Wakamboona here kuti amai vako, baba, kana mudiwa wako akwegura ari kukanganwa zvinhu? Dzimwe nguva kukanganwa mazita, kero, kana kutoyeuka kuti magirazi ako ari kupi zvakajairika sezvaunokura. Asi kana kukanganwa uku kuchiwedzera zvishoma nezvishoma uye usingakwanise kuita mabasa ezuva nezuva wega, zvinogona kunge zviri chiratidzo cheAlzheimer's Disease. Ipapo mubvunzo mukuru unouya mupfungwa dzedu ndewekuti, 'Sei nyika yakasimukira kudai isati yawana mushonga wechirwere ichi?' Ngatitaurei nezvazvo zvakadzama nhasi.
Chirwere ichi chakatanga kuwanikwa sei?
Nyaya iyi inotanga makore anopfuura zana apfuura, muna 1901. Chiremba wekuGermany ainzi Alois Alzheimer akaongorora uropi hwemukadzi akafa nechirwere chepfungwa. Akaona chimwe chinhu chinoshamisa. Pakati pema neuron muuropi, rudzi rweprotein rwakanga rwava kunamira uye rwakabatana, sema plaques. Aya akazonzi "plaques." Akaonawo kuti rumwe rudzi rweprotein rwakanga rwabatana uye rwakabatana seshinda mukati mema neuron. Aya ainzi "tangles."
Nekufamba kwenguva, masayendisiti akawana kuti mavanga acho akagadzirwa nepuroteni inonzi beta-amyloid . Vakaonawo kuti mavanga acho akagadzirwa nepuroteni inonzi tau . Pakupedzisira, chirwere ichi chakazotumidzwa zita rekuti "Alzheimer's disease" vachikudza chiremba akachiwana.
Nyaya huru ye "Amyloid Hypothesis"
Saka, kuma1990, pfungwa huru yakanga yatanga pakati pevaongorori. Izvi zvaive chikonzero chikuru chechirwere ichi chaive ma beta-amyloid plaques aiungana muuropi. Pfungwa iyi yainzi "Amyloid Hypothesis." Zvichitaurwa zviri nyore, vaifunga kuti ma amyloid plaques aya ndiwo aikonzera kuti masero europi afe uye kuti ndangariro isashande.
Saka, kwemakore makumi matatu apfuura , tsvakiridzo zhinji pamusoro pechirwere cheAlzheimer pamwe nekuedza kwakawanda kutsvaga mushonga kwakavakirwa pafungidziro iyi yeamyloid.
Asi izvi zvakabudirira here? Kwete chaizvo. Mazana emishonga akaedzwa kubvisa ma plaque aya e amyloid, asi hapana chakachinja zvakanyanya hupenyu hwevarwere. Mishonga inoderedza huwandu hwe amyloid muuropi haina kumisa kurasikirwa nendangariro dzemurwere kana kuvandudza hupenyu hwavo hwezuva nezuva. Kunyangwe mushonga uchangobva kubvumidzwa we 'lecanemab' wakangodzora zvishoma kuipa kwechirwere, asi hausi mushonga.
Takaramba takabatirira munzira imwe chete here?
Nekuda kwemhedzisiro iyi isina kubudirira, vaongorori vazhinji vava kubvunza kuti, "Tiri kuenda munzira isiriyo here?" Kutaura zvazviri, sainzi haisi chinhu chinogona kuita mutsauko mukuru panguva imwe chete. Zvakafanana nengarava huru, haigone kutendeutswa panguva imwe chete. Vaongorori vanodzidza nyaya imwe chete kwemakore, vobva vaita tsvakurudzo yakawanda pamusoro penyaya imwe chete. Zvadaro, boka guru revanhu neruzivo zvinovakwa papfungwa imwe chete. Paunoenda kubasa nepfungwa itsva, nzira dzakakodzera neruzivo hazvipo. Saka, panyaya yeAlzheimer's, ngarava iyi huru yaifamba ichienda ku "amyloid." Saka, kutarisirwa kushoma kwakapihwa kune zvimwe zvikonzero, zvakaita sekuzvimba, hutachiona hwakasiyana-siyana, kana zvirwere zve autoimmune.
Asi, nyaya iyi yeamyloid haina kuipa zvachose. Pamwe dambudziko riri pamushonga. Kana kuti, nguva yemushonga ingave isiriyo. Pamwe mishonga iyi inofanira kutanga kushandiswa makore akawanda zviratidzo zvisati zvaonekwa.
Paiva nerimwe dambudziko. Kusvika makore gumi apfuura, pakanga pasina nzira yekusimbisa chirwere cheAlzheimer 100% munhu achiri mupenyu, kunze kwekunge aongorora uropi hwake mushure mekufa. Saka, vamwe vevanhu vakapinda muzvidzidzo zvekare vakanga vasina chirwere cheAlzheimer. Saka data kubva muzvidzidzo izvozvo rakanga risina kururama, handiti?
Asi ikozvino mamiriro acho akasiyana. Neruzivo rutsva, kunyanya PET scans uye bvunzo dze cerebrospinal fluid, zvinokwanisika kuona kuvapo kwemapuroteni e amyloid ne tau muuropi hwemunhu mupenyu.
'Kujairira Kwemotokari' Mukati Meuropi uye Tsvagiridzo Itsva
Iye zvino, pachinzvimbo chekungofunga nezvekubvisa maplaque iwayo, vaongorori vari kutanga kutarisa chikonzero chikuru chedambudziko iri, vachibvunza kuti, "Sei maplaque aya achiumbwa?" Zvinoita sekunge haugone kugadzirisa dambudziko racho usingazive kuti riri kupi chaizvo. Iye zvino, kune dzidziso itsva dzinoverengeka pamusoro peizvi. Ngationei kuti ndedzipi.
| Nhungamiro Itsva Yekutsvaga | Nemashoko akareruka... |
|---|---|
| Dambudziko reMasero | 'Kujairika kwemotokari' kunoitika muhurongwa hunofambisa mapuroteni mukati memasero europi. Izvi zvinokonzera kuti mapuroteni e-amyloid ne-tau aungane. Vatsvaguriri vari kutsvaga nzira dzekubvisa 'jai' iyi. |
| Chirwere che autoimmune | Zvinoenderana nedzidziso iyi, amyloid chikamu chemuviri wekudzivirira muviri muuropi. Zvisinei, nekuda kwekukanganisa kwakaitwa, muviri uyu unotanga kurwisa masero europi ane hutano panzvimbo pekurwisa hutachiona. |
| Utachiona uye Kuzvimba | Pane humbowo hwekuti kuzvimba muuropi kunokonzerwa nehutachiona hwakasiyana, hwakadai seherpes, kunogona kunge kuri iko kunokonzera chirwere cheAlzheimer's. |
| Chirwere cheMetabolic | Vamwe vanhu vanodana izvi kuti "chirwere cheshuga cheuropi" kana kuti "chirwere cheshuga cherudzi rwechitatu." Muizvi, masero europi haapindure zvakanaka ku insulin (insulin resistance), zvichikonzera kuzvimba nekumwe kukuvara. |
Saka hapana chatingaita here? Ngatitaurei nezvekudzivirira.
Paunonzwa zvese izvi, ungafunga kuti, 'Haa, hapana chaunogona kuita nezvazvo.' Asi usafunge kudaro. Mashoko akanaka ndeekuti chirwere cheAlzheimer chinotora nguva yakareba kuti chibude, makore angangoita makumi maviri kusvika makumi matatu. Izvi zvinoreva kuti tine nguva yakawanda yekumisa kana kunonotsa kufambira mberi kwechirwere.
Kunyangwe paine simba remajini, kune zvinhu zvakawanda zvinogona kuchinja zvinogona kukanganisa kukura kwechirwere cheAlzheimer. Izvi ndeizvi:
- Kufuta
- Chirwere cheshuga
- Chirwere chemwoyo
- Kolesteroli yakakwira
- Kukwira kweropa
- Kurasikirwa nekunzwa
- Kuora mwoyo uye kusurukirwa
Izvi zvinoreva kudzora BP yako, cholesterol, uye huwandu hweshuga , kuchengetedza huremu hwakanaka, kurovedza muviri, uye kudya kudya kwakaringana ndizvo zvinhu zvakanakisisa zvaunogona kuita kuderedza njodzi yako yeAlzheimer's. Dzimwe nguva, kunyangwe chimwe chinhu chiri nyore sekushandisa chinhu chinobatsira kunzwa padambudziko rekunzwa chinogona kuita mutsauko mukuru.
Chinhu chikuru chine zvakanakira zvinhu izvi ndechekuti hazvina njodzi yakawanda, hazvidhuri zvakanyanya, uye zviri nani pahutano hwedu hwese. Zvinobatsira sei kuchinja mararamiro edu pane kushandisa mazana ezviuru zvemadhora pagore kutenga mushonga mutsva?
Mune ramangwana, kurapwa kweAlzheimer, sekurapa kenza, kunogona kusanganisira musanganiswa wenzira dzakasiyana-siyana nemishonga, "cocktail," kwete mushonga mumwe chete. Zvisinei, masayendisiti ari kusava nechokwadi nezvezvitendero zvavo zvekare uye kutsvaga nzira itsva dzekurwisa chirwere ichi, uye tariro huru mukurwisa chirwere ichi ndeyekuwana nzira itsva dzekurapa.
Mharidzo Yekuenda Nayo Kumba
- Chirwere cheAlzheimer chirwere chakaoma kunzwisisa. Hachigumiri pakuunganidzwa kwema plaque e amyloid muuropi.
- Saka, hazvizokwanisike kurapa chirwere ichi ne "piritsi remashiripiti" rimwe chete munguva pfupi iri kutevera.
- Vatsvagurudzi vava kutarisa zvinhu zvakasiyana-siyana zvakaita sematambudziko ekudzivirira muviri, hutachiona, uye zvirwere zve metabolic.
- Chinhu chinonyanya kukosha: Unogona kuderedza njodzi yako. Zvakakosha kudzora BP yako, chirwere cheshuga, cholesterol, kurovedza muviri, uye kudya chikafu chine hutano.
- Kana uine zvinokunetsa kana kutya nezvekurangarira kwako kana kurangarira kwemudiwa wako, usanonoka kutaura nachiremba wako nezvazvo. Kana ukakurumidza kutaura nezvazvo, zviri nani.
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