Izwi rekuti "kenza" rinotityisa zvishoma, handiti? Asi nekufambira mberi kwesainzi yezvekurapa, nzira dzakawanda itsva uye dzinobudirira dzekurwisa kenza dzakabuda. Nhasi, tichataura nezvenzira yekurapa inobudirira iri kutaurwa nezvayo zvakanyanya, kunyanya yekenza yemazamu. Iyi inonzi Targeted Therapy . Ngatitarisei kuti chii, kuti inoshanda sei, uye zvaunoda kuziva nezvayo.
Zvichitaurwa zviri nyore, chii chinonzi Targeted Therapy?
Funga nezvazvo, chemotherapy, sezvatinowanzoziva, inoparadza masero anokamuka nekukurumidza. Izvi zvinogona kukuvadza kwete masero ekenza chete asiwo masero ane hutano mumuviri wedu. Ndosaka chemotherapy ichiwanzokonzera migumisiro yakaipa yakaita sekurasikirwa nebvudzi uye kuda kurutsa.
Asi nzira iyi yekurapa inonzi Targeted Therapy yakasiyana zvikuru neiyo. Kutaura chokwadi, iyi inzira yekurapa 'yakangwara'. Inonanga uye inorwisa masero ekenza chete . Nzira iyi yekurapa inoshandisa masoja emuviri wedu kuparadza masero ekenza, kana kudzivirira zviratidzo zvekuti masero ekenza anoda kukura. Izvi zvinokonzera kukuvara kushoma kumasero ane hutano. Chinhu chakanaka ndechekuti migumisiro yacho inowanzova mishoma pane yechemotherapy.
Kurapa uku kunoshanda nenzira mbiri huru:
1. Kushandiswa kweMaAntibodies: MaAntibodies aya anogadzirwa nemasero akakosha muimmune system yemuviri wedu. MaAntibodies aya anogadzirwa murabhoritari uye anopiwa mumuviri semushonga. Aya anonamatira kumasero ekenza uye anoamisa kukura kana kuaparadza.
2. Mishonga midiki yemamorekuru: Iyi mishonga inogona kutorwa semapiritsi. Inoshanda nekuvhara nzira dzinoshandiswa nemasero egomarara dzinobatsira kupatsanurana nekukura.
Chiremba wako ndiye achasarudza kuti ndeipi nzira yekurapa yakakunakira zvichienderana nerudzi chairwo rwekenza yemazamu yaunayo.
Kenza yezamu ine HER2-Positive uye Kurapwa Kwayo
Vanhu vanosvika 20% vane kenza yemazamu, kana kuti munhu mumwe chete pavashanu, vane dambudziko mujini rinonzi `HER2`. Dambudziko iri rinoita kuti jini riite makopi akawanda. Kana paine protein ye`HER2` yakawandisa pamasero ekenza, tinoidaidza kuti kenza iyi "HER2-positive breast cancer."
Kana kenza yako iri `HER2-positive`, kune nzira dzakasiyana dzekurapa gomarara iri dzinoshanda zvikuru.
- Trastuzumab :Uyu ndiwo mushonga mukuru unorapwa negomarara re'HER2-positive'. Mushonga uyu unowanikwa pasi pemazita akasiyana-siyana akadai se'Herceptin', 'Kanjinti', 'Ogivri'. Ijekiseni rinopihwa mutsinga. Zvinotendwa kuti rinodzora gomarara nenzira nhatu huru:
- Masero egomarara anonamira pamusoro uye anoadzivisa kukura.
- Zvinobatsira kuparadza masero ekenza nekuratidza simba remuviri wedu.
- Kana ikashandiswa pamwe chete nechemotherapy, inowedzera kubudirira kwemishonga iyoyo.
- Pertuzumab: Mushonga uyu, unobva pasi pezita rekuti `Perjeta`, ndeimwe antibody inopihwa kugomarara re`HER2-positive`. Unowanzopihwa pamwe chete ne`Trastuzumab` nemushonga wechemotherapy `docetaxel`. Zvisinei, hauna kukodzera vakadzi vane pamuviri, sezvo unogona kukuvadza mwana asati aberekwa.
- Mimwe mishonga: `Ado-trastuzumab emtansine (Kadcyla), `Margetuximab (Margenza), uye `Fam-trastuzumab deruxtecan-nxki (Enhertu)` mishonga yemazuva ano inopihwawo kune rudzi urwu rwekenza, kunyanya kana kenza yapararira (yakakura) kana kuti dzimwe nzira dzekurapa dzisiri kushanda.
- Mapiritsi: Lapatinib (Tykerb) neNeratinib (Nerlynx) mishonga inotarirwa kenza ine HER2 inogona kutorwa semapiritsi. Aya anowanzo kupiwa mushure memamwe marapirwo.
Kurapa Kenza yeHer2-Negative Breast Cancer
Kana masero ako egomarara asina chikanganiso chemajini che'HER2' chataurwa pamusoro apa, zvichireva kuti hapana puroteni ye'HER2' yakawandisa, saka gomarara iroro rinonzi "gomarara remazamu reHER2-negative." Ipapo uchapihwa imwe nzira yekurapa yakasiyana.
Kune mishonga chaiyo yekurapa kenza yerudzi urwu zvakare.
- Mishonga yakaita se'Everolimus (Afinitor), 'Palbociclib (Ibrance),' uye 'Ribociclib (Kisqali)' inopihwa pamwe chete nekurapwa nemahormone. Iyi mishonga inopiwa kuvakadzi, kunyanya mushure mekuguma kuenda kumwedzi, avo vane kenza yakapararira.
- Zvidziviriri zvePARP: Kana kenza yako isina HER2 uye uine BRCA gene mutation, unogona kupihwa mhando yemishonga inonzi PARP inhibitors, yakadai seOlaparib (Lynparza) neTalazoparib (Talzenna). Iyi mishonga inonangwawo zvakanangana nemasero ekenza.
Chinhu chakakosha ndechekuti mishonga yese iyi inotariswa zvichienderana nehuwandu hwemajini nemasero egomarara rako. Saka zvakakosha kuti unyatsokurukura izvi nachiremba wako wosarudza mushonga wakakunakira.
Ndezvipi migumisiro inowanzoonekwa?
Sezvambotaurwa, kunyangwe paine migumisiro mishoma pane chemotherapy, kurapwa kwakanangana kunogona kukonzera mimwe migumisiro. Izvi zvinosiyana kubva pamushonga mumwe kuenda kune mumwe. Kana ukasangana nemhedzisiro , taurira chiremba wako nekukasika . Kazhinji, zvinogona kudzorwa.
| Migumisiro Yakajairika |
|---|
| Kurwara neallergy - mapundu eganda, kuvaviwa. |
| Kusvotwa uye manyoka. |
| Fivha nechando. |
| Kurwadziwa kwemuviri, kuneta, uye kushaya simba. |
| Kunetseka nekufema uye kuzvimba. |
| Dzungu . |
Nzira yekuziva sei dambudziko rekukurumidza?
Kana ukaona chimwe kana kupfuura chezviratidzo zvinotevera, zvinogona kunge zviri zvekukurumidzira. Usambozvifuratira. Fonera chiremba wako nekukasika. Kana usingakwanise kumubata, enda kuEmergency Department (ETU) yechipatara chiri pedyo.
| Nyatsoteerera zviratidzo izvi! | |
|---|---|
| Fivha: Fivha inodarika 100.4 Fahrenheit (38 Celsius). Kana ukatanga fivha mushure mekutonhorwa, taurira chiremba wako nekukasika. | Matambudziko emuromo: Maronda matsva mumuromo, mavanga machena, rurimi rwakazvimba, kana mazino anobuda ropa. |
| Huro inorwadza: Kunzwa kuoma, kurwadza, kukwenya, kana "kuzvimba" pahuro. | Kukosora: Kukosora kutsva kana kunoramba kuripo. |
| Matambudziko eweti: Kugara uchiita weti, utachiona hwemunzira yeweti, kana ropa muweti. | Matambudziko emudumbu: Chirungurira chakanyanya, kuda kurutsa, kurutsa, kuvimbiwa, kana manyoka zvinogara kwemazuva anopfuura 2-3. |
| Kutadza kufema: Kushaya mweya kunyangwe kana ukashanda nesimba zvishoma. | Kubuda ropa zvisina kujairika: Ropa riri mutsvina. |
| Kuzvimba: Kuzvimba mumakumbo kana muzvitsitsinho. | Kuneta kwakanyanya: Kunzwa kuneta zvekuti haugone kuita chero chinhu. |
Mharidzo Yekuenda Nayo Kumba
- Targeted Therapy inzira yemazuva ano yekurapa inonyanya kurwisa masero ekenza yemazamu, yakasiyana nechemotherapy yenguva dzose.
- Rudzi rwekurapwa kwaunowana runoenderana nerudzi rwegomarara raunaro (semuenzaniso, ingave riri `HER2-positive` kana `HER2-negative`). Miedzo yakakosha inoitwa kuti ionekwe izvi.
- Kurapa uku kunogonawo kuva nemigumisiro yakaipa, saka taura nachiremba wako nezvekuchinja kana kusagadzikana kwaunonzwa.
- Gara uchitarisa zviratidzo zvekukurumidzira zvakaita sefivha yakanyanya, kunetseka kufema, uye kuzvimba kusingawanzoitiki. Kana ukaona chimwe cheizvi, tsvaga rubatsiro rwechiremba nekukasika.
- Kurapwa kwegomarara rwendo. Chiremba wako nechikwata chehutano ndivo vabatsiri vako vakanakisisa parwendo urwu. Saka vimba navo uye shanda navo.
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