Yintoni ubudlelwane phakathi kwe-estrogen nomhlaza? Masifunde ngeMithi yomhlaza exhomekeke kwi-estrogen ngendlela elula!

Molo! Mhlawumbi ukhe weva ngehomoni i-estrogen. Sihlala sisiva eli gama ngokunxulumene nempilo yabasetyhini. Kodwa usenokungazi ukuba i-estrogen inokuchaphazela nophuhliso lweentlobo ezithile zomhlaza. Yiloo nto siza kuthetha ngayo namhlanje, ngokulula, ngendlela onokuyiqonda.

Yintoni i-estrogen? Masiyiqonde kuqala!

Ngamafutshane, i-estrogen yikhemikhali yendalo eveliswa yimizimba yethu. Sikwayibiza ngokuba yi-hormone. Le hormone ye-estrogen ihamba ngegazi lethu iye kwiiseli kunye nezicubu zomzimba wethu.

Abantu abaninzi bacinga ukuba i-estrogen yinto ekhawulelwe kubafazi. Enyanisweni, ii-ovari, eziyinxalenye yenkqubo yokuzala yabasetyhini, zivelisa i-estrogen eninzi kakhulu. Kodwa okumangalisayo kukuba, wonke umntu, nokuba ungowaluphi na uhlobo lwesini, uvelisa umlinganiselo othile we-estrogen emizimbeni yakhe, kuquka izicubu zamabele kunye neeseli zamafutha.

Kwabasetyhini, ukufikisa kubangelwa yindibaniselwano ye-estrogen kunye nenye i-hormone yesini, i-progesterone. Oku kuthetha izinto ezifana nokukhula kwamabele kunye nokukhula kweenwele zasesibelekweni. Kwakhona yi-hormone ye-estrogen elawula umjikelo wokuya exesheni wenyanga.

Nangona kunjalo, i-hormone i-estrogen idlala indima ebaluleke kakhulu nakumadoda. Ichaphazela uphuhliso lwengqondo, ukusebenza kakuhle ngokwesondo, kunye ne-libido.

Ngoko ke, zithini ii-cancer ezixhomekeke kwi-estrogen?

Ngoku makhe sijonge ukuba zeziphi ezi cancer ezixhomekeke kwi-estrogen. Ngamanye amaxesha ungaziva zibizwa ngokuba yi -estrogen receptor-positive , i-hormone-dependent , i-hormone-positive , i-hormone receptor-positive , okanye i-hormone-sensitive . Nokuba yeyiphi na indlela, zithetha into enye.

Ngamafutshane, oku kuthetha ukuba i-hormone i-estrogen inceda iiseli zomhlaza zikhule, oko kukuthi, zikhule kwaye zisasazeke. Kanye njengokuba isityalo sifuna amanzi, i-hormone i-estrogen ibalulekile kwezi ntlobo zomhlaza.

Kukho iintlobo ezahlukeneyo zomhlaza ezixhomekeke kakhulu kwi-estrogen. Ezona ziphambili zezi:

• Umhlaza webele
• Umhlaza wesibeleko
• Umhlaza wesibeleko – Oku kukwabizwa ngokuba ngumhlaza we-endometrial.

Ingaba i-estrogen ibangela umhlaza ngenene? ​​Oku kuyadida kancinci, akunjalo?

Oku ngenene libali elintsonkothileyo. Ihomoni i-estrogen ngamanye amaxesha ibizwa ngokuba yi-carcinogen. Oko kuthetha ukuba inamandla okubangela umhlaza. Kodwa kufuneka siqonde ukuba oko kwenzeka njani.

Phantse yonke iseli emzimbeni wethu inohlobo oluthile lweproteni ebizwa ngokuba yi-hormone receptors. I-estrogen esegazini lethu iyafika ize ibopheleleke kwezi receptors. Oku kudla ngokuba yimfuneko kwimisebenzi emininzi emzimbeni wethu. Kwiiseli ezisempilweni, i-estrogen inceda iiseli ukuba zisebenze ngokuqhelekileyo kwaye zikhule kakuhle.

Nangona kunjalo, ngezizathu ezithile, xa izinto ezithile zidibana, iiseli eziphilileyo zinokuguquka zibe ziiseli zomhlaza. Kwimeko enjalo, i-estrogen iqala ukusebenza njengentlantsi. Oko kukuthi, i-estrogen inceda iiseli zomhlaza esele zenziwe ukuba zahlukane ngokukhawuleza, ziphindaphindeke, kwaye zisasazeke ukusuka kwenye indawo ukuya kwenye emzimbeni.

Ngoko ke, endaweni yokuthi i-estrogen yodwa ibangela umhlaza, kuchaneke ngakumbi ukuthi i-estrogen, kunye nezinye izinto ezinegalelo ekuphuhlisweni komhlaza, inceda ukukhula komhlaza okhoyo .

Zeziphi izinto ezibangela umngcipheko wokuba nomhlaza oxhomekeke kwi-estrogen ngolu hlobo?

Kukho izinto ezininzi ezibangela umngcipheko wokuba nomhlaza oxhomekeke kwi-estrogen ukuya kwinqanaba elithile. Makhe sijonge ukuba zeziphi:

• Ukuba namanqanaba aphezulu e-estrogen emzimbeni: Abanye abantu bane-estrogen ephezulu ngokwemvelo.
• Ukuthatha unyango lokutshintshwa kweeHormone (HRT): Olu lunyango oluhlala lunikwa ukunyanga ukungakhululeki emzimbeni (umz. ubushushu obugqithisileyo, ukubila ebusuku) okwenzeka emva kokuya exesheni. Khawuthelekelele ukuba umama okanye umakhulu wakho wayenikwe amayeza ehomoni ngugqirha ngenxa yeempawu zakhe zasemva kokuya exesheni. Yiyo loo nto iHRT.
• Ukutyeba kakhulu: Njengoko amafutha omzimba esanda, imveliso ye-estrogen nayo inokwanda.
• Ukuba nesifo esibizwa ngokuba yiPolycystic Ovary Syndrome (PCOS): Oku kukwanxulunyaniswa nokungalingani kwamahomoni.
• Ukusetyenziswa kweDiethylstilbestrol (DES): Le yi-estrogen yokwenziwa eyanikwa abafazi abakhulelweyo ukuthintela ukuphuphuma kwezisu ukususela ngo-1938 ukuya ku-1971. Ukuba umama wasebenzisa i-DES ngeli xesha, okanye ukuba umama wayechaphazeleka yi-DES ngexesha lokukhulelwa waza wazala umntwana, umntwana usemngciphekweni wokufumana olu hlobo lomhlaza kamva ebomini.

Yintoni ubudlelwane phakathi kwe-estrogen nomhlaza webele?

Xa kufikwa kumhlaza webele, malunga nesibhozo kwishumi lemihlaza yebele ine-hormone receptor-positive . Ngamafutshane, le mihlaza ifuna i-estrogen, i-progesterone, okanye zombini ezi hormone ukuze ikhule.

Umngcipheko womhlaza webele uyanda xa ixesha elide usetyenziswa kakhulu kwi-estrogen. Ezona zizathu ziphambili zezi:

• Unyango lokutshintshwa kwamahomoni (HRT) ngexesha lokuya exesheni.
• Ukuba namanqanaba aphezulu e-estrogen emzimbeni.
• Isifo seKlinefelter sisifo semfuza esichaphazela amadoda (amadoda anale meko anamanqanaba aphezulu e-estrogen).

Ngaphambili, amanye amadoda ayenikwa i-hormone i-estrogen njengonyango lomhlaza we-prostate. Kodwa ngoku oogqirha abacebisi kangako olo nyango kuba lukwanyusa umngcipheko womhlaza webele kumadoda.

Yintoni ubudlelwane phakathi kwe-estrogen kunye nomhlaza wesibeleko?

Ukuvezwa kwi-estrogen ubomi bonke kunokunyusa umngcipheko wokuba nomhlaza wesibeleko. Izinto ezinobungozi ziquka:

• Ukuqala ukuya exesheni ngaphambi kokuba ufikelele kwiminyaka eli-12 ubudala (oko kuthetha ukufikisa kwasekuqaleni).
• Ukungakhulelwa.
• Ukuya exesheni (oko kuthetha ukuba nexesha elide) emva kweminyaka engama-55 ubudala.
• Ukuthatha unyango oludibeneyo lweehomoni (unyango lweehomoni) emva kokuya exesheni, oluqulethe zombini iihomoni ze-estrogen kunye ne-progesterone.

Yintoni ubudlelwane phakathi kwe-estrogen kunye nomhlaza wesibeleko?

Umhlaza wesibeleko, okanye njengoko besitshilo ngaphambili, umhlaza we-endometrial, ukhula kwi- uterus yakho. Abafazi banamathuba amaninzi okufumana lo mhlaza emva kokuya exesheni.

Umngcipheko onxulumene ne-estrogen unokwanda ngenxa yezinto ezifana nezi:

• Unyango lokutshintshwa kwe-estrogen: I-estrogen inceda ekunciphiseni ukungakhululeki kokuya exesheni, njengobushushu obuphezulu, ukubila ebusuku, kunye nokomisa kwelungu lobufazi. Nangona kunjalo, ukuthatha unyango lwe-estrogen kuphela kwandisa umngcipheko wokuba nomhlaza wesibeleko. Oku kungenxa yokuba i-estrogen ikhuthaza ukukhula kolwelo lwesibeleko. Yiyo loo nto i-estrogen idla ngokunikezelwa kunye nehomoni ebizwa ngokuba yi-progesterone (unyango lwehomoni edibeneyo). Oku kunciphisa umngcipheko womhlaza wesibeleko. Nangona kunjalo, ukuba ukhe wakhutshwa i-hysterectomy, awuyi kuba nalo mhlaza kuba awunaso isibeleko.
• Ukusetyenziswa kweTamoxifen: I-Tamoxifen liyeza elibaluleke kakhulu elisetyenziselwa ukunyanga umhlaza webele kunye nokuthintela umhlaza ukuba ungabuyi. Isebenza njengeSelective Estrogen Receptor Modulator (SERM) kwaye ithintela iziphumo ze-estrogen kwizicubu zebele. Nangona kunjalo, kubafazi abasele beyekile ukuya exesheni, i-tamoxifen isebenza njenge-estrogen kwisibeleko. Oku kukhuthaza ukukhula kolwelo lwesibeleko, nto leyo enyusa umngcipheko womhlaza we-endometrial ukuya kwinqanaba elithile. Kodwa ungakhathazeki, umngcipheko wokufumana umhlaza we-endometrial ngenxa ye-tamoxifen uhlala ungaphantsi kwe-1% ngonyaka. Kukwakho nomngcipheko omncinci kakhulu wokufumana i-uterine sarcoma, uhlobo olungaqhelekanga lomhlaza olukhula kwimisipha okanye kwezinye izicubu zesibeleko.

Umhlaza oxhomekeke kwi-estrogen ufunyanwa njani? Oogqirha bafumanisa njani oku?

Ukuba ukrokrela ukuba unomhlaza, into yokuqala ugqirha wakho aza kuyenza kukuthatha iqhekeza elincinci lesicubu sethumba (esikubiza ngokuba yi-tumor biopsy) aze alithumele kwilebhu. Apho, baza kusebenzisa uvavanyo olukhethekileyo ukujonga ukuba ezo seli zinayo na i-hormone receptors.

Ukuba iziphumo zovavanyo zibuya njenge -hormone receptor positive (HR+) , oko kuthetha ukuba i-estrogen, i-progesterone, okanye zombini ezi hormone zinceda umhlaza wakho ukuba ukhule, oko kukuthi, uwutya.

Iphathwa njani imingxunya efana nale exhomekeke kwi-estrogen?

Kubalulekile ukuba oogqirha bazi imeko ye-hormone receptor yomhlaza, njengoko ezinye iindlela zonyango zisebenza kuphela kumhlaza one-hormone-positive. Ezinye zeendlela eziphambili zonyango kwezi ntlobo zomhlaza zezi:

• Izithinteli zeAromatase: La mayeza asebenza ngokuthintela umzimba ekuguquleni ii-androgens, i-hormone, zibe yi-estrogen. Olu nyango lusebenza kuphela kubafazi abaye badlula kwixesha lokuya exesheni (oko kukuthi, ama-ovari abo ayekile ukuvelisa i-estrogen).
• Ezinye iindlela zonyango lweehomoni: Ezi zinciphisa okanye ziyekisa ukuveliswa kwe-estrogen emzimbeni.
• I-Tamoxifen kunye nezinye iziyobisi ze-SERM: Njengoko besitshilo ngaphambili, ezi zisebenza ngokuthintela ii-receptors zehomoni ekubopheni kwi-estrogen.
• Utyando lokukhupha i-oophorectomy: Kwezinye iimeko, ama-ovari, amalungu aphambili avelisa i-estrogen, asuswa ngotyando. Oku kunokunciphisa kakhulu amanqanaba e-estrogen emzimbeni.

Ngaba iipilisi zokulawula ukukhulelwa zinokuyinciphisa ngokwenene ingozi yalo mhlaza?

Impendulo koku ingaba 'ewe' okanye 'hayi'. Kwenzeka njani oko?

Ezinye izifundo zibonise ukuba abafazi abasebenzisa iindlela zokulawula ukuzala ngeehomoni, njengeepilisi, banokuba nomngcipheko omncinci kakhulu (malunga ne-7%) wokufumana umhlaza webele .

Nangona kunjalo, kwelinye icala, ukuthatha iipilisi zokulawula ukukhulelwa kunokunciphisa umngcipheko wokufumana ezi ntlobo zilandelayo zomhlaza:

• Umhlaza womlomo wesibeleko
• Umhlaza weColoral
• Umhlaza wesibeleko
• Umhlaza wesibeleko

Ngoko ke, njengoko ubona, oku kunzima kancinci. Ngoko ke, kungcono ukuthetha nogqirha wakho uze ugqibe ukuba yeyiphi indlela yokulawula inzala efanelekileyo kuwe, kwaye yeyiphi ekhuselekileyo.

Yintoni esinokuyenza ukuthintela uphuhliso lomhlaza oxhomekeke kwi-estrogen?

Uninzi lomhlaza lukhula ngaphandle kwesizathu esicacileyo. Oku kuthetha ukuba ngamanye amaxesha umhlaza ungakhula nokuba silumke kangakanani na. Nangona kunjalo, kukho izinto ezilula esinokuzenza ukunciphisa umngcipheko womhlaza ngandlela thile.

• Ukuba kunokwenzeka, ncancisa abantwana bakho. Ukuncancisa kuye kwafunyaniswa ukuba kunciphisa umngcipheko womhlaza webele.
• Nciphisa ukusetyenziswa kotywala kangangoko unako kwaye uphephe ukutshaya ngokupheleleyo. Ezi zizinto ezibangela umhlaza omninzi.
• Zama ukutya ukutya okunempilo. Yitya imifuno neziqhamo ezingaphezulu. Kwakhona, qhelisa umzimba yonke imihla kwaye ube nomzimba osebenzayo.
• Ukuba utyebile kakhulu, oko kukuthi, utyebile kakhulu, zama ukunciphisa umzimba.
• Thetha nogqirha wakho malunga nendlela yokulawula inzala ekhuselekileyo kuwe.
• Ukuba ufuna ukulawula ukungakhululeki kokuyeka ukuya exesheni, funa ingcebiso kagqirha malunga nonyango lweehomoni ezidibeneyo okanye unyango olungelulo olwehomoni.

Zeziphi imibuzo ebalulekileyo ekufuneka ndiyibuze ugqirha wam?

Ukuba unenkxalabo malunga nale meko, okanye malunga nomngcipheko womhlaza onxulumene ne-estrogen, ungaze ungathandabuzi ukubuza ugqirha wakho. Kubalulekile ukususa amathandabuzo akho. Nazi ezinye zemibuzo onokuzibuza:

• Ingaba umhlaza endinawo/endinawo uxhomekeke kwi-estrogen okanye i-hormone-receptor-positive?
• Ziziphi iindlela zonyango ezilungileyo ezikhoyo ngoku zolu hlobo lomhlaza?
• Zithini iingozi kunye nemiphumo emibi yale mithi?
• Zeziphi iinguqu endinokuzitshintsha kwindlela endiphila ngayo ukuze ndikhusele impilo yam kwaye ndinciphise umngcipheko wokuba nomhlaza?
• Ngaba kufuneka nditshintshe indlela yokulawula inzala endiyisebenzisayo ngoku? Yeyiphi indlela efanelekileyo kum?
• Ngaba kufanelekile ukuba ndithathe unyango lweehomoni? Ngaba kukho naziphi na iingozi kum?

Okokugqibela, yintoni ekufuneka uyikhumbule (Umyalezo Wokuya Ekhaya)

Uninzi lwexesha, i-hormone i-estrogen idlala indima eluncedo emizimbeni yethu, iyinceda isebenze kakuhle. Nangona kunjalo, umhlaza oxhomekeke kwi-estrogen awukho. Kwezi cancer zithile, i-estrogen inceda umhlaza ukuba ukhule, oko kukuthi, uyondla umhlaza.

Ukuba ufunyaniswe ukuba unomhlaza kwaye ugqirha wakho ukrokrela ukuba usenokuba nesifo esichaphazela iihomoni, ngokuqinisekileyo uza kwenza uvavanyo olufunekayo ukuze afumanise ukuba unxulumene ne-estrogen na. Ngokusekelwe kolo lwazi, ugqirha wakho uya kukwazi ukukhetha unyango olusebenzayo nolufanelekileyo kuwe.

Ngoko ke, ngaphandle koloyiko okanye ukuzibamba, xoxa ngokukhululekileyo ngayo yonke imibuzo yakho kunye namathandabuzo akho nogqirha wakho. Ibaluleke kakhulu kwimpilo yakho nakwimpilo-ntle yakho yengqondo.

I- estrogen, umhlaza, iihomoni, umhlaza webele, umhlaza wesibeleko, umhlaza wesibeleko, impilo yabasetyhini