Unoziva here nezvemutumwa mudiki uyu ari mumuviri wako? (Adrenocorticotropic Hormone - ACTH)

Wakambozvibvunza here kuti chii chinoitika mumuviri wako kana wakaneta kana kuti uchinzwa kumanikidzwa kwakanyanya? Muviri wedu une shamwari diki yatisingaoni inotibatsira munguva dzakadai. Anonzi ACTH. Nhasi, tichataura nezve ACTH iyi.

Chii chinonzi ACTH?

Zvichitaurwa zviri nyore, ACTH ihormone inogadzirwa negland rako repituitary. Inoita basa guru mukuita kwemuviri wako kune kushushikana . Kana ACTH yaburitswa, inoudza magland ako eadrenal kuti agadzire cortisol, iyo yatinoziva tese se "stress hormone," uye boka remahormone ebonde anonzi androgens.

Zvino ungangove uchishamisika kuti mahormone aya chii, handiti? Mahormone makemikari anobatanidza mabasa akasiyana-siyana mumuviri wako. Akaita senhume. Mashoko aya anofamba neropa rako achienda kunhengo dzako, ganda, tsandanyama, nedzimwe nhengo dzemuviri. Zviratidzo izvi zvinoudza muviri wako zvekuita uye nguva yekuzviita.

Gland rako repituitary igland diki, rakakura sepizi riri pasi peuropi hwako, pasi pehypothalamus. Iri chikamu chehurongwa hwako hwe endocrine. Gland repituitary rine zvikamu zviviri: chikamu chepamberi nechikamu cheposterior. Gland rako repituitary repamberi ndiro rinogadzira uye rinoburitsa ACTH.

Chii chaizvo chinoitika neACTH?

Basa guru reACTH nderekukurudzira ma adrenal glands ako kuti abudise hormone inonzi cortisol. Funga nezvazvo sekuti ACTH yakafanana nemukuru wemauto ari kuudza ma adrenal glands ako kuti agadzire cortisol.

Cortisol ihormone inokosha zvikuru inodiwa nemiviri yedu. Inokanganisa nhengo dzese dzemuviri. Cortisol inozivikanwa se "hormone yekushungurudzika," asi ine mamwe mabasa akawanda akakosha mumiviri yedu.

Heano mamwe mashoko akakosha nezve cortisol:

• Unodzora kuti muviri wako unopindura sei kana wasangana nekushushikana .
• Zvinobatsira kudzora mashandisiro anoita muviri wako mafuta, mapuroteni, uye makabhohaidhiretsi, ndiko kuti, metabolism yako.
• Kuzvimba , zvinoreva kuzvimba uye kutsvuka munzvimbo dzakasiyana dzemuviri, kunoderera.
• Inodzora BP .
• Inodzora huwandu hweshuga muropa .
• Zvinobatsirawo kudzora kurara kwako nekumuka .

Hazvisi izvi chete, ACTH inoita zvimwe. Kureva kuti, inokurudzira ma adrenal glands kuti aburitse mahormone epabonde anonzi androgens. Pamusoro pezvo, ACTH inobatsira kugadzira makemikari anokurudzira kugadzirwa kwemahormone akawanda, akadai seadrenaline ne noradrenaline.

Mazinga eACTH anodzorwa sei?

Mazinga eACTH emuviri wako anodzorwa nesystem inonakidza zvikuru. Inonzi system yefeedback. Inosanganisira hypothalamus yako, pituitary gland, adrenal glands, uye mamwe mahormone. Isu tinodana system yese iyi kuti Hypothalamic-Pituitary-Adrenal (HPA) axis . Zvinonzwika zvakaoma zvishoma, handiti? Asi zviri nyore.

Fungidzira kuti pituitary gland yako yakabatana nehypothalamus yako netsinga diki yeropa netsinga. Izvi zvinonzi pituitary gand. Kuburikidza netsinga iyi, hypothalamus inotaura netsinga yepituitary yoiudza kuti iburitse mamwe mahormone. Hypothalamus yako chikamu cheuropi hwako chinodzora zvinhu zvakaita seBP, kurova kwemoyo, tembiricha yemuviri, uye kugaya chikafu.

Matumbu eadrenal glands madiki maviri, akaita setriangle ari pamusoro peitsvo dzako.

Zvino ngationei kuti iyi nzira yekupa mhinduro inodzora mazinga eACTH inoshanda sei:

• Kana huwandu hwecortisol mumuviri wako hwadzikira, hypothalamus yako inoburitsa hormone inonzi Corticotrophin-Releasing Hormone (CRH) .
• CRH iyi inosimudzira chikamu chepituitary chepamberi kuti chibudise ACTH.
• ACTH inobva yakurudzira ma adrenal glands ako, kunyanya adrenal cortex, kuti aburitse cortisol uye androgens.
• Kana huwandu hwecortisol hukawedzera seizvi, hunotumira chiratidzo ku hypothalamus kuti huderedze huwandu hweCRH. Uye ndizvo zvinopedzwa. Zvakafanana ne 'switch on-off' .

Hazvisi izvi chete, kana uine stress , kureva kuti, mupfungwa dzakaoma, kugadzirwa kweACTH kunosimudzirwa uye mazinga e cortisol anowedzera.

Zvisinei, kana paine dambudziko ne hypothalamus yako, pituitary gland, kana adrenal glands, kuenzana kwemahormone anobatanidzwa mukuita uku, kureva ACTH, kunogona kukanganiswa.

Nzira yekutarisa mazinga eACTH?

Kuongororwa ropa kunoitwa kuti uone huwandu hweACTH yako. Izvi zvinosanganisira kutora ropa diki kubva mutsinga iri muruoko rwako.

Vanachiremba vanowanzo raira bvunzo ye cortisol pamwe chete nebvunzo yeACTH kuti vaone kana paine matambudziko ne pituitary gland kana adrenal glands.

Zvakare, vanachiremba dzimwe nguva vanogona kuita chimwe chinhu chinonzi bvunzo yekukurudzira ACTH . Izvi zvinoongorora kuti adrenal glands ako anopindura sei kuACTH. Izvi zvinogonawo kubatsira kuona matambudziko ane pituitary uye/kana adrenal glands.

Chii chinonzi ACTH level yakajairika?

Kufanana ne cortisol, huwandu hweACTH muropa rako hunowanzo wedzera mangwanani-ngwanani. Hunodzikira zvishoma nezvishoma sezvo zuva richienderera mberi, huchisvika padanho rakaderera pakati pehusiku. Zvisinei, kana ukashanda usiku uye ukarara panguva dzakasiyana dzezuva, maitiro aya anogona kuchinja.

Saka, bvunzo dzeACTH dzinowanzo da kuti ropa ribudiswe mangwanani. Kazhinji, mwero weACTH pakati pe7:00 a.m. na10:00 a.m. i7.2 kusvika 63.3 picograms pa milliliter (7.2 kusvika 63.3 pg/mL) .

Asi yeuka chinhu chimwe chete. Kuwanda uku kwakajairika kunogona kusiyana kubva murabhoritari kuenda kune imwe, nguva nenguva, uye kubva kumunhu nemunhu. Kana ukaongororwa neACTH, chiremba wako ndiye achaverenga zvawakawana uye achakuudza kana zvichidikanwa kuongororwazve kana kuti kwete.

Chii chinoitika kana mazinga eACTH akawedzera?

Kana huwandu hweACTH yako hwakakwira, zvingangoita kuti huwandu hwecortisol yako hwakakwirawo. Nekuti cortisol inokanganisa muviri nenzira dzakawanda, unogona kusangana nemigumisiro ye cortisol yakakwira pane zviratidzo zve ACTH yakakwira. Mune zvimwe zviitiko, kana adrenal glands yako isiri kugadzira cortisol yakakwana, huwandu hweACTH hunogona kuwedzera. Muzviitiko izvozvo, unogona kusangana nezviratidzo zve cortisol yakaderera, kwete ACTH yakakwira.

Pane zvikonzero zvakawanda zvinogona kukonzera kukwira kwemazinga eACTH:

• Chirwere chaCushing: Ichi ndicho chikonzero chinowanzoita kuti huwandu hweACTH huwedzere. Izvi zvinokonzerwa nebundu risiri rekenza (adenoma) mugland repituitary rinoburitsa ACTH yakawandisa. Izvi zvinobva zvaita kuti huwandu hwecortisol huwedzere. Zvakakosha kunzwisisa mutsauko uripo pakati pechirwere chaCushing nechirwere chaCushing . Chirwere chaCushing chimwe chezvikonzero zvakawanda zvinokonzera chirwere chaCushing.
• Bundu rehomoni readrenocorticotropic reEctopic: Kashoma, bundu rinobuda kunze kwegland repituitary rinogona kuburitsa ACTH yakawandisa. Mabundu anogona kugadzira ACTH nenzira iyi (kunyange zvisingawanzoitiki) anosanganisira bundu rekenza remapapu risiri rekenza, bundu repancreas, medullary carcinoid yethyroid, bundu remasero madiki emapapu, uye bundu rethymus gland .
• Kusakwana kweadrenal glands: Izvi zvinoitika kana chimwe chinhu chakuvadza adrenal glands ako uye asingakwanise kugadzira cortisol zvakanaka.Ichi ndicho chikonzero chinowanzoita kuti adrenal gland isashande zvakanaka. Nekuda kweizvozvo, pituitary gland yako inoburitsa ACTH yakawanda nekuti inoda kukurudzira adrenal glands.

Chii chinoitika kana mazinga eACTH akadzikira?

Kana huwandu hweACTH hwakaderera nekuda kwedambudziko repituitary gland, huwandu hwecortisol hunowanzovawo hwakaderera. Zvisinei, kana huwandu hwecortisol hwakakwira nekuda kwedambudziko readrenal gland, huwandu hweACTH hunogona kuva hwakaderera.

Pane zvikonzero zvakawanda zvinoita kuti mazinga eACTH ave akaderera:

• Cushing's syndrome: Cushing's syndrome, iyo inogona kukonzerwa nebundu readrenal gland kana kushandisa kwenguva refu mishonga ye corticosteroid kune zvimwe zvirwere, inogona kukonzera kudzikira kwemazinga eACTH. Izvi zvinokonzerwa nekuti pituitary gland yako haigone kuburitsa ACTH zvakajairika nekuda kwe cortisol yakawandisa.
• Hypopituitarism: Ichi chirwere chisingawanzoitiki. Apa ndipo apo pituitary gland yako inogadzira mahormone mashoma, akawanda, kana ese. ACTH ndeimwe yemahormone anogona kukanganiswa. Chero kukuvara kupi zvako ku pituitary gland yako, senge bundu, kuvhiyiwa, kana kurapwa nemwaranzi, kunogona kukonzera hypopituitarism.

Pari zvino pamwe wava kunzwisisa kuti ACTH inokosha pakugadzirisa huwandu hwe cortisol yako. Kana uri kuona zviratidzo zve cortisol yakakwira kana yakaderera, zvakaita sekuwedzera kana kudzikira kwehuremu, BP yakakwira kana yakaderera, iva nechokwadi chekuona chiremba wako. Anogona kuita bvunzo dzeropa dze cortisol ne ACTH kuti aone kana adrenal glands yako kana pituitary gland zviri izvo zvinokonzera zviratidzo zvako.

Saka ndezvipi zvinhu zvatinofanira kurangarira?

ACTH ihomoni inokosha zvikuru inogadzirwa negland repituitary iyo inobatsira kudzora kushushikana mumuviri wedu.

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- Izvi ndizvo zvinokurudzira ma adrenal glands kuti agadzire "hormone yekushungurudzika" cortisol .

- Cortisol inodzora zvinhu zvakawanda, zvakaita sekushandiswa kwemuviri wedu, BP, uye huwandu hweshuga muropa.

- Mazinga eACTH anodzorwa nehurongwa hwakaoma hunosanganisira hypothalamus, pituitary gland, uye adrenal glands .

- Kana huwandu hweACTH hukawedzera kana kudzikira, zvinogona kukonzera chirwere cheCushing, chirwere cheAddison.Matambudziko akasiyana-siyana ehutano anogona kuitika.

- Kana uine zviratidzo panyaya iyi, zvakanaka kuona chiremba usingatyi uye kutsvaga mazano.

ACTH , Adrenocorticotropic Hormone, Cortisol, Pituitary gland, Adrenal glands, Mahormone, Stress