarwa bw'umubiri

• Imiti igabanya ubudahangarwa bw'umubiri:Iyi miti ifasha guhagarika cyangwa kugenzura imikorere y' "ubwirinzi" bw'ubudahangarwa bw'umubiri wawe. Muganga wawe ashobora kukwandikira iyi miti niba indi miti idakubuza ibimenyetso. Urugero, umuti witwa prednisone ushobora gutangwa hamwe na azathioprine cyangwa cyclosporine cyangwa ntayo.
• Guhinduranya plasma: Muri ubu buryo, imashini itandukanya igice cy'amazi cy'amaraso yawe (plasma) n'uturemangingo tw'amaraso. Uturemangingo twawe tuba turi muri iyi plasma. Nyuma yo gutandukana, amaraso asubizwa mu mubiri wawe. Muganga wawe ashobora gusuzuma ubu buryo bwo kuvura niba ufite ibimenyetso bikomeye kandi ukeneye kuvurwa byihutirwa.
• Immunoglobulini: Ku bantu bamwe, kuvura immunoglobulini nyinshi bishobora gufasha gukumira indwara kurushaho.

Ese LEMS ishobora kwirindwa?

Impamvu nyayo ya LEMS ntabwo irasobanuka neza, bityo ntibiramenyekana niba hari uburyo bwo kwirinda iyi ndwara.

Ariko, kubera ko LEMS ishobora kwanduza abantu barwaye kanseri y'ibihaha, ushobora gufasha mu kwirinda kanseri y'ibihaha ukoresheje:

• Ntukanywe itabi. Niba unywa itabi, saba muganga wawe ubufasha bwo kurireka.
• Irinde umwotsi w'itabi ukoreshejwe n'abandi.
• Reba niba ufite gaze ya radon mu rugo rwawe. Guhura n'gaze ya radon igihe kirekire bishobora kongera ibyago byo kurwara kanseri y'ibihaha.

Ushobora kandi gufata ingamba zo gukomeza kugira ubuzima bwiza:

• Kurya imbuto n'imboga nyinshi. Kurikira indyo yo mu nyanja ya Mediterane cyangwa DASH.
• Komeza kugira ibiro bizima.
• Imyitozo ngororamubiri nk'uko muganga wawe yabigutegetse.
• Gira ibitotsi bihagije - ubusanzwe amasaha arindwi kugeza ku icyenda.
• Gabanya stress yawe. Stress ishobora gutuma ibimenyetso birushaho kwiyongera.
• Irinde koga mu mazi ashyushye. Ubushyuhe bushobora kongera ibimenyetso bya LEMS.
• Jyana na muganga wawe buri gihe, kandi umumenyeshe ako kanya niba ubuzima bwawe buhindutse cyangwa niba ugaragaje ibimenyetso bishya.

Ese LEMS ishobora gukira burundu?

Ikibabaje ni uko nta muti uhari wa LEMS. Kuvura kanseri ifitanye isano na LEMS byagaragaye ko bigabanya ibimenyetso bya LEMS. Imiti igabanya ubudahangarwa bw'umubiri ishobora gufasha mu kugenzura igitero cy'umubiri, kandi hari n'uburyo bwo kuvura bushobora gufasha mu kugabanya ibimenyetso binyuze mu kongera ingano ya acetylcholine mu mitsi no kunoza imbaraga z'imitsi.

Niba ufite LEMS udafite kanseri, ushobora kwitega kubaho ubuzima busanzwe. Niba ufite LEMS na kanseri, ibimenyetso byawe bishobora kwiyongera uko igihe kigenda (nubwo bitaba burundu) iyo kanseri igaragaye kandi igafatwa hakiri kare.

Ubuzima bwawe bushingiye ahanini ku buremere bw'ibimenyetso byawe.

Ni ryari nkwiye kuvugana na muganga wanjye niba mfite `(LEMS)`?

Niba hari impinduka mu buzima bwawe, cyangwa ibimenyetso byawe bikarushaho kwiyongera, hamagara muganga wawe igihe icyo ari cyo cyose . Ntutinye, ntugatinye. Abaganga barahari kugira ngo bagufashe.

Ni irihe tandukaniro riri hagati ya `(LEMS)` na `(Myasthenia Gravis - MG)`?

Indwara ya Lambert-Eaton myasthenic syndrome (LEMS) na myasthenia gravis (MG) bifite ibimenyetso bimwe bisa. Byombi bitera intege nke z'imitsi n'umunaniro.

Ariko, myasthenia gravis (MG) ikunze kugira ingaruka ku mitsi ikikije amaso yawe n'imitsi ikoreshwa mu kumira. Nyuma, ishobora kugira ingaruka ku mitsi rusange, harimo imitsi yo guhumeka n'imitsi y'amaguru.

Ubusanzwe LEMS itangirana n'intege nke mu bibero byo hejuru, hanyuma ikajya mu maboko yawe. LEMS ishobora kandi gutera intege nke mu mitsi y'amaso yawe, ariko ubusanzwe iba yoroshye kurusha myasthenia gravis (MG).

Mu ndwara ya myasthenia gravis (MG), intege nke cyane z'imitsi yo guhumeka (imitsi igufasha guhumeka) zishobora kwica. Ibi ntibikunze kubaho muri LEMS.

Abantu barwaye myasthenia gravis (MG) akenshi ntibagaragaza ibimenyetso byinshi by’imikorere mibi y’imitsi (urugero: amaso yumye, umunwa wumye, kuribwa mu nda, kubura ibyuya, imikorere mibi y’imibonano mpuzabitsina). Ibinyuranye n’ibyo, abantu barwaye LEMS bakunze kugira ibi bibazo, kandi ibi bimenyetso rimwe na rimwe bishobora gufasha mu gutandukanya indwara zombi.

Amaherezo, ibintu byo kwibuka (Ubutumwa bwo kujyana mu rugo)

Kugeza ubu ushobora kuba usobanukiwe ko Lambert-Eaton Myasthenic Syndrome (LEMS) ari indwara iterwa n'ubudahangarwa bw'umubiri bukora cyane. Uturemangingo tw'imitsi yawe ntitwohereza ubutumwa buhagije ku mitsi yawe ngo "yiyongere." Ingaruka ni intege nke z'imitsi n'ibindi bimenyetso.

Wibuke ko abantu bagera kuri 60% barwaye LEMS bafite kanseri y’ibihaha y’uturemangingo duto. Niba ufite LEMS ariko udafite kanseri, menya neza ko wowe na muganga wawe musuzuma kanseri buri mezi make nibura imyaka ibiri nyuma yo kuyirwara.

Hari uburyo bwo kuvura kanseri iyo ihari, ndetse no gufata imiti ifasha mu gutumanaho kw'imitsi n'uturemangingo tw'imitsi birushaho kuba byiza. Kunoza uburyo bwo kuvura bishobora kongera imbaraga z'imitsi n'ibindi bimenyetso.

Ndizera ko aya makuru azaba ingirakamaro kuri wewe.Wibuke ko niba ufite ikibazo cy'ubuzima, ni byiza kubivuganaho na muganga w'inararibonye.

Lambert -Eaton myasthenic syndrome, LEMS, indwara ziterwa n'ubwiyongere bw'umubiri, intege nke z'imitsi, kanseri y'ibihaha by'uturemangingo duto, aho imitsi ihurira, acetylcholine