Pane dambudziko here nemaburi emuchiropa chako? Ngatidzidzei chaizvo nezvePrimary Biliary Cholangitis (PBC)!

Maiwe, unonzwawo sekunge waneta zvakanyanya, waneta kunyangwe usina kuita chero chinhu here? Kana kuti dzimwe nguva unonzwa sekunge uri kukwenya ganda rako pasina chikonzero here? Dzimwe nguva, kunyangwe tisinganyatso teerera izvi, zvinogona kuva chiratidzo chedambudziko rechiropa, chimwe chezvikamu zvakakosha mumuviri wedu. Nhasi tichataura nezvechirwere chakadai chinokanganisa chiropa, uye kunyangwe zita racho ringaita serakaoma zvishoma, zviri nyore kunzwisisa. Izvi zvinoreva (Primary Biliary Cholangitis) , inozivikanwawo se (PBC) muchidimbu.

Chii chinonzi Primary Biliary Cholangitis (PBC)? Ngatizvinzwisise zviri nyore!

Zvakanaka, zita iri rinoita serakareba zvishoma, handiti? Ngationei kuti rinorevei.

"Cholangitis" kuzvimba kwemutsinga dzemudumbu . Unoziva, mvura inonzi bile, inogadzirwa muchiropa chedu, inofamba nemumachubhu madiki. Machubhu iwayo anonzi bile ducts. "Biliary" zvinorevawo chimwe chinhu chine chekuita neaya machubhu emudumbu. "Primary" zvinoreva "basic" kana "start".

Zvadaro, paunobatanidza zvese izvi, Primary Biliary Cholangitis zvinoreva kuti, kwete nekuda kwechimwe chirwere, hutachiona, kana kuvharika, asi nekuda kwechirwere ichi, pane kuzvimba kwemutsinga dzenyongo mukati mechiropa chako . Sezvo kuzvimba uku kusingaitike nekuda kwechinhu chero chipi zvacho, hauzive kuti kuchamira riini. Saka chirwere chinoenderera mberi zvishoma nezvishoma.

Chirwere ichi chaimbonzi Primary Biliary Cirrhosis nekuti chinogona kukonzera kuti chiropa chiome uye chive nemavanga, zvichikonzera chirwere chinonzi cirrhosis .

(PBC) inokanganisa sei muviri wedu?

Fungidzira, chii chinoitika kana chikamu chemuviri wedu chikaramba chichizvimba? Kazhinji, kuzvimba kwechinguvana chikamu chekupora. Asi kana rudzi urwu rwekuzvimba rukaramba ruchienderera mberi, panzvimbo pekupora, nzvimbo yacho inotanga kuva nemavanga.

Ndizvo zvinoitika kumaburi enyongori ari muchiropa chako muPBC. Maburi aya anova matete uye anovharwa nemavanga . Ipapo nyongori inogadzirwa nechiropa haigone kuyerera zvakanaka. Nyongori iyi inotanga kudzokera mukati mechiropa. Kana nyongori iyi yaungana, inokuvadza masero echiropa uye inokonzera kuzvimba muchiropa. Nekufamba kwenguva, chiropa ichi chine hutano chinotsiviwa nemavanga. Pakupedzisira, chiropa chinotadza kushanda zvakanaka, izvo zvatataura kare (cirrhosis) .

PBC chirwere chakakomba here?

Ehe, chirwere chePrimary Biliary Cholangitis chirwere chisingaperi uye chinoenderera mberi . Izvi zvinoreva kuti hachingori nani chete, chinogona kuipa nekufamba kwenguva. Hachiwedzere kuipa kamwe chete, chinokura zvishoma nezvishoma, kuburikidza nematanho akasiyana. Ungasava nezviratidzo pakutanga.

Zvisinei, chinhu chine njodzi zvikuru panyaya iyi ndechekuti zvinogona kupedzisira zvaita kuti chiropa chisashande zvakanaka uye kunyange kufa kana chiropa chikasaiswa.

Asi, nerombo rakanaka, kune mishonga inogona kunonotsa kufambira mberi kwechirwere ichi . Uye havasi vese vanosvika padanho rekupedzisira iri. Saka musazvidya mwoyo.

Ndeupi musiyano uripo pakati pe (PBC) ne (PSC)?

Ungave wakambonzwa nezvechimwe chirwere chinonzi Primary Sclerosing Cholangitis, kana kuti PSC. Zviviri izvi zvakafanana zvikuru, asi pane misiyano mishoma mikuru.

• MuPBC , maburi enyongo ari muchiropa (intrahepatic bile ducts) ndiwo chete anokanganiswa.
• Zvisinei, muPSC, ducts dze bile dziri mukati mechiropa pamwe nekunze kwechiropa (extrahepatic ducts) dzinokanganiswa .
• Kunewo musiyano pakati pevanhu vanonyanya kurwara nezvirwere izvi zviviri.
• Chinhu chakakosha ndechekuti, kunyangwe paine mishonga yekurapa (PBC), hapana mushonga unobudirira wakawanikwa we (PSC) .

Ndiani ane mukana mukuru wekuwana chirwere ichi (PBC)?

Kunyangwe izvi zvingaita sezvinoshamisa, vakadzi vane mukana wekuwana PBC kakapetwa kagumi kupfuura varume (10:1) . Zvichienderana nehuwandu hweUnited States, vakadzi vanosvika makumi matanhatu pa100,000 vane chirwere ichi, zvichienzaniswa nevarume vanosvika gumi nevashanu pa100,000.

Vanhu vazhinji vanoonekwa vaine chirwere ichi mushure memakore makumi mana. Chirwere ichi chinowanzoonekwa muScotland, nyika dzeScandinavia, uye kuchamhembe kwakadziva kumabvazuva kweEngland.

Uyewo, kana iwe kana mumwe munhu mumhuri yako aine chimwe chirwere che autoimmune, une mukana wekuti PBC iite . Izvi zvinoratidza kuti panogona kunge paine hukama hwemajini .

Ndezvipi zviratidzo zvechirwere (PBC)?

Vanhu vazhinji vane PBC havana zviratidzo pakutanga. Zviratidzo zvine chekuita ne nyongo zvinotanga kuoneka chete kana chirwere ichi chaenderera mberi. Zviratidzo zvekutanga uye zvinonyanya kuonekwa muvanhu vane PBC ndeizvi:

• Kuneta kwakanyanya (vanhu vanosvika 65%)
• Ganda rinokwenya (vanhu vanosvika 55%)

Zviratidzo izvi zvinobata munhu wese zvakasiyana. Vamwe vanhu vanogona kuzviwana pakutanga kwechirwere, vamwe vanogona kuzviwana gare gare. Zvinogonawo kunge zvakanyanya kana zvishoma pane chero danho rechirwere. Hapana hukama hwakakura pakati pekukomba kwezviratidzo zvako uye kukura kwechirwere. Zvisinei, kumwe kutsvagurudza kunoratidza kuti vanhu vane zviratidzo zvakakomba pakutanga vanogona kukurumidza kukura kwechirwere .

Ndezvipi zvinetso zvezvirwere zvemudumbu?

Pakutanga, ungasaona kuti une dambudziko nemaburi emudumbu mako. Asi chirwere ichi chichiwedzera, matambudziko akasiyana-siyana anotanga kuitika. Dumbu risingakwanise kuyerera zvakanaka, rakoZvinotanga kubuda ropa muropa, izvo zvinokonzera zvirwere. Uyewo, kana bile rikasakwanisa kusvika mudumbu zvakanaka, kugaya chikafu kunokanganiswawo. Nekuti bile rinokosha pakugaya chikafu.

Gare gare, mavanga echiropa anogona kukanganisawo tsinga dzeropa dzinopfuura nemuchiropa, zvichikonzera chirwere chinonzi portal hypertension , zvinoreva kukwira kweropa mutsinga idzodzo.

1. Kusanyorova mafuta

Kana kugaya chikafu chako kusina nyongo yakakwana, hachikwanise kupwanyika zvakanaka nekupinza mafuta ari muchikafu chako. Kudzikira kwemafuta aya kunogona kukonzera zvinotevera:

• Kolesteroli yakawanda muropa .
• Mafuta anoungana pasi peganda .
• Tsvina ine mafuta kana manyoka .
• Kuderedza huremu .
• Kuderera kwehuwandu hwevhitamini inonyunguduka mumafuta A, D, E, uye K.
• Osteoporosis chirwere chekutetepa kwemapfupa chinokonzerwa nekusapinza vhitamini D inonyungudika mumafuta.

2. Kukwira kweropa kwakanyanya padivi remuviri (portal BP)

Kana tsinga dzeropa dzinopfuura nemuchiropa dzikavharika nekuda kwemavanga, hypertension ye portal yataurwa pamusoro apa inoitika, zvinoreva kuti BP iri mutsinga idzodzo nedzimwe tsinga dzakabatana nadzo inowedzera. Hypertension iyi ye portal inogona kukonzera zvinotevera:

• Chiropa chakakura .
• Chidende chakakura .
• Dzihwa nezvirwere zvakasiyana-siyana (kudzikira kwesimba remuviri).
• Kutsvuka uye kubuda ropa zviri nyore (maplatelet eropa mashoma - (thrombocytopenia) ).
• Kuonekwa kwetsinga dzeropa dzvuku, dzakaita sedandemutande (spider angiomas) pamusoro peganda.
• Tsinga dzakazvimba kana kuti dzakapfumbira mudumbu nemudumbu (tsinga dzakazvimba - varices) .
• Kubuda ropa mudumbu .
• Kuungana kwemvura mudumbu (ascites) .
• Kuzvimba (edema) kwemuviri wepazasi.
• Dzimwe nguva kuvhiringidzika kwepfungwa kunoitika nekuda kwekuunganidzwa kwechepfu muropa.

Ndezvipi zvinokonzera (PBC)?

MuPBC, masoja emuviri wako anorwisa masero ari mumigero ye bile yechiropa chako . Zvinoita sekuti masoja emuviri anoona masero aya seanopinda muropa. Ichi ndicho chatinodaidza kuti chirwere che autoimmune., kana zvirwere zve autoimmune. Pasina chikonzero chakajeka, masoja emuviri anoparadza masero ane hutano, uye hapana simba rekuzvimisa. Kuzvimba uku kuri kuramba kuripo ndiko kunokonzera mavanga.

Hatinyatsozivi kuti sei zvirwere izvi zve autoimmune zvichikura. Zvisinei, zvinoita sekunge pane chikonzero chemajini . Vanhu vazhinji vanorwara nezvirwere zve autoimmune vane nhoroondo yemhuri yechirwere ichi, uye vanogona kukura nezvirwere zvinopfuura chimwe chete zve autoimmune.

Zvinoita sekuti pane chimwe chinhu chiri munharaunda chinogona kukonzera chirwere ichi. Chinogona kunge chiri kemikari yauri kusangana nayo, kana kuti chingave hutachiona.

PBC inoonekwa sei?

Chiremba wako achatanga nekukubvunza nezvenhoroondo yako yezvekurapa nezviratidzo, obva akuongorora muviri wako, obva atora ropa kuti aone kana uine PBC.

Kuongororwa kweropa uku kunonyanya kutsvaga ma antibodies chaiwo ane chekuita nePBC, kunyanya antibody inonzi antimitochondrial antibody (AMA) . Kunotsvagawo ma enzymes echiropa akakwira, kunyanya alkaline phosphatase (ALP), ayo anoratidza kukuvara kwechiropa.

Kana mhinduro dzebvunzo dzako dziine PBC, chiremba wako achada kutarisa mifananidzo yechiropa chako nehurongwa hwenyongo . Izvi zvinogona kubatsira kubvisa zvimwe zvinokonzera zviratidzo zvako uye kuona kuti chirwere chacho chakura zvakadii. Kazhinji, chimwe chinhu chiri nyore senge ultrasound yemudumbu chinotanga chaitwa. Asi dzimwe nguva, bvunzo yakaita seMRI (magnetic resonance imaging) inogona kudiwa kuti uwane mifananidzo yakajeka.

Vanhu vanosvika 5% vane PBC vanogona kunge vaine bvunzo yeAMA isina kunaka, asi vanogona kunge vaine zvimwe zviratidzo. Kana izvi zvikaitika, chiremba wako angangoda kutora chidimbu chidiki chenyama kubva muchiropa chako (biopsy yechiropa) kuti asimbise kuti une PBC. Izvi zvinowanzoitwa padivi pemubhedha, netsono ichipinzwa muchiropa chako. Sampuro diki yenyama inotorwa kubva mutsono inotumirwa kurabhoritari kuti iongororwe pasi pemaikorosikopu.

Ndeipi mishonga yekurapa chirwere chePrimary Biliary Cholangitis?

Vanachiremba vanoshandisa zvinotevera kurapa PBC:

Mishonga

PBC haigone kurapwa zvachose . Zvisinei, mishonga inogona kudzora kufambira mberi kwechirwere uye kugadzirisa mamiriro ako ezvinhu .

(Ursodeoxycholic acid - UDCA)Imhando ye bile acid. Inobatsira kubvisa bile kubva muchiropa uye kuderedza kukuvara kwechiropa. Mushonga uyu unoshanda zvakanaka kune inenge hafu yevanhu vane PBC, kunyanya pakutanga kwechirwere. Kune vanhu vasingapindure kuUDCA, vanachiremba dzimwe nguva vanokurudzira imwe mhando yebile acid inonzi obeticholic acid .

Uyewo, zviratidzo zvako zvega zvega zvinogona kurapwa nemishonga yakasiyana.

• Kune ganda rinokwenya: mishonga inorwisa mabhakitiriya (semuenzaniso, diphenhydramine - yakafanana neBenadryl®), kurapwa nechiedza che ultraviolet, kana mishonga inobvisa bile acid yakaita secholestyramine inogona kupihwa.
• Dzivirira migumisiro yakaipa yakadai sekushaya mavhitamini uye osteoporosis: Mishonga yekuwedzera mavitamini inogona kubatsira.
• Vamwe vanhu vane kuneta vanogona kubatsirwa nemishonga inosimudzira muviri yakaita semodafinil.

Kuvhiya

Kana mamiriro ako ezvinhu asingavandudzike nekushandisa mishonga, uye mashandiro echiropa chako achiramba achidzikira, chiremba wako anogona kukuisa pane runyorwa rwevanhu vakamirira kuisirwa chiropa . Vanhu vane PBC vane mhedzisiro yakanaka kwazvo nekuvhiyiwa kwechiropa.

Kufanana nezvimwe zvirwere zve autoimmune, PBC inogona kudzoka mushure mekuisirwa chiropa, asi mwero wekukura kwechirwere unononoka zvikuru kechipiri. Nguva yekurarama mushure mekuisirwa chiropa yakajairika.

Chii chaunofanira kutarisira paunenge uchirarama nechirwere ichi?

Kazhinji, chirwere chePrimary Biliary Cholangitis chinokura zvishoma nezvishoma . Kuonekwa nekukurumidza uye kurapwa nekukurumidza kunogona kudzivirira kana kunonotsa matanho ekupedzisira echirwere nematambudziko acho.

Vanhu vazhinji vanogona kudzora zviratidzo zvavo zvakanaka nemishonga. Zvisinei, kurapa kuneta kunoitika nePBC kunogona kuramba kuri dambudziko. Vanhu vazhinji vanorarama kwemakore vasina kukanganisa hupenyu hwavo hwezuva nezuva nekuda kwePBC.

Zvisinei, havasi vese vanoonekwa vaine chirwere chePBC vachiri kutanga. Uye vamwe vanhu vanotanga chirwere ichi zvine simba. Zviratidzo zvakaita sekuneta kwakanyanya uye huwandu hwakawanda hwebilirubin muropa zvinogona kuratidza kuti chirwere ichi chinogona kukurumidza kufambira mberi kusvika pakukundikana kwechiropa. Kana ukasvika padanho iroro, uchada kuisirwa chiropa kuti urarame. Asi kune avo vane PBC vakaisirwa chiropa zvakanaka, fungidziro yacho yakanaka kwazvo.

Unogona kugara kwenguva yakareba sei nechirwere ichi (PBC)?

Kazhinji zvinotora makore ari pakati pe15 ne20 kuti chirwere ichi chisvike padanho rekupedzisira.

Danho rekutanga, zvinoreva kuti kunyangwe wakaongororwa ukawanikwa uine PBC, unogona kunge uchiri nezviratidzo kwenguva yakareba. Vanhu vanosvika hafu vachatanga kuratidza zviratidzo mukati memakore mashanu kusvika gumi anotevera.Kana wangotanga zviratidzo, avhareji yehupenyu hunotarisirwa imakore angangoita gumi. 65% yevanhu vakabatsirwa nekuisirwa chiropa zvakanaka vanorarama makore gumi.

Ndingazvitarisira sei kana ndine chirwere chepfungwa (PBC)?

Kudya zvine hutano uye mararamiro akanaka kuchakubatsira kuchengetedza chiropa chako chine hutano kwenguva yakareba sezvinobvira.

Semuyenzaniso:

• Rega kusvuta, kunwa doro, uye kushandisa zvinodhaka nemishonga zvisina kunaka kana kuti nekuda kwekunakidzwa.
• Idya zvishoma zvekudya zvakagadzirwa uye zvakaputirwa uye udye zvakawanda zvekudya zvakakwana.
• Deredza mafuta akazara uye idya mafuta asina mafuta ane hutano akawanda.
• Famba-famba nekukurumidza zuva nezuva. Kurovedza muviri kunorema kunogona kubatsira kuchengetedza hutano hwemapfupa.

Vanhu vazhinji vane chirwere chePrimary Biliary Cholangitis vanogona kurarama kwemakore vasina matambudziko makuru. Zvisinei, kuva nechirwere chinopfuurira, dzimwe nguva chinouraya kunogona kukukanganisa. Taura nachiremba wako nezvenzira dzekuderedza kushushikana kwako mumuviri, mupfungwa, uye mupfungwa . Uyewo, bvunza nezvemasangano ekutsigira anobatsira vanhu vanorarama nePBC. Yeuka, hutano hwako hwese hwakakura kupfuura chirwere chete.

Mharidzo Yekuenda Nayo Kumba

Chirwere chePrimary Biliary Cholangitis (PBC) chirwere chisingaperi chinokanganisa ducts yenyongo muchiropa. Chinofungidzirwa kuti chinokonzerwa nechirwere che autoimmune . Kunyangwe zviratidzo zvingasaonekwa pakutanga, zviratidzo zvakaita sekuneta uye kuvaviwa kweganda zvinogona kukura nekufamba kwenguva. Sezvo chirwere ichi chichienderera mberi , chinogona kukonzera cirrhosis uye kutadza kushanda kwechiropa.

Zvisinei, kana chirwere ichi chikaonekwa nekukurumidza uye chikashandiswa mishonga yakaita se (UDCA), chinogona kudzorwa . Vamwe vanhu vangatoda kuisirwa chiropa.

Chinhu chinonyanya kukosha kutsvaga mazano echiremba uye kurarama hupenyu hune hutano kana uine zviratidzo izvi. Hausi wega, usatya kutaura nezvazvo uye kuwana rubatsiro.

` Primary Biliary Cholangitis, PBC, chirwere chechiropa, ducts ye bile, cirrhosis, autoimmune