Dzidza nezve Herceptin (Trastuzumab) kurapwa kwekenza yemazamu ine HER2-positive

Kana iwe kana mumwe munhu mumhuri yako akaonekwa aine kenza yemazamu, zvakaoma kutaura kutya kwako nekuzvidya mwoyo kwaunonzwa. Inguva inoshungurudza zvikuru. Asi, chinhu chakakosha ndechekuti nesainzi yezvekurapa yatinayo ikozvino, tinogona kuva netariro. Chiremba wako achafunga nezvezvinhu zvakawanda, zvakaita serudzi rwekenza yaunayo, zera rako, uye kana uine zvimwe zvirwere, kuti asarudze nzira dzakanakisa dzekurapa. Kenza yemazamu inowanzo rapwa nekuvhiyiwa, chemotherapy, uye radiation.

Nhasi tiri kutaura nezvekurapa kwakasiyana zvishoma, kwakanangana. Izvi zvinonzi " targeted therapy." Herceptin ndeimwe yemishonga yakadaro. Zita rayo rekurapa ndiTrastuzumab . Ungave wakambonzwa ichitumidzwa mamwe mazita akadai saKanjinti, Herzuma, Ogivri. Aya anonzi "biosimilars." Zvichitaurwa zviri nyore, aya makopi emushonga mumwe chete naHerceptin.

Chii chinonzi Targeted Therapy naHerceptin?

Funga nezvazvo, mishonga yechemotherapy yenguva dzose inokanganisa kwete masero ekenza chete, asiwo masero ane hutano anopatsanuka nekukurumidza. Asi mishonga yakanangwa haina kudaro. Inoshanda nekutarisa zvakananga. Mishonga iyi inodzora mapuroteni chaiwo anobatsira masero ekenza kukura nekupararira. Ndosaka isingashande kune ese makenza. Mapuroteni anonangwa nemushonga anofanira kunge aripo akawanda mumasero iwayo ekenza.

Mushonga weHerceptin unonanga puroteni inonzi HER2 . (Zita rakazara reizvi ndi human epidermal growth factor receptor 2). Saka, kana puroteni iyi yeHER2 ikagadzirwa yakawanda mumasero ekenza, tinoidaidza kuti kenza yemazamu yerudzi irworwo ye HER2-positive. Kurapwa kweHerceptin kunongopihwa kune kenza yemazamu yerudzi rwe HER2-positive chete.

Mushonga uyu weHerceptin unoshanda sei mumuviri?

Kuti tinzwisise izvi, ngatitangei tatarisa kuti HER2 chii. HER2 ireceptor iri pamusoro pemasero. Funga nezvayo se antenna diki iri pamusoro pesero. Aya ma antenna ndiwo anogamuchira masaini kubva kunze kwesero uye anoshanda paari. Musero rine hutano, ma HER2 receptors aripo kudzora kukura kwemasero.

Asi chimwe chinhu chakasiyana chinoitika mumasero ekenza e "HER2-positive". Masero aya ane mamwe makopi emajini anogadzira puroteni yeHER2. Saka, masero aya anogadzira puroteni yeHER2 yakawandisa. Zvakaita sekunge kune maantenna akawanda pasero. Zvadaro, masero ekenza anowana zviratidzo zvakawanda zvekuti "akure, apatsanurwe," uye anokura asingadzoreki, nekukurumidza.

Herceptin iantibody yakakosha yakagadzirwa nemasayendisiti. Yakafanana nemaantibody echisikigo anogadzira miviri yedu kurwisa utachiona patinorwara. Iyi antibody yekugadzira inonamatira kune mamwe maantenna eHER2 ari pamasero ekenza. Izvi zvinovhara chiratidzo chinoudza sero kuti "rikure." Nenzira iyi, Herceptin inobatsira kudzora kukura nekupararira kwemasero ekenza.

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Kurapwa kweHerceptin kwakakodzera kenza yangu here?

Uyu mubvunzo unokosha zvikuru. Kana kenza yemazamu yako iri HER2-negative, zvichireva kuti masero ekenza haana puroteni yeHER2 yakawedzerwa, saka kurapwa kweHerceptin hakuzoshande. Mazhinji ekenza yemazamu ari HER2-negative. Anenge 20% ane HER2-positive. Chiremba wako achakuudza rudzii rwekenza yaunayo kuburikidza nekuongororwa.

Kurapa kweHerceptin kunoshandiswa pakutanga kwekenza yemazamu, pamwe chete nepadanho repamusoro apo kenza yapararira (metastatic).

• Kune kenza iri padanho rekutanga: Kana kenza yako iri HER2-positive uye iri padanho rekutanga, Herceptin inopihwa kudzivirira kenza kuti isadzoke mushure mekuvhiyiwa. Izvi zvinowanzopihwa nechemotherapy kana endocrine therapy. Kurapa uku kunowanzoitwa kana kenza yakakura kana kuti yapararira kulymph nodes.

• Kune kenza yakura: Kana kenza yapararira kunzvimbo dziri kure dzemuviri (metastatic), Herceptin inogona kubatsira kumisa kana kunonoka kukura kwayo . Dzimwe nguva, kana bundu rakakura zvekuti harikwanise kubviswa nekuvhiyiwa, Herceptin nedzimwe nzira dzekurapa dzinogona kurideredza usati wavhiyiwa.

Chinhu chinonyanya kukosha kutaura pachena nachiremba wako uye kunzwisisa zvese nezvekuti kurapwa kwakakunakira, kuchapihwa sei, uye kuti nei kwakasarudzwa.

Chii chaunofanira kutarisira paunenge uchirapwa?

Herceptin inopihwa semushonga unopinzwa mutsinga (intravenous - IV) . Inopihwa semushonga une saline. Izvi zvinoitwa nekuti mushonga unofanirwa kupinzwa zvakananga muropa. Zvinogona kutora pakati pemaminitsi makumi matatu kusvika makumi mapfumbamwe kuti upere.

Kunewo rudzi rweizvi runopihwa sejekiseni. Runonzi Herceptin Hylecta. Zvidzidzo zvakaratidza kuti izvi zvinoshanda zvakafanana neIV. Chiremba wako ndiye achasarudza kuti ndeipi nzira yakakunakira.

Kuti unofanira kutora Herceptin kwenguva yakareba sei uye kangani zvinoenderana nedanho rekenza yako pamwe nemimwe mishonga yauri kutora. Kana kenza yakura (metastatic), ungangoda kuramba uchirapwa chero bedzi mushonga wacho uchishanda uye pasina migumisiro yakaipa.

Zvakakosha: Chiremba wako achaongorora mashandiro emoyo wako nguva dzose usati warapwa naHerceptin uye panguva yekurapwa, sezvo mushonga uyu dzimwe nguva uchigona kukanganisa moyo.

Pamusoro peizvi, mimwe migumisiro inogona kuitika. Saka, usati watanga kurapwa, unofanira kudzidza nokungwarira zviratidzo zvekuchenjerera uye nguva yekuudza chiremba wako ipapo ipapo. Kurapa kweHerceptin hakupiwi kuvakadzi vane pamuviri kana vari kuedza kuva nepamuviri.

Kurapa uku kunobudirira sei?

Herceptin mushonga wakachinja zvakanyanya kurapwa kwegomarara rezamu reHER2-positive mushure mekunge wabvumidzwa muna 1998.

• Kune kenza yakakwira: Herceptin, kana ikanwiwa yoga kana ne chemotherapy, inogona kunonoka kukura kwekenza uye kubatsira varwere kurarama kwenguva yakareba. Zvisinei, dzimwe nguva mushonga unogona kushanda kwenguva yakati wozomira kushanda.

• Kune kenza iri padanho rekutanga: Apa ndipo panowanikwa kubudirira kukuru. Zvidzidzo zvakaratidza kuti kuwedzera Herceptin pakurapa chemotherapy mushure mekuvhiyiwa kunogona kuderedza njodzi yekuti kenza idzoke neinenge 50% . Izvi zvinoreva kuti vakadzi vakawanda vanotora Herceptin vanorarama kwenguva yakareba vasina kenza.

Kunyangwe kurapwa kuchitanga kwaitwa kwegore rimwe kana maviri, zvidzidzo zvitsva zvinoratidza kuti kune vanhu vazhinji, kutora Herceptin kwemwedzi mitanhatu chete kwakakwana. Aya mashoko akanaka kune avo vane hanya nemigumisiro.