Une chirwere cheshuga cherudzi rwechipiri here? Kana kuti uri kunetseka nehuremu hwakanyanya (kufuta)? Saka chiremba wako angangodaro akakuudza nezvemhando itsva yemishonga iri kutaurwa nezvayo nevanhu vazhinji mazuva ano. Saka nhasi, ngatitaure nezvemhando iyi yemishonga inonzi GLP-1 agonists. Ngatitaurei nezvemishonga iyi, mashandiro ayo, uye kuti yakakodzera ani.
Chii chinonzi GLP-1 agonists?
Zvichitaurwa zviri nyore, maGLP-1 agonists imhando yemishonga inobatsira kudzora huwandu hweshuga muropa (glucose), kunyanya kuvanhu vane chirwere cheshuga cheType 2. Mimwe yemishonga iyi inobatsirawo kudzora kufuta, kana huremu hwemuviri hwakawandisa .
Mishonga iyi mizhinji inouya sejekiseni. Izvi zvinoreva kuti unofanira kushandisa sirinji netsono kubaya mushonga wemvura. Jekiseni iri rinopinzwa munyama ine mafuta pasi peganda (subcutaneous injection). Jekiseni iri rinowanzopinzwa munzvimbo dzine mafuta mudumbu, kumashure kwezvidya, kumagaro ekumusoro, nekumashure kwemaoko. Kunewo mishonga inonwiwa inowanikwa, yakaita semapiritsi eSemaglutide (Rybelsus®).
Boka iri remishonga rinozivikanwawo nemamwe mazita akati wandei:
- Maagonist akaita seGlucagon-peptide-1
- Maagonist eGLP-1 receptor
- Incretin mimetics
Mishonga iyi mitsva. GLP-1 agonist yekutanga (exenatide) yakatenderwa muna 2005. Vaongorori vachiri kutsvaga mamwe mashandisirwo emishonga iyi.
Asi chinhu chimwe chete chekurangarira: Mishonga yeGLP-1 agonists chete haigone kurapa chirwere cheshuga kana kufuta zvachose. Matambudziko ese ari maviri anoda kudya kwakanaka uye kuchinja mararamiro .
Mushonga uyu unoshanda sei mumuviri?
Kuti tinzwisise mashandiro anoita mushonga uyu, ngatitangei tatarisa hormone inogadzirwa mumiviri yedu inonzi GLP-1. GLP-1 ihormone inogadzirwa neura hwedu hudiki. Inoita zvinhu zvakawanda mumuviri wedu.
- Inobatsira pancreas kuburitsa insulin: Insulin ihormone inokosha pakushandura chikafu chatinodya kuita simba. Inoderedza huwandu hweshuga muropa. Kana pasina insulin yakakwana, huwandu hweshuga muropa hunowedzera uye chirwere cheshuga chinokura.
- Homoni yeGlucagon inovharika: Glucagon ihomoni inowedzera huwandu hweshuga muropa kana zvichidikanwa. Saka, GLP-1 inodzivisa izvi, ichidzivirira shuga isingakoshi kuti iungane muropa.
- Zvinoderedza mwero wekubuda kweshuga mudumbu: Kana chikafu chatinodya chikagayiwa uye chikabviswa mudumbu zvishoma nezvishoma, shuga inobva muchikafu inonyudzwa muropa. Izvi zvinodzora kukwira kamwe kamwe kweshuga muropa.
- Kudya kunoita kuti munhu anzwe kuguta (kuguta):Homoni yeGLP-1 inokanganisa zvikamu zvehuropi hwedu zvinodzora nzara nekuguta.
Zvino, zvinoitwa nemushonga uyu weGLP-1 agonist ndezvekuita semahormone eGLP-1 mumuviri wedu. Kureva kuti, unoshanda 'sezvauri'. Mushonga uyu unobatanidza mareceptor eGLP-1 uye unokonzera zviito zvakafanana nehormone yechisikigo. Kana mushonga wacho wakanyanya, mhedzisiro iyi inowedzera.
Mushonga uyu unokurudzirwa kushandisirwa ani?
Vanachiremba vanonyanya kunyora mishonga iyi yeGLP-1 agonist yezvirwere zviviri: Type 2 diabetes uye kufuta.
Kune vane chirwere cheshuga cherudzi rwechipiri
Mishonga yeGLP-1 inogona kunyorerwa nachiremba wako, pamwe chete nemishonga mikuru yechirwere cheshuga (metformin), kana isingadzore shuga yeropa rako zvakakwana, kana nekuda kwezvimwe zvikonzero.
- Kana kudzora shuga muropa kusina kukwana ne metformin chete.
- Kana usingakwanise kutora metformin nekuda kwezvimwe zvikonzero zvehutano.
- Kana nhanho yako yeA1C yakakwira zvakanyanya kupfuura chinangwa.
- Kana uine zvimwe zvirwere zvakaita sechirwere chemwoyo, kusagadzikana kwemoyo, kana chirwere cheitsvo chisingaperi pamwe chete nechirwere cheshuga.
Kune Kufutisa
Mishonga yeGLP-1 agonists yakaita seSemaglutide neLiraglutide inotenderwawo senzira yekurapa kufuta nekuti inobatsira pakuderedza uremu. Kufutisa kunotsanangurwa se body mass index (BMI) ye30 kana kupfuura. Vanachiremba vanogonawo kupa mishonga iyi kuvanhu vakafuta (BMI 25-29.9) uye vane mamwe matambudziko ehutano (semuenzaniso, BP yakakwira, cholesterol), sezvo kuderedza uremu kunogona kubatsira kudzora mamiriro iwayo.
Vanhu vane chirwere cheshuga cherudzi rwekutanga vanogona kutora izvi here?
Izvi zvichiri muchikamu chekutsvagisa. Hazvisati zvabvumidzwa zviri pamutemo semushonga wechirwere cheshuga cherudzi rwekutanga. Zvisinei, vamwe vanachiremba vanogona kukunyorera kuti "zvisashandiswe" kana zvichidikanwa. Zvakanaka kutaura nachiremba wako nezveizvi.
Dzidza nezvekushandiswa kwemishonga uye migumisiro yayo.
Chiremba wako ndiye achasarudza kuti unofanira kutora mushonga uyu kangani. Zvakakosha kutevedzera mirairo iyoyo nemazvo.
| Zita remushonga (GLP-1 Agonist) | Kuwanda kwekutora |
|---|---|
| Dulaglutide (Trulicity®) | Kamwe chete pasvondo |
| Exenatide (Byetta®) | Kaviri pazuva |
| Liraglutide (Victoza®) | Kamwe chete pazuva |
| Semaglutide (Ozempic®, Rybelsus®) | Kamwe chete pasvondo (jekiseni) / zuva nezuva (mapiritsi) |
Ndeipi migumisiro yemushonga uyu?
Kufanana nemushonga upi zvawo, izvi zvinogona kuva nemigumisiro yakaipa.
- Migumisiro inowanzoonekwa: Izvi zvinonyanya kuonekwa pakutanga kwekurapwa.
- Kuda kudya
- Kusvotwa
- Kurutsa
- Manyoka
- Mimwe migumisiro:
- Dzungu
- Kurova kwemoyo kunokurumidza zvishoma
- Musoro
- Dumbu rakagumbuka
- Migumisiro isingawanzoitiki asi inogona kunge yakakomba:
- Chipembenene
- Rudzi rwekenza yethyroid (Medullary thyroid cancer)
- Kukuvara kwakanyanya kweitsvo
- Kuora kwe retinopathy inokonzerwa nechirwere cheshuga
Ndeipi njodzi dzemishonga iyi?
Kunyange zvazvo mushonga uyu wakachengeteka, pane zvinhu zvishoma zvekuziva.
Kusawirirana neAllergy
Vamwe vanhu vanogona kunge vaine allergy kana mushonga uyu uchishandiswa. Kana mukaramba muchivaviwa kana kutsvuka panzvimbo yakabayiwa jekiseni, taurirai chiremba wenyu. Zvisinei, allergy yakanyanya inonzi anaphylaxis idambudziko guru.
Kana ukaona zviratidzo zvakaita sekuoma kufema, kurwadziwa kwemuviri, kuoma kumedza, kana kuoma kwechipfuva , enda kuchipatara chiri pedyo neEmergency Department (ETU) nekukasika.
Shandisa panguva yekuzvitakura
Mishonga yeGLP-1 agonists haikurudzirwi kushandiswa panguva yekuzvitakura . Kana uri kutora mushonga uyu, unofanira kushandisa nzira yakavimbika yekudzivirira pamuviri. Kana ukaita pamuviri panguva yekutora mushonga uyu, enda kuna chiremba wako nekukasika.
Shuga shoma muropa (Hypoglycemia)
Njodzi yekubuda ropa rakawanda muropa ishoma kana ukatora mushonga uyu wega. Zvisinei, kana ukautora pamwe chete nemimwe mishonga yeshuga, yakaita se insulin kana sulfonylureas, njodzi yekubuda ropa rakawanda muropa inenge yakakwira. Kana shuga yako yeropa ikadonha pasi pe70 mg/dL, unogona kuona zviratidzo zvakaita sekubvunda, kudikitira, dzungu, uye nzara yakanyanya. Kana izvi zvikaitika, unofanira kudya chimwe chinhu chine shuga (senge chinwiwa chine shuga, bhanana) nekukurumidza sezvinobvira.
Mharidzo Yekuenda Nayo Kumba
- Mishonga yeGLP-1 agonists imhando yemishonga inoshandiswa kurapa chirwere cheshuga cherudzi rwechipiri uye kufuta, uye inonyanya kupihwa sejekiseni.
- Mushonga uyu unoshanda seGLP-1 hormone mumuviri wedu, uchiwedzera kugadzirwa kwe insulin, uchiita kuti munhu anzwe kuguta, uye unobatsira nekuderedza shuga nehuremu.
- Pakushandisa mushonga uyu, zvakakosha kuchinja mararamiro uye maitiro ekudya. Mishonga chete haina kukwana.
- Migumisiro yakaita sekuda kurutsa uye kurutsa inowanzoonekwa pakutanga. Zvisinei, kana ukaona zviratidzo zvekurwara zvakanyanya (zvakadai sekunetseka kufema) , enda kuETU nekukasika.
- Dzivisa kushandisa mushonga uyu panguva yekuzvitakura.
- Ingotaura nachiremba wako kana mushonga uyu wakakunakira, mashandisirwo awo, uye kuti mushonga wacho ndewei.
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