Ngaba ubusoloko unengxaki yamalungu okanye imeko yamathumbu avuvukalayo ixesha elide? Ngaba ukhe waphawula iimpawu ezintsha ezifana nemilenze evuvukileyo okanye umchamo onamagwebu? Le isenokuba yimeko entsha enxulumene nemeko yakho yakudala. Namhlanje sithetha ngemeko engaqhelekanga kodwa ebalulekileyo ekufuneka uyiqaphele. Yi-AA Amyloidosis.
Yintoni i-AA Amyloidosis?
Ngamafutshane, esi sisifo esingaqhelekanga esichaphazela iiproteni emizimbeni yethu. Sesinye seentlobo ze-amyloidosis, iqela elikhulu lezifo.
Cinga ngeeproteni emizimbeni yethu njengempahla egoqwe kakuhle. Zinemilo ethile kunye nomsebenzi othile. Kodwa kwesi sifo, ulwakhiwo lwe-3D lweeproteni ezithile luyaphazamiseka, kwaye ziyabhityaniswa kwaye zibhityaniswe njengeebhola zentambo. Kufana nesiqwenga sempahla esiqhekekileyo saba yingxubakaxaka saza saphoswa ecaleni. Ezi ziqu zeproteni ezingalungelelananga, esizibiza ngokuba yi-amyloid deposits , ziqala ukuqokelelana kwizitho zethu zomzimba, ngakumbi kwiindawo ezifana nezintso nesibindi.
Oku kukwabizwa ngokuba yi-'secondary amyloidosis'. Isizathu soku kukuba asisosifo esizenzekela ngokwaso. Sivela njengesiphumo esibi okanye ingxaki yesinye isifo sokuvuvukala esihlala ixesha elide emzimbeni. Xa kukho ukudumba emzimbeni wethu ixesha elide, inqanaba leproteni ebizwa ngokuba yi-'serum A protein' liyakhula egazini. Eli nqanaba liphezulu yilo libangela i-AA amyloidosis.
Le meko ichaphazela njani umzimba wam?
I-AA amyloidosis inokonakalisa amalungu abalulekileyo amaninzi emzimbeni wakho.
- Izintso: Izintso zezona zonakala kakhulu kwaye zidla ngokonakala sesi sifo.
- Isibindi
- Ispleen
- Isisu namathumbu
- Intliziyo: Intliziyo ayichaphazeleki rhoqo.
Ukongeza ekonakalisa la malungu omzimba, le meko inokubangela ukwanda kweproteni kumchamo wakho kunye notshintsho kumanqanaba e-cholesterol egazini.
Esi sifo singabulala ukuba asinyangwa. Eyona nto ingcono kukuba xa isifo esibangela esi sifo sinyangwa, imeko ye-AA amyloidosis nayo inokulawulwa.
Yintoni ebangela i-AA amyloidosis?
Njengoko besitshilo ngaphambili, esona sizathu siphambili soku kukudumba okungapheliyo emzimbeni ixesha elide. Ukuphendula oku kudumba, isibindi sethu sivelisa iproteni ekhethekileyo eninzi ebizwa ngokuba yi-'serum A protein'. Ngokwesiqhelo, le protein iyasetyenziswa ize iphele. Nangona kunjalo, xa kukho ukudumba okuqhubekayo, ezi proteni ziyaqokelelana kakhulu, zitshintshe imo yazo, kwaye, njengoko bekutshiwo ngaphambili, ziqala ukuhlangana kunye kwaye zihlale kwizitho zomzimba.
Kukho iimeko ezininzi zempilo ezinokubangela ukudumba ixesha elide ngale ndlela.
| Udidi lwezifo | Imizekelo |
|---|---|
| Izifo Ezingapheliyo | Usulelo lweentsholongwane oluhlala ixesha elide olufana namanxeba angapholiyo ixesha elide, isifo sephepha. |
| Izifo zeRheumatic | Isifo samathambo esibizwa ngokuba yi-rheumatoid arthritis, i-Ankylosing Spondylitis. |
| Izifo Zamathumbu Ezivuthayo | Isifo sikaCrohn, iUlcerative Colitis. |
| Ezinye iintlobo zomhlaza | Ezinye iintlobo zomhlaza ezinxulumene negazi. |
| Iimeko Ezizuzwe Njengelifa | Iimeko ezidluliselwa kwilifa ezibangela umkhuhlane ngamanye amaxesha, njengeFamilial Mediterranean Fever. |
Zithini iimpawu zesi sifo?
Iimpawu zesi sifo zidla ngokuxhomekeka kwilungu elichaphazelekileyo. Ekubeni izintso zixhaphake kakhulu, iimpawu ezinxulumene noko zixhaphake kakhulu.
| Uphawu | Ingcaciso elula |
|---|---|
| Ukudumba kwemilenze okanye amaqatha | Oku kulandelayo kunokwenzeka ngenxa yokuqokelelwa kolwelo emzimbeni ngenxa yokusebenza kakubi kwezintso. |
| Umchamo onegwebu okanye onamagwebu | Umchamo unokuba namagwebu afana namanzi anesepha njengoko izintso zikhupha iiproteni. Olu luphawu olubaluleke kakhulu . |
| Ukuphuma komchamo okuncinci kunesiqhelo | Inokuba luphawu lwesifo sezintso esingapheliyo. |
| Urhudo olungapheliyo | Ii-Amyloid deposits emathunjini zinokuphazamisa ukufunxwa kokutya. |
| Isibindi okanye izintso ezikhulisiweyo | Oku kunokubonwa ngexesha lovavanyo lwezonyango. |
| Uxinzelelo lwegazi oluphantsi | Usenokubakho isiyezi, ingakumbi xa umile. |
| Isicaphucaphu nokuhlanza | Oku kunokwenzeka xa inkqubo yokugaya ukutya ichaphazeleka. |
Ugqirha uyifumana njani le nto?
Ukuba ugqirha wakho urhanela esi sifo ngokusekelwe kwiimpawu zakho, eyona ndlela iphambili yokuqinisekisa ukuba sikhona kukwenza i-biopsy. Oku kuthetha ukuthatha iqhekeza elincinci lesicwili uze ulihlole phantsi kwe-microscope.
I-biopsy yamafutha esiswini
Olu luvavanyo olulula kakhulu. Kuthathwa iqhekeza elincinci kakhulu lomaleko wamafutha phantsi kwesikhumba sesisu sakho lize lihlolwe. Kwiimeko ezininzi, olu vavanyo lunokuxilonga isifo.
i-biopsy yomzimba
Ngamanye amaxesha, kuyimfuneko ukuthatha iqhekeza elincinci lesicubu kwisitho esirhanelwa ukuba sonakele (umzekelo, izintso) uze usivavanye.
Kunye nezi mvavanyo, oogqirha bajonga nezinye iintlobo ze-amyloidosis, ezifana ne-AL amyloidosis, eneempawu ezifanayo kodwa inzima kancinci.
Zithini iindlela zonyango zoku?
Eyona nto ibalulekileyo koku kunyango lwesifo esibangele i-AA amyloidosis, endaweni yokusinyanga ngokuthe ngqo.
Khawuthelekelele ukuba une-rheumatoid arthritis. Emva koko oogqirha baya kukunika amayeza okulawula i-rheumatoid arthritis yakho kangangoko banako. Emva koko ukudumba emzimbeni kuya kuncipha. Xa ukudumba kuncipha, ukuveliswa kwe-'serum A protein' ekhathazayo kuya kuncipha. Emva koko ii-amyloid deposits ezintsha ziya kuyeka, kwaye iimpawu ziya kuqala ukuncipha kancinci kancinci.
Oko kuthetha ukuba ukunyanga isifo esisisiseko lolona nyango luphambili lwe-AA amyloidosis.
Ukongeza, uphando luyaqhubeka ngamayeza amatsha anokususa iidipozithi ze-amyloid esele zenziwe.
Ngaba esi sifo sinokunyangeka ngokupheleleyo?
Ewe, esi sifo sinokulawulwa kwaye siguqulwe. Kodwa kuxhomekeke ngokupheleleyo ekubeni silawulwa njani isifo esibangela ukudumba esisibangeleyo.
Eyona nto ibalulekileyo kukufumanisa isifo ngokukhawuleza kwaye uqale ukunyanga unobangela oyintloko. Oku kuya kunceda ukulawula umonakalo kwizitho zomzimba kunye nokuthintela umonakalo ongakumbi.
Ndingazinyamekela njani?
Ukuba une-AA amyloidosis, eyona nto ingcono onokuyenza kukusebenzisana nogqirha wakho ukuze ufumane unyango lwesi sifo.
- Buza ugqirha wakho ngononophelo ukuze afumanise ukuba isifo sakho sokuqala sichaphazele njani oku, loluphi unyango olunikwayo ngenxa yaso, kunye nendlela yokulandela olo nyango ngokuchanekileyo.
- Ukongeza kwisifo sakho sakudalaUkuba ubonakalisa iimpawu ezintsha (ezifana nemilenze evuvukileyo, umchamo onamagwebu), musa ukuzityeshela ngokungathi zizinto ezincinci. Xelela ugqirha wakho ngazo ngoko nangoko.
I-AA amyloidosis yingxaki engaqhelekanga kodwa enzima yesifo esiqhelekileyo. Ngethamsanqa, inokulawulwa ngokunyanga isifo esisisiseko. Ngoko ke, qaphela naluphi na utshintsho emzimbeni wakho. Thetha nogqirha wakho malunga nazo naziphi na iimpawu ezintsha. Uya kukwazi ukukunika isikhokelo osidingayo.
Umyalezo Wokuya Ekhaya
- I-AA Amyloidosis ayisosifo esizenzekela ngokwaso. Yingxaki yesinye isifo esingapheliyo sokuvuvukala, njenge-rheumatoid arthritis.
- Oku kubangelwa ziiproteni emzimbeni ezihlangana ngokungacwangciswanga kwaye zibekwe ikakhulu kwizitho ezifana nezintso.
- Ukuba unesifo esinganyangekiyo, musa ukuzityeshela iimpawu ezifana nokudumba kwemilenze kunye nokuvela kwamagwebu amaninzi kumchamo wakho.
- Unyango oluphambili lwale nto kukulawula isifo esibangele oku .
- Ukufunyanwa kwangoko kunye nokuqhubeka nonyango lwemeko engundoqo kunokukhokelela kwiziphumo ezilungileyo kakhulu. Thetha nogqirha wakho malunga nazo naziphi na iimpawu ezintsha.
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