Wakambonzwa nezvenhoroondo yemhuri yekenza here? Kana kuti wechidiki ari kuita kenza inowanzobata vanhu vakuru? Dzimwe nguva panogona kunge paine chikonzero chiri shure kwezvinhu izvi chatisingazive. Ndizvo zvatichataura nezvazvo nhasi, chirwere chisingawanzoitika mumajini chinoitika mumhuri uye chinowedzera njodzi yekenza zvakanyanya. Chinonzi Li-Fraumeni Syndrome.
Zvichitaurwa zviri nyore, chii chinonzi Li-Fraumeni Syndrome?
Ichi chirwere chemajini chisingawanzoitiki. Chinokonzerwa nekuchinja kwemajini mumuviri wedu. Kuchinja kwemajini uku kunowedzera mukana wekuti iwe nemhuri yako muve nerudzi rumwe kana kupfuura rwekenza.
Funga izvi: Munhu ane chirwere ichi ane mukana we90% wekuva nekenza pazera remakore makumi matanhatu. Uye, hafu yevanhu ava vanova nekenza vasati vasvitsa makore makumi mana. Kunyanya, vakadzi vane Li-Fraumeni Syndrome vane mukana we100% wekuva nekenza yemazamu muhupenyu hwavo hwese.
Izvi zvinganzwika sekutyisa zvishoma. Asi chinhu chakakosha ndechekuti kunyangwe tisingakwanise kudzivirira chirwere ichi, nekuongorora kenza nguva nenguva uye kuwana kurapwa kwakakodzera , tinogona kuderedza zvakanyanya kukanganisa kwacho muhupenyu hwedu.
Dambudziko iri rakajairika zvakadii?
Chirwere cheLi-Fraumeni chirwere chisingawanzoitiki. Vaongorori vakawana mhuri dzinosvika chiuru pasi rose dzine chirwere ichi chekuchinja kwemajini. Saka hapana chikonzero chekuchitya zvisina kufanira.
Ndezvipi zviratidzo zveLi-Fraumeni Syndrome?
Chinhu chakakosha apa ndechekuti hapana zviratidzo zvakananga zvine chekuita nechirwere chinonzi Li-Fraumeni Syndrome. Kureva kuti, munhu ane chirwere ichi haaoni shanduko kunze.
Saka unozviziva sei izvi? Chiratidzo chikuru chechirwere ichi kuitika kwemhando dzakasiyana dzekenza uchiri mudiki . Saka, zviratidzo zvaunosangana nazvo zvinoenderana nerudzi rwekenza yaunayo. Semuenzaniso, kenza yeuropi icharatidza zviratidzo zvine chekuita nazvo, uye kenza yemazamu icharatidza zviratidzo zvine chekuita nazvo.
Ndeapi marudzi egomarara anowanzobatanidzwa nechirwere ichi?
Mhando dzegomarara dzinopfuura gumi dzakabatana neLi-Fraumeni Syndrome. Dzimwe gomarara dzakajairika kuvanhu vane chirwere ichi zvekuti dzinonzi "magomarara makuru." Ngationei kuti chii.
| Chikamu chegomarara | Tsananguro |
|---|---|
| Kenza huru | |
| Sarcomas | Kenza dzinoitika mumapfupa (Osteosarcoma) uye munyama dzakapfava (Soft Tissue Sarcoma). |
| Kenza yemazamu | Vakadzi vane chirwere ichi vane njodzi yehupenyu hwavo hwese yekuchibata ne100%. |
| Kenza yeUropi | Izvi zvinosanganisira mhando dzakasiyana-siyana dzakadai seGliomas, Choroid Plexus Carcinoma, uye Medulloblastoma. |
| Kansa yeAdrenocortical | Kenza inokura muchikamu chekunze cheadrenal glands, chiri pamusoro peitsvo dzedu. |
| Leukemia | Izvi zvinosanganisira acute leukemia, kenza yemasero eropa. |
| Dzimwe kenza dzisingawanzobatanidzwa | |
| Kenza yemudumbu, Kenza yeitsvo, Lymphoma, Kenza yemapapu, Kenza yeovary, Kenza yepancreatic, Kenza yeprostate, Kenza yeganda, Kenza yemudumbu, Kenza yematesticular, Kenza yethyroid. | |
Sei mamiriro ezvinhu aya achiitika?
Kuti tinzwisise kuti sei izvi zvakadaro, tinofanira kuziva nezve kamuchengeti kadiki mumuviri wedu. Tine jini rinonzi TP53 . Rakaita se "muchengeti wengirozi" mumuviri wedu. Basa guru rejini iri nderekudzivirira masero mumuviri wedu kuti asakure zvisina kujairika uye asingadzoreki uye ave bundu.
Puroteni inogadzirwa nejini iri reTP53 inonzi puroteni yeP53. Izvi ndizvo chaizvo zvinoita basa rekuchengetedza.
Zvino, zvinoitika kumunhu ane Li-Fraumeni Syndrome ndezvekuti pane shanduko, kana kuti kuchinja, mujini rinodzivirira rinonzi TP53 . Chinoitika ndechekuti jini harigone kugadzira puroteni yeP53 inoshanda nemazvo. Kana jini iri rinodzivirira rarasika, masero anotanga kupatsanuka zvisingadzoreki. Ndizvo zvinokura kuita kenza.
Kazhinji, mwana anogara nhaka jini iri reTP53 risina kunaka kubva kuvabereki vake. Izvi zvinonzi Autosomal Dominant Pattern . Zvichitaurwa zviri nyore, kunyangwe mubereki mumwe chete akagara nhaka jini iri risina kunaka, kungava amai kana baba, mwana anogona kuramba aine chirwere ichi uye kuva nenjodzi yakakura yekubatwa nekenza .
Zvisinei, kashoma, shanduko iyi yemajini inogona kuitika mumuviri wemunhu pasina mumwe munhu mumhuri ane chirwere ichi. Izvi zvinonzi De Novo Mutation.
Chirwere ichi chinoonekwa sei?
Vanachiremba vanoshandisa bvunzo dzemajini kuti vaone chirwere chacho. Asi vasati vaita izvi, vachanyatsoongorora nhoroondo yako neyemhuri yako yezvekurapa. Pane zvikonzero zvakawanda zvinoita kuti chiremba afungire kuti ane Li-Fraumeni Syndrome:
- Kana wakamboonekwa uine kenza yesarcoma usati wasvitsa makore makumi mana nemashanu.
- Kana mumwe wehama dzako dzegiredhi rekutanga (vabereki, vanun'una, vana) akaonekwa aine kenza asati asvitsa makore makumi mana nemashanu.
- Kana paine hama dzako dzechipiri (vanasekuru navanasekuru, vanatete, vanababamunini, vazukuru, vazukuru) vakaonekwa vaine kenza vasati vasvitsa makore makumi mana nemashanu.
Kana chimwe chezviyero izvi chikazadzikiswa, chiremba anogona kukutumira kunoongororwa majini.
Kana ukaonekwa uine chirwere ichi, chinhu chinotevera chakakosha ndechekushanda pachirongwa chekuongororwa kenza. Nekuona chiremba wako nguva dzose uye kuongororwa, chero kenza inomuka inogona kuonekwa uye kurapwa padanho rekutanga .
Inorapwa sei?
Hapana mushonga chaiwo wechirwere cheLi-Fraumeni Syndrome. Vanachiremba vanorapa kenza dzinokonzerwa nechirwere ichi. Marapirwo acho akafanana zvikuru neaya anopiwa munhu asina chirwere ichi. Izvi zvinosanganisira kuvhiyiwa uye chemotherapy.
Asi pane musiyano wakakosha zvikuru pano.
Vanhu vane Li-Fraumeni Syndrome vanonyanya kunzwa kubatwa nemwaranzi. Saka, pane njodzi yekuti kenza itsva dzitange nemwaranzi. Nekuda kweizvi, chiremba wako achaedza kudzivirira kana kuderedza kurapwa nemwaranzi kana ukaita kenza.
Chii chaunofanira kutarisira paunenge uchirarama nechirwere ichi?
Kuziva kuti une Li-Fraumeni Syndrome zvinoreva kuti iwe nemhuri yako munofanira kushanda pamwe chete pakuongorora kenza nguva dzose. Tsvagiridzo yakaratidza kuti kuongororwa kenza nguva dzose kunowedzera mikana yekuponesa hupenyu hwevanhu ava .
Zvirongwa zvebvunzo izvi zvakasiyana zvevana nevakuru. Muenzaniso unotevera ndewekuti chiremba wako ndiye achagadzira purogiramu yakakunakira.
| Boka rezera | Musiyano wenguva | Miedzo inofanira kuitwa |
|---|---|---|
| Kune vana (kusvika makore gumi nemasere) | ||
| Kusvika makore gumi nemasere ekuberekwa | Mwedzi mitatu kusvika mina yega yega | Kuongororwa kwemuviri kwakakwana uye kuongororwa kwemudumbu neultrasound. |
| Kamwe chete pagore | Kuongororwa kweMRI yeuropi uye kuongororwa kweMRI yemuviri wese. | |
| Kune vakuru | ||
| Vakuru | Mwedzi mitanhatu yega yega | Ongororwa zamu nachiremba (kubva pamakore 20-25). |
| Kamwe chete pagore | Kuongororwa kwemuviri, MRI yemazamu, MRI yeuropi nemuviri wese, scan yemudumbu nechiuno, kuongororwa kweganda rose rekenza yeganda. | |
| Makore maviri kusvika matatu ega ega | Kuongororwa kweColonoscopy neUpper Endoscopy. | |
Mamiriro ezvinhu aya haagone kudzivirirwa here?
Hapana nzira yekudzivirira chirwere chemajini chinonzi Li-Fraumeni Syndrome. Chinhu chinouya nemajini edu. Asi unogona kudzivirira zvinhu zvinowedzera njodzi yako yekenza.
- Dzivisa kusvuta zvachose.
- Dzivisa kunwa doro zvakanyanya .
- Kana uchienda kuzuva, usagara panze kwenguva yakareba usina dziviriro yakaita sekuchengetedza zuva .
Vamwe vakadzi vanobviswa mazamu ese ari maviri vachivhiyiwa vasati vatanga kenza kuti vaderedze njodzi yekubatwa nekenza yemazamu. Izvi zvinonzi prophylactic mastectomy .
Kunyangwe paine matanho ese aya ekudzivirira, munhu ane chirwere ichi anogona kuramba achirwara negomarara. Ndosaka chinhu chakanakisa chekuita ndechekuongororwa nguva nenguva uye kubata gomarara nekukurumidza kana rikaitika.
Unozvitarisira sei iwe nemhuri yako?
Kurarama nechirwere chakadai kweupenyu hwese kunogona kunetsa mumuviri nemupfungwa.
1. Usapotsa kuongororwa: Tevedzera purogiramu yako yekuongororwa kenza nemazvo.
2. Kuronga mhuri: Kana uchironga kuva nevana, zvakakosha kutaura nenyanzvi yezvemajini. Unofanira kunzwisisa njodzi yekupa majini aya asina kunaka kumwana.
3. Hutano hwepfungwa: Usatakura mutoro uyu wega. Tsvaga rubatsiro kubva kumupi wezano wehutano hwepfungwa ane ruzivo rwekushanda nevarwere vegomarara kana avo vane zvirwere zvisingaperi. Bvunza chiremba wako nezvemapoka ekutsigira akadai.
Kana ukaona chero shanduko dzisingawanzoitika mumuviri wako, dzakadai sekurwadziwa kana bundu, usazviregeredza, uchifunga kuti, "Izvi zvinofanira kunge zvakajairika." Usamirire kusvika bvunzo yako inotevera, asi ona chiremba wako nekukasika .
Mharidzo Yekuenda Nayo Kumba
- Li-Fraumeni Syndrome chirwere chisingawanzoitiki, chinogarwa nhaka uye chinowedzera njodzi yekenza zvakanyanya.
- Hapana zviratidzo zvine chekuita nechirwere ichi pachacho. Zviratidzo zvacho zvinokonzerwa nekenza inozobuda.
- Kunyangwe chirwere ichi chisingadzivirirwi, kuongororwa kenza nguva dzose uye nekukurumidza kunowedzera mukana wekuponesa hupenyu.
- Kana uine chirwere ichi, zvakakosha kuti usashandise radiation therapy. Chiremba wako anogona kunge achiziva izvi.
- Sezvo izvi zvichiri zvenhaka, zvakakosha kutsvaga mazano echiremba nezvekuti vamwe vemumhuri vaende kunoongororwa majini.
- Kungofanana nehutano hwemuviri, hutano hwepfungwa hunokoshawo panguva iyi yerwendo. Usazeza kutsvaga rubatsiro kana uchida rubatsiro.
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