Ngaba kukho umntu kusapho lwakho one "Sickle Cell Disease"? Masifumanise ngokuqinisekileyo!

Namhlanje siza kuthetha ngemeko entsha kubantu abaninzi, kodwa enokuba kufutshane kakhulu nezinye iintsapho. Ibizwa ngokuba yiSickle Cell Disease (SCD). Usenokuba ukhe wayiva le gama ngaphambili. Enyanisweni sisifo esinxulumene negazi lethu, oko kukuthi, esinxulumene negazi, kwaye sidluliselwa kwilifa. Makhe sijonge ukuba yintoni kanye kanye, kutheni isenzeka, kunye nokuba yintoni enye enokwenziwa ngayo.

Yintoni iSickle Cell Disease? Masiyiqonde ngokulula!

Ngamafutshane, isifo se-sickle cell (SCD) sisifo esichaphazela iiseli ezibomvu zegazi emzimbeni wethu, esizuzwe ngabazali ukuya ebantwaneni. Esi sesinye sezifo zegazi ezixhaphakileyo emhlabeni. Ngoku khangela, ngaphakathi kweeseli zethu ezibomvu zegazi kukho iproteni ebizwa ngokuba yi-hemoglobin . Le hemoglobin ibaluleke kakhulu. Kuba, yile protein ethwala ioksijini emzimbeni wethu wonke. Ifana neteksi yeoksijini. Iiseli ezibomvu zegazi zomntu ophilileyo zihlala zingqukuva kwaye ziguquguquka. Njengeebhola zerabha ezincinci. Ngenxa yoku, zinokurhubuluza ngokulula kwimithambo yegazi emincinci emzimbeni (sizibiza ngokuba zii-capillaries) kwaye zinike ioksijini kuzo zonke izitho zethu kunye nezicubu. Nangona kunjalo, okwenzekayo kumntu onesifo se-sickle cell kukuba kukho utshintsho oluncinci kule hemoglobin. Le hemoglobin engaqhelekanga ibizwa ngokuba yi-hemoglobin S. Oku kubangela ukuba iiseli ezibomvu zegazi zibe yi-crescent, okanye zibe yi-half-moon, endaweni yokuba zingqukuva kwaye ziguquguquke. Akunjalo kuphela, kodwa ezi seli ziqinile kakhulu, azigobi lula, kwaye zinamathelane. Khawucinge, kwenzeka ntoni xa ezi seli zimile njenge-sickle zihamba kuloo mithambo yegazi mincinci? Ziyabambeka! Emva koko ukuhamba kwegazi kuyaphazamiseka. Oko kuthetha ukuba, amalungu ethu abalulekileyo kunye nezicubu zethu azifumani ioksijini eyaneleyo. Yiyo loo nto iingxaki ezinzima ezifana neentlungu ezinzima, usulelo olwahlukeneyo, umonakalo wamalungu omzimba, kunye nokungasebenzi kakuhle komzimba kunokwenzeka. Enye into kukuba ezi seli zimile okwesikele aziphili ixesha elide njengeeseli ezibomvu zegazi eziqhelekileyo. Zifa ngokukhawuleza. Emva koko umzimba uhlala unqongophala kweeseli ezibomvu zegazi. Oku sikubiza ngokuba yi-anemia . Isifo se-Sickle cell yimeko yobomi bonke. Kodwa ungakhathazeki, kukho unyango loku. Ngolu nyango, unokunciphisa iimpawu kwaye wandise ubomi bakho.

Ngaba kukho iintlobo ezahlukeneyo zesifo se-sickle cell?

Ewe, kukho iintlobo ezahlukeneyo zesifo se-sickle cell. Ezi ntlobo zimiselwa ziijini umntu azizuza kubazali bakhe.

I-Hemoglobin SS (HbSS)

Olu lolona hlobo lubi kakhulu lwesifo se-sickle cell. Malunga nama-65% abantu abane-SCD banolu hlobo. Aba bantu bazuza ilifa le-hemoglobin S gene kubazali bobabini. Oku kuthetha ukuba uninzi okanye yonke i-hemoglobin yabo ayiqhelekanga. Oku kubangela ukuba babe ne-anemia engapheliyo.

IHemoglobin SC (HbSC)

Oku kuncinci okanye kuphakathi.Uhlobo olukwinqanaba eliphezulu. Malunga nama-25% abantu abane-SCD banalo olu hlobo. Aba bantu bazuza i-hemoglobin S gene komnye umzali kwaye i-gene yolunye uhlobo lwe-hemoglobin olungaqhelekanga olubizwa ngokuba yi-hemoglobin C komnye umzali.

I-Hemoglobin (HbS) Beta Thalassemia

Aba bantu bafumana ilifa le-hemoglobin S gene kumzali omnye kunye ne-gene engaqhelekanga ebizwa ngokuba yi-beta thalassemia komnye umzali. Kukwakho neentlobo ezimbini zale gene:

• “Plus” (HbS beta +): Olu luhlobo oluchaphazela malunga ne-8% yabantu abane- SCD kwaye ludla ngokuba buthathaka.
• “Zero” (HbS beta 0): Olu luhlobo oluchaphazela malunga ne-2% yabantu abane-SCD kwaye lunokuba nzima njengesifo se -hemoglobin SS (HbSS).

Ezinye iintlobo ezinqabileyo

Ukongeza koku, kukho nezinye iintlobo ezingaqhelekanga ezifana ne -hemoglobin SD (HbSD), i-hemoglobin SE (HbSE), kunye ne-hemoglobin SO (HbSO) . Aba bantu bazuza ilifa le-gene enye ye-hemoglobin S kunye nenye i-gene engaqhelekanga ebizwa ngokuba yi-D, E, okanye i-O.

Yintoni umahluko phakathi kweSickle Cell Anemia kunye neSickle Cell Disease?

Kulapho abantu abaninzi badideka khona. ISickle Cell Disease (SCD) ligama eliqhelekileyo lazo zonke iintlobo ezahlukeneyo zesifo se-sickle cell ezikhankanyiweyo apha ngasentla. Sifana nesambrela. Zonke ezinye iintlobo ziwela phantsi kweso sambrela. Oogqirha basebenzisa igama elithi "Sickle Cell Anemia" kuphela kwiintlobo ze-SCD ezinzima kakhulu ezibangela i-anemia . Oko kukuthi, iintlobo ezibizwa ngokuba yi-hemoglobin SS (HbSS) kunye ne-hemoglobin beta zero thalassemia. Uyayazi?

Yintoni umahluko phakathi kweSickle Cell Charit kunye neSifo?

Abanye abantu baneempawu ze-sickle cell kuphela. Oku kuthetha ukuba bazuza i-hemoglobin S gene kumzali omnye kuphela . Omnye umzali ufumana i-gene ephilileyo. Ngokwesiqhelo, abantu abaneempawu ze-sickle cell ababonisi zimpawu zesifo se-sickle cell. Nangona kunjalo, banokudlulisela esi sifuzo singaqhelekanga kubantwana babo. Oku kuthetha ukuba bangabathwali bale jini. Nangona kunjalo, kunqabile kakhulu, nabantu abaneempawu ze-sickle cell banokuba neengxaki zempilo ukuba baphelelwa ngamanzi emzimbeni okanye ukuba benza umthambo onzima . Uphando lusaqhubeka ngale nto.

Ixhaphake kangakanani isifo se-sickle cell?

Abaphandi baqikelela ukuba malunga nabantu abayi-100,000 eMelika kuphela banesifo se-sickle cell. Sixhaphake kakhulu kubantu baseAfrika. Sikwafumaneka nakumaHispanic aseMelika, kunye nabantu baseMeditera, eMbindi Mpuma, eIndiya, naseAsia. Kukwakho nabantu abanale meko eSri Lanka.

Yintoni ebangela isifo se-sickle cell?

Isifo seSickle cell sibangelwa kukuguquka kwezakhi zofuzo kwijini ebizwa ngokuba yi-HBB gene . Le jini ye-HBB inoxanduva lokwenza inxalenye enye ye-hemoglobin. Abantu abane-SCD bafumana iijini ezimbini ze-HBB eziguquliweyo ezenza i-hemoglobin engaqhelekanga - enye evela kumzali ngamnye. Oku kubizwa ngokuba yi-autosomal recessive inheritance. Oku kuthetha ukuba bobabini abazali bomntwana one-SCD baphethe ikopi enye yejini eguquliweyo (oko kuthetha ukuba banokuba nophawu lwe-sickle cell). Nangona kunjalo, abo bazali abadli ngokubonisa zimpawu.

Ngubani osengozini enkulu yokufumana isifo se-sickle cell (SCD)?

Amanye amaqela abantu anethuba elikhulu lokufumana esi sifo. La ngawa:

• Abantu abazalwa eAfrika (umz. abantu abamnyama baseMelika).
• AmaHispanic aseMelika eMzantsi Melika nakuMbindi Melika.
• Abantu abavela kwimvelaphi yaseMeditera, eMbindi Mpuma, eIndiya naseAsia.

Zithini iimpawu zesifo se-sickle cell?

Iimpawu zesifo se-sickle cell zihlala ziqala ukubonakala xa umntwana eneminyaka emalunga ne-5 ukuya kwe-6 ubudala. Ezi mpawu zinokwahluka kumntu nomntu. Abanye abantu baneempawu ezingephi, ngelixa abanye benokuba neengxaki ezinkulu. Iimpawu eziphambili ezinokubonwa zezi:

• Iintlungu ezihlala zisenzeka.
• I-anemia : Oku kunokubangela ukudinwa okukhulu, ukuphaphatheka, kunye nobuthathaka.
• I-Jaundice : Ukutyheli kolusu kunye namhlophe emehlweni.
• Ukudumba okubuhlungu kwezandla neenyawo.

Zithini iingxaki zale meko?

Isifo seSickle cell sinokuchaphazela iindawo ezininzi zomzimba. Ezinye iziphumo ziqala ngequbuliso (ngokuqatha), ngelixa ezinye zihlala ixesha elide (ezingapheliyo). Ezi ngxaki ziqala kwangethuba kwaye zihlale ubomi bonke.

Intlungu

Le yeyona ngxaki ixhaphakileyo yesifo se-sickle cell. Intlungu yenzeka xa iiseli ezimile okwesickle zibhajwa kwimithambo yegazi kwaye zivale ukuhamba kwegazi. Usenokuba nentlungu ekhawulezileyo neqatha. Oku kukwabizwa ngokuba yi-pain crisis, sickle cell crisis, vaso-occlusive crisis (VOC), okanye i-vaso-occlusive episode (VOE) . Ezi crisis zentlungu zinokuba ncinci okanye zibe nzima, kwaye zingaqala ngequbuliso kwaye zihlale ixesha elide. Intlungu idla ngokuba sesifubeni, emqolo, emilenzeni nasezingalweni. Abanye abantu banokuba nentlungu engapheliyo , oko kuthetha intlungu ehlala ixesha elingaphezu kweenyanga ezintandathu.

I-anemia

Isifo seSickle cell sibangela i-anemia kuba iiseli ezibomvu zegazi ziyafa ngokukhawuleza. I-anemia kukungabikho kweeseli ezibomvu zegazi eziphilileyo ezinokuthwala ioksijini emzimbeni wonke. Yiyo loo ntoUkudinwa kakhulu, i-jaundice, ukungazinzi, isiyezi, kunye nokungabi nangqondo kunokwenzeka.

Isifo Sesifuba Esibukhali

Le yingxamiseko yezonyango esongela ubomi . Ingonakalisa imiphunga, ibangele ubunzima bokuphefumla, kwaye inciphise ukubonelelwa komoya-mpilo kwamanye amalungu omzimba. Le ngxaki yenzeka xa iiseli zesickle zivala ukuhamba kwegazi kunye nomoya-mpilo ukuya emiphungeni.

Amahlwili egazi

I-Sickle cell anemia inyusa umngcipheko wokuqhekeka kwegazi. Oku kwandisa umngcipheko wokuba nehlwili legazi kumthambo onzulu (deep vein thrombosis - DVT). I-DVT isenokuqhekeka ize ihlale emiphungeni (pulmonary embolism - PE).

Istroke

Ukuba iiseli zesickle zibambeka kwimithambo yegazi ekhokelela ebuchotsheni, ukuhamba kwegazi ukuya ebuchotsheni kuyavalwa. Ingqondo ayifumani ioksijini eyaneleyo yokusebenza. Oku kunokubangela istroke . Malunga ne-10% yabantu abane-SCD baya kuba nestroke. Abantu abane-sickle cell anemia basengozini enkulu yestroke.

Iingxaki Zokubona

Iiseli zesikele zinokuvala imithambo yegazi emehlweni. Oku kwenzeka rhoqo kwi-retina . Ngamanye amaxesha akukho zimpawu kwaye umbono unokulahleka ngequbuliso, kwaye kunokukhokelela ekubeni ube yimfama engapheliyo.

Ukuzimisela (Priapism)

I-Priapism yimeko apho iiseli ezimile okwesikele kwilungu lobudoda lendoda zivaleka khona, nto leyo ebangela ukuba ukunqamka okungapheliyo nokubuhlungu ( priapism ). Ukongeza kwiintlungu, i-priapism inokubangela umonakalo osisigxina kunye nokungasebenzi kakuhle kokunqamka . I-Priapism ehlala ngaphezulu kweeyure ezine yimeko engxamisekileyo yezonyango.

Ukonakala kwamalungu omzimba kunye nokungaphumeleli kwawo

Abantu abanesifo se-sickle cell basengozini yokuba neengxaki zentliziyo, imiphunga, izintso, kunye nezinye izitho zomzimba kuba abafumani igazi neoksijini eyaneleyo. I-SCD inokukhokelela ekungasebenzini kwamalungu amaninzi .

Ngaba uphawu okanye isifo se-sickle cell siyayichaphazela i-pregnancy?

Abafazi abaninzi abanesifo se-sickle cell bakhulelwe kakuhle. Kodwa iingozi ziphezulu. I-SCD inokunyusa umngcipheko woxinzelelo lwegazi oluphezulu, amahlwili egazi, ukukhulelwa okuphumileyo, ukuzalwa kweentsana ezinobunzima obuphantsi, kunye nokuzalwa kwangaphambi kwexesha . Ngoko ke kubalulekile ukulandela icebiso likagqirha wakho.

Isifo se-sickle cell sichongwa njani?

ESri Lanka, njengakwamanye amazwe amaninzi kwihlabathi liphela, lonke usana olusandul’ ukuzalwa luhlolwa isifo se-sickle cell njengenxalenye yokuhlolwa kosana olusandul’ ukuzalwa . Oku kuquka ukuthatha isampuli yegazi elincinci esithendeni somntwana nokulivavanya. Oku kukwajonga nezinye izifo ezininzi. Ukuqinisekisa ukuxilongwa, ugqirha womntwana uya kwenza uvavanyo lwe -hemoglobin electrophoresis . Kwakhona, isifo se-sickle cell sinokufunyanwa ngaphambi kokuba umntwana azalwe ngovavanyo lokukhulelwa . Ezi mvavanyo ziquka:Ezi ziquka i-chorionic villus sampling kunye ne -amniocentesis .

Ngaba ikho indlela yokunyanga isifo se-sickle cell ngokupheleleyo?

Ewe, ukufakelwa kwethambo lomongo , okwaziwa ngokuba kukufakelwa kweseli yesiqu, kunokunyanga isifo se-sickle cell. Oku kuquka ukuthatha umongo wethambo ophilileyo kumntu ophilayo, ohambelana nofuzo (njengomntakwenu) aze awufake kwisigulana. Nangona kunjalo, malunga ne-18% yabantu abane-SCD kuphela abanokufumana olu hlobo lonyango. Kukwakho neengozi kunye neengxaki zolu tyando. Ugqirha wakho uza kuxoxa nawe ngale nto.

Ziziphi iindlela zonyango zesifo se-sickle cell?

Unyango lwesifo se-sickle cell luquka amayeza, utofelo-gazi, ukufakelwa komongo wethambo, kunye nonyango lwezakhi zofuzo . Unyango lunokuqala ngee -antibiotics . Iintsana ezisandula ukuzalwa ezine-SCD enzima zinikwa ii-antibiotics kabini ngemini ukuya kuthi ga kwiminyaka emi-5 ukuthintela usulelo.

Amanye amayeza

Abantu abaninzi abane-SCD basebenzisa amayeza okunciphisa ubukhali besifo sabo nokunyanga iimpawu. Ezinye zezi ziquka:

• I-Voxeletor: Oku kunokuthintela iiseli ezibomvu zegazi ekubeni zimile okwesikela kwaye zinamathele kunye. Oku kunokunciphisa ukutshatyalaliswa kwezinye iiseli ezibomvu zegazi, kuphucule ukuhamba kwegazi ukuya kwizitho zomzimba, kwaye kunciphise umngcipheko we-anemia.
• I-Crizanlizumab: Eli yeza linceda ukuthintela iiseli ezibomvu zegazi ezimile okwesikele ukuba zinganamatheli eludongeni lwemithambo yegazi . Oku kunokuphucula ukuhamba kwegazi nokunciphisa ukudumba kunye nentlungu.
• I-Hydroxyurea : Oku kunokunciphisa okanye kuthintele iingxaki ezininzi ze-SCD, ezifana neengxaki zentlungu rhoqo, isifo sesifuba esibukhali, kunye ne-anemia enzima.
• I-L-glutamine: Le sisithomalalisi sentlungu. Inokunceda ekunciphiseni inani leentlungu onazo. Ezinye izithomalalisi zentlungu ziquka amayeza angengo-steroidal anti-inflammatory (NSAIDs) kunye ne-opiates .

Utofelo-gazi

Ugqirha wakho unokucebisa utofelo-gazi oluthile ukuze anyange kwaye athintele iingxaki ze-SCD.

• Utofelo-gazi olukhawulezileyo:Ezi zinceda ekunyangeni iingxaki ezibangela i-anemia enzima. Oogqirha banokuzisebenzisa nakwiingxaki ezifana nesifo sohlangothi, isifo sesifuba esibukhali, kunye nokungasebenzi kakuhle kwamalungu omzimba.
• Utofelo-gazi olubomvu: Oku kunokunyusa inani leeseli ezibomvu zegazi emzimbeni kwaye kunike iiseli ezibomvu zegazi eziqhelekileyo ezingamili njengesikele.

Ukufakelwa kweeseli zesiqu (okubizwa ngokuba kukufakelwa komongo wethambo)

I-SCD inokunyangeka ngokufakelwa i-stem cell. Oku kufuna umntu onikelayo ofanelekileyo (njengomntakwenu). Kukwaqhutywa uphando lokuphucula ukufakelwa kwe-substances kubazali okanye kubantakwenu abangafaniyo ngokupheleleyo. Ugqirha wakho uza kuxoxa ngeengozi kunye neenzuzo zolu nyango ngokusekelwe kwimeko yakho ethile.

Unyango lweZizalo

Abaphandi okwangoku baphanda unyango lwezakhi zofuzo ukunyanga i-SCD. Oku kuquka ukulungisa i-gene engaqhelekanga ye-hemoglobin okanye ukufaka i-gene ye-hemoglobin esempilweni kwiiseli ze-stem zomntu. Idatha yokuqala ngale nto iyathembisa kakhulu. Ithemba kukuba unyango lwezakhi zofuzo ngenye imini luya kuba lunyango oluqhelekileyo lwe-SCD.

Ngaba oku kungathintelwa?

Isifo seSickle cell sisifo semfuza, ngoko ke asinakuthintelwa . Ukuba ukhulelwe, kungcono ukuthetha nogqirha wakho malunga novavanyo lwemfuza okanye iingcebiso ngemfuza . Oku kuya kukunceda wena neqabane lakho nazi ukuba ninayo na imfuza kunye nomngcipheko wokuyidlulisela kubantwana benu.

Yintoni enokulindelwa ngumntu onesifo se-sickle cell?

Abantu abanesifo se-sickle cell banokuba nexesha elifutshane lokuphila kunoluntu ngokubanzi. Nangona kunjalo, unyango olutsha lwe-SCD luye lwaphucula kakhulu ixesha lokuphila kunye nomgangatho wobomi . Ukuba esi sifo silawulwa kakuhle, abantu abanesifo se-sickle cell banokuphila bade bafikelele kwiminyaka yabo engama-50.

Ndingamnyamekela njani umntwana wam ukuba unesifo se-sickle cell?

Ukuba umntwana wakho unesifo se-sickle cell, zininzi izinto onokuzenza ukulawula imeko yakhe:

• Soloko usisa umntwana wakho kugqirha.
• Nika umntwana wakho zonke izitofu ezicetyiswayo ngexesha.
• Nceda umntwana wakho enze umthambo rhoqo kwaye atye ukutya okunempilo okunempilo .
• Xa kuvela ingxaki yeentlungu, nika umntwana wakho ulwelo oluninzi kunye neyeza elichasene nokuvuvukala elingeyo-steroidal (NSAID) . Ukuba iintlungu azinakulawuleka ekhaya, mse esibhedlele ukuze afumane amayeza anamandla okuthomalalisa iintlungu.

Kufuneka uye nini kwiYunithi yoNyango oluNgxamisekileyo (i-ETU) ?

Isifo seSickle cell sinokubangela iingxaki ezahlukeneyo ezisongela ubomi. Ukuba wena okanye umntwana wakho nifumana naziphi na kwezi mpawu zilandelayo, fowunela u-911 okanye uye kwigumbi likaxakeka elikufutshane (ER) ngoko nangoko:

• Intlungu ebuhlungu.
• Iimpawu ze-anemia enzima: ukudinwa kakhulu, isiyezi, kunye nokuphelelwa ngumphefumlo.
• Umkhuhlane ongaphezulu kwama-degrees Fahrenheit ayi-101.3 (38.5 degrees Celsius).
• Iingxaki zokubona.
• Ubunzima bokuphefumla.
• Ukuma kwepenisi okuhlala iiyure ezine nangaphezulu (priapism).
• Iimpawu zesifo sesifuba esibukhali: iintlungu zesifuba, ukukhwehlela, umkhuhlane.
• Iimpawu zestroke: Ubuthathaka ngequbuliso kwelinye icala lomzimba, ukuba ndindisholo, kunye nokulahlekelwa zingqondo.

Kutheni isifo se-sickle cell sibangela iintlungu?

Ngamafutshane, iiseli zegazi ezibomvu ezimile okwesikele zifana nonobumba u-C, okanye inyanga ecwebezelayo. Njengoko zihamba ngemithambo yegazi yakho, ziyabhajwa kwaye zivale ukuhamba kwegazi. Kulapho ke kuvela khona intlungu. Cinga ngayo njengengxinano yezithuthi endleleni.

Ngaba i-sickle cell sisifo sokuzikhusela komzimba?

Hayi. Nangona isifo se-sickle cell sineempawu ezithile zezifo ezibangelwa kukuzikhusela komzimba , oogqirha abasiboni isifo se-SCD njengesifo esibangelwa kukuzimela komzimba. Basibona isifo se-SCD njengesifo esibangelwa kukufuzo .

Isifo seSickle cell sisifo esihlala ubomi bonke. Ukufakelwa kwee-stem cell, okunokubonelela ngonyango olupheleleyo, akusoloko kusenzeka, kwaye kuyingozi. Nangona kunjalo, ukuxilongwa kwangoko kunye nonyango kunokunceda ukunciphisa iimpawu kunye nokunciphisa umngcipheko weengxaki. Ngonyango oluqhelekileyo, ungaphila ubomi obupheleleyo nobusebenzayo.

Okokugqibela, ezinye izinto ezibalulekileyo ekufuneka uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, ngoko ke sithethe kakhulu ngesifo se-sickle cell. Nazi izinto ezibalulekileyo ekufuneka uzikhumbule:

• Isifo seSickle cell (SCD) sisifo segazi esizuzwe njengelifa apho imo yeeseli ezibomvu zegazi itshintsha khona, nto leyo ebangela iingxaki ngokuhamba kwegazi.
• Isizathu esiphambili sale nto luhlobo olungaqhelekanga lwe-hemoglobin olubizwa ngokuba yi-hemoglobin S.
• Iintlungu, i-anemia, usulelo, kunye nokonakala kwamalungu omzimba ziqhelekile.
• Ukufunyanwa kwangoko kunye nonyango olufanelekileyo kubaluleke kakhulu. Iintsana ezisandul' ukuzalwa ziyahlolwa oku.
• Nangona ukufakelwa umongo wethambo kunokuba lunyango, alufanelekanga kuye wonke umntu. Kukho ezinye iindlela zonyango, ezifana namayeza kunye notofelo-gazi.
• Ungaphila kakuhle nesi sifo ngokwenza utshintsho kwindlela ophila ngayo, ulandele iingcebiso zonyango ezifanelekileyo, kwaye wenze ngokukhawuleza xa kukho imeko engxamisekileyo .

Ukuba wena okanye umntu omaziyo unemibuzo malunga nesifo se-sickle cell, qiniseka ukuba ubona ugqirha ukuze akunike ingcebiso. Akukho nto umele uyoyike okanye ube neentloni ngayo. Eyona nto ibalulekileyo kukwazi! Isifo se-sickle cell, i-hemoglobin, iiseli ezibomvu zegazi, i-anemia, izifo zemfuza, iingxaki zentlungu, unyango lwe-sickle cell