Ngaba unesifo sesibindi esibizwa ngokuba yi-PBC, okanye i-Primary Biliary Cholangitis? Ukuba kunjalo, amayeza okuqala owawanikwa ngugqirha wakho asenokungasebenzi kakuhle njengoko ubulindele. Ungakhathazeki ngawo. Abantu abaninzi baye baba namava afanayo. Into ebalulekileyo kukuhlala unethemba kwaye uqaphele into onokuyenza ngokulandelayo. Namhlanje, masithethe ngento onokuyenza ngexesha elinje kunye nonyango olutsha olufumanekayo.
Okokuqala, yintoni i-PBC ngokulula?
I-PBC yimeko enzima, ehlala ixesha elide apho amasosha omzimba wethu ahlasela imibhobho yenyongo emincinci esibindini sethu. Cinga ngale mibhobho yenyongo njengemibhobho emincinci esibindini sethu. Umsebenzi wayo ophambili kukuthwala inyongo, ulwelo olunceda ekugayeni ukutya, iphume esibindini.
Ngoku, kwimeko ye-PBC, iiseli zethu zenkqubo yomzimba yokuzikhusela ziyazonakalisa ezi payipi. Emva koko ezi payipi ziyavalwa, kwaye i-bile ayihambi kakuhle kwaye ibambeke ngaphakathi kwesibindi. Kanye njengokuba iimoto zibambeka kwiindlela zokuhamba. Xa i-bile iqokelelana ngale ndlela, iqala ukonakalisa iiseli zesibindi. Ekuhambeni kwexesha, lo monakalo unokubangela amanxeba esibindi. Siwubiza ngokuba yi- fibrosis . Xa le meko iba mandundu, inokukhokelela kumngcipheko we-cirrhosis, imeko ebizwa ngokuba kukusilela kwesibindi.
Oku kwahlukile kancinci kwezinye izifo ezibangelwa kukuzikhusela komzimba. Kuba i-PBC ayiphenduli kakuhle kumayeza athintela inkqubo yomzimba yokuzikhusela asetyenziswa kwezinye izifo ezibangelwa kukuzimela komzimba. Esinye isizathu sisenokuba kukuba isibindi sele sonakele ngandlela ithile ngexesha isifo sifunyanwa ngalo. Kodwa ungakhathazeki, ngokuhambela phambili kwesayensi, ngoku kukho unyango olufanelekileyo loku.
Inyathelo lokuqala kunyango: amayeza e-UDCA
Kukho iinjongo eziphambili ezininzi ekunyangeni i-PBC: ukunciphisa ukuqhubela phambili kwesi sifo, ukulawula iimpawu, kunye nokuthintela iingxaki ezibangelwa kukonakala kwesibindi.
Wakuba ufunyenwe une-PBC, iyeza lokuqala ugqirha wakho aza kukuqalisa ngalo yi -Ursodeoxycholic acid , okanye i-UDCA ngamafutshane. Usenokuba uyazi ngegama elithi Ursodiol. Eli yeza lisebenza ngokunceda isibindi sikhuphe inyongo ebambeke esibindini kwaye linciphise ukwakheka kwamanxeba (fibrosis) esibindini. Oku kubalulekile, kuba amanxeba yinto enokubangela ukuba isibindi siqine kwaye singaphumeleli.
Kodwa inyani yile, i-UDCA ayisebenzi kuwo wonke umntu. Le yeyona ngongoma sithetha ngayo namhlanje.
Kutheni i-UDCA yodwa inganelanga?
Uphando lufumanise ukuba phakathi kwama-25% nama-50% ezigulana ezisebenzisa i-UDCA azifumani ziphumo zilindelekileyo kwiyeza. Oku kuthetha ukuba uvavanyo lwabo lokusebenza kwesibindi alubonisi phuculo lubalulekileyo.
Ngale ndlela, umntu ongasabeli kakuhle kwi-UDCA unobungozi obuphindwe kahlanu bokuqalwa yi-cirrhosis. Kwaye umngcipheko wokufa ngenxa yesi sifo uphindwe kathathu . Ngoko ke ukuba i-UDCA ayisebenzi, kubalulekile ukuthetha nogqirha wakho ngamanyathelo alandelayo, kunokuqhubeka nje uyisebenzisa.
Ngaba uyazibuza ukuba kutheni i-UDCA ingasebenzi kakuhle? Kunokubakho izizathu ezininzi zoko.
| Izizathu zokungaphumeleli konyango lwe-UDCA | Ingcaciso elula |
|---|---|
| Sele ndinezibazi zesibindi (i-cirrhosis) | Ukuba isibindi sele sonakele ngandlela ithile xa sifunyaniswa ukuba sinesifo, kunokuba nzima ukusilawula nge-UDCA yodwa. |
| Amanqanaba aphezulu e-GGT | Ukuba uvavanyo lwakho lwegazi lubonisa amanqanaba aphezulu kakhulu e-enzyme yesibindi ebizwa ngokuba yi-gamma-glutamyl transferase (GGT) xa ufunyaniswa ukuba unesifo okokuqala, oko kungaba sisizathu sokuba impendulo yakho kunyango inciphe. |
| Umzimba awukwazi ukunyamezela iyeza. | Imizimba yabanye abantu ayinakukwazi ukuyinyamezela i-UDCA, oko kuthetha ukuba abanakukwazi ukusela amayeza ngokwedosi emiselweyo ngenxa yeziphumo ebezingalindelekanga. |
Ukuba unesinye okanye ngaphezulu kwezi zizathu, lixesha lokuba ucinge ngonyango lwesibini . Injongo apha ayikokuphucula nje iziphumo zovavanyo lwakho lwegazi. Kubalulekile nokulawula iimpawu ezichaphazela umgangatho wobomi bakho, ezinje ngokurhawuzelela okunganyamezelekiyo, ukudinwa kakhulu, kunye nokungalali . Kuba i-UDCA ayiniki ncedo kangako kwezi mpawu.
Unyango lodidi lwesibini: Zeziphi ezi ndlela zintsha?
Iindlela zonyango lwe-PBC zitshintsha ngokukhawuleza. Amayeza amatsha amaninzi akwinqanaba lokugqibela lokuvunywa. Makhe sijonge unyango lwangoku noluzayo.
I-Obeticholic acid (OCA)
Ukuba i-UDCA ayisebenzi kakuhle, okanye ukuba awukwazi ukuyinyamezela i-UDCA, iyeza elilandelayo eliphambili ugqirha wakho aza kulisebenzisa yi -obeticholic acid , okanye i-OCA . Idla ngokuba phantsi kwegama lophawu lwe-Ocaliva.
Ngamanye amaxesha i-OCA inokunikwa kunye ne-UDCA. Oko kukuthi, omabini la mayeza asetyenziswa kunye. I-OCA ikwiqela lamayeza abizwa ngokuba yi-farnesoid X receptor agonists . Ngamazwi alula, isenzo sayo kukuba,
1. Yehlisa ubungakanani benyongo eveliswa sisibindi.
2. Inceda ekukhupheni inyongo esibindini.
Ngale ndlela, xa i-OCA isetyenziswa yodwa okanye kunye ne-UDCA, ukusebenza kwesibindi kuyaphucuka kwaye izinga lokuqhekeka kwesibindi liyancipha.
Kodwa enye yeziphumo ebezingalindelekanga ze-OCA kukuba inokunyusa ukurhawuzelela kwizigulane ezine-PBC. Ke ngoko, ukuba ukurhawuzelela kuyanda emva kokuqalisa eli yeza, ngokuqinisekileyo kufuneka uxelele ugqirha wakho ngalo mba. Emva koko unokutshintsha idosi okanye akunike unyango olwahlukileyo.
Icandelo lonyango lwe-PBC lihlala litshintsha, ngoko ke kubalulekile ukuba impilo yakho ihlale inxibelelana nogqirha wakho kwaye ixoxe ngonyango olutsha.
Umyalezo Wokuya Ekhaya
- I-PBC sisifo sesibindi esihlala ixesha elide esifuna unyango. Musa ukusityeshela.
- I-UDCA liyeza elibaluleke kakhulu kudidi lokuqala loku, kodwa lisenokungabi naziphumo ezifanayo kuye wonke umntu.
- Ukuba awufumani ziphumo zilungileyo kwi-UDCA okanye awukwazi ukunyamezela iziphumo ebezingalindelekanga, ayikokuphela konyango. Ngoku kukho unyango olusebenzayo lodidi lwesibini, olufana ne-OCA.
- Musa ukwenza izigqibo zonyango wedwa. Soloko uthetha ngokukhululekileyo nogqirha wakho malunga nonyango lwakho, uvavanyo lwegazi, kunye neempawu.
- Ukufumana uhlolo lwezonyango kunye novavanyo lwegazi (ingakumbi uvavanyo lokusebenza kwesibindi) ngexesha elifanelekileyo kubalulekile ekulawuleni esi sifo.
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