Ko mapfupa ako emubofu haasi kushanda zvakanaka here? Ngatitaurei nezve myelosuppression!

Unonzwawo sekuti hausi kunzwa zvakanaka, uri kurwara nguva dzese, kana kuti uri kubuda ropa kubva paganda diki, kungave uri kurapwa kenza kana chimwe chirwere here? Seri kwezvinhu izvi, panogona kunge paine myelosuppression , chirwere chekuti bone morrow haishande zvakanaka . Usazvidya moyo, ngatitaurei nezvazvo zviri nyore.

Chii chinonzi myelosuppression? Kutaura chokwadi, kuderera kwemapfupa emupfupa here?

Zvichitaurwa zviri nyore, hongu! Mupfupa wemapfupa inhengo yakapfava, yakaita sechiponji iri mukati memapfupa ako. Funga nezvayo sefekitori yemuviri wedu inogadzira ropa . Fekitori iyi inogadzira mabhiriyoni emasero matsvuku eropa, masero machena eropa, uye maplatelet, ayo akakosha kuti tirarame, uye anowedzera muropa redu. Rudzi rumwe nerumwe rwesero rune basa rakasiyana remuviri wedu. Mupfupa wemapfupa unowedzera kana kuderedza kugadzirwa uku zvichienderana nezvinodiwa nemuviri wedu.

Iye zvino, mune chirwere chinonzi myelosuppression , basa remufekitori uyu wemapfupa rinokanganiswa nekuda kwechimwe chikonzero. Zvadaro, masero eropa nemaplatelet hazvigone kugadzirwa nemazvo. Chikonzero chikuru cheizvi kurapwa kwekenza nechemotherapy . Zvisinei, mamwe marudzi ekenza yeropa nemamwe mavhairasi anogonawo kukonzera kutadza kushanda kwemapfupa emapfupa.

Ndezvipi zviratidzo zve myelosuppression?

Zviratidzo zvinogona kusiyana kubva pamunhu kuenda kune mumwe, zvichienderana nekuti mupfupa wako unoburitsa masero matsvuku eropa, masero machena eropa, kana maplatelet.

Kana masero matsvuku eropa akadzikira - Anemia

Masero matsvuku eropa anotakura okisijeni mumuviri wako wese. Kana asina kukwana , anemia inotanga kuitika. Zviratidzo zvinogona kusanganisira:

• Kuneta
• Kushaya mweya / kupererwa nemhepo
• Dzungu
• Kurova kwemoyo nekukurumidza kana kusina kurongeka / arrhythmia
• Kunzwa ruzha rwekurira munzeve, dzimwe nguva rwuchiperekedzwa neruzha rwe "kurova" uye kurova kwemoyo (Pulsatile tinnitus)
• Musoro
• Kuchenuruka kweruvara rweganda
• Kurwadziwa kwechipfuva

Neutropenia - kudzikira kwemasero machena eropa (kunyanya ma neutrophils)

Masero machena eropa anorwisa utachiona hunopinda mumiviri yedu uye anotidzivirira kubva kuhutachiona . Rumwe rudzi rwemasero machena eropa runonzi neutrophils . Kana muroro wemapfupa uchigadzira ma neutrophils mashoma nekuda kwe myelosuppression, chirwere ichi chinonzi neutropenia . Neutropenia haina zviratidzo zvakananga, asi nekuda kweizviKutapukirwa kunogona kuitika kakawanda, uye ndipo panotanga kuoneka zviratidzo.

• Fivha (dzimwe nguva inonzi febrile neutropenia )
• Kuneta
• Huro/hutachiona (Huro/pharyngitis)
• Manodhi elymph akazvimba
• Maronda mumuromo kana pedyo ne anus
• Manyoka
• Kupisa paunenge uchiita weti, kunzwa sekunge unoda kuita weti nekukurumidza, kuita weti kakawanda

Kana maplatelet akadzikira - Thrombocytopenia

Maplatelet anobatsira kudzora kubuda ropa . Kana huwandu uhwu hukadzikira, chirwere chinonzi thrombocytopenia chinoitika. Izvi zvinogona kukonzera:

• Kubuda ropa kusingamire kwenguva yakareba, kunyangwe kubva paronda diki, kana kuoma kumisa kubuda ropa mumhino.
• Maronda anoonekwa nekukurumidza kupfuura zvakajairika.
• Kuonekwa kwemavanga madiki matsvuku (senge mapundu) pamakumbo epasi - izvi zvinonzi petechiae .
• Mavara matsvuku, epepuru, kana mashava paganda - izvi zvinonzi purpura .

Kana marudzi ese emasero eropa akadzikira - Pancytopenia

Dzimwe nguva, masero ese matatu eropa—masero matsvuku eropa, masero machena eropa, uye maplatelet—anogona kunge akaderera panguva imwe chete . Dambudziko iri rinonzi pancytopenia . Kufanana neutropenia, ichi hachisi chirwere pachacho, asi chinogona kuva chiratidzo chechirwere chiripo.

Sei paine myelosuppression? Ndezvipi zvinokonzera?

Sezvatakambotaura, chemotherapy ndiyo inonyanya kukonzera chirwere ichi . Zvisinei, kune zvimwe zvikonzero zvakare.

Kurapa nemakemikari, immunotherapy, uye myelosuppression

Mhando dzakasiyana dzemishonga yechemotherapy dzinogona kukonzera izvi. Mimwe yemishonga inonyanya kushandiswa ndeiyi:

• Fluorouracil
• Oxaliplatin
• Irinotecan
• Capecitabine

Pamusoro pezvo, kurapwa neCAR T-cell, rudzi rwe immunotherapy , kunogonawo kukanganisa mashandiro emapfupa uye kuderedza kugadzirwa kwemasero eropa nemaplatelet.

Kenza dzeropa uye kudzvanywa kweropa

Mamwe magomarara eropa anogonawo kukanganisa kugadzirwa kwemasero eropa kwakajairika. Semuenzaniso, mumagomarara akadai seleukemia, lymphoma, uye myeloma , masero egomarara asina kujairika anokura zvakanyanya mumongo wemapfupa uye anomisa kugadzirwa kwemasero eropa ane hutano nemaplatelet.

Mavhairasi uye kudzvinyirirwa kwemasero

Humwe utachiona hunogona kukanganisawo maitiro ekuumbwa kweropa mumongo wemapfupa. Fungidzira kuti kana hutachiona hukapinda mumuviri, dziviriro yemuviri wedu, kureva masero machena eropa, inorwisa hutachiona. Munguva yekurwa uku, mongo wemapfupa unogona kugadzira masero matsvuku eropa nemaplatelet mashoma. Dzimwe ongororo dzinoratidza kuti mamwe mavhairasi anopinda zvakananga mumasero anogadzira ropa mumongo wemapfupa, zvichideredza huwandu hwemasero eropa. Mamwe mavhairasi akawanikwa aine chekuita nechirwere ichi chemyelosuppression ndeaya:

• Utachiona hweEpstein-Barr (EBV)
• Utachiona hweHepatitis C
• Parvovirus B19
• Cytomegalovirus (CMV)
• Utachiona hunokonzera chickenpox (Chickenpox / varicella zoster)
• Utachiona hweHIV (Human immunodeficiency virus)
• Fivha yeDengue

Kudzvinyirirwa kwemapfupa (myelosuppression) kunogona kukonzera matambudziko akakomba here?

Ehe, dzimwe nguva izvi zvinogona kukonzera matambudziko anotyisidzira hupenyu . Semuenzaniso, kudzikira kamwe kamwe kwemasero matsvuku eropa (acute anemia) kana kudzikira kwemaplatelet (kubuda ropa kusingadzoreki) .

Zvakakosha: Kana ukaona chimwe chezviratidzo izvi, kunyanya kana uri kurapwa kenza, zvakakosha kuti utsvage rubatsiro rwechiremba nekukasika.

Vanachiremba vanoongorora sei chirwere ichi nemazvo?

Izvi zvinonyanya kuongororwa kuburikidza nekuongororwa kweropa . Kuongororwa kweropa uku kunoongorora kana mapfupa ako ari kugadzira masero eropa nemaplatelet zvakanaka.

Kuongororwa kweropa kwakadai kunogona kuitwa:

• Kuverengwa kweropa rose (CBC)
• Kuongororwa kweMCV (Avhareji yehuwandu hwemuviri / bvunzo yeMCV)
• Kuongororwa kweRDW (Upamhi hwekugoverwa kwemasero matsvuku / bvunzo yeRDW)
• Kuwanda kwemasero eropa
• Kuongororwa kweropa rekunze
• Kuongororwa kweMPV (Kuongororwa kwehuwandu hweplatelet / MPV)

Ndeipi mishonga yekurapa myelosuppression?

Vanachiremba vanorapa izvi nenzira idzi:

• Kana chikonzero chekumanikidzwa kwemasero eropa (myelosuppression) chiri chechemotherapy, mushonga wechemotherapy unofanira kuderedzwa kana kumira kwenguva pfupi .
• Kuwedzerwa ropa kuti kuwedzere huwandu hwemasero matsvuku eropa nemaplatelet.
• Kukupa mishonga inobatsira mupfupa wako kugadzira masero eropa nemaplatelet akawanda.

Mamiriro ezvinhu aya anogona kudzivirirwa kuti asaitike here?

Kudzikira kweropa (myelosuppression) kunowanzoitika semhedzisiro yekurapwa kwegomarara. Nokudaro, vanachiremba vanogara vachitsvaga migumisiro iyi panguva yekurapwa kwegomarara. Vachaongorora ropa rako nguva nenguva uye vachachinja hurongwa hwako hwekurapwa kana zvichidikanwa.

Chii chandingatarisira kana ndiine myelosuppression?

Vanhu vazhinji vanobatwa nechirwere ichi nekuti vari kugamuchira chemotherapy. Kana zvakadaro, chiremba wako achanyatsoongorora kuti chemotherapy iri kukanganisa sei mapfupa ako. Ungangoda kumbomira kwenguva pfupi kubva pakurapwa kenza kuti mapfupa ako akwanise kuwedzera huwandu hwemasero eropa.

Ndinozvitarisira sei?

Kudzikira kwemasero eropa (myelosuppression) kunogona kuwedzera njodzi yekutapukirwa nehutachiona uye kubuda ropa . Unogona kuita zvinhu izvi kuderedza njodzi iyi:

• Wana majekiseni ekudzivirira kubva kumavhairasi akajairika.
• Kudzidzira tsika dzakanaka dzehutsanana , dzakadai sekugeza maoko ako nguva nenguva uye kugara kure nevanhu vanorwara.
• Zvidzivirire kubva mumamiriro ezvinhu aunogona kukuvara kana kuchekwa . Semuenzaniso, chenjerera paunenge uchishandisa zvombo zvakapinza.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Unogona kubvunza chiremba mibvunzo yakaita seiyi:

• Sei ndine chirwere ichi chekumanikidzwa kwemapfupa (myelosuppression)?
• Dambudziko iri rinokanganisa sei muviri wangu?
• Ndedzipi nzira dzekurapa dzandinadzo?
• Kurapwa kuchapedza zvachose kudzvinyirirwa kwangu kwemasero here?

Pfupiso: Zvekurangarira (Mharidzo Yekuenda Nayo Kumba)

Mupfupa wako chikamu chakakosha chemuviri wako. Masero matsvuku eropa anotakura okisijeni, masero machena eropa anorwisa hutachiona, maplatelet anobatsira kuumbwa kweropa rako - zvese zvinogadzirwa ipapo. Kudzvanywa kwemapfupa (myelosuppression) ndiko kana mupfupa wako wamira kushanda nekuda kwechimwe chikonzero. Chikonzero chinowanzo shandiswa chemotherapy yekenza, asi inogonawo kukonzerwa nemamwe magomarara eropa nemavhairasi. Usazvidya moyo. Vanachiremba vachawana chikonzero chacho vochirapa zvakakodzera. Chinhu chinonyanya kukosha kutsvaga rubatsiro rwechiremba kana uine zviratidzo zvisingawanzoitiki uye tevera mazano avo nokungwarira. Hausi wega, uye kune vanachiremba vanogona kukubatsira parwendo urwu.

Kudzikiswa kweMyelosuppression , Kudzikiswa kweBone Morrow, Bone Morrow, Masero Matsvuku Eropa, Masero Machena Eropa, Maplatelet, Chemotherapy, Kenza, Anemia, Neutropenia, Thrombocytopenia, Utachiona