Chiremba wako akakuudza here kuti une chirwere chisingawanzoitiki chinonzi Systemic Mastocytosis ? Unganzwa kutya uye kunetseka zvishoma paunonzwa izvozvo. Zvakajairika. Asi usazvidya mwoyo. Iye zvino kune mishonga yakanaka uye inoshanda yezvirwere zvakadaro. Nhasi tichataura nezvemushonga weAyvakit (avapritinib) wawakanyorerwa. Ngatinzwisise zvese nezvechirwere ichi nemushonga zviri nyore uye zvakajeka.
Chii chaizvo chinonzi Systemic Mastocytosis (SM)?
Zvichitaurwa zviri nyore, Systemic Mastocytosis chirwere chisingawanzoitiki apo rudzi rwesero rinonzi 'mast cells' mumuviri wedu runokura zvakanyanya. Mast cells aya chikamu chesystem yedu yekudzivirira muviri. Kufanana nemauto ekudzivirira enyika yedu. Kana chimwe chinhu chisiri chemumuviri chikapinda mumuviri, masero aya anova activated uye anoburitsa makemikari akaita se 'histamine'.
Fungidzira kuti kana umhutu ukakuruma, nzvimbo yacho inokwenya uye inotsvuka, handiti? Ndizvo zvinoitika nekuda kwehistamine iyi. Asi mumunhu ane Systemic Mastocytosis, mast cell aya anoungana mumuviri nenzira isingadzoreki. Anoungana muganda, mumwongo wemapfupa, kana nhengo dzemukati dzakadai sechiropa nespleen. Nekuda kweizvi, muviri unogona kusangana nezviratidzo zvekurwara, zvakaita sekurumwa, kutsvuka kweganda, kurwadziwa mudumbu, uye dzungu, pasina chikonzero chakajeka.
Izwi rekuti "systemic" rinoreva kuti rinogona kukanganisa muviri wese, kwete nzvimbo imwe chete. Kune mhando dzakasiyana dzechirwere ichi, kubva pamhando dzisina kusimba, dzinokura zvishoma nezvishoma (dzisingashande) kusvika kune mhando dzekenza dzakakura.
Ndingaziva sei kana Ayvakit akandinakira?
Chiremba wako achaita bvunzo dzakawanda kuti aone kuti rudzii rweSystemic Mastocytosis yaunayo. Mhedzisiro yebvunzo idzodzo nezviratidzo zvako ndizvo zvicharatidza kana Ayvakit yakakunakira. Pari zvino Ayvakit yakatenderwa kurapa mhando dzakasiyana dzeSystemic Mastocytosis muvanhu vakuru.
| Rudzi rwechirwere | Tsananguro iri nyore |
|---|---|
| Advanced Systemic Mastocytosis (AdvSM) - rudzi rwakakomba, runopararira nekukurumidza | |
| Mastocytosis yeHurukuro yeSystemic | Kuwanda kwemasero emuviri (mast cells) kunokonzera kusashanda zvakanaka kwenhengo dzakadai sechiropa, nzira yekugaya chikafu, uye mapfupa. |
| SM ine chirwere cheropa chakabatana (hematological neoplasm) | Sezvo masero emasero eropa achiwedzera, zvimwe zvirwere zvine chekuita neropa (semuenzaniso myelodysplastic syndromes) zvinogona kukura. |
| Leukemia yemasero mast | Iyi igomarara risingawanzoitiki, rinokura nekukurumidza umo masero emasero anoungana akawanda (anopfuura 20%) munyama. |
| Indolent Systemic Mastocytosis (ISM) - rudzi rwechirwere chinokura zvishoma nezvishoma, chisina kusimba | |
| Mastocytosis yeSindolent Systemic (ISM) | Iyi haisi kenza. Masero emuviri anokura zvishoma nezvishoma. Kunyangwe achigona kukonzera zviratidzo zvisingafadzi, nhengo dzemuviri hadziwanzoitiki. |
Zvakakosha: Zvinogona kuva nengozi kushandisa Ayvakit kana huwandu hwemaplatelet eropa rako hwakaderera zvakanyanya. Maplatelet rudzi rwemasero anobatsira kumisa kubuda ropa. Chiremba wako achaongorora huwandu hwemaplatelet ako nguva nenguva usati watanga kutora mushonga uyu uye paunenge uchitora. Izvi zvinoitirwa kuderedza njodzi yemigumisiro yakakomba, yakadai sekubuda ropa muuropi.
Mushonga uyu weAyvakit unoshanda sei pamuviri?
Ayvakit mushonga uri muboka remishonga inonzi 'kinase inhibitors'. Kinases rudzi rweprotein yeenzyme inobatsira kutumira zviratidzo pakati pemasero mumuviri wedu. Zviratidzo izvi zvakakosha zvikuru pazvinhu zvakaita sekukura nekupatsanurwa kwemasero.
Vanhu vazhinji vane Systemic Mastocytosis vane shanduko muprotein inonzi KIT inowanikwa mumasero emuviri . Kuchinja uku kunoita kuti protein yeKIT ishande zvakanyanya, zvichiita kuti masero emuviri akure zvisingadzoreki.
Mushonga weAyvakit unonyanya kurwisa puroteni yeKIT yakachinja uye unomisa kushanda kwayo.Kufanana nekunyaradza shongwe iri kupa chiratidzo chisiri icho. Izvi zvinomisa kugadzirwa kwakawandisa kwemasero emuviri, zvinoderedza zviratidzo, uye zvinodzora kukuvara kwenhengo.
Ndinofanira kushandisa sei mapiritsi eAyvakit?
Ayvakit ipiritsi. Chinhu chinonyanya kukosha kana uchitora mushonga uyu ndechekutora usina chinhu mudumbu . Izvi zvinoreva kuti, unofanira kuutora awa imwe chete usati wadya, kana maawa maviri mushure mekudya. Ndipo panonyatsopinda mushonga uyu mumuviri.
Madosi anowanzo nyorwa ndeaya anotevera:
- Kune Advanced Systemic Mastitis TOS (AdvSM): 200mg kamwe chete pazuva.
- Kune Indolent Systemic Mastocytosis (ISM): 25mg kamwe chete pazuva.
Iyi inowanzo kuve mishonga yenguva refu. Chiremba wako achakuudza kuti urambe uchitora mushonga kusvika wawana mhedzisiro yakanaka kubva pairi uye usina migumisiro yakaipa. Kana uine migumisiro yakaipa, chiremba wako anogona kusarudza kuderedza mushonga wako, kurega kwenguva pfupi, kana kurega zvachose.
Gara uchitevedzera mirairo yachiremba wako nemazvo. Usamborega kutora mushonga wako kana kuchinja mwero wemushonga usina kutaura nachiremba wako. Tsvaga rubatsiro rwechiremba nekukasika kana ukasangana nemigumisiro yakaipa.
Tsvagiridzo inoti chii nezvekubudirira kweAyvakit?
Kune ruzivo nezvemiedzo mitatu yekiriniki yakaitwa kuti iongorore kushanda uye kuchengetedzeka kwemushonga weAyvakit.
Kune AdvSM (yakakomba): Muzvidzidzo zviviri, EXPLORER nePATHFINDER, 57% yevanhu vakatora Ayvakit, kana kupfuura hafu, vakaderera zviratidzo uye vakapora kushanda kwenhengo dzakabatwa. Hafu yeavo vakaratidza mhedzisiro vakaramba vachivandudza kwemwedzi makumi matatu nemasere, kana anopfuura makore matatu.
Kune ISM (rudzi rwakapfava): Muchidzidzo chePIONEER, avo vakatora Ayvakit vaiva nezviratidzo zvishoma (zvakadai sekurutsa, kurwadziwa mudumbu, uye kuneta) pane avo vakatora placebo. Izvi zvinoreva kuti mushonga uyu wakapa zororo guru mukuvandudza hupenyu.
Zvidzidzo izvi zvinoratidza kuti Ayvakit inzira inoshanda zvikuru yekurapa Systemic Mastocytosis. Zvisinei, yeuka kuti hairapi chirwere chose, uye mhedzisiro yacho haizove yakafanana kune wese munhu.
Panogona kuva nematambudziko nemimwe mishonga here? (Kudyidzana Kwemishonga)
Ehe, Ayvakit inogona kushanda pamwe chete nemimwe mishonga. Kunyanya iyo inokanganisa enzyme CYP3A muchiropa chedu. Mimwe mishonga inogona kuwedzera huwandu hweAyvakit mumuviri uye kuwedzera migumisiro, nepo mimwe mishonga ichigona kuderedza huwandu hweAyvakit uye kuderedza kushanda kwayo.
Saka, iva nechokwadi chekuzivisa chiremba wako nezvemishonga yese yauri kutora (mishonga yezvimwe zvirwere, mavhitamini, mishonga yechivanhu, mishonga yekuwedzera). Anogona kubva atarisa kana paine matambudziko uye, kana zvichidikanwa, kuchinja mimwe mishonga yako kana kuchinja chiyero cheAyvakit.
Uyewo, kana uchitora mishonga inobvisa ropa rakanyanya kukora, yakadai sewarfarin (Coumadin, Jantoven) , njodzi yako yekubuda ropa muuropi kubva kuAyvakit inogona kuwedzera zvishoma. Saka, chiremba wako achakutarisa zvakanyanya kana uchitora mishonga yakadaro.
Nzira yekuwana mushonga weAyvakit sei?
Ayvakit mushonga unongopihwa nachiremba chete, unowanzo pihwa nachiremba weropa kana wekenza.
Uyu hausi mushonga waunogona kuwana ku pharmacy yenguva dzose . Unowanikwa ku 'specialty pharmacy'. Kana chiremba wako angotumira mushonga wacho ku pharmacy iyoyo, vanogona kutumira mushonga wacho kumba kwako kana kuhofisi yachiremba wako.
Mharidzo Yekuenda Nayo Kumba
- Systemic Mastocytosis (SM) chirwere chisingawanzoitiki chinokonzerwa nekuwanda kwemasero emasero mumuviri.
- Ayvakit mushonga wemazuva ano unoshanda zvikuru uye unoshanda zvakanyanya, unotarisa chinokonzera chirwere ichi uye unochirapa.
- Mushonga uyu unofanira kutorwa usina chinhu mudumbu (awa imwe usati wadya kana maawa maviri mushure mekudya).
- Zvakakosha kuzivisa chiremba wako nezvemimwe mishonga yese, mavhitamini, uye zvimwe zvinovaka muviri zvauri kutora.
- Haufanire kurega kutora mishonga kana kuchinja mwero wemushonga usina kupiwa mazano nachiremba.
- Taura nachiremba wako nekukasika nezve chero kusagadzikana kana migumisiro. Usatya, ziva ruzivo rwakakodzera, uye nekurapwa kwakakodzera, unogona kurarama hupenyu hune hutano.
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