Chiremba wako akakuudza here nezvemhando yemushonga unonzi SERMs kana SERDs yekurapa kenza yemazamu? Usanetseke, mazita aya anogona kunzwika seakaoma. Nhasi, tichataura zviri nyore nezvezvaari, mashandiro awo, uye zvaunofanira kuziva nezvazvo. Aya ndiwo marudzi maviri emishonga akakosha anogona kutibatsira kurwisa kenza yemazamu .
Chii chinonzi SERMs? Dzinoshanda sei?
Zvichitaurwa zviri nyore, maSERM (Selective Estrogen Receptor Modulators) imhando yemishonga inomisa kukura kwemasero ekenza yemazamu. Zvisinei, anoshanda chete pamhando chaiyo yekenza. Ndiyo mhando yekenza inozivikanwa seEstrogen Receptor-Positive . 75% chete yekenza yemazamu inoonekwa munyika medu ndeyemhando iyi.
Fungidzira, masero egomarara aya ane "maantenna" mashoma pamusoro pawo. Mukurapa, tinoadaidza kuti mareceptor aya. Kana hormone estrogen mumuviri wedu yakabatana neaya maantenna, sero regomarara rinogamuchira chiratidzo chekuti "riparadzane uye rikure zvakanyanya."
Izvi ndizvo zvinoitwa neSERMs :
Vanoenda vovhara maantenna iwayo, kureva mareceptor. Ipapo estrogen hormone haina kwainosvika yozvibatanidza. Nekuti haigamuchire chiratidzo, kukura kwemasero ekenza kunomira kana kuti kunodzorwa zvakanyanya.
Chinhu chakakosha ndechekuti, inonzi 'selective' nechikonzero. Kunyange zvazvo mishonga iyi ichidzivirira kushanda kweestrogen mumazamu, inobvumira hormone iyi kushanda zvakanaka mune dzimwe nhengo dzemuviri, dzakadai semapfupa nechibereko. Ndizvo zvinoita kuti ive yakakosha.
Mhando dzeSERMs uye mashandisirwo adzo
Kune mhando dzakawanda dzeSERMs dzinotenderwa kenza yemazamu .
| Zita remushonga uyu | Mashandisirwo makuru |
|---|---|
| Tamoxifen |
|
| Toremifene | |
| Raloxifene |
Saka chii chinonzi SERDs?
SERDs (Selective Estrogen Receptor Downregulators) imhando yemushonga unoshanda nesimba zvishoma kupfuura SERMs. Kufanana neSERMs, dzinovharawo estrogen receptors. Asi pamusoro pezvo, SERDs dzinoderedza huwandu hwemareceptors (dzinoderedza) uye dzinochinjawo mashandiro emareceptors asara, zvichiita kuti asashande zvakanaka.
Parizvino kune mhando mbiri dzeSERDs dzakatenderwa:
- Fulvestrant
- Elastrant
Izvi zvinonyanya kupihwa kune kenza yemazamu ine hormone receptor-positive uye HER2-negative . HER2-negative zvinoreva kuti masero ekenza haana puroteni inonzi HER2 pamusoro pawo inoabatsira kukura.
Mushonga uyu ungashandiswa sei?
- MAVIMBISO: Mazhinji acho anouya ari mapiritsi . Chiremba wako achakuudza kuti utore 20mg kusvika 40mg pazuva. Kana uri kutora mishonga iyi kudzivirira kenza kuti isadzoke, unowanzo fanira kuramba uchiitora kwemakore mashanu kusvika gumi.
- SERDs: Semuenzaniso, Fulvestrant inouya sejekiseni.Chechipiri. Majekiseni maviri aya anoiswa mutsandanyama iri pamagaro. Anopihwa katatu mumwedzi wekutanga wekurapwa uye kamwe chete pamwedzi mushure mezvo.
MaSERM nemaSERD anopiwa mumamiriro api ezvinhu?
Pane mamiriro akati wandei apo chiremba wako anogona kukupa mishonga iyi.
| Mukana | Tsananguro |
|---|---|
| Usati wavhiyiwa (Neoadjuvant Therapy) | Kana bundu rako rakakura, mushonga uyu unogona kupiwa usati wavhiyiwa kuti ritete uye zvive nyore kubvisa. |
| Mushure mekuvhiyiwa (Adjuvant Therapy) | Kurapa uku kunoitwa kuti kuparadze masero madiki egomarara anogona kuramba aripo mushure mekuvhiyiwa uye kudzivirira kenza kuti isadzoke. |
| Kune Kenza Yekupedzisira | Kana kenza yapararira kune dzimwe nhengo dzemuviri dziri kunze kwezamu, mishonga iyi inogona kubatsira kudzora kana kunonoka kukura kwayo. |
| Kudzivirira | Kunyangwe usati wambova nekenza yemazamu, kana njodzi yako yekuibata iri yakakwira kupfuura avhareji nekuda kwezvinhu zvakaita semajini, maSERM anogona kunyorerwa kuderedza njodzi iyoyo. |
Ndezvipi migumisiro nenjodzi dzekurapa uku?
Kufanana nemishonga yese, izvi zvinogona kuva nemigumisiro yakaipa. Asi havasi vese vanoiwana. Zvakakosha kuziva nezvemigumisiro inogona kuitika.
Migumisiro yeSERMs
Migumisiro inowanzoonekwa yakafanana neyainoitika panguva yekuenda kumwedzi.
- Kupisa kunopisa
- Kuoma kwechikadzi, kubuda ropa, kana kubuda ropa zvishoma
- Kudikitira husiku
- Kusvotwa
- Kuchinja kwemanzwiro
Migumisiro isingawanzoitiki asi yakakomba:
- Kuwedzera kudiki kwazvo kwengozi yekubatwa nekenza yemuchibereko
- Kugwamba kweropa mumakumbo (Deep Vein Thrombosis, kana DVT) kana kugwamba kweropa mumapapu (Pulmonary Embolism)
- Matumbu emusoro
- Kutetepa kwemapfupa kuvakadzi vasati vasvika pakuguma kuenda kumwedzi
Migumisiro yeSERDs
- Kurwadziwa kwenguva pfupi panzvimbo yejekiseni
- Kusvotwa
- Kurwadziwa kwepfupa, tsandanyama, kana majoini
- Musoro
- Kushanda nesimba
- Kupisa kunopisa
Zvakakosha: Mishonga yeSERD inogona kuderedza huwandu hwemaplatelet, izvo zvinobatsira kuumbwa kweropa. Izvi zvinogona kuwedzera njodzi yekubuda ropa zvishoma. Zvakare, mishonga iyi yese haimbokurudzirwi panguva yekuzvitakura kana kana uri kuedza kubata pamuviri . Zvakakosha kushandisa nzira yekudzivirira pamuviri isiri yemahormone paunenge uchitora mishonga iyi uye kwegore rimwe chete mushure mekumira kurapwa.
Kana chiremba wako akakurudzira mushonga uyu, taura naye nezvazvo. Usatya kubvunza mibvunzo yakaita sekuti, "Mushonga uyu uchandibatsira sei?", "Ndingatarisira migumisiro ipi?", uye "Ndichatora mushonga uyu kwenguva yakareba sei?"
Mharidzo Yekuenda Nayo Kumba
- MaSERM nemaSERD mushonga unoshanda zvikuru wekenza yemazamu ine estrogen receptor. Anodzivisa kushanda kwehormone estrogen, iyo inokosha pakukura kwemasero ekenza.
- Haisi mishonga yese iyi yakakodzera munhu wese. Chiremba wako chete ndiye anogona kukuudza mushonga wakanakira iwe zvichienderana nerudzi rwegomarara, zera rako, uye hutano hwako.
- Migumisiro inogona kuitika, asi mizhinji yacho inorapika. Taura nachiremba wako nezve chero kusagadzikana kwaunosangana nako, zvisinei nekuti kudiki sei.
- Zvakakosha kudzivirira kubata pamuviri paunenge uchitora mushonga uyu. Iva nechokwadi chekubvunza chiremba wako nezvenzira dzakakodzera dzekudzivirira pamuviri.
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