I-Acromegaly: Ngaba amalungu akho nobuso bakho bukhulu ngokungaqhelekanga? Masithethe!

Ngaba wakha waphawula ukuba imilo yeengalo zakho, imilenze, okanye ubuso bakho iyatshintsha? Mhlawumbi umsesane owunxibayo uhlala uvakala ngathi uqinile, okanye ubungakanani bezihlangu zakho butshintshile? Ezi ayizozinto nje ezingaqhelekanga, zinokuba ziimpawu zesifo esingaqhelekanga kodwa esinokuba yingozi esibizwa ngokuba yi-acromegaly . Ungakhathazeki, siza kuthetha ngale nto ngokweenkcukacha nangokulula namhlanje.

Yintoni i-Acromegaly? Ngamafutshane...

I-Acromegaly yimeko ebangelwa ngamanqanaba aphezulu ekhemikhali ebizwa ngokuba yiGrowth Hormone (GH) emzimbeni wakho. Ngokwesiqhelo, le hormone yokukhula (GH) iveliswa yi -pituitary gland , i-gland enobukhulu be-pea esezantsi kwengqondo yethu. Nangona kunjalo, kwi-acromegaly, le hormone iveliswa ngokugqithisileyo ngenxa yethumba kwi-pituitary gland okanye kwenye indawo emzimbeni.

Ubusazi na ukuba i-pituitary gland yi-gland encinci kodwa ebaluleke kakhulu. Ikhupha iihomoni ezisibhozo, enye yazo yi-growth hormone (GH).

Yintoni i-hormone yokukhula (GH) kuthi?

I-Growth Hormone, ekwaziwa ngokuba yi- Human Growth Hormone (hGH) okanye i-Somatotropin , yi-hormone yendalo. Ibalulekile ekukhuleni kwamalungu ahlukeneyo omzimba wethu nasekukhuleni ngexesha lobuntwana. Nangona kunjalo, njengoko sikhula, emva kokuba ii-epiphyses zamathambo ethu zivaliwe, imizimba yethu isafuna le GH. Uyazi ukuba kutheni? Inceda ukugcina ulwakhiwo olusempilweni lwamathambo ethu, i-cartilage, kunye nezitho zangaphakathi, kwaye inceda kwi-metabolism, ngakumbi ukugcina amanqanaba ethu eglucose egazini kumanqanaba afanelekileyo.

Ngoko ke, ukuba i-hormone yokukhula komzimba (GH) iyanda kakhulu emva kokuba umntu emdala, iingxaki ezinjengokukhubazeka kwamathambo, ukwanda kwamalungu omzimba, kunye nokunyuka kwamanqanaba eswekile egazini (i-hyperglycemia) zinokwenzeka.

Yintoni umahluko phakathi kwe-Acromegaly kunye ne-Gigantism?

Zombini zibangelwa kukwanda kwehomoni yokukhula (GH). Nangona kunjalo, umahluko ulele ekubeni le meko ichaphazela bani. Abantu abadala baba ne-acromegaly. Abantwana baba ne -gigantism .

Ukuba amanqanaba e-growth hormone (GH) ayanda ebantwaneni ngaphambi kokuba ii-growth plates emathanjeni abo zivale (oko kukuthi, ngaphambi kokuba bafikelele ebuntwini obutsha), baya kukhula babe bade ngendlela engaqhelekanga. Oku kubizwa ngokuba yi-gigantism. Kunqabile kune-acromegaly. Abanye oogqirha bakwabiza ngokuba yi-"pediatric acromegaly."

Nangona kunjalo, ukuba amanqanaba e-growth hormone (GH) yakho ayanda emva kokuba ii-growth plates zakho zivaliwe, awuyi kukhula ube mde. Nangona kunjalo, loo hormone igqithisileyo inokuchaphazela ukuma kwamathambo akho, ubungakanani bamalungu akho, kunye nezinye izinto zempilo. Loo meko ibizwa ngokuba yi-acromegaly.

Ngubani onokuthi abe ne-acromegaly?

Ingakhula nakweyiphi na iminyaka emva kokufikisa. Nangona kunjalo, oogqirha badla ngokuyixilonga kubantu abaphakathi kweminyaka engama-40 ukuya kwengama-50, oko kukuthi, abakwiminyaka ephakathi.

Kuqheleke kangakanani oku?

I-Acromegaly sisifo esingaqhelekanga . Bamalunga nama-31 kuphela kubantu abayi-100,000 abaye bafunyanwa benale sifo. Ngoko ke musa ukoyika ngokungeyomfuneko, kodwa kubalulekile ukuba uqaphele iimpawu.

I-acromegaly ichaphazela njani umzimba wam?

Xa umntu omdala efumana i-acromegaly, oko kukuthi, xa kukho ukwanda kwehomoni yokukhula (GH), amathambo, i-cartilage, amalungu omzimba, kunye nezinye izicubu ziqala ukukhula ngobukhulu. Kukho utshintsho olucacileyo kwinkangeleko . Umzekelo:

• Ukwandiswa kwezandla neenyawo.
• Ukwandiswa kweendlebe, imilebe, nempumlo.
• Umhlathi ophumileyo, ibunzi elikhulu.

I-hormone yokukhula (GH) inika isibindi sethu imiqondiso yokuba sivelise enye i-hormone ebizwa ngokuba yi -Insulin-like Growth Factor 1 (IGF-1) . Le hormone, ebizwa ngokuba yi-IGF-1, inceda amathambo ethu kunye nezicubu zomzimba zikhule, kwaye ikwachaphazela indlela umzimba wethu olawula ngayo iswekile yegazi (i-glucose) kunye namafutha (i-lipids). Ngoko ke, xa amanqanaba e-GH enyuka, amanqanaba e-IGF-1 nawo ayanda. Oku kunokukhokelela kwiimeko ezifana ne -Type 2 Diabetes , i-High Blood Pressure (i-Hypertension) , kunye ne-Heart Disease .

Khawucinge nje, njengempompo eshiywe ixesha elide ichitha amanzi, la mahormone, xa ephezulu kakhulu, anemiphumo eyahlukeneyo emzimbeni.

Zithini izizathu ze-acromegaly?

Eyona nto ixhaphakileyo ebangela i-acromegaly yi-tumor kwi-pituitary gland. Oku kubizwa ngokuba yi-pituitary adenoma . Le tumor ibangela ukuba i-pituitary gland ikhuphe i-growth hormone eninzi kakhulu (GH).

Okungakumbi malunga ne-Pituitary Adenoma...

Ezi adenomas zepituitary zihlala zingenabungozi. Oko kukuthi, azinazo umhlaza. Uninzi lweethumba ezibangela i-acromegaly zikhula kancinci kakhulu. Ngoko ke, usenokungaziboni naziphi na iimpawu zale GH igqithisileyo kangangeminyaka.

Ngokuxhomekeke kubukhulu nendawo ekuyo ithumba, linokucindezela kwezinye iindawo ze-pituitary gland kwaye lichaphazele nezinye iihomoni eziveliswa yi-pituitary gland. Ukuba ithumba likhulu, linokucindezela nakwiindawo ezikufutshane zobuchopho, nto leyo ebangela iintloko ezibuhlungu kunye neengxaki zokubona .

Zithini iimpawu ze-Acromegaly?

Xa umntu omdala efumana i-acromegaly, ichaphazela amathambo kunye nezicubu zomzimba, nto leyo ebangela ukuba akhule ngendlela engaqhelekanga. Oku kunokubangela ezi mpawu zilandelayo:

• Izandla okanye iinyawo ezikhulisiweyo: Mhlawumbi amaringi akho aqala ukuqina, kwaye ubungakanani bezihlangu zakho, ingakumbi ububanzi, buyanda.
• Utshintsho kwimilo yobuso: Ukuvela okanye ukwanda kwendawo yomhlathi kunye/okanye ibunzi.
• Ukwandiswa kwemilebe, impumlo, kunye/okanye ulwimi.
• Ukubila kakhulu okanye ulusu olunamafutha.
• Ukutshona kwelizwi nokutshona.

Ezinye iimpawu:

• Intloko ebuhlungu
• Intlungu yamalungu
• Utshintsho lombono
• Ukwanda kokubonakala kweethegi ezincinci zesikhumba
• Ubuthuntu ezandleni
• I-apnea yokulala (i-apnea yokulala)
• I-Carpal tunnel syndrome okanye iingxaki zomgogodla.

Iimpawu ze-Acromegaly zihlala zikhula kancinci , ngamanye amaxesha ngokuhamba kweminyaka. Ngoko ke kunokuba nzima ukuzibona ekuqaleni. Abanye abantu baqaphela kuphela ukuba izandla zabo zinkulu xa iringi abayinxibileyo iqina okanye ubungakanani bezihlangu zabo butshintsha.

Khawucinge nje, kukho umntu ogama linguNilanthi. Ebesoloko evakalelwa kukuba iringi yakhe yomtshato iqinile okwethutyana ngoku. Izihlangu zakhe azikaqini njengoko zazinjalo ngaphambili, ziqinile kancinci. Wayecinga ukuba usandula ukukhula. Kodwa kwangaxeshanye, abahlobo bakhe bathi ubuso bakhe bahlukile kancinci kunangaphambili, kwaye isilevu sakhe sikhulu kancinci. Ezi zizinto ezincinci eziqatshelwayo kuqala.

Ukuba unale mpawu, kubaluleke kakhulu ukuthetha nogqirha.

Ifunyanwa njani i-Acromegaly?

Ngenxa yokuba iimpawu zibonakala kancinci kakhulu, kwiminyaka emininzi, kunokuba nzima ukuzifumanisa.

Ugqirha wakho angakuthumela kwi -endocrinologist , ugqirha ogxile kwizifo ezinxulumene namahomoni. Uza kwenza uxilongo ngokusekelwe kwimbali yakho yezonyango, uvavanyo lweklinikhi, kunye novavanyo olukhethekileyo (olufana novavanyo lwegazi kunye novavanyo lwemifanekiso).

Zithini iimvavanyo zokuxilonga?

Ukuba ufunyaniswe une-acromegaly, ugqirha wakho unokuyalela uvavanyo olongezelelekileyo ukuze abone ukuba imeko ichaphazele amanye amalungu omzimba wakho na. Oku kungabandakanya:

• Uvavanyo lwe-echocardiogram ukujonga iingxaki zentliziyo.
• Uvavanyo lovavanyo lokulala ukuze kubonwe ukuba uyafuthaniseka na xa ulele.
• I-Colonoscopy ukujonga impilo ye-colon.
• Jonga impilo yamathambo nge-X-ray okanye i-DEXA scan .

Iphathwa njani i-Acromegaly?

Kukho iindlela ezahlukeneyo zonyango lwe-acromegaly. Ngokuxhomekeke kwiimpawu zakho kunye nemeko yakho, ugqirha wakho uya kucebisa unyango olulungele wena.

Iindlela zonyango ezisetyenziswa kakhulu zezi:

• Utyando
• Amayeza
• Unyango ngemitha

Utyando lwe-Acromegaly

Kwiimeko ezininzi, utyando lunokunciphisa kakhulu okanye lunyange ngokupheleleyo iimpawu ze-acromegaly. Oogqirha badla ngokusebenzisa indlela ebizwa ngokuba yi -transsphenoidal surgery , equka ukwenza utyando ngempumlo nange-sphenoid sinus (indawo engenanto emva kwemibhobho yempumlo, ngaphantsi kwengqondo).

Iinkcukacha zotyando zixhomekeke kubukhulu nendawo yethumba. Injongo ephambili yotyando kukususa ngokupheleleyo ithumba elibangela ukuveliswa kwehomoni yokukhula engaphezulu (GH). Ukuba ugqirha wotyando unako ukususa inxalenye enkulu yethumba, usenokungadingi naluphi na unyango olongezelelweyo. Nangona kunjalo, ukuba yinxalenye yethumba kuphela esusiweyo, unokufuna amayeza okanye unyango lwemitha ukulawula iimpawu kunye nokunciphisa ukuveliswa kwehomoni yokukhula (GH).

Amayeza e-Acromegaly

Ugqirha wakho unokukunika iyeza elinye okanye indibaniselwano yamayeza. La mayeza asebenza ngeendlela ezahlukeneyo ukulungisa amanqanaba e-hormone yokukhula (GH) emzimbeni wakho kunye nokunciphisa iimpawu. Kwezinye iimeko, amayeza anikwa de ithumba linciphe, ukuze ugqirha angayisusa ngokukhuselekileyo. Abanye abantu banokufuna ukuthatha amayeza ixesha elide ukulawula amanqanaba kunye neempawu ze-hormone yokukhula (GH).

Ngaba i-acromegaly inganyangeka ngokupheleleyo?

I-Acromegaly ngamanye amaxesha inokunyangeka, kodwa ayisoloko inyangeka. Xa ithumba le-pituitary elibangela i-acromegaly lisuswa ngotyando, izinga lokunyangwa limalunga ne-85% kwiithumba ezincinci . Kwizithumba ezinkulu, liphakathi kwe-40% kunye ne-50%.

Amayeza awanakunyanga ngokupheleleyo i-acromegaly, kodwa anokubonelela ngonyango olukhuselekileyo noluhlala ixesha elide .

Ngaba i-acromegaly ingathintelwa?

Ngelishwa, akukho nto unokuyenza ukuthintela i-acromegaly. Izazinzulu azikaqiniseki ukuba yintoni ebangela iithumba zepituitary ezibangela i-acromegaly. Nangona kunjalo, zikholelwa ukuba ezinye izinto zemfuza zinokudlala indima.

Ithini i-prognosis ye-acromegaly?

Imbono yoku ixhomekeke kubunzulu besifo kunye nendlela iimpawu ezilawulwa ngayo ngonyango. Abantu abaninzi babona ukwehla okukhulu kweempawu emva konyango.

Ukuba ayinyangwa, i-acromegaly inokutshintsha kakhulu inkangeleko yakho kunye nokuma kwamathambo akho. Ezi mpawu zinokuba nefuthe elikhulu ekuzithembeni kwakho kunye nomgangatho wobomi bakho. Amaqela enkxaso anceda abanye abantu ukuba bajongane nemingeni ye-acromegaly.

I-Acromegaly inokubangela iingxaki zempilo, ezifana nesifo sentliziyo okanye isifo seswekile sohlobo lwesibini, esinokunciphisa umgangatho wobomi kwaye sinciphise ixesha lokuphila. Ke ngoko, kubalulekile ukubona ugqirha ukuba uneempawu kwaye, ukuba ufunyenwe, ulandele isicwangciso sonyango ngokusondeleyo.

Zeziphi iingxaki ezinokwenzeka ukuba azinyangwa?

Ukuba ayinyangwa, i-acromegaly inokukhokelela kwiingxaki ezifana nezi:

• Uhlobo lwesibini lweswekile
• Uxinzelelo lwegazi oluphezulu (uxinzelelo lwegazi oluphezulu)
• Isifo sentliziyo
• Isifo semisipha yentliziyo (iCardiomyopathy)
• Isifo samathambo
• Iipolyps zekholoni - Ezi zinokuba ngumhlaza ukuba azinyangwa.
• Ukungasebenzi kakuhle kwamalungu omzimba

Ingakanani ixesha lokuphila komntu one-acromegaly?

Oku kuxhomekeke kubukhulu besifo kunye nokuba kukho ezinye iimeko zempilo, ezidla ngokubangelwa yi-acromegaly enganyangwanga.

Ukuba amanqanaba akho e-growth hormone (GH) akalawulwa ngokufanelekileyo kwaye unezinye izifo ezifana nesifo sentliziyo kunye nesifo seswekile, ubomi bakho bunokuncipha ngeminyaka eli-10.

Nangona kunjalo, ukuba une-acromegaly, unyangwa ngokufanelekileyo, kwaye une-hormone yokukhula eqhelekileyo (GH) kunye namanqanaba e-IGF-1, kusenokwenzeka ukuba uphile ubomi obuqhelekileyo.

Ndifanele ndimbone nini ugqirha malunga ne-acromegaly?

Ukuba uneempawu ze-acromegaly, kubaluleke kakhulu ukuthetha nogqirha.

Ukuba ufunyaniswe une-acromegaly, kuya kufuneka ubone ugqirha wakho rhoqo ukuqinisekisa ukuba unyango lwakho lusebenza kakuhle.

I-Acromegaly yimeko engaqhelekanga kodwa imbi kakhulu. Iindaba ezimnandi zezokuba inokunyangeka ngotyando, amayeza, kunye/okanye unyango lwe-radiation. Ukuba uqaphele ukuba izandla zakho, iinyawo, kunye/okanye iimpawu zobuso ziya zikhula, thetha nogqirha wakho. Angenza uvavanyo olulula ukuze abone ukuba amanqanaba akho e-growth hormone (GH) ayimbangela yeempawu zakho.

Okokugqibela, umyalezo oya ekhaya

• I-Acromegaly yimeko engaqhelekanga kubantu abadala ebangelwa kukwanda kwehomoni yokukhula (GH).
• Iimpawu zingabandakanya ukudumba kwamalungu nobuso, ukubila kakhulu, kunye nokutshintsha kwelizwi . Ezi zinto zinokubonakala kancinci, ngoko usenokungaziboni.
• Eyona nto ibangela oku sisimila, esidla ngokuba singesomhlaza, esikhula kwi-pituitary gland.
• Ukufunyanwa kwangoko kunye nonyango kunokuthintela iingxaki ezininzi kwaye kuphucule umgangatho wobomi.
• Ukuba unale mpawu, ungathandabuzi ukufuna ingcebiso kugqirha. Leyo yeyona nto ilungileyo onokuyenza.

Nceda ukhumbule, olu lwazi lujolise ekunikeni ulwazi kuphela. Alufanele lusetyenziswe endaweni yeengcebiso zonyango. Ukuba uneengxaki zempilo, nceda uqhagamshelane neengcali zonyango ezifanelekileyo.

I- Acromegaly, iHormone yoKhula, iGland yePituitary, iGigantism, i-IGF-1, iSifo seHormonal, i-Endocrine