Fungidzira, dai waiziva pachine nguva kuti zvechokwadi waizobatwa nechirwere cheAlzheimer mune ramangwana, waizoitei? Kutaura zvazviri, tingaitei mushure mekuziva chinhu chakadaro? Iri idambudziko guru rinosangana navanachiremba nevaongorori vazhinji nhasi. Munguva pfupi yapfuura, boka revaongorori rakaona kuti vanhu vanosvika 20% vanobatwa nechirwere cheAlzheimer vanogona kuonekwa nekukurumidza nekutarisa majini avo. Ndosaka zvichikosha kutaura nezvazvo.
Chii chinonzi APOE4 iyi? Sei ichibatanidzwa nechirwere cheAlzheimer?
Zvichitaurwa zviri nyore, iyi 'APOE' ijini riri mumuviri wedu. Basa rayo guru nderekubatsira kutakura mafuta akadai secholesterol muropa redu. Kune mhando dzakasiyana dzejini iyi ye'APOE'. Tinowana jini iri, rimwe kubva kuna amai vedu uye rimwe kubva kuna baba vedu.
Vanhu vazhinji vane shanduko inonzi `APOE3`, asi vamwe vanhu vanogona kunge vaine shanduko inonzi `APOE4`.
- Paavhareji, vanhu vanosvika 20% vane kopi imwe chete yejini re'APOE4'.
- Zvisinei, vanhu vanosvika 2% vanogara nhaka makopi maviri ejini re'APOE4' (kubva kuna amai nababa). Mukurapa, tinovadaidza kuti '(APOE4 homozygotes)'.
Zvagara zvichizivikanwa kuti vanhu vane makopi ese ari maviri eAPOE4 gene vane njodzi huru yekubatwa nechirwere cheAlzheimer's .
Tsvagiridzo yazvino inoti chii?
Ongororo ichangobva kuburitswa mumagazini yezvekurapa ine mukurumbira inonzi Nature Medicine yakaongorora izvi zvakadzama. Vakaongorora ruzivo rwehutano rwepfungwa 3,300 dzakapihwa uye vanhu 10,000.
Ikoko vakawana chimwe chinhu chinoshamisa: 95% yevanhu vane makopi ese ari maviri ejini reAPOE4 vaive neshanduko (biomarkers) dzine chekuita nechirwere cheAlzheimer muuropi hwavo kana mumvura yemuviri.
Kuchinja uku kwaiwanzotanga pazera remakore makumi mashanu nemashanu. Zviratidzo zvakatanga pazera remakore makumi matanhatu nemashanu. Pakupedzisira, dementia , kudzikira kukuru kwekuyeuka nekugona kufunga, yakaonekwa pazera remakore makumi manomwe nemana.
Zvichitaurwa zviri nyore, vaongorori vanoti kuva nemakopi maviri eAPOE4 kunonyanya kutsanangura pane kuti 'kunowedzera njodzi.' Kana izvi zviri zvechokwadi, chirwere cheAlzheimer chinogona kuva chirwere chinogara nhaka chakajairika pasi rose.
Chinhu chakanakisa pane izvi ndechekuti mune ramangwana, panogona kuva nemukana wekuziva nekurapa vanhu vane chirwere chepfungwa zviratidzo zvisati zvaonekwa.
Saka, munhu wese anofanira kunyora bvunzo iyi here?
Heino mubvunzo unonyanya kukosha. Mhinduro ndeiyi, kwete! Zvichienderana nemamiriro ezvinhu aripo parizvino, masangano ezvekurapa haakurudzire bvunzo iyi kune wese munhu, zvisinei nezviratidzo. Pane zvikonzero zvakati wandei zveizvozvo.
Nzwisisa zvipingamupinyi zvetsvagurudzo iyi
- Rudzi: Tsvagiridzo iyi yakaitwa zvakanyanya pavanhu vachena vane dzinza rekuEurope. Saka hazvisati zvanyatsojeka kuti mhedzisiro iyi inoshanda kusvika papi kuvanhu vari munyika yedu, kureva, vekuAsia.
- Rudzi rwemuenzaniso: Data rakaunganidzwa kubva kuvanhu vakapinda muongororo yeAlzheimer, saka vanogona kunge vaine mafungiro akasiyana zvishoma neavanhuwo zvavo nezvechirwere ichi.
Haasi munhu wese anowana zviratidzo.
Ichi ndicho chinhu chinonyanya kunyaradza . Tsvagiridzo yacho pachayo inoti havasi vese vane makopi ese ari maviri e'APOE4' vane zviratidzo . Vamwe vanhu vakararama kusvika pamakore ekuma80 vasina zviratidzo zvechirwere chepfungwa. Zvakare, zera rinotanga zviratidzo rinogona kusiyana zvakanyanya kubva pamunhu nemunhu.
| Zvakanakira kuita bvunzo | Zvakashata & Njodzi dzeKutora Bvunzo |
|---|---|
| Unogona kuziva nezvenjodzi yacho pachine nguva. | Panogona kunge paine kushushikana kwakanyanya uye kuzvidya mwoyo. |
| Pane muedzo mukuru wekuchinja mararamiro (kudya, kunwa, kurovedza muviri). | Mhedzisiro yacho haina chokwadi zvachose. Hazvigoneki kutaura chokwadi kana chirwere ichi chichatanga kana kuti chichatanga pazera ripi. |
| Ungave wakakodzera kurapwa kutsva kana kutsvagurudzwa mune ramangwana. | Parizvino hapana mushonga usingaperi unogona kudzivirira chirwere ichi. |
| Mhuri dzinogonawo kunzwisisa njodzi dzavanosangana nadzo. | Zvinhu zvakaita seinishuwarenzi nebasa zvinogona kukanganiswa mune ramangwana (nyaya dzetsika). |
Kana uri kufunga nezvebvunzo iyi, unofanira kuitei?
Fungidzira kuti mumwe munhu mumhuri mako ane chirwere cheAlzheimer's uye uri kunetseka nacho. Kana uri kufunga nezvebvunzo iyi ye'APOE4', hezvino zvimwe zvinhu zvekurangarira.
1. Usangonyora bvunzo chete: Usangonyora bvunzo dzerudzi urwu nekuda kwekuda kuziva chete. Chenjerera zvakanyanya nebvunzo dzakatengwa online.
2. Taura nachiremba wako: Kutanga, taura nachiremba wemhuri yako kana chiremba wetsinga nezvenyaya iyi. Buda pachena nezvenhoroondo yemhuri yako uye zvaunotya.
3. Kupiwa Mazano Ezvemajini kwakakosha : Kana uchizoongororwa seizvi, hazvifanirwe kungova nyaya yekuwana mushumo chete. Zvakakosha kutaura nenyanzvi yezvemajini kana chiremba ane ruzivo nezveizvi usati waita uye wapedza. Unofanira kutsanangura zvinorehwa nemhedzisiro yacho, kuti ichakanganisa sei hupenyu hwako, uye kuti ungagadzirisa sei kukanganisa kwepfungwa kwaichaita.
4. Funga nezvezvinhu zvaunogona kudzora: Hatigoni kuchinja majini edu. Asi pane zvinhu zvakawanda zvatinogona kudzora. Chinhu chakanakisa chatingaita ndechekurarama hupenyu hwakanaka pahutano hwehuropi .
- Idya chikafu chakakwana.
- Rovedza muviri nguva dzose .
- Rara zvakanaka husiku.
- Dzora BP, chirwere cheshuga, uye huwandu hwecholesterol.
- Ita zvinhu zvinoedza pfungwa (kuverenga mabhuku, kugadzirisa mapuzzle, kudzidza chimwe chinhu chitsva).
- Iva neushamwari nevamwe.
Mumwe chiremba ane ruzivo rwakakura anoti, "Ndakatochinja mutauro wandinotaura nevarwere iye zvino. Handimboti mumwe munhu 'ari kurwara nechirwere.' Ndinoti ari kurarama nekuchinja kweuropi.'" Izvi zvinoratidza kukosha kwetariro nemafungiro akanaka.
Mharidzo Yekuenda Nayo Kumba
- Jini rekuti `APOE4` ndiro rinonyanya kukonzera chirwere cheAlzheimer, kunyanya kana uine makopi maviri aro, izvo zvinowedzera njodzi yako zvikuru.
- Kunyangwe tsvakiridzo yazvino ichisimbisa hukama uhwu, tsvakiridzo yakawedzerwa inodiwa kuti ione kuti mhedzisiro yacho inoenderana sei nehuwandu hwevanhu vedu.
- Havasi vese vane jini iri vanozorwara nechirwere ichi. Kune vanhu vanokwegura vasina zviratidzo.
- Parizvino, hazvikurudzirwi kuti vanhu vasina zviratidzo vaongorore APOE4 nguva nenguva.
- Kana muine zvinokunetsai kana mibvunzo nezvenyaya iyi, chinhu chakanakisa chekuita ndechekukurukura nachiremba wenyu, kusanganisira mazano ezvemajini.
- Pane kunetseka nezvemajini, unogona kuderedza njodzi yako nekushandisa mararamiro anobatsira pfungwa dzedu atinogona kudzora.
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