Uri kuwana mapundu asinganzwisisike paganda rako here? Izvi zvinogona kunge zviri Muir-Torre Syndrome here?

Wakambotanga kubuda mapundu madiki paganda rako here? Ungafunga kuti izvi zvakajairika. Zvisinei, dzimwe nguva shanduko idzi dzeganda dzinogonawo kusanganiswa nematambudziko emukati. Nhasi tichataura nezvechirwere chisingawanzoitiki asi chakakosha kwazvo chekuziva. Chinonzi Muir-Torre Syndrome.

Chii chinonzi Muir-Torre Syndrome? Zvichitaurwa zviri nyore...

Muir-Torre Syndrome chirwere chisingawanzoitika mumajini chinowedzera njodzi yekubatwa nekenza yemhando dzakasiyana muhupenyu hwako. Vanhu vane chirwere ichi vanowanzoita bundu reganda, ringave rekenza kana kuti reganda risina njodzi (kureva kuti, risina njodzi) muganda ravo. Vanogonawo kuita kenza imwe kana kupfuura mumuviri, kunyanya mudumbu .

Funga nezvazvo, muviri wedu wakaumbwa nemamiriyoni emasero madiki. Kana masero aya akapatsanuka, dzimwe nguva shanduko diki (kuchinja) mumajini dzinogona kuitika. Ndizvo zvinokonzera shanduko iyi yemajini.

Saka Muir-Torre Syndrome yakafanana here neLynch Syndrome?

Kazhinji, hongu. Chirwere cheMoore-Torre chinoonekwa sechimwe chezviratidzo zveLynch syndrome . Chirwere cheLynch chirwere chinowedzerawo njodzi yekenza nekuda kwekuchinja kwemajini. Dzimwe nguva vanachiremba vanochidanawo kuti Hereditary Non-Polyposis Colorectal Cancer (HNPCC). Izvi zvinoreva kuti kenza inokura muura husina mapolyps. Saka, Moore-Torre chikamu cheLynch syndrome chinoratidza hunhu hweganda.

Nyaya iyi yakajairika zvakadii? Tinofanira kunetseka here nezvenyaya iyi muSri Lanka?

Chirwere cheMoore-Torre chirwere chisingawanzoitiki . Vanhu vanosvika mazana maviri chete ndivo vakaonekwa pasi rose. Zvisinei, izvi hazvirevi kuti hatifaniri kuzviziva. Vanhu vanosvika 9.2% vane `HNPCC` vanogona kuratidza zviratidzo izvi zveMoore-Torre. Zvinoita sekuti chinokanganisawo varume zvishoma kupfuura vakadzi (kureva vakadzi vaviri pavarume vatatu vega vega). Kunyangwe pasina nhamba chaiyo yekuti vanhu vangani muSri Lanka, zvakakosha kuziva nezvezvirwere zvakadaro.

Ndezvipi zviratidzo zveMoore-Torre syndrome? Tinozviziva sei?

Izvi zvinonyanya kukonzerwa nekuonekwa kwemapundu kana shanduko paganda uye zviratidzo zvekenza yemukati . Dzimwe nguva matambudziko eganda anogona kuitika kenza yemukati isati yatanga, panguva imwe chete, kana mushure mekunge yatanga. Zvisinei, shanduko dzeganda dzinowanzova chiratidzo chekutanga kuonekwa . Dzimwe kenza dzingasaratidza zviratidzo pakutanga.

Ndezvipi shanduko dzaunogona kuona paganda?

Zvinotevera zvinogona kuonekwa paganda remunhu ane chirwere cheMoore-Torre:

• Matumbu eSebaceous: Aya ndiwo matambudziko eganda anowanzoonekwa (80% - 99%). Aya mabundu asiri ekenza (asina kuipa). Anokura mumatumbu eSebaceous, ayo ari mafuta ari muganda redu. Anowanzo kuwanikwa mumusoro nemutsipa, uye kune vanhu vane chirwere cheMoore-Torre, anowanzoonekwa pachipfuva, mudumbu, muhudyu, nemusana . Anotaridzika semapundu madiki, akaomarara, eyero kana ane ruvara rweganda .
• Sebaceous carcinoma: Iri ibundu rekenza (rinokuvadza) rinokura mumagland e sebaceous. Rinogona kutaridzika se sebaceous adenoma. Asi rinopararira nekukurumidza, kunyanya kutenderedza maziso . Mabundu aya anogona kubuda ropa kana kubuda ropa rine ganda.
• Keratoacanthoma: Iri ibundu reganda. Rinogona kukura mumusoro, mumutsipa, muhudyu, uye mumaoko pedyo nebvudzi. Rinogona kuva rekenza kana kuti risiri rekenza . Rinotaridzika sebundu diki, rakatenderera, dzimwe nguva rine mitsipa yeropa inoonekwa pamusoro, uye pfundo rekeratin pakati . Rinokura nekukurumidza, saizi inosvika masendimita matatu mumavhiki mashoma, uye rozodzikira zvishoma nezvishoma kwemwedzi kana makore. Panogona kunge paine rimwe kana kupfuura.
• Mavara eFordyce: Nekuti maronda emafuta anowanzobatanidzwa muMoore-Torre syndrome, vamwe vanachiremba vanoona aya "mavara eFordyce" sechiratidzo. Aya maronda emafuta akawandisa, akakura zvishoma anoonekwa munzvimbo dzisina bvudzi, senge dzakatenderedza miromo . Zvidzidzo zvakaratidza kuti anowanzo kuwanikwa muMoore-Torre syndrome.

Yeuka, kana ukaona bundu idzva kana shanduko yakaita seiyi paganda rako, kunyanya kana richikura nekukurumidza, richichinja ruvara, kana kubuda ropa, unofanira kuona chiremba.

Ndezvipi zvirwere zvegomarara zvinobatanidzwa neMoore-Torre syndrome?

Mhando dzakasiyana dzegomarara dzinogona kuitika nechirwere ichi. Gomarara rinonyanya kuzivikanwa nezviratidzo zvaro nderinotevera:

• Gomarara remudumbu: Iri ndiro rudzi rwegomarara rinowanzoonekwa . Rinobata vanhu vanosvika hafu yevanhu vese. Rinokonzerwa nekukura kwemasero egomarara mudumbu remudumbu kana rectum. Kusiyana neizvi, naMoore-Torre, gomarara iri rinogona kutanga makore 15-20 risati rasvika nguva dzose, kazhinji pazera remakore makumi mashanu. Rinogonawo kupararira nekukurumidza . Zviratidzo zvinosanganisira kurwadziwa mudumbu, kuzvimba, kuchinja kwemaitiro emudumbu, uye ropa mutsvina .
• Kenza yemudumbu: Iyi ikenza inowanzoonekwa neMoore-Torre. Zviratidzo zvinogona kusanganisira kurwadziwa mudumbu, kuzvimba, ropa mutsvina, kuoma kugaya chikafu, kuda kurutsa, uye kushaya chido chekudya .
• Kenza yemudumbu:Inonziwo `(Urothelial carcinoma)` kana `(transitional carcinoma)`. Izvi zvinokanganisa chikamu chemukati menzira yeweti. Zvinogona kukonzera kurwadziwa pakuita weti uye ropa muweti .
• Kenza yechibereko: Iyi ikenza inokura muchibereko, mukati mechibereko . Inogona kukonzera kurwadziwa kwepazasi pedumbu, kurwadziwa kwechiuno, uye kubuda ropa kusingawanzoitiki kana kubuda ropa .

Pamusoro pezvo, mamwe marudzi akawanda ekenza anogona kusanganiswa nechirwere ichi, anosanganisira:

• Kenza yemudumbu
• Kenza yeprostate
• Kenza yedundira
• Kenza yeitsvo
• Kenza yemudumbu mudiki
• Kenza yechiropa
• Kenza yemapapu
• Kenza yeropa
• Kune kenza yeuropi nedzimwe mhando.

Rondedzero iyi ingaita seinotyisa. Asi chinhu chakakosha ndechekuti haisi kenza yese iyi inokura mumunhu wese. Uye, kana ikaonekwa nekukurumidza, inogona kurapwa .

Sei chirwere cheMoore-Torre chichiitika? Chii chinokonzera?

Zvichitaurwa zviri nyore, chirwere cheMoore-Torrell chinokonzerwa nekuchinja kwemajini ako . Kuchinja kwemajini kuchinja kweDNA yedu. DNA iyi inokopwa kana masero edu akapatsanuka ogadzira masero matsva. Dzimwe nguva zvikanganiso zvinogona kuitika. Kana sero risingawanzoitiki rikaramba richipatsanuka, rinogona kukonzera zvirwere zvakasiyana-siyana, kusanganisira kenza.

Ndezvipi zvakasiyana-siyana zvemajini zvinokanganisa izvi?

Kune mhando mbiri zvikuru:

• Chirwere cheType 1 Moore-Torre (Type 1 MTS): Izvi zvinokonzerwa nekuchinja kwemajini mune rimwe remajini anoita zvikanganiso muDNA yako . Kana majini aya asingakwanise kugadzirisa zvikanganiso, masero asina kujairika anoungana mumatishu. Muzviitiko 90%, jini rinonzi MSH2 rinokanganiswa. Zvisinei, mamwe majini akati wandei, akadai seMLH1, MSH6, uye PMS2, anogona kunge aripo.
• Type 2 Moore-Torrell Syndrome (MTS): Izvi zvinokonzerwa nekuchinja kwemujini weMUTYH. Jini iri ndiro rinogadzirisa kukuvara kweoxidative kuDNA yedu. Vanhu vanosvika chikamu chimwe muzvitatu vane MTS vane rudzi urwu. Kuoxidation kunokonzera shanduko mumorekuru weDNA, izvo zvinogona kutungamira mukukura kwemasero kusingadzoreki (kureva kenza). Kana jini rakachinja risingakwanise kugadzirisa kukuvara uku, kukuvara kunoramba kuripo.

Izvi zvinobva kuzvizvarwa nezvizvarwa here?

Zvingangoita kuti, hongu, inoberekwa nhaka . Zvisinei, dzimwe nguva munhu anogona kutanga kuchinja kwemajini matsva pasina mumwe munhu mumhuri make akambova nako. Vanenge 60% yevarwere vanogona kuwana nhoroondo yemhuri yeMoore-Torre syndrome. Zvisinei, nekuti havasi vese vane kuchinja kwemajini uku vanova nezviratidzo, hukama hwemhuri iyi hausi pachena nguva dzose.

Vamwe vanhu vanogona kunge vaine chirwere ichi vasina zviratidzo, uye vangasatombozviziva. Zvakare, dzimwe nguva kana masoja emuviri asina simba, iyi 'MTS' isina kujeka' inogona kushanda. Vamwe vanhu vakave nechirwere ichi mushure mekuisirwa nhengo yakasimba uye kutora mishonga inodzvinyirira masoja emuviri.

Izvi zvinopfuudzwa sei kubva kuzvizvarwa kusvika kuzvizvarwa?

• Mhando yekutanga yeMTS chirwere chinonzi "autosomal dominant". Izvi zvinoreva kuti unongoda kopi imwe chete yejini rakachinja kuti ugare nhaka chirwere ichi. Kana mumwe wevabereki vako aine gene mutation iyi, une mukana we50% wekuigara nhaka zvakare. Zvisinei, maitiro aunoita zviratidzo anogona kusiyana nemubereki wawakagara nhaka jini racho.
• Rudzi rwechipiri rweMTS chirwere chinonzi "autosomal recessive". Izvi zvinoreva kuti kuti ugare nhaka chirwere ichi, vabereki vako vese vanofanira kunge vaine majini akafanana. Izvi hazviwanzoitiki. Zvisinei, vabereki vane kopi imwe chete yejini iri re "autosomal recessive" vanogona kunge vasina zviratidzo, saka vanogona kusaziva kuti vanaro.

Vanachiremba vanoongorora sei Muir-Torre Syndrome?

Kana uine mapundu eganda akaita seaya ataurwa pamusoro apa, kunyanya pahudyu yako, kana kuti akaonekwa achiri mudiki, chiremba anogona kufungidzira kuti une chirwere cheMoore-Torrell. Achakubvunzawo nezvezvimwe zviratidzo zvinogona kuratidza kenza yemukati, uye kana paine munhu mumhuri yako ane nhoroondo yekenza.

Ndedzipi mhando dzebvunzo dzinoitwa pakuita izvi?

Chiremba wako anogona kuita bvunzo dzinoverengeka dzekutanga asati akurudzira kuongororwa kwemajini. Semuenzaniso:

• Immunohistochemistry (IHC): Sampuro diki yebundu riri paganda rako inotorwa, yozoiswa dhayi chaiyo, uye yoongororwa nemaikorosikopu kuti ione kana sampuro yacho ine majini chaiwo.

Nemhedzisiro yebvunzo idzi nedzimwe ruzivo, chiremba wako anogona kukurudzira kuongororwa kwemajini kuti aongorore shanduko mumajini ane chekuita neMoore-Torre syndrome. Vachabva vatora sampuro yeropa rako votsvaga shanduko mumajini ekugadzirisa asina kuenderana MSH2, MLH1, MSH6, PMS2, kana gene rekugadzirisa rebase excision MUTYH.

Munhu ane chirwere cheMoore-Torre syndrome anofanira kuongororwa kenza kakawanda sei?

Zvakakosha kuti vanhu vane chirwere ichi vaongororwe kenza nguva nenguva , nekuti kuonekwa kwayo nekukurumidza kunowedzera mikana yekurapwa zvakanaka. Miedzo inogona kukurudzirwa navanachiremba inogona kusanganisira:

• Colonoscopy: Kuongorora ura hukuru.
• Endoscopy yepamusoro (EGD): Kuongororwa kwegurokuro, dumbu, uye chikamu chekutanga cheura hudiki.
• Kuongororwa kweprostate ( kuvarume)
• Mammogram: Kuongororwa kweMammogram:Kuongororwa kenza yemazamu (kuvakadzi)
• Kuongororwa kwechiuno ( kwevakadzi)
• Kuongororwa kwegomarara remuchibereko (pap smear): Kuongororwa kwegomarara remumuromo wechibereko (kuvakadzi)
• Cytology yeweti: Kune kenza yemudumbu.
• Kuongororwa kwebasa rechiropa
• Kuverengwa kweropa rose (CBC)
• Kuongororwa kwemuviri
• Kuongororwa kweganda
• X-ray yechipfuva

Chiremba wako ndiye achasarudza kuti unofanira kuita bvunzo idzi kangani.

Ndeipi mishonga yekurapa chirwere cheMoore-Torre?

Chinangwa chikuru chekurapa chirwere cheMoore-Torre ndechekutsvaga nekubvisa kenza kana ikaitika . Uchafanirwa kuongororwa kenza nguva dzose uye kutora biopsy yenyama chero ipi zvayo inofungirwa. Kana chiremba wako akawana kenza, achairapa zvichienderana nerudzi rwayo uye nhanho yayo. Kuvhiyiwa kubvisa kenza kazhinji ndiyo nzira yekutanga yekurapa .

Mimwe mishonga yekurapa kenza inogona kusanganisira:

• Kurapwa nemakemikari
• Kurapa nemwaranzi
• Kurapa kwemahormone
• Kurapa nekudzivirira muviri
• Kurapa kwakanangana
• Kuisirwa mapfupa emongo

Pamusoro pezvo, retinoid yemuromo inonzi isotretinoin inogona kubatsira kudzivirira maronda matsva eganda kuti asaumbwe. Kana colonoscopy yako ikawana ma polyps akawanda emudumbu (ari panjodzi huru yekuva nekenza), chiremba wako anogona kukurudzira kuti ubvise chikamu chemudumbu wako wese.

Chii chingave chiri fungidziro yemunhu ane chirwere cheMoore-Torre?

Kufungidzira kwako kunoenderana nekuti kenza ngani dzauchawana uye kuti dzinopararira kusvika papi. Nhamba dzinoratidza kuti hafu yevanhu vane chirwere cheMoore-Torre vanowana kenza inopfuura imwe chete. Vanopfuura hafu vanowana kenza yakapararira (kenza yakapararira kune dzimwe nhengo dzemuviri uye yakaoma kurapa).

Kenza dzine chirwere cheMoore-Torre dzinowanzoonekwa dzinenge dzava nemakore makumi mashanu. Kenza idzi dzinogona kukura nekukasira kupfuura muvanhuwo zvavo. Saka, kuonekwa kwekenza nekukurumidza kwakakosha . Zvakare, pane mukana mukuru wekuti kenza idzoke kunyangwe yabviswa. Saka, kuongororwa nguva nenguva mushure mekurapwa kwakakosha.

Pane nzira yekudzivirira izvi here?

Kazhinji hazviiti. Izvi zvinodaro nekuti chirwere chaunozvarwa nacho. Zvisinei, havasi vese vanozove nezviratidzo. Kunyangwe avo vanove nezviratidzo vanogona kunge vakanyanya kubatwa nechirwere kupfuura vabereki vavo. Masayendisiti haasati aziva kuti sei izvi zvichiitika. Zvisinei, zvakaonekwa kuti chirwere ichi chinogona kuipa kana masoja emuviri akaneta .

Kuziva kuti une chirwere ichi kunogona kukubatsira kuita sarudzo dzekudzivirira. Semuenzaniso, kuongororwa kwemajini uye kupa mazano kumajini zvinogona kukubatsira kudzivirira kutapurira chirwere ichi kuvana vako. Zvakare, kuziva izvi kunogona kukubatsira kuona kenza nekukurumidza uye kutanga kurapwa, kudzivirira mhedzisiro yakaipa.

Kunyange hazvo chirwere cheMoore-Torre chisingawanzoitiki, hazvisi nyore kubata nechirwere chakadai. Zvinogona kuita sekunge zvakaoma kurwisa chimwe chinhu chiri muDNA yedu. Asi, ruzivo isimba . Nekuziva uye kurapwa nenguva, iwe nachiremba wako munogona kutarisana nedambudziko iri.

Pakupedzisira, meseji yekudzokera nayo kumba

Zvakanaka, ngatipfupisei zvimwe zvezvinhu zvaunofanira kurangarira kubva pane zvatataura nezvazvo:

• Muir-Torre Syndrome chirwere chemajini chinowedzera njodzi yekuve nemabundu eganda uye kenza yemukati (kunyanya mudumbu).
• Kana ukaona bundu idzva risingawanzoitiki paganda rako, kunyanya pahudyu yako, tsvaga rubatsiro rwechiremba nekukasika. Rinogona kunge risiri iro, asi zvakanaka kuti uriongorore.
• Iyi imhando yechirwere cheLynch. Kana paine munhu mumhuri yako ane nhoroondo yekenza, udzawo chiremba wako nezvazvo.
• Kuongororwa kwegomarara nguva isati yakwana uye kuongororwa nguva nenguva kwakakosha zvikuru. Izvi zvinogona kubatsira kuona gomarara nguva isati yakwana uye kurirapa zvinobudirira.
• Kuongororwa kwemajini uye kupiwa mazano zvinogona kubatsira kuona kana chirwere ichi chiripo uye kana chichikanganisa nhengo dzemhuri.
• Usatya, asi chenjera. Hausi wega, uye vanachiremba varipo kuti vakubatsire.

Ndinovimba ruzivo urwu ruchakubatsira. Ramba uine hutano hwakanaka!

Muir -Torre Syndrome, Lynch Syndrome, Kenza yeganda, Zvirwere zvemajini, Kenza yemudumbu, Kuongorora Kenza, Kuchinja kwemajini