Fungidzira kuti wakapihwa stem cell kubva kumunhu ane hutano semushonga wechirwere chakadai seleukemia. Izvi zvinotarisirwa kurapa chirwere chako. Asi kashoma, masero matsva aya akauya kuzokubatsira, muviri wako unoafungidzira se "muvengi" wotanga kurwisa masero ako. Ndiyo mamiriro akaoma atinodaidza kuti "Graft versus Host Disease" kana kuti GvHD muchidimbu.
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Chii chinonzi GvHD muchidimbu?
Kuti tinzwisise izvi, tinofanira kuziva mazwi maviri. "Graft" zvinoreva chinhu chinosimwa, kureva, masero emuviri ane hutano anopiwa kwauri kubva kunze. "Host" zvinoreva host, kureva, muviri wako unogamuchira masero iwayo. Saka "Graft versus Host" zvinoreva "graft versus host."
Kazhinji, rudzi urwu rwekuisirwa masero ekutanga, runonzi allogeneic transplant, runoitirwa kurapa magomarara akadai seleukemia nelymphoma, kana zvirwere zvebone marrow failure zvakaita seaplastic anemia . Masero aya anoisirwa ndiwo anotanga muviri wako kugadzira masero matsva eropa.
Asi, dzimwe nguva masero matsva aya haazive masero ako. Anofunga kuti anopinda mumasero ekunze. Saka, anotanga kurwisa nhengo dzako dzine hutano, dzakadai seganda rako, chiropa, uye ura. Ndizvo zvakaita GvHD.
Kune mhando mbiri huru dzeGvHD:
GvHD inogona kukamurwa kuita mhando mbiri huru. Kare, iyi yakakamurwa zvichienderana nenguva yekutanga kwezviratidzo. Asi ikozvino, vanachiremba vanosarudza rudzi chairwo nekutarisa zviratidzo, mhedzisiro yebvunzo, uye nguva yekutanga kwezviratidzo.
- Acute GvHD (aGvHD): Izvi zvinowanzoitika mukati memazuva zana ekutanga mushure mekuisirwa chibereko. Asi dzimwe nguva zvinogona kuitika gare gare. Rudzi urwu runonyanya kukanganisa ganda rako, matumbu ), nechiropa.
- Chirwere cheGvHD Chisingaperi (cGvHD): Rudzi urwu runogona kuitika chero nguva mushure mekuisirwa chibereko, asi runonyanya kuitika mukati memakore maviri ekutanga . Runogona kukanganisa chero chikamu chemuviri, kusanganisira ganda, muromo, chiropa, mapapu, ura, tsandanyama, majoini, uye nhengo dzesikarudzi.
Munhu akamboisirwa nhengo yemuviri anogona kuva neimwe yemhando mbiri idzi, dzose dziri mbiri, kana kuti anogona kuva neutano hwakanaka asina imwe yadzo.
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Check Availability →Ndezvipi zviratidzo zveGvHD?
Zviratidzo zveGvHD zvinogona kubva pane zvishoma, kusvika pakati nepakati, kusvika pakanyanya, uye zvichitouraya. Ngatitarisei zviratidzo zvine chekuita nemarudzi maviri aya.
| Rudzi rweGvHD | Zviratidzo zvakajairika |
|---|---|
| Chirwere cheAcute GvHD (aGvHD) (Inonyanya kukanganisa ganda, ura, chiropa) |
|
| Chirwere cheGvHD Chisingaperi (cGvHD) (Inogona kukanganisa chero chikamu chemuviri) |
Sei GvHD iyi ichiitika?
Izvi zvine chekuita nesainzi, asi ndichazvitsanangura zviri nyore.
Kazhinji, masero emuviri wedu wekudzivirira muviri anotidzivirira kubva kuzvirwere nekurwisa zvipembenene zvekunze zvakaita semavhairasi nemabhakitiriya. Asi masero iwayo haamborwisi masero edu. Chikonzero cheizvi ndechekuti pane puroteni yakakosha pamusoro pemasero edu ese. Izvi zvinonzi Human Leukocyte Antigens (HLA) .
Funga nezveHLA iyi sechinhu chakafanana nekadhi reID. Masero edu ekudzivirira muviri anotarisa kadhi iri reID obva ati, "Oh... uyu mumwe wedu."
Kunze kwemapatya akafanana, HLA yemunhu wese yakasiyana.
Kana waiswa masero ekutanga, masero matsva eropa anogadzirwa kubva mumasero iwayo ane HLA yemunhu akakupa masero acho. Kana HLA iyoyo yakasiyana zvakanyanya neHLA yako, masero matsva iwayo anotarisa masero ari mumuviri wako ofunga kuti, "Uyu murwi, ID yake haienderane neyedu." Ndipo apo masero iwayo anotanga kurwisa muviri wako.
Nekuda kwechikonzero ichi, vanachiremba vanoongorora nekuchenjera HLA yemupi neanogamuchira kuti vave nechokwadi chekuti vari pedyo nepedyo vasati vaita transplant. Asi kunze kwekunge masero atorwa kubva kumapatya, pane mukana wekuti pave neGvHD.
Ndiani ari panjodzi huru yekubatwa neGvHD?
Chinhu chinonyanya kukosha panjodzi kusawirirana kweHLA, asi zvimwe zvinhu zvakawanda zvinogonawo kuita basa racho.
| Chinhu chine njodzi | Tsananguro |
|---|---|
| Kusawirirana kweHLA | - Kuisirwa masero asina kufanana neHLA, kunyangwe akatorwa kubva kuhama. - Kunyangwe zvichibva kune mumwe munhu asina hukama, uye HLA ichienderana zvakanaka, kuchine njodzi. |
| Zvimwe zvinhu |
|
Uyewo, kana wakambova neAcute GvHD (aGvHD), uri panjodzi huru yekubatwa neChronic GvHD (cGvHD).
Dambudziko iri rinoonekwa sei uye rinorapwa sei?
Kuongorora chirwere
Chiremba wako achaongorora GvHD nekuita bvunzo yemuviri, kutarisa zviratidzo zvako, uye kuita bvunzo dzeropa uye biopsy. Biopsy inosanganisira kutora ganda diki kana nyama yakakanganiswa woiongorora pasi pemaikorosikopu. Nekuti zvimwe zvezviratidzo zveGvHD isingaperi zvakafanana nezvimwe zvirwere, chiremba wako achabvisa zvimwe zvirwere asati aongorora GvHD.
Kurapa
Kuti udzivise GvHD mushure mekuisirwa nhengo yemuviri, uchapihwa mishonga inodzvinyirira masoja emuviri wako. Mishonga iyi inoshanda nekuderedza kugona kwemasero ekunze kurwisa muviri wako.
Kana GvHD ikaitika pasinei nekutora mushonga uyu, chiremba wako ndiye achasarudza marapirwo zvichienderana nekuoma kwechirwere chako uye rudzi rweGvHD.
- Kune acute GvHD (aGvHD): Kazhinji, corticosteroids inopihwa semapiritsi, majekiseni, kana sekirimu inoiswa paganda. Kana izvi zvikasadzora chirwere, mimwe mishonga yakaita seRuxolitinib (Jakafi®) kana miedzo yekiriniki inogona kufungwa nezvayo.
- Kune chirwere cheGvHD Chisingaperi (cGvHD): Mishonga inodzvinyirira immune system inopihwawo kwenguva refu. Kana chirwere ichi chisingadzoreki, mishonga yakaita seRuxolitinib (Jakafi®), Belumosudil (Rezurock™), Ibrutinib (Imbruvica®) kana mishonga chaiyo yakaita sephotopheresis inogona kudiwa.
Migumisiro yekurapwa
Mishonga iyi inodzvinyirira masoja emuviri wako, izvo zvinoderedza kugona kwemuviri wako kurwisa hutachiona. Izvi zvinowedzera njodzi yako yekubatwa nehutachiona hwefungus, bacteria, uye virus. Chiremba wako achakupawo mishonga yekubatsira kudzivirira hutachiona uhwu hunogona kuisa hupenyu panjodzi.
Mimwe migumisiro inogona kuitika nekuda kweGvHD
GvHD inotyisidzira hupenyu here?
Ehe, GvHD inogona kuisa upenyu panjodzi. Chirwere cheGvHD chisingarapiki, kunyanya, ndicho chinokonzera rufu mushure mekuisirwa stem cell, kunze kwechirwere chikuru. Ndosaka zvichikosha kukurukura njodzi dzacho nachiremba wako usati wapihwa chero kurapwa.
Pane pundutso here kubva kuGvHD?
Zvinoshamisa kuti hongu. GvHD ine zvimwe zvayakanakira. Masero matsva aya ekudzivirira muviri anorwisa masero ako ane hutano anotsvagawo nekuparadza chero masero ekenza angangosara mumuviri wako. Izvi zvinonzi "mhedzisiro yegraft-versus-bumor." Saka, zvidzidzo zvakaratidza kuti varwere vanowana GvHD havawanzo kudzoka kwekenza yavo.
Zvinhu zvaunogona kuita kuti uchengetedzeke
Chiremba wako achakutsanangurira kuti unofanira kuzvitarisira sei mushure mekuisirwa chibereko. Chenjerera zvakanyanya nezvezvinhu izvi kana uri panjodzi yekubatwa neGvHD.
- Zvidzivirire kubva kuzuva: Kupisa zuva kunogona kuita kuti GvHD iwedzere kuipa. Saka pfeka hembe dzine maoko marefu nemabhurugwa marefu paunenge uchienda panze. Shandisa mafuta ekudzivirira zuva ane SPF 50.
- Kuchenesa mazino: Shamba mazino ako zvakanaka kuti uderedze njodzi yekubatwa nechirwere chemazino.
- Zvekudya Nezvinwiwa: Dzivisai zvinonhuhwirira, zvine mafuta, uye zvekudya zvinogona kukonzera maronda mumuromo.
- Zvidzivirire kubva kuhutachiona: Sezvo masoja emuviri wako asina simba, dzivisa nzvimbo dzine zvirwere zvinopararira uye dzine vanhu vakawanda. Gara wakachengeta maoko ako akachena.
Ndinofanira kuona chiremba rini?
Zvakakosha kuzivisa chiremba wako nekukasika kana ukaona shanduko mumuviri wako, kunyanya zviratidzo zvehutachiona kana fivha ye38 degrees Celsius (100.4 Fahrenheit) kana kupfuura. Hutachiona hunogona kukura nekukurumidza kana uchitora mishonga inodzvinyirira masoja emuviri.
Chiremba wako achakutarisa nguva nenguva mushure mekuisirwa kwako chibereko kuti aone kana paine matambudziko akadai seGvHD. Kana zviratidzo zvikaonekwa, achachinja mishonga yako kana kunyora mimwe mitsva. Zvakakosha kutora mishonga yese yawakanyorerwa uye kutevedzera mirairo yachiremba wako.
Mharidzo Yekuenda Nayo Kumba
- Chirwere cheGraft vs. Host Disease (GvHD) idambudziko rinowanzoitika mushure mekuisirwa stem cell, apo muviri wemunhu anenge agamuchira chirwere ichi unorwisa masero akapihwa.
- Kune mhando mbiri huru dzechirwere ichi, chinokasira uye chisingaperi. Zviratidzo zvinosiyana zvichienderana neizvi.
- Nzira yakanakisisa yekudzivirira GvHD ndeyekuona kuti mupi neanogamuchira vane HLA inoenderana zvakanaka.
- Nekuti mishonga inodzvinyirira masoja emuviri inoshandiswa pakurapa, njodzi yekutapukirwa yakakura kwazvo.
- Zivisa chiremba wako nekukasika kana paine zviratidzo zvitsva, kunyanya fivha.
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