Dzimwe nguva unotanga kuvaviwa, ganda rako rikaita dzvuku uye rinotanga mapundu here? Kana kuti unonzwa kurwara mudumbu wonzwa kuda kurutsa here? Dzimwe nguva zvinhu izvi zvinoitika mushure mekushandisa perfume, kana mushure mekudya chimwe chikafu, uye dzimwe nguva zvinogona kuitika pasina chikonzero zvachose. Kana usingakwanise kuwana chikonzero cheizvi, uye uine zviratidzo zvakasiyana panguva dzakasiyana, zvinogona kunge zvisiri kungorwara chete. Nhasi tiri kutaura nezvechimwe chirwere chakadai, Mast Cell Activation Syndrome (MCAS).
Chii chinonzi Mast Cell Activation Syndrome (MCAS)?
Zvichitaurwa zviri nyore, MCAS chirwere apo rudzi rwesero mumuviri wedu runonzi 'mast cells' rinotanga kushanda zvakanyanya zvisina kufanira, richiburitsa huwandu hwakawanda hwemakemikari ari mumuviri.
Iye zvino ngatitarisei kuti masero aya mast cell chii. Funga nezvemasero aya sevarindi vemuviri. Iwo chikamu cheimmune system yedu. Basa rawo guru nderekurwisa hutachiona. Asi allergies inokonzerwawo nemasero aya. Kazhinji, kana chimwe chinhu chinotikuvadza, semuenzaniso, chinopinda mumuviri, masero aya mast cell anova activated uye anoburitsa makemikari anonzi 'mediators'. Makemikari aya ndiwo anokonzera allergy response mumuviri wedu. Mumunhu ane hutano, maitiro aya ndeekutidzivirira.
Asi, kune munhu ane MCAS, mast cells aya anonyanya kunzwa . Anonyanya kufarira kunyange chinhu chidiki uye anoburitsa makemikari akawanda panguva imwe chete. Zvakafanana nekuunza uto rese kuti ribate mbavha diki. Makemikari aya asingadiwi ndiwo anokonzera zviratidzo zvakawanda zvisingawanzoitiki, zvinonetsa zvatakataura nezvazvo kare.
Pane zvinhu zvakawanda zvinogona kukonzera mast cells aya:
- Utachiona
- Mimwe mishonga
- Chepfu inobva pakurumwa nezvipembenene
- Zvinonhuhwirira
- Kushushikana
- Kurovedza muviri
- Zvimwe zvekudya
- Kuchinja kamwe kamwe kwekupisa
MCAS neMastocytosis zvinhu zvakasiyana here?
Ehe, musavhiringe zvinhu zviviri izvi. Kunyangwe mamiriro ese ari maviri aine mast cells, akasiyana.
| Dambudziko rehutano | Zvichitaurwa zviri nyore, chii chinoitika? |
|---|---|
| Mastocytosis | Chinoitika apa ndechekuti muviri unogadzira huwandu hwakawanda hwemasero emuviri. Zvakafanana nekutsvaga varindi vekuchengetedza vakawandisa. Masero aya akawandisa anoungana munhengo dzakadai seganda, chiropa, uye ura. Ichi chirwere chisingawanzoitiki. |
| Chirwere cheMast Cell Activation Syndrome (MCAS) | Chinoitika munyaya iyi ndechekuti huwandu hwemasero emuviri mumuviri hwakajairwa, asi masero aripo anova anoshanda zvakanyanya. Varindi varipo vanofara nechinhu chidiki-diki voburitsa makemikari. |
Ndezvipi zvikonzero zveMCAS?
MCAS inogona kuiswa muzvikamu zvitatu zvikuru zvichienderana nechikonzero chacho.
1. MCAS Yekutanga: Izvi zvinokonzerwa nedambudziko remasero emuviri pachawo. Kazhinji, kuchinja kwejini ``(KIT)`` kunoita kuti masero aya aite zvisina kujairika. Mastocytosis ndiyo chirwere chikuru murudzi urwu.
2. Secondary MCAS: Izvi zvinoitika kana mast cells akurudzirwa nechimwe chikonzero chekunze. Semuenzaniso, izvi zvinogona kukonzerwa ne allergic reaction yakanyanya, hutachiona husingaperi, kana chimwe chirwere.
3. Idiopathic MCAS: "Idiopathic" zvinoreva kuti "hapana chikonzero chingawanikwa." Ruzhinji rwevarwere veMCAS vane rudzi urwu. Izvi zvinoreva kuti hapana chikonzero chaicho nei masero aya ari kuita zvisina kujairika. Zviratidzo zvinogona kuoneka kune zvinhu zvitsva chero nguva.
Ndezvipi zviratidzo zvingangove zveMCAS?
Chimwe chezvinetso zvikuru neMCAS ndechekuti zviratidzo zvakasiyana-siyana uye zvinogona kukanganisa masisitimu emuviri akawanda panguva imwe chete.
| Chikamu chezviratidzo | Zviratidzo zvinowanzoonekwa |
|---|---|
| Ganda uye hunhu hwakazara | Kusviba, kuvaviwa, mapundu/mapundu, kuzvimba, kudikitira zvakanyanya, kuneta kusingaperi, kurwadziwa kwemuviri. |
| Sisitimu yekugaya chikafu | Kurwadziwa kwemudumbu, kuda kurutsa, kurutsa, manyoka, kuvimbiwa. |
| Sisitimu yetsinga (yetsinga) | Musoro, matambudziko ekurangarira uye ekufunga (Brain fog), dzungu, kupera simba, kuzvidya mwoyo, kuora mwoyo, kushaya hope. |
| Moyo nehurongwa hwekufema | Kurova kwemoyo nekukurumidza kana kusina kurongeka (kurova kwemoyo), kuoma kufema, kusimba kwechipfuva. |
Kunyatsotarisirwa: Anaphylactic Shock
Anaphylaxis ndiyo chirwere chine njodzi zvikuru uye chinotyisidzira hupenyu chinogona kuitika kuvanhu vane MCAS. Ichi chirwere chinoda kurapwa nekukurumidza.
Zviratidzo zve anaphylaxis:
- Kutadza kufema zvakanaka, kunzwa sekunge pahuro pako pakaoma
- Kuzvimba kwemiromo, rurimi, kana kumeso
- Kurova kwemoyo kunokurumidza zvikuru.
- Kudonha kamwe kamwe kweBP
- Dzungu rakakomba uye kupera simba
- Kurutsa uye manyoka
- Kutsvuka kamwe kamwe uye mapundu mumuviri wese
Kana ukaona chimwe chezviratidzo izvi kana kupfuura, usanonoka. Fonera amburenzi nekukasika kana kuenda kuEmergency Department (ETU) yechipatara chiri pedyo.
Ndingaziva sei kana ndine MCAS?
Kuziva MCAS kunogona kuoma nekuti zviratidzo zvacho zvakasiyana-siyana. Chiremba wako anowanzo tsvaga zvinhu zvitatu.
1. Zviratidzo: Kuvapo kwezviratidzo zvinogara zvichiitika, zvakafanana neallergy muzvikamu zviviri kana kupfuura zvemuviri (semuenzaniso, ganda neura).
2. Kuongororwa: Miedzo yeropa kana weti inotorwa kana zviratidzo zvaonekwa inoratidza huwandu hwakakwira hwemakemikari akadai se "tryptase" uye "histamine", ayo anoburitswa nemasero emuviri.
3. Mhinduro yekurapwa: Zviratidzo zvinodzikira kana zvikapihwa mishonga inovhara mashandiro emasero emuviri, senge antihistamines.
Kana zvese izvi zvitatu zvikazadzikiswa, chiremba anogona kufungidzira kuti ane MCAS. Dzimwe nguva MCAS inoperekedzwa nechirwere chinonzi ``(POTS)`` - Postural Orthostatic Tachycardia Syndrome. Apa ndipo apo kurova kwemoyo kunowedzera zvisina kujairika kana wamira.
Inorapwa sei?
Hapana mushonga weMCAS parizvino. Zvisinei, zviratidzo zvinogona kudzorwa zvakanaka uye hupenyu hwemazuva ese hunogona kuwanikwa. Kurapwa kune zvinangwa zvikuru zviviri.
1. Kudzivisa Zvinokonzera: Chinhu chinonyanya kukosha ndechekuona kuti chii chinokonzera zviratidzo zvako wozvidzivisa.
2. Kudzora zviratidzo nekushandisa mishonga: Chiremba achakupa mishonga yakasiyana-siyana.
- Mishonga yeH1 neH2 antihistamines: Mishonga yakaita seCetirizine, Loratadine, Famotidine.
- Mast Cell Stabilizers: Mishonga inodzivirira kuburitswa kwemakemikari kubva mumasero emuviri.
- Leukotriene Inhibitors: Mishonga yakaita seMontelukast.
- Kana paine njodzi yekukanganisika kweropa: Kana paine njodzi ye anaphylaxis, vanachiremba vanokurudzira kugara uine auto-injector (yakadai seEpiPen) ine `(epinephrine)` pedyo.
Zvinhu zvekufunga nezvazvo kana uchigara neMCAS
Kugara neMCAS kunogona kuoma, asi kana ukagara uchitarisirwa zvakanaka , unogona kurarama nechirwere ichi zvinobudirira.
- Kudya: Zvimwe zvekudya zvinogona kukonzera MCAS. Chenjerera zvakanyanya nezvezvikafu zvine histamine yakawanda (chizi chakaviriswa, hove dzemumagaba, madomasi, sipinachi, chokoreti). Zvakanaka kubvunza chiremba wako uye kuona nyanzvi yezvekudya kuti akugadzirire chirongwa chekudya chakakunakira.
- Kudzora kushushikana: Kushushikana ndicho chinhu chikuru chinokonzera MCAS. Saka, zvakakosha kuti pfungwa dzako dzigare dzakagadzikana. Zvinhu zvakaita sekufungisisa, yoga, uye kuita chimwe chinhu chaunofarira zvinogona kubatsira.
- Wana rutsigiro: Taura nemhuri neshamwari nezvechirwere chako. Zvinogonawo kubatsira kubatana nemapoka ekutsigirana nevanhu vari kusangana nemamiriro ezvinhu akafanana.
- Kugara uchitaurirana nachiremba wako: Taura nachiremba wako nguva nenguva uye gadzirisa hurongwa hwako hwekurapa kana zvichidikanwa.
Mharidzo Yekuenda Nayo Kumba
- Mast Cell Activation Syndrome (MCAS) haisi nyaya yekufungidzira, asi chirwere chaicho chine chekuita nemasoja emuviri.
- Zviratidzo zvinogona kusiyana zvikuru kubva pamunhu nemunhu. Kana uine zviratidzo zvakasiyana-siyana zvausingakwanise kuwana chikonzero, enda kuna chiremba.
- Kuziva uye kudzivirira zvinokonzera zviratidzo zvako chikamu chakakosha chekurapa.
- Anaphylaxis idambudziko rinotyisidzira hupenyu rinoda kurapwa nekukasika. Ziva zviratidzo zvaro.
- Kana ukarapa zvakanaka uye ukachinja mararamiro ako, MCAS inogona kudzorwa zvakanaka uye unogona kurarama hupenyu hwakajairika uye hune simba. Shanda pamwe chete nachiremba wako kuti uite izvi.
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