Tinoziva kuti zvakaoma sei kurarama negomarara. Asi nekufambira mberi kwesainzi yezvekurapa, nzira dzekurapa gomarara dzave nani zvikuru nhasi. Pane kungoshandisa chemotherapy kana radiation therapy sekare, ikozvino kune mishonga chaiyo inongorwisa masero egomarara chete. Mishonga inodzivirira gomarara yePARP rudzi rwemushonga wakaunza tariro itsva munyika yekurapa gomarara. Nhasi, tichataura nezvazvo zviri nyore, nenzira yaunogona kunzwisisa.
Zvichitaurwa zviri nyore, chii chinonzi PARP Inhibitors idzi?
Kuti tinzwisise izvi, ngatitangei tafunga nezvemasero ari mumuviri wedu. Sero rega rega mumuviri wedu rine chimwe chinhu chinonzi DNA. DNA iyi yakaita se 'master plan' ine mirairo yese iyo sero rinoda kuti rishande. Dzimwe nguva DNA iyi inogona kukuvara. Kana ikakuvara, muviri wedu une nzira yakakosha yekuigadzirisa.
Imwe yenhengo huru mukugadzirisa uku ipuroteni inonzi PARP. PARP inomiririra Poly (ADP-ribose) polymerase. Kunyange zvazvo zita racho richinzwika serakaoma, basa raro rakareruka: Kana paine kutyoka kana kutyoka muDNA, puroteni yePARP inopinda yoigadzirisa. Izvi zvakakosha kumasero ane hutano.
Asi heino dambudziko. Masero egomarara anoshandisawo puroteni iyi yePARP kuti zvivabatsire. Kana masero egomarara akapatsanuka nekukurumidza, DNA yavo inokuvara. Zvadaro sero regomarara rinoshandisa 'bass' iyi yePARP kugadzirisa DNA yaro, kukura zvakanyanya, uye kutanga kupararira mumuviri wese.
Mishonga inodzivirira PARP inoshanda nekumisa PARP 'bass' kuti isashande. Kutaura chokwadi, inodzivirira puroteni yePARP kuti isagadzirise DNA. Izvi zvinodzivirira sero rekenza kuti risagadzirise DNA yaro, uye pakupedzisira sero rinofa.
Iyi inonziwo mishonga yakanangana nayo , nekuti mishonga iyi inotarisa uye inorwisa kusasimba kwemasero ekenza pane masero ane hutano hwakanaka.
Mishonga iyi inoshandiswa kumhando dzipi dzekenza?
Mishonga inhibitor yePARP inowanzo shandiswa kune kenza dzakanyanya kukura kana kuti dzakapararira. Zvisinei, haipiwi kune kenza dzese. Inonyanya kushanda kune kenza dzine chekuita nekuchinja kwemajini.
Hukama huripo pakati pegene reBRCA nePARP inhibitors
Kune majini anodzivirira mumuviri wedu anodzivirira kuumbwa kwegomarara. Rimwe remajini makuru ijini reBRCA . Rimwe remabasa ejini iri reBRCA nderekugadzirisa kukuvara kweDNA. Izvi zvinoreva kuti kune masisitimu maviri makuru ekugadzirisa DNA mumasero edu: rimwe iPARP, uye rimwe iBRCA.
Fungidzira, munhu anozvarwa aine shanduko mujini reBRCA.Izvi zvinoreva kuti imwe yenzira dzake dzekugadzirisa DNA yatove isina simba. Saka sero rake rekenza rinenge richitovimba nePARP system iyoyo kugadzirisa DNA.
Saka chii chinoitika kana tikapa munhu akadaro mushonga wePARP inhibitor? Pamusoro pehurongwa hweBRCA hwatove hwakatyoka, tinomisawo hurongwa hwePARP hwaishanda zvakanaka. Ipapo sero rekenza harina nzira yekugadzirisa DNA yaro. Nekuda kwe 'kurohwa kaviri' uku, sero rekenza rinoparadzwa zviri nyore.
Saka, maPARP inhibitors mushonga unoshanda zvikuru wegomarara rine BRCA gene mutations.
| Mhando huru dzegomarara dzinorapwa nePARP inhibitors |
|---|
| Kenza yemazamu |
| Kenza yemudumbu |
| Kenza yemuchubhu yefallopian |
| Kenza yeprostate |
| Kenza yepancreatic |
| Kenza yepakutanga ye peritoneal |
Kurapwa uku kunopiwa sei uye kwenguva yakareba sei?
Chimwe chinhu chakanaka chekurapa uku ndechekuti hakufanirwe kupihwa sejekiseni. Mishonga yese iyi inodzivirira PARP inouya muchimiro chemapiritsi kana makapisiri. Inowanzo nyorerwa kuti itorwe kamwe chete kana kaviri pazuva.
Dzimwe nguva, zvichienderana nerudzi rwekenza yaunayo, mushonga uyu unogona kupihwa semushonga wega. Kana kuti, unogona kupihwa pamwe chete nedzimwe nzira dzekurapa, dzakadai sechemotherapy. Semuenzaniso, mushure mekunge munhu apihwa chemotherapy nemasero ekenza akakuvara, mushonga uyu wePARP inhibitor unotanga kutangwa. Zvadaro, unobvisa zvachose mukana wekuti masero ekenza akakuvara azvigadzirise ega.
Nguva yekurapwa inosiyana kubva pamunhu nemunhu. Kune vamwe, mushonga uyu unopiwa kwenguva yakatarwa, senge makore maviri kusvika matatu mushure mekunge chemotherapy yapera. Kune vamwe, unoenderera mberi chero bedzi mushonga uchishanda, zvichireva kuti kenza yave pasi pesimba. Sarudzo yakanakisisa nezveizvi ndeyekutaura nachiremba wako uye kuyedza mabhenefiti ekurapwa uchienzanisa nemigumisiro inogona kuitika.
Mabhenefiti uye migumisiro inogona kuitika yekurapa uku
Mishonga inodzivirira kenza (PARP inhibitors) inogona kusarapa kenza zvachose. Zvisinei, kubatsira kwayo kukuru ndekwekuti inowedzera "kurarama pasina kufambira mberi kwechirwere." Muchidimbu, mishonga iyi inobatsira kudzora kenza uye kuidzora kwenguva yakareba. Izvi zvinoreva kuti murwere ane nguva yakawanda yekurarama hupenyu hune hutano hwakanaka pasina chirwere ichi chichiwedzera kuipa .
Kufanana nekurapa kwegomarara, izvi zvinogona kukonzera migumisiro yakaipa, asi havasi vese vanoiwana.
| Migumisiro yakajairika yePARP inhibitors | |
|---|---|
| Kusagadzikana kwemuviri |
|
| Kuchinja mukuongororwa kweropa | |
| Njodzi dzisingawanzoitiki asi dzakakomba | |
Unofanira kufonera chiremba rini nekukasika?
Zvakakosha kuti ugare pedyo nachiremba wako panguva yese yekurapwa uku. Kana ukaona zviratidzo zvitsva kana kuti zvimwe zvezviratidzo zvako zvikawedzera, zivisa chiremba wako nekukasika. Anogona kukwanisa kugadzirisa dose yako kana kunyora mimwe mishonga yekubatsira pamigumisiro yakadai sekuda kurutsa.
Kana ukaona zviratidzo zvinotevera, fonera chiremba wako nekukurumidza :
- Zviratidzo zvehutachiona: fivha, kutonhora, uye kudedera.
- Zviratidzo zvehutachiona hwemapapu (Pneumonitis): Kutadza kufema, kunzwa kubatwa muchipfuva, kana kufemera.
- Zviratidzo zvekugwamba kweropa: kuzvimba kamwe kamwe, kutsvuka, uye kurwadziwa kwegumbo, kana kurwadziwa kamwe kamwe muchipfuva uye kuoma kufema.
Kana ukaona chimwe chezviratidzo izvi zvakakomba, unofanira kufonera chiremba wako nekukasika kana kuenda kuEmergency Department (ETU) yechipatara chiri pedyo.
Mharidzo Yekuenda Nayo Kumba
- Mishonga inodzivirira PARP imhando ye 'nzira yakanangana' inomisa masero ekenza kugadzirisa DNA yawo uye inoaparadza.
- Izvi zvinonyanya kushanda pazvirwere zvakaita sekenza yemazamu, ovarian, uye prostate ine BRCA gene mutations.
- Kurapa uku kunopihwa semapiritsi kana makapisi uye kunobatsira kudzora kukura kwegomarara uye kuwedzera nguva yaunogona kuramba uine hutano hwakanaka.
- Sezvinongoitawo mamwe marapirwo, migumisiro inogona kuitika, saka zvakakosha kushanda pamwe chete nachiremba wako munguva yese yekurapwa.
- Chiremba wako achaona kana kurapwa kwePARP inhibitor kwakakunakira, achifunga nezvemamiriro ako ehutano, zvabuda muongororo yemajini, uye hutano hwako hwese.
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