Kana chiremba wako akakuudza iwe kana mumwe munhu waunoziva kuti ane kenza yemazamu, vanogona kunge vakataura nezvekurapa nehomoni. Unganetseka zvishoma paunonzwa izvi. Asi usazvidya mwoyo. Nhasi tiri kutaura nezvemhando yemushonga unoshanda zvikuru unopiwa kuvanhu vane masero ekenza anonzwa hormone yeestrogen (`Estrogen Receptor-Positive` kana `ER+`). Aya anonzi Aromatase Inhibitors.
Zvichitaurwa zviri nyore, chii chinonzi Aromatase Inhibitors idzi?
Zvakanaka, ngatitsanangure izvi. Mishonga inodzivirira kukwegura, kana kuti AIs muchidimbu, imhando yemishonga inowanzo shandiswa mukurapa mahormone. Inoshandiswa kurapa kenza yemazamu yeER+, kunyanya kuvakadzi vasvika panguva yekupedza kuenda kumwedzi .
Zvino, tarisai, estrogen ihormone inokosha kumiviri yedu, kunyanya pahutano hwekubereka kwevakadzi. Zvisinei, kune mamwe masero ekenza yemazamu, iyi hormone yeestrogen yakafanana nechikafu. Kureva kuti, kana estrogen iripo, masero ekenza iwayo anokura nekukurumidza.
Apa ndipo panopinda mishonga ye'AI'. Zvinoitwa nemishonga iyi kuvharira enzyme inonzi aromatase mumuviri wedu. Iyi aromatase enzyme inoshandura mamwe mahormone kuita estrogen. Saka, kana mushonga uyu ukamisa enzyme yearomatase kushanda, huwandu hweestrogen mumuviri hunoderera. Ipapo masero ekenza iwayo anorasikirwa ne "chikafu" chawo, anomira kukura, uye kenza inodzorwa. Unonzwisisa here?
Zvichitaurwa zviri nyore, mushonga uyu unomisa masero ekenza kuti asawane "mafuta" aanoda.
Mushonga uyu unokurudzirwa mumamiriro api ezvinhu?
Pane mamiriro akati wandei apo chiremba wako angakurudzira kurapwa uku kwe "AI":
- Kana wakambovhiyiwa kenza yemazamu yeER+, mushonga uyu unopihwa kuderedza njodzi yekuti kenza idzoke zvakare .
- Kana kenza yapararira kune ma lymph nodes ari pedyo.
- Kana gomarara rapararira kune dzimwe nhengo dzemuviri (semuenzaniso mapapu, mapfupa, uropi, chiropa), tinoridaidza kuti gomarara rakapararira.
- Kana uine kenza iyi ye 'ER+' usati waenda kumwedzi. Panguva ino, mazai ako achiri kugadzira estrogen, saka unogona kupihwa mamwe marapirwo ekudzora hormone iyoyo ye estrogen pamwe chete nemushonga we 'AI'.
- Kana murume akabatwa nekenza yemazamu inonzi `ER+`. (Hongu, varume vanobatwawo nekenza yemazamu, uye vanewo estrogen shoma mumuviri wavo).
- Dzimwe ongororo dzakaratidza kuti vanhu vane njodzi yakakura yekubatwa nekenza yemazamuMushonga uyu unonzi unobatsira kuderedza njodzi iyoyo, asi hausati wawana mvumo yepamutemo.
Mhando dzinonyanya kushandiswa dze aromatase inhibitors
Kune mhando dzakasiyana dzemishonga iyi ye "AI" dziri kutengeswa. Chiremba wako achasarudza inonyatsokodzera chirwere chako.
| Zita reMushonga |
|---|
| Letrozole |
| Anastrozole |
| Exemestane |
Ndingawana sei kurapwa uku uye kunotora nguva yakareba sei?
Mushonga uyu we "AI" ipiritsi raunofanira kunwa zuva nezuva . Dzimwe nguva, kurapwa kunotanga nemushonga uyu. Dzimwe nguva, chiremba wako anogona kutanga akupa mumwe mushonga wehomoni unonzi tamoxifen kwemakore mashoma ozobva akuchinja kuenda kumushonga we "AI".
Kazhinji, kurapwa uku kunoenderera mberi kwemakore angangoita mashanu . Mushure memakore mashanu, kana usina zviratidzo zvegomarara uye bvunzo dzacho dzakajairika, unogona kurega kurapwa.
Zvisinei, zvimwe zvidzidzo zvakaratidza kuti kenza inogona kudzoka mushure memakore makumi maviri mushure mekurapwa. Izvi zvinonzi 'kudzoka kwechirwere kunonoka'. Saka, zvakakosha kutaura pachena nachiremba wako nezvenjodzi dzakanangana nemamiriro ako ezvinhu.
Mabhenefiti ekurapwa uye migumisiro inogona kuitika
Chinhu chikuru chekurapa uku ndechekuti kunogona kurapa kenza yemazamu yeER+. Zvidzidzo zvakaratidza kuti 95% yevanhu vanowana kurapwa uku kweAI mushure mekuvhiyiwa havazodzoki kenza yavo mukati memakore mashanu . Aya mashoko akanaka, handiti?
Asi, semishonga yese, iyi inogona kuva nemigumisiro yakaipa. Nekuti, sezvatakambokurukura, estrogen ihormone inobatsirawo kuchengetedza mapfupa edu nemoyo yedu zvine hutano. Saka, kana ukadzikisa huwandu hweestrogen ne `AI`, mimwe migumisiro inogona kuitika.
| Mhedzisiro Yepadivi | Zvichitaurwa zviri nyore... |
|---|---|
| Osteoporosis uye kutyoka kwemapfupa | Mapfupa anoshaya simba uye njodzi yekutyoka inowedzera zviri nyore. |
| Kurwadziwa kwetsandanyama (Myalgia) | Kurwadziwa kwetsandanyama. |
| Kurwadziwa kwemajoini | Kurwadziwa kwemajoini, senge mabvi nemagokora. Uyu ndiwo mhedzisiro inowanzoonekwa. |
| Kupisa kunopisa | Ndakangoerekana ndanzwa kupisa kwakanyanya uye kudikitira. |
| Kuoma kwechikadzi | Kurwadziwa kunogona kuitika panguva yepabonde. |
| Njodzi yezvirwere zvemwoyo | Njodzi yechirwere chemwoyo yakawedzera zvishoma. |
Ungagadzirisa sei migumisiro yakaipa?
Usavhunduke nemhedzisiro iyi. Chinhu chakakosha kutaura nachiremba wako nezvazvo. Kunyanya kana zvinhu zvakaita sekurwadziwa kwemajoini zvakanyanya, haufanirwe kuzvitsungirira. Chiremba wako anogona kukupa mhinduro. Semuenzaniso:
- Mishonga inouraya marwadzo, kunyanya NSAIDs (semuenzaniso, ibuprofen), inogona kunyorerwa.
- Kana zvichikuomera kutsungirira, unogona kushandisa imwe mhando yeAI panzvimbo peAI yauri kushandisa parizvino.
- Mune zvimwe zviitiko, tamoxifen inogona kutsiva AI.
Chinhu chinonyanya kukosha ndechekuzivisa chiremba wako nezvekusagadzikana kupi zvako, pane kuita sarudzo wega.
Unofanira kutaura nachiremba rini?
Muzviitiko zvinotevera, iva nechokwadi chekutaura nachiremba wako.
- Kana migumisiro yacho yakaipa kupfuura zvawaitarisira.
- Kana mushonga wakapihwa nachiremba usingape zororo kubva pamigumisiro yakaipa.
- Kana ukaona zviratidzo zvekudzokera kwegomarara (semuenzaniso mapundu matsva, kurwadziwa kunoramba kuripo, kunetseka kufema) , bvunza chiremba wako kuti zviratidzo zvipi zvekutarisa.
Mharidzo Yekuenda Nayo Kumba
- Aromatase inhibitors mushonga unoshanda zvikuru uye unoshanda wemahormone ekurapa kenza yemazamu inobatwa neestrogen (ER+).
- Mishonga iyi inoshanda nekuderedza huwandu hweestrogen mumuviri uye kumisa kukura kwemasero ekenza.
- Kurapa uku kunoderedza zvikuru njodzi yekudzoka kwekenza.
- Migumisiro yakaipa yakadai sekurwadziwa kwemajoini uye kutetepa kwemapfupa inogona kuitika, asi yakawanda yacho inogona kugadziriswa.
- Chinonyanya kukosha: Usamborega kutora mushonga wako kana kuchinja mushonga wacho usina kurairwa nachiremba wako. Taura naye pachena nezve chero kusagadzikana kwaunonzwa.
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