Une hanyawo here nekuwedzera kwemahormone evarume mumuviri? Ngatitaurei nezve hyperandrogenism!

Uri kunetseka here nezvekuchinja kuri kuitika mumuviri wako? Pamwe chikonzero chiri kuwedzera kwehuwandu hwe androgen, rudzi rwehormone yechirume, mumuviri. Chirwere ichi chinonzi hyperandrogenism mune zvokurapa. Usazvidya mwoyo, tichataura nezvazvo nenzira iri nyore, nenzira yaunogona kunzwisisa.

Chii chinonzi hyperandrogenism?

Zvichitaurwa zviri nyore, hyperandrogenism zvinoreva kuti muviri wako une androgens dzakawandisa, rudzi rwehormone yebonde. Androgens dzakakosha pakuyaruka, hutano hwekubereka, uye kukura kwemuviri.

Zvino tarisai, mahormone makemikari ari mumiviri yedu. Akaita senhume. Anofamba neropa uye anoudza nhengo dzedu, tsandanyama, nedzimwe nyama zvekuita uye nguva yekuzviita.

MaAndrogen anogadzirwa mumuviri wemunhu wese. Asi varume ndivo vanogadzira zvakawanda. Vakadzi vanogadzira chikamu chimwe muzvina gumi nezviviri zvehuwandu huri mumuviri wemurume. Testosterone ndiyo inonyanya kukosha pane idzi androgens.

Mahormone aya anogadzirwawo nematesticles muvarume uye maovari muvakadzi. Mahormone aya anogadzirwawo nema adrenal glands ari pamusoro peitsvo dzedu. Anobatsirawo kushandura ma androgens asina simba kuita akasimba munzvimbo dzakadai semafuta neganda.

Zviratidzo zvechirwere ichi, chinonzi hyperandrogenism, zvinogona kusiyana zvichienderana nezera rako uye murume kana mukadzi. Pane zvikonzero zvakawanda zvinogona kukonzera, uye kune nzira dzekurapa.

Ko Hyperandrogenism nePCOS zvakafanana here?

Vanhu vazhinji vanofunga kuti hyperandrogenism ne polycystic ovary syndrome (PCOS) chirwere chimwe chete. Kunyangwe paine hukama hwepedyo pakati pezviviri izvi, hazvina kufanana.

Hyperandrogenism chinhu chikuru chinoitika kuPCOS. PCOS kusawirirana kwemahormone kunokonzerwa nemaovari anoburitsa mahormone echirume akawandisa. Inokanganisa vakadzi.

Saka, kunyange hazvo PCOS iriyo inowanzo kukonzera hyperandrogenism, panogona kunge paine zvimwe zvinokonzera hyperandrogenism. Saizvozvowo, PCOS ine zvimwe zviratidzo, zvakaita sema cysts emumazai, pamusoro pezviratidzo zvehyperandrogenism.

Ndiani anonyanya kubatwa nechirwere ichi? Chinowanzoitika sei?

Hyperandrogenism inogona kukanganisa chero ani zvake - vana vadiki, vakuru, munhu wese. Zvisinei, inonyanya kuitika kuvakadzi vari pazera rekubereka .

Pakati pe5% ne10% yevakadzi vari pazera rekuberekaIzvi zviri kukanganisa. Izvi zvinoreva kuti izvi hazvisi zvisinganzwisisike sezvaungafunga.

Dambudziko iri hariwanzobata vakomana nevarume vakuru.

Ndezvipi zviratidzo zveizvi?

Zviratidzo zve hyperandrogenism zvinosiyana zvichienderana nekuti uri murume here kana kuti kwete uye kuti wakamboyaruka here.

Asi hechino chinhu chakakosha chekurangarira. Kunyangwe uine zviratidzo izvi, huwandu hwe androgen muropa rako hunogona kunge hwakajairwa. Izvi zvinodaro nekuti chimwe nechimwe chezviratidzo izvi chinogona kunge chiine zvimwe zvikonzero. Zvakare, kunyangwe bvunzo dzeropa dzikaratidza kuti huwandu hwe androgen muropa rako hwakakwira, ungasave nezviratidzo zvikuru.

Chinhu chinonyanya kukosha ndechekuti kana zviratidzo izvi zvikaonekwa kamwe kamwe uye nekukurumidza, unofanira kuona chiremba nekukurumidza sezvinobvira, nekuti muzviitiko zvakadaro, chikonzero chingave bundu rinoburitsa androgen.

Zvino ngationei kuti izvi zvinokanganisa sei vanhu vakasiyana.

Kune vasikana (vasati vasvika pazera rekuyaruka)

• Kiri rakakura .
• Mapundu neganda rine mafuta.
• Kukura kwebvudzi remuviri kusingadiwe (hirsutism) . Izvi zvinoreva kuti "bvudzi rebrown rakachenuruka" rinotsiviwa nebvudzi rakakombama, rakakombama munzvimbo dzakadai semuromo wepamusoro, chirebvu, chipfuva, dumbu, uye musana.

Kune vana vechirume (vasati vasvika pazera rekuyaruka)

• Nhengo yakakura .
• Kukura kwebvudzi nekukurumidza kana zvakanyanya munzvimbo yakavanzika uye muhapwa.
• Kudzika kwezwi.

Kune vakadzi vakuru

• Mapundu neganda rine mafuta.
• Kukura kusingadiwi kwebvudzi remuviri ( hirsutism) .
• Kuenda kumwedzi kwemwedzi kusingaenderane nenguva.
• Kuomerwa nekuva nevana (kusabereka) .
• Kurasikirwa nebvudzi kwevarume ( androgenic alopecia) .

Kune varume vakuru

Kuti izvi zvinokanganisa sei varume vakuru zvinoenderana nekuti mahormone akawedzerwa anobva kuma adrenal glands here kana kuti kubva kune chimwe chinhu chinotorwa kunze (senge majekiseni e anabolic steroid ). Kana ma androgens anobva kuma adrenal glands akawedzera, varume vakuru vanogona kusaona shanduko huru dzemuviri. Zvisinei, zvinogona kuderedza mashandiro ema testes uye kuita kuti zviome kuva nevana.

Sei izvi zvichiitika? Ndezvipi zvikonzero?

Mahormone eAndrogen anogadzirwa nemazai, maadrenal glands, uye masero emafuta muvakadzi, uye nematesticle nemaadrenal glands muvarume.

Kune mamwe mahormone akawanda anokanganisa kugadzirwa nekuburitswa kwema androgens aya. Semuenzaniso , luteinizing hormone (LH) uye adrenocorticotrophic hormone (ACTH) . Mahormone ese aya anoburitswa ne pituitary gland.

Kana imwe kana kupfuura yenhengo idzi, kana imwe yemahormone aya, isingashande zvakanaka, hyperandrogenism inogona kuitika.

Kune zvikonzero zvikuru zvinoverengeka zveizvi:

• Polycystic ovary syndrome (PCOS) - Ichi ndicho chikonzero chinowanzoitika.
• Congenital Adrenal Hyperplasia (CAH) .
• Chirwere chaCushing .
• Matumbu anoburitsa androgen.
• Mimwe mishonga.

Zvino ngatitarisei chimwe nechimwe chezvikonzero izvi zvakadzama.

Chirwere chePolycystic ovary (PCOS)

Pakati pevakadzi vadiki nevakuru, PCOS ndiyo inonyanya kukonzera hyperandrogenism isingaperi mushure mekuyaruka. Pakati pe80% ne90% yevakadzi vane hyperandrogenism vanewo PCOS .

MuPCOS, maovari anogadzira ma androgens akawanda nekuda kwehuwandu hwakawanda hweLH ne insulin (hyperinsulinemia). Pamusoro pezvo, huwandu hwakawanda hwe insulin hunotadzisawo chiropa kugadzira puroteni inonzi Sex Hormone Binding Globulin (SHBG) . Izvi zvinowedzera huwandu hwe testosterone yemahara muropa.

Kukura kweAdrenal Hyperplasia (CAH)` yekuzvarwa nayo

Congenital adrenal hyperplasia (CAH) iboka rezvirwere zvemajini zvinokanganisa magland eadrenal.

MuCAH, kuchinja kwemajini kunokonzera kushomeka kweenzyme inonzi 21-hydroxylase , iyo inobatsira muviri kugadzira mahormone. Muvanhu vazhinji vane CAH, kushomeka kwemaenzyme uku kunoita kuti adrenal glands igadzire mamwe mahormone akawanda, akadai se testosterone.

Chikonzero chinowanzo kukonzera hyperandrogenism muvakadzi vane adrenal hyperplasia i non-classical congenital adrenal hyperplasia . Ichi chirwere apo enzyme 21-hydroxylase inenge isina kukwana. Chirwere ichi chinokanganisa vanenge 2% yevakadzi vane hyperandrogenism.

Chirwere chaCushing

Chirwere cheCushing chirwere chemhando yeCushing chinonzi Cushing syndrome . Chirwere cheCushing chirwere chisingawanzoitiki chinoitika kana muviri uine cortisol yakawandisa (inonziwo hormone).

Chirwere cheCushing chinokonzerwa nebundu risiri rekenza riri mugland repituitary. Bundu iri rinoburitsa ACTH (adrenocorticotropic hormone) yakawandisa, iyo inowedzera huwandu hwecortisol.

ACTH yakawandisa inoita kuti ma adrenal glands abudise ma androgens akawandisa, izvo zvinokonzera hyperandrogenism.

Chirwere cheCushing chine zvimwe zviratidzo:

• Mavanga epepuru padumbu.
• Kuwedzera uremu nekukurumidza pachiso, mudumbu, uye mumutsipa.
• Kukwira kweropa.

Kana uine zviratidzo zvakadai, zvakakosha kuti uone chiremba nekukurumidza.

Matumbu anoburitsa androgen

Mamwe mabundu eadrenal gland, kana kuti mabundu ari mumazai kana mumachende, anogona kugadzira nekuburitsa ma androgens. Izvi zvinoita kuti mazinga e androgen mumuviri ave akakwirira kupfuura akajairwa. Mamiriro e hyperandrogenism anokonzerwa nemabundu aya anowanzo kuve akaoma zvikuru uye anouya kamwe kamwe .

Hyperandrogenism, inokonzerwa negomarara remuchibereko kana adrenal, haiwanzoitiki. Inongobata vanhu vanosvika 0.2% chete. Zvisinei, kana ukangoerekana wava nezviratidzo zvehyperandrogenism, enda kuna chiremba nekukasika.

Mimwe mishonga

Mimwe mishonga inogonawo kukonzera hyperandrogenism. Mishonga mikuru inokonzera izvi ndeiyi:

• MaAnabolic-androgenic steroids (aya marudzi e testosterone akagadzirwa, anoshandiswa zvisirizvo nevamwe vatambi kuti vawedzere kushanda zvakanaka).
• Maprogestin ekugadzira (aya mishonga inokonzera shanduko muchibereko uye inoshandiswa pazvinhu zvakasiyana-siyana).
• Mishonga yekudzivirira pfari ( mishonga yekudzivirira pfari ).

Unowana sei izvi? (Kuongororwa)

Kana uri mukadzi uye uchifungidzira kuti une hyperandrogenism, chiremba wako achakuongororwa muviri uye achatarisa zviratidzo zvakaita sekumera kwebvudzi kusingadiwe. Vachakubvunzawo mibvunzo mishoma nezvenhoroondo yako yehutano:

• Zera iro mazamu anotanga kukura.
• Zera iro bvudzi rinotanga kuoneka munzvimbo yakavanzika.
• Zera pakutanga kuenda kumwedzi.
• Unobvisa bvudzi here (kugera ndebvu, wakambobviswa bvudzi ne laser)?
• Wakamboshandisa mishonga ye anabolic steroids kana testosterone usina kunyorerwa nachiremba here?
• Zvinhu zvakaita sekuti kuenda kumwedzi kunouya kangani, mazuva mangani anoitika, uye kuti wakabuda ropa rakawanda sei.

Kana chiremba wako achifungidzira kuti une hyperandrogenism, achakurayira kuti uongororwe ropa kuti vaone huwandu hwemahormone. Maedzo aya anogona kubatsira kuona chirwere chacho.

Ndedzipi mhando dzebvunzo dzinoitwa?

Kana uine zviratidzo zve hyperandrogenism, chiremba wako anogona kuraira kuongororwa kweropa seizvi:

• Testosterone yose: Izvi zvinoyera huwandu hwese hwe testosterone muropa rako. Huremu uhwu hunogona kunge hwakakwira zvishoma kuvakadzi vane PCOS. Kana hwakakwira zvakanyanya, hunogona kunge huri bundu riri mumazai kana mumachende.
• Testosterone yemahara : Testosterone iyi haina kusungwa nepuroteni chero ipi zvayo. Iyi i testosterone shoma. Nhamba iyi inogonawo kuwedzerwa kuvakadzi vane PCOS.
• Androstenedione : Iyi ihormone yesteroid ine simba shoma re androgenic mumuviri. Zvisinei, inonyanya kushanda sedanho repakati mukugadzirwa kwe testosterone ne estrogen mumuviri. Kana huwandu hwayo hwakakwira, PCOS inogona kunge iripo.
• Dehydroepiandrosterone sulfate (DHEAS) : DHEAS ihormone yebonde inogadzirwa nema adrenal glands. Saka, chiratidzo chakanaka chekuumbwa kwe adrenal androgen. Zvakajairika kuti vakadzi vane PCOS vave nemazinga eDHEAS akakwira zvishoma. Kana akakwira zvakanyanya, zvinogona kuva chiratidzo chebundu re adrenal.
• 17-hydroxyprogesterone : Kuyera huwandu hwe17-hydroxyprogesterone muropa inzira yekutanga yekutarisa kuvapo kwe non-classic congenital adrenal hyperplasia, chirwere chiri chimwe chezvikonzero zve hyperandrogenism.

Sezvo paine zvimwe zvikonzero zvezviratidzo zve hyperandrogenism, chiremba wako acharaira kuongororwa kweropa kuti aone kana zvikonzero izvozvo zviri zvechokwadi.

Uyezve, bvunzo dzekufungidzira dzakadai dzinogona kuitwa kuti paonekwe chikonzero che hyperandrogenism:

• Kuongororwa kweultrasound muchiuno kuti uone kana paine ma cysts mu ovarian (chimwe chiratidzo chePCOS) kana mamwe mapundu.
• Kuti utarise bundu remudumbu , bvunzo dzeCT scan (Computed tomography - CT) kana MRI scan (Magnetic resonance imaging - MRI) dzinoitwa.

Vanachiremba vane chinangwa chekuderedza kugadzirwa kwe androgen kubva mumazai kana muma adrenal glands, kuderedza huwandu hwe androgen husina kubhadharwa, uye kudzivirira kushanda kwe androgen.

Zvisinei, vanhu vane hyperandrogenism vanowanzo tsvaga rubatsiro rwechiremba kuti varape zviratidzo zvikuru, zvakaita sekumera kwebvudzi risingadiwe, mapundu, uye kuenda kumwedzi kusingawanzoitiki.

Ndezvipi zvinorapwa izvi?

Kurapwa kwe hyperandrogenism kunoenderana nechikonzero. Semuenzaniso:

• Hyperandrogenism yeadrenal inogona kudzorwa nekushandisa corticosteroids shoma.
• Kana paine bundu mumaovari, machende, kana adrenal glands, rinogona kubviswa nekuvhiyiwa. Muvakadzi vari pedyo nekuguma kuenda kumwedzi kana vari pedyo nekuguma kuenda kumwedzi vane hyperandrogenism yakanyanya, oophorectomy (kuvhiyiwa kubviswa kweovari imwe kana ese ari maviri) inogonawo kudiwa.
• Kana hyperandrogenism ichikonzerwa nemushonga wauri kutora, chiremba wako anogona kukurudzira kuti urege mushonga wacho kana kuti uchinje kune mumwe mushonga.

Mishonga inoderedza androgens inowanzo shandiswa pakurapa hyperandrogenism. Inodzivisa migumisiro ye androgens, senge testosterone.

Kune mhando dzakasiyana dzemishonga inorwisa androgen:

• Mishonga yekudzivirira pamuviri/yekudzivirira pamuviri ine ethinyl estradiol (estrogen) uye antiandrogenic progesterone: Mienzaniso inosanganisira mapiritsi ane cyproterone acetate (semuenzaniso Diane®-35), drospirenone (semuenzaniso Yasmin®, Yaz®) kana dienogest (semuenzaniso Valette®). Izvi zvinogona kurapa mapundu, kukura kwebvudzi kusingadiwe uye kuenda kumwedzi kusingawanzoitiki.
• Spironolactone (Aldactone®) : Iyi antiandrogen inorapa mapundu uye kukura kwebvudzi kusingadiwe kunokonzerwa nemahormone.
• Cyproterone : Mushonga uyu unobatsira kurapa PCOS, kuderedza testosterone, uye kuderedza kugadzirwa kwemafuta anokonzera mapundu.

Kurapa kwezviratidzo

Vanhu vane hyperandrogenism vanogona kutsvaga kurapwa kwezviratidzo zvavo:

• Mapundu : Kurapa mapundu kunosanganisira mishonga inotorwa nemaoko, mishonga inorwisa mabhakitiriya inonwiwa yakaita se tetracycline , mishonga inorwisa maandrogens (kusanganisira kurapa nemahormone, mapiritsi ekudzivirira pamuviri), uye mapiritsi e isotretinoin .
• Kukura kwebvudzi risingadiwe : Vakadzi vazhinji vane hirsutism vanoshandisa nzira dzakadai sekupukuta bvudzi, kugerwa, uye kubvisa bvudzi ne laser. Vanogonawo kunwa mapiritsi ekudzivirira pamuviri.
• Kuenda kumwedzi zvisina kurongeka : Vakadzi vanogona kushandisa nzira dzekudzivirira pamuviri dzine mahormone kuti vagadzirise nguva yavo yekuenda kumwedzi.

Kana zviratidzo izvi zvikasapindura kurapwa kwakajairika nekuda kwekusagadzikana kwemahormone, chiremba wako anogona kufunga nezvemishonga ine simba yekurwisa androgen.

Izvi hazvigone kudzivirirwa here?

Zvinosuwisa kuti hapana nzira yakajeka yekudzivirira hyperandrogenism.

Hapana nzira yakasimbiswa yekudzivirira PCOS, iyo inonyanya kukonzera hyperandrogenism. Asi unogona kutora matanho madiki ekuderedza zviratidzo zvako. Semuenzaniso, kudya chikafu chinovaka muviri,Kurovedza muviri nguva dzose uye kudzora huremu hwako kunogona kubatsira kuderedza migumisiro yePCOS uye hyperandrogenism.

Remangwana richange rakaita sei? (Kufungidzira)

Matambudziko mazhinji anokonzera hyperandrogenism anoda kurapwa kwehupenyu hwese. Dzimwe nguva, vakadzi vane hyperandrogenism nekuda kwePCOS vanodzikira huremu uye PCOS yavo inopera. Zvisinei, vanhu vazhinji vanoda kurapwa kwehupenyu hwese kuti vaderedze zviratidzo zve hyperandrogenism.

Zviratidzo zveHyperandrogenism zvinogona kukanganisa kuzviremekedza kwako uye hutano hwepfungwa. Kana zviratidzo izvi zviri kuita kuti unzwe kushushikana, kuzvidya mwoyo, uye/kana kuora mwoyo, zvakakosha kutsvaga rubatsiro kubva kuna chiremba wepfungwa kana mupi wezano.

Ndinofanira kuona chiremba rini?

Kana ukaonekwa uine hyperandrogenism uye uri kutora mishonga yekurapa, unofanira kuona chiremba nguva nenguva kuti uve nechokwadi chekuti kurapwa kwako kuri kushanda nemazvo.

Kana hyperandrogenism iri kukanganisa hutano hwepfungwa dzako, zvakakosha kuti uone chiremba wepfungwa kana mupi wezano kuti akubatsire.

Pakupedzisira, meseji yekuenda nayo kumba:

Hyperandrogenism chirwere chinowanzoitika pakati pevakadzi. Zviratidzo zvacho zvinogona kuita kuti unzwe kunyara uye kusagadzikana. Asi yeuka, hausi wega, uye chirwere ichi chinogona kurapwa. Taura nachiremba wako nezvesarudzo dzekurapa. Zvakare, kana chiri kukanganisa hutano hwepfungwa dzako, iva nechokwadi chekuona chiremba wepfungwa kana mupi wezano. Kutarisira hutano hwako ndicho chinhu chakakosha.

` Hyperandrogenism, Androgen, Testosterone, PCOS, Hirsutism, Acne, Hormonal Imbalance, Hutano hweVakadzi, Hormonal Imbalance