Ese wigeze wumva ubwoko bw'iyi miti? Reka tuyige mu buryo bworoshye (Fosfodiesterase Inhibitors)

Ushobora kuba warumvise ibiyobyabwenge nka Viagra. Abantu benshi bazi ko ibi ari imiti itangwa ku ndwara zidakora neza mu mibonano mpuzabitsina. Ariko se wari uzi ko imiti yo mu bwoko butandukanye, yitwa Phosphodiesterase Inhibitors, ikoreshwa mu kuvura indwara zitandukanye, kuva ku ndwara z'umutima kugeza ku ndwara z'ibihaha, indwara z'uruhu, n'indwara z'ingingo? Uyu munsi, reka tuvuge kuri ubu bwoko butangaje bw'imiti. Reka dusobanukirwe gusa icyo ari cyo, uko ikora, n'ibyiza n'ibibi byayo.

Mu magambo make, ni iki kigabanya ubukana bwa Phosphodiesterase Inhibitors (PDE inhibitors)?

Iyi ni ubwoko bw'umuti wagura imiyoboro y'amaraso mu mubiri wacu, ukagabanya ubukana bwayo, kandi ukoroshya gutembera kw'amaraso. Tekereza ko iyo umuyoboro w'amazi uzibye, iyo uwugize munini gato, amazi arushaho gutembera byoroshye. Ibi bigabanya umuvuduko w'amaraso kandi bikanoza gutembera kw'amaraso mu bice bitandukanye by'umubiri. Kubera ubwo bushobozi, ubu bwoko bw'umuti bukoreshwa mu kuvura indwara zitandukanye.

Uyu muti ukora ute?

Kugira ngo tubisobanukirwe, tugomba kubanza kumenya ikintu gito cy’ubutabire mu mubiri wacu. Izina ryacyo ni Phosphodiesterases , cyangwa PDE mu magambo ahinnye. Iyi PDE ni ubwoko bwa enzyme . Enzymes ni nk'uturemangingo duto twihutisha kandi tworohereza izindi gahunda z'ubutabire mu mubiri wacu.

Hari ubwoko butandukanye bw'izi enzymes za PDE mu mibiri yacu. Abahanga mu bya siyansi bakoresheje imibare kugira ngo bayitandukanye. Ikintu cyihariye ni uko buri bwoko bwa PDE bukora cyane mu bice bimwe na bimwe by'umubiri.

• PDE-3: Ubwo bwoko buboneka cyane cyane mu mutima wawe no mu miyoboro y'amaraso . Bugira uruhare mu mikorere yo kuvura amaraso.
• PDE-4: Iyi ikunze kuboneka mu bihaha . Ikora mu gukaza imitsi yo mu nzira z'ubuhumekero.
• PDE-5: Ubwo bwoko buboneka mu bihaha no mu gitsina cy'umugabo .

Rero, imiti yitwa Phosphodiesterase Inhibitors (PDE inhibitors) ikora mu kubuza imikorere ya enzymes za PDE twavuze haruguru. Ni nko gufunga urugi. Hari imiti imwe n'imwe igabanya PDE ikora mu buryo bwo guhitamo . Ni ukuvuga ko yibasira ubwoko runaka gusa, nka PDE-5. Hari indi miti ikora idatoranyije . Ni ukuvuga ko ishobora kugira ingaruka ku bwoko bwose bwa PDE ku rugero runaka.

Ni izihe ndwara zivurwa n'uyu muti?

Ubwoko bw'imiti yitwa PDE inhibitors yemejwe n'ibigo nka FDA (U.S. Food and Drug Administration) kugira ngo ivure indwara zirenga icumi na ebyiri. Dore zimwe muri zo.

Ni izihe nyungu za PDE Inhibitors?

Ubu bwoko bw'imiti ni ingirakamaro cyane mu kuvura indwara zimwe na zimwe. Hari impamvu nyinshi zibitera.

• Byoroshye gukoresha: Iyi miti iza mu buryo butandukanye. Iboneka nk'ibinini binyobwa, amavuta yo kwisiga, n'inshinge za intravenous. Hari imiti ikenera gufatwa buri munsi, indi ishobora gufatwa gusa igihe bikenewe.
• Uburyo bwo kuvura hifashishijwe ikoranabuhanga: Nkuko nabivuze mbere, imiti imwe n'imwe yibasira ubwoko runaka bwa PDE, bityo ikaba idakunze gutera ingaruka mbi ku bindi bice by'umubiri. Ni nk'aho umuti ukora neza aho indwara iri.
• Ibyiza byinshi by'umuti umwe: Hari igihe indwara ebyiri zifitanye isano zishobora kugaragara ku muntu umwe. Urugero, indwara ya benign prostatic hyperplasia (BPH) n'indwara yo kunanirwa gusohora igitsina (ED) byombi bishobora kubaho hamwe. Tadalafil inhibitor ya PDE-5 yemerewe kuvura izo ndwara zombi. Mu buryo nk'ubwo, hari imiti ishobora kuvura goutte n'indwara ya rubagimpande.

Ni izihe ngaruka mbi n'ingaruka mbi z'uyu muti?

Ingaruka zikomeye ziterwa n'ubwoko bw'umuti ubuza PDE uwo muti urimo.

Ni nde utagomba gufata uyu muti?

Kuri bamwe, ubwo bwoko bw'imiti yitwa PDE inhibitors bushobora kuba budakwiye bitewe n'izindi ndwara zabo cyangwa indi miti bafata. Ibi tubyita contraindications . Hari ubwoko bubiri bw'imiti:

1. Ibibujijwe rwose:

• Ku muti uwo ari wo wose ubuza PDE: Niba wigeze kugira ubwivumbure bukomeye (hypersensitivity) kuri uyu muti cyangwa undi usa nawo.
• Kuri Cilostazol: Niba ufite ikibazo cy'umutima.
• Ku birebana n'imiti igabanya ubukana bwa PDE-5 (nka Sildenafil, Tadalafil): indwara zikomeye z'umutima, ububabare bwo mu gatuza budahamye (angina idahamye), indwara y'umutima cyangwa indwara yo gucika intege mu gihe gishize.

2. Ibinyuranye n'ibyo umuntu ashobora gukoresha:

• Ku miti igabanya umuvuduko wa PDE-5: Niba ufata imiti ya nitrati cyangwa alpha-blockers, ugomba kuvugana na muganga wawe kuko ishobora gutuma umuvuduko w'amaraso yawe ugabanuka mu buryo bukabije.
• Kuri Cilostazol: Niba ufite ibibazo byo kuva amaraso.
• Kuri Pentoxifylline: Niba uherutse kuva amaraso mu bwonko cyangwa mu jisho.

Niba utwite, ugerageza gusama, cyangwa wonsa, banza uganire na muganga wawe mbere yo gufata imiti iyo ari yo yose. Hari ibimenyetso bigaragaza ko zimwe mu mbogamizi za PDE zishobora kugira ingaruka ku mwana uri mu nda mu bushakashatsi ku nyamaswa.

Ni ryari ukwiye kujya kwa muganga?

Niba ibimenyetso byawe bihindutse cyangwa bikagira ingaruka ku mirimo yawe ya buri munsi, ni byiza kubimenyesha muganga wawe. Ariko, niba uhuye na kimwe muri ibi bikurikira , jya kwa muganga cyangwa mu cyumba cy’ubutabazi bwihuse (ETU).

• Ibimenyetso by'indwara y'umutima: kubabara mu gatuza, guhumeka nabi, kubira ibyuya, kuzerera, isesemi.
• Priapism: Guhagarara kubabaza kumara amasaha arenga 4 nta mibonano mpuzabitsina iteye. Ibi bishobora kwangiza burundu iyo bidavuwe vuba.
• Gutakaza ubushobozi bwo kubona cyangwa kumva bitunguranye: Niba uhuye n'ikibazo cyo kutabona bitunguranye, guta ubwenge, cyangwa guta amatwi, shaka ubufasha bwa muganga vuba. Gutinda bishobora gutera kwangirika burundu.

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