Wakambonzwa nezveLynch Syndrome here? Zita iri ringave idzva kwauri. Asi chirwere chemajini chinopfuudzwa kubva kuchizvarwa kuenda kune chimwe ndicho chinowedzera njodzi yedu yekuva nekenza. Izvi zvinowedzera njodzi yekuva nekenza, kunyanya usati wasvika makore makumi mashanu. Zvakajairika kunzwa kutya zvishoma paunonzwa mazwi ekuti "ungangowana kenza". Asi chinonyanya kukosha ndechekuva neruzivo rwakakwana nezvezvirwere zvakadaro. Saka nhasi tichataura nezvazvo zviri nyore, nenzira yaunogona kunzwisisa.
Zvichitaurwa zviri nyore, chii chinonzi Lynch Syndrome?
Fungidzira kuti muviri wedu wakaita semuchina wakaoma unoshanda zvichienderana nebhuku guru remirayiridzo (DNA). Majini edu akafanana nemavara ari mubhuku remirayiridzo iri. Dzimwe nguva, pane zvikanganiso mubhuku remirayiridzo iri, kana kuti 'kukanganisa kwekunyora'. Mukurapa, izvi zvinonzi genetic mutations.
Lynch syndrome chirwere chinokonzerwa nekuchinja kwemajini. Muviri wedu une rudzi rwakakosha rwejini rinoona nekugadzirisa zvikanganiso muDNA yedu. Izvi zvinonzi ``kusawirirana kugadzirisa (MMR)`` gene. Zvakafanana ne ''timu yekugadzirisa'' mumuviri wedu. Munhu ane Lynch syndrome ane dambudziko mune rimwe remajini ari mu ''timu yekugadzirisa'' iyi. Nokudaro, zvikanganiso muDNA hazvigadziriswi zvakanaka. Masero ane zvikanganiso izvi anoungana uye nekufamba kwenguva, anogona kuva nekenza.
Dambudziko iri rinogona kukanganisa chero munhu. Nekuti chirwere chemajini. Dzimwe nguva unogona kugara nhaka jini iri risina kunaka kubva kuna amai kana baba vako. Kashoma, kuchinja kwemajini uku kunogona kuitika mumuviri wemunhu mutsva pasina munhu mumhuri. Kana ukatarisa nhamba dziri munyika yakaita seAmerica, zvinofungidzirwa kuti munhu mumwe chete pavanhu 279 ane chirwere ichi.
Ndezvipi zviratidzo zvingaonekwa nemunhu ane chirwere cheLynch?
Chinhu chakakosha kuziva apa ndechekuti chirwere cheLynch hachina zviratidzo chaizvo. Asi, chiratidzo chegomarara rinokonzerwa nechirwere ichi. Chinonyanya kuzivikanwa igomarara remudumbu.
Saka, heano mamwe ezviratidzo zvinowanzoonekwa zvinogona kunge zvakabatana nekenza ye colorectal:
| Chiratidzo | Tsananguro |
|---|---|
| Ropa muchigaro chetsvina | Tsvina inogona kunge yakatsvuka kana kuti yakasviba ine ropa rakasanganiswa. |
| Kurwadziwa kwemudumbu kana kuda kurutsa | Kurwadziwa kana kusagadzikana mudumbu nguva nenguva. |
| Kuchinja maitiro emudumbu | Kuerekana wava nedambudziko rekuzvimba kana manyoka, kana tsvina yakatetepa kupfuura yakajairika. |
| Kuneta kakawanda | Kugara kuneta kunyangwe kuzorora zvakanaka. |
| Kuzvimba kana kuzvimba | Kunzwa kuguta kana kuzvimba kunyangwe mushure mekudya zvishoma. |
| Kusvotwa kana kurutsa | Kusvotwa kana kurutsa pasina chikonzero chiri pachena. |
Chinhu chakakosha ndechekuti havasi vese vanowana zviratidzo izvi. Dzimwe nguva kenza inogona kusaratidza zviratidzo kusvika yakura zvakanyanya. Saka, kana ukaramba uine chimwe chezviratidzo izvi kana kupfuura, iva nechokwadi chekuona chiremba wako kuti akupe mazano.
Ndeapi marudzi egomarara anogona kukura nekuda kwechirwere ichi?
Chirwere cheLynch hachisi chirwere chinovhura mukana werudzi rumwe chete rwekenza. Chinowedzera njodzi yekubatwa nekenza munzvimbo dzakasiyana-siyana dzemuviri. Nhengo dziri panjodzi dzinogona kusiyana zvichienderana nejini risina kunaka. `MLHL`, `MSH2`, `MSH6`, `PMS2` uye `EPCAM` ndiwo majini mashanu makuru anobatanidzwa.
Heano mamwe marudzi egomarara anowedzera njodzi yechirwere cheLynch.
| Rudzi rwegomarara | Chikamu chemuviri chakakodzera |
|---|---|
| Kenza yemudumbu nerectal | Sisitimu yekugaya chikafu |
| Kenza yechibereko/Endometrial | Sisitimu yekubereka yevakadzi |
| Kenza yemudumbu | Sisitimu yekubereka yevakadzi |
| Kenza yemudumbu | Sisitimu yekugaya chikafu |
| Kenza yemudumbu mudiki | Sisitimu yekugaya chikafu |
| Kenza yepancreatic | Sisitimu yekugaya chikafu |
| Kenza yemudumbu rekumusoro | Sisitimu yeweti |
| Kenza yehuropi | Sisitimu yetsinga |
| Kenza yeganda | Ganda |
Kenza dzemudumbu dzinokonzerwa neLynch syndrome dzakasiyana zvishoma. Dzinokura nekukurumidza kupfuura kenza dzinowanzo buda.Kunyange zvazvo zvichitora makore angangoita gumi kuti ganda diki remunhu akajairwa rive kenza, zvinotora gore rimwe chete kana maviri kuti munhu ane chirwere cheLynch syndrome.
Uyewo, nekuda kwechirwere ichi, munhu akamborwara nekenza yemudumbu uye akapora ane mukana mukuru wekuwana mhando imwe chete yekenza zvakare.
Funga nezvenyaya iyi, pane mukana wekuti kenza itangezve mukati memakore gumi mushure mekunge kenza yekutanga yabviswa. Njodzi iyi inogona kuwedzera kusvika 40% mushure memakore makumi maviri, uye kusvika 60% mushure memakore makumi matatu. Izvi zvinoratidza kukosha kwekuongororwa nguva dzose.
Izvi zvinopfuudzwa sei kubva kuzvizvarwa kusvika kuzvizvarwa?
Lynch syndrome chirwere chinopfuudzwa kubva kuchizvarwa kuenda kune chimwe nenzira ye "autosomal dominant". Izvi zvinongoreva kuti kunyangwe mubereki mumwe chete, angave amai kana baba, vane jini rakakanganisika, pane mukana we50% wekuti mwana acharigara nhaka. Izvi zvinoreva kuti mwana wega wega ane mukana we50% wekurigara nhaka uye mukana we50% wekusarigara nhaka.
Saka, kana iwe kana mumwe munhu mumhuri yako akaonekwa kuti ane chirwere cheLynch syndrome, zvakakosha kuzivisa vamwe vese vemumhuri mako. Kunyanya vanun'una vako, vana, nevabereki vanofanira kuudzwa nezvenjodzi iyi. Kuvaendesa kunoongororwa majini uye kupiwa mazano kunogona kutoponesa hupenyu hwavo.
Ndingaziva sei kana ndine chirwere ichi? Ndedzipi bvunzo dzandinofanira kuita?
Nzira yakanakisisa yekuziva kana uine chirwere cheLynch ndeyekuita bvunzo dzemajini . Izvi zvinowanzo sanganisira kutora ropa. Kana kuti buccal swab inotorwa kubva mukati memuromo mako. Kuongororwa uku kunogona kuona nemazvo kana uine shanduko mumajini atakataura nezvawo kare, akadai seMLHL neMSH2.
Kana ukaonekwa uine chirwere cheLynch syndrome, chinhu chinotevera chakakosha ndechekuongororwa nguva nenguva kuti uone kenza nekukurumidza. Chiremba wako achagadzira purogiramu yekuongororwa yakakunakira.
| Bvunzo | Maitiro ekuzviita uye nguva inokurudzirwa |
|---|---|
| Colonoscopy | Colonoscopy inzira inopinzwa chubhu tete ine kamera kuburikidza nepaburi kuti iongorore ura. Inowanzo kurudzirwa gore rega rega kana maviri . |
| Ultrasound yeTransvaginal | Kuvakadzi, kuongororwa kwechiuno, kunosanganisira kuisa mudziyo wekuskena nepanhengo yemukadzi uye kuongorora chibereko nemazai, kunokurudzirwa gore rega rega kana maviri . |
| Kuongororwa kweweti | Wana ruzivo rwekutanga nezvegomarara rinokonzerwa neitsvo nekuongorora weti. Zvinokurudzirwa kuita izvi gore rega rega . |
| Endoscopy Yepamusoro | Chubhu ine kamera inopinzwa nemuromo kuti iongorore dumbu nechikamu chepamusoro cheura hudiki. Zvinokurudzirwa makore matatu kusvika mashanu ega ega . |
| Kuongororwa kwemuviri | Kana paine nyama inofungirwa kana bundu panguva yekuongororwa kwataurwa pamusoro apa, sampuli diki inotorwa yoongororwa masero ekenza. |
Chirwere cheLynch chinorapwa sei?
Parizvino hapana mushonga wechirwere cheLynch syndrome. Saka, chinangwa chikuru chekurapa ndechekuona nekubvisa masero ekenza mumuviri nekuvhiyiwa. Kana kenza ikagona kuonekwa yobviswa isati yapararira kune dzimwe nhengo dzemuviri, mhedzisiro yacho inobudirira zvikuru.
Izvi zvinoda chikwata chevanachiremba vane hunyanzvi hwakasiyana-siyana. Semuenzaniso, vanachiremba vezvekudya, vanachiremba vezvekuvhiya, vanachiremba vezvirwere zvemadzimai, uye vanachiremba vezvezvirwere zveganda vanoshanda pamwe chete kurapa chirwere ichi.
Vamwe vanhu, kunyanya vakadzi vakapedza mhuri dzavo, vanosarudza kubviswa chibereko kana kubviswa mazai vasati varwara kuti vaderedze njodzi yavo yekuva nekenza yemuchibereko kana yemuchibereko mune ramangwana. Saizvozvowo, avo vari panjodzi huru yekenza yemudumbu vanogona kusarudza kubviswa chibereko. Izvi zvisarudzo zvemunhu oga, uye zvinofanira kuitwa mushure mekukurukurirana kwakawanda nachiremba wako.
Lynch syndrome neHNPCC zvakafanana here?
Ungave wakambonzwawo zita rekuti `HNPCC (Hereditary Non-Polyposis Colorectal Cancer)`. Lynch syndrome neHNPCC zvinowanzo shandiswa zvakafanana, asi pane musiyano mudiki pakati pezviviri izvi.
Zvichitaurwa zviri nyore, zita rekuti HNPCC rinoshandiswa zvichibva panhoroondo yemhuri. Kureva kuti, kana nhengo dzinoverengeka dzemhuri dzakaita rudzi urwu rwegomarara, mhuri iyoyo inonzi ine HNPCC. Asi Lynch syndrome izita rinopiwa mushure mekunge gene mutation chaiyo inoita kuti ionekwe. Saka, nhengo dzese dzemhuri ine HNPCC dzinogona kuva neLynch syndrome gene mutation. Zvakare, munhu anogadzira gene mutation itsva asina mumwe munhu mumhuri anogonawo kunzi ane Lynch syndrome.
Hapana anofarira kunzwa mashoko ekuti, "Une kenza." Munhu ane chirwere cheLynch syndrome angangofanira kunzwa mashoko iwayo pane imwe nguva muhupenyu hwake. Asi hazvisirizvo kuguma kwenyika. Kana uchiziva nezvechirwere chako, shanda nachiremba wako, uye uchiongororwa kenza nguva dzose, chero kenza inogona kuonekwa uye kurapwa padanho rayo rekutanga. Kuonekwa nekukurumidza uye kurapwa ndiyo nzira yakanakisisa yekurarama hupenyu hune hutano uye hunofadza.
Mharidzo Yekuenda Nayo Kumba
- Lynch syndrome chirwere chemajini chinopfuudzwa kubva kuchizvarwa kuenda kune chimwe uye chinowedzera njodzi yekubatwa nekenza.
- Kunyangwe mubereki mumwe chete ari iye ane jini iri risina kunaka, mwana ane mukana we50% wekurigara nhaka.
- Kana iwe kana mumwe munhu mumhuri yako akaonekwa aine chirwere ichi, zvakakosha zvikuru kuzivisa vamwe vemhuri yepedyo nezvazvo.
- Kunyangwe chirwere ichi chemajini chisingagoni kurapwa, nzira yakanakisisa yekudzivirira kana kuona kenza nekukurumidza ndeyekuongororwa nachiremba nguva dzose.
- Kuonekwa nekurapwa kwegomarara nekukurumidza kunogona kuunza mhedzisiro inobudirira uye kukubvumira kurarama hupenyu hune hutano.
- Gara uchibvunza chiremba wako kuti ugadzire purogiramu yekuongororwa inokodzera iwe uye kugadzirisa chero zvinokunetsa.
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