Ngaba wakha waziva ngathi umphimbo wakho uyavaleka kwaye unengxaki yokuginya ukutya? Mhlawumbi wena okanye umntu omaziyo unesifo esibizwa ngokuba yi-Eosinophilic Esophagitis. Isenokuba ligama elide, kodwa linokuba nefuthe elikhulu kubomi bakho bemihla ngemihla. Kodwa kukho iindaba ezimnandi! I-Dupixent lelona yeza litsha livunyiweyo ukunyanga esi sifo. Makhe sithethe ngayo ngokulula nangokucacileyo namhlanje.
Ngamafutshane, yintoni i-Eosinophilic Esophagitis?
Le yimeko engapheliyo echaphazela amajoni ethu omzimba. Cinga ngayo, kukho iintlobo ezahlukeneyo zeeseli emzimbeni wethu ezisikhusela kwizifo, akunjalo? Olunye uhlobo olunjalo lweeseli ezimhlophe zegazi lubizwa ngokuba yi-eosinophil . Nangona zihlala zisinceda, kumntu one-Eosinophilic Esophagitis, ezi seli ziqokelelana kakhulu kwaye zibangele ukudumba kwi -esophagus , ityhubhu esiginya ngayo ukutya.
Oku kuvutha kubangela ukuba umphimbo udumbe kwaye unciphe. Kwenzeka ntoni ke emva koko? Kuba nzima ukuba ukutya kudlulele esiswini. Oku...
- Kuba nzima ukuginya ukutya.
- Ukutya kunamathela emqaleni.
- Intlungu okanye ukutsha esifubeni kunokubakho.
- Kusenokubakho ukugabha.
Le meko idla ngokunxulunyaniswa nokunganyamezelani nokutya okuthile.
Isebenza njani iDupixent kwesi sifo?
Ngokwesiqhelo, oogqirha baqala ngokunika amayeza anciphisa i-asidi yesisu (Proton Pump Inhibitors). Umzekelo, usenokuba ukhe weva ngamayeza anje nge-"omeprazole" kunye ne-"lansoprazole". Ngamanye amaxesha, banika nee-steroids (corticosteroids) ukunciphisa ukudumba.
Kodwa iDupixent isebenza ngendlela eyahlukileyo ngokupheleleyo.
I-Dupixent sisitofu sokugonya esichaphazela ngqo inkqubo yethu yomzimba yokuzikhusela kwaye silawula ukudumba okubangela esi sifo.
Isithako esisebenzayo kwiDupixent yidupilumab . Ngamafutshane, isebenza ngokuthintela umsebenzi weeproteni ezimbini ezibizwa ngokuba yi-interleukin-4 kunye ne -interleukin-13, eziyimiqondiso evela kwinkqubo yethu yokuzikhusela komzimba ebangela ukudumba. Xa ezi mpawu zivaliwe, inani lee-eosinophils eziqokelelana kwi-esophagus liyancipha, nto leyo enciphisa ukudumba kunye nokudumba. Oku kunciphisa nobunzima bokuginya.
Yintoni etyhilwe luphando ngale ziyobisi?
Kuye kwenziwa izifundo ezimbini ezinkulu zeklinikhi ukuze kubonwe ukuba eli yeza lisebenza kwaye likhuselekile kangakanani. Bonke abathathi-nxaxheba kwezi zifundo ngabantu ababekhe basebenzisa i-proton pump inhibitor kangangeenyanga ezimbini kodwa iimpawu zabo azizange ziphucuke.
- Uphononongo lokuqala: Abathathi-nxaxheba babeneminyaka eli-12 nangaphezulu.
- Uphando lwesibini: Abantwana abancinci abaphakathi kweminyaka eli-1 ukuya kweli-11 ubudala bathathe inxaxheba.
Kwezi zifundo, elinye iqela lanikwa i-Dupixent vaccine. Elinye iqela lanikwa i-placebo. Oku sikubiza ngokuba yi-placebo . Kodwa akukho mntu waxelelwayo ukuba ufumana iyeza lokwenyani okanye i-placebo.
Zinjani iziphumo?
Ukujonga emva emva kweenyanga ezi-4-6, iziphumo ziyakhuthaza ngokwenene.
1. Inani le-Eosinophils: Ngaphezulu kwama-60% abo bathatha i-Dupixent baye banciphisa kakhulu inani leeseli ze-eosinophil kwi-esophagus yabo, nto leyo eyafikelela ekuxolelweni. Oku bekunjalo malunga ne-5% kuphela yabo bathatha i-placebo.
2. Ubunzima bokuginya: Kuphononongo lwabantu abaneminyaka engaphezulu kwe-12 ubudala, abo bathathe iDupixent babenobunzima obuncinci bokuginya kunabo bathathe i-placebo.
Ndingayisebenzisa njani le yeza?
I-Dupixent lulwelo. Inikwa njengenaliti engaphantsi kwesikhumba . Ugqirha wakho uya kugqiba ukuba uza kuyinika kanye ngeveki okanye qho emva kweeveki ezimbini, kuxhomekeke kwiminyaka yakho nobunzima bakho. Idla ngokunikezelwa ethangeni, esiswini, okanye engalweni engentla.
Eli yeza liza ngeendlela ezimbini:
- Ipeni ezaliswe kwangaphambili: Kulula kakhulu ukuyisebenzisa. Akunyanzelekanga ukuba ukhathazeke ngesirinji.
- Isirinji ezaliswe kwangaphambili: Le idla ngokusetyenziswa kubantwana abancinci.
Eyona nto ibalulekileyo kukuba ngaphambi kokuba uyisebenzise okokuqala, ugqirha wakho okanye umongikazi oqeqeshiweyo uza kukubonisa indlela yokuyijova. Kubaluleke kakhulu nokufunda nokuqonda incwadana yemiyalelo eza neyeza.
Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?
Njengayo nayiphi na imithi, iDupixent inokubangela iziphumo ebezingalindelekanga ezincinci. Kodwa ungakhathazeki, uninzi lwazo ziyalawuleka.
| Iziphumo ebezingalindelekanga eziqhelekileyo | Indlela yokulawula |
|---|---|
| Iimpendulo zesikhumba kwindawo yokutofa(Ububomvu, iintlungu, ukudumba, ukukrweleka) | Eyona ndlela ilungileyo yokwenza oku kukujikeleza iindawo zokujova . Umzekelo, ukuba ujova ethangeni lakho lasekunene kube kanye, faka ethangeni lakho lasekhohlo kwixesha elizayo. Kuphephe ukujova kwiindawo ezonakeleyo, ezikruqukileyo, okanye ezibuhlungu. |
| Usulelo lwendlela yokuphefumla (umkhuhlane, umphimbo obuhlungu) | Landela iindlela ezilungileyo zokuzikhusela kwiintsholongwane. Hlamba izandla zakho rhoqo. Hlala kude nabantu abagulayo. Fumana inaliti yakho yonyaka yomkhuhlane ngokukhawuleza. |
Ezi zezona ziphumo ziphambili ezinokubonwa. Kodwa ukuba uziva into eyahlukileyo okanye ungonwabanga, qiniseka ukuba uxelele ugqirha wakho .
Ngaba kukho iingxaki ngamanye amayeza?
Ewe, ngoko ke le nto ibaluleke kakhulu.
- Xelela ugqirha wakho ngawo onke amayeza owasebenzisayo: Ngaphambi kokuba uqale iDupixent, kufuneka uxelele ugqirha wakho ngawo onke amayeza owasebenzisayo (kuquka iivithamini, amayeza ezityalo, kunye nezongezo). Oku kubaluleke kakhulu ukuba usebenzisa amayeza e-asthma.
- Lumka ngemigonyo: Ezinye imigonyo ephilayo azikhuthazwa xa usebenzisa eli yeza. Ngoko ke ukuba uza kufumana umgonyo, thetha nogqirha wakho ngayo ngaphambi kokuba uqale ukusebenzisa eli yeza.
Ungaze uyeke ukuthatha amayeza ngaphandle kokubonisana nogqirha wakho , kuba iimpawu zisenokuphinda zibe mbi ngakumbi.
Umyalezo Wokuya Ekhaya
- I-Eosinophilic Esophagitis yimeko ehlala ixesha elide enxulumene nenkqubo yomzimba yokuzikhusela ebangela ubunzima bokuginya.
- I-Dupixent yinaliti entsha engaphantsi kwesikhumba evunyiweyo ukunyanga esi sifo.
- Oku kuthintela iimpawu zomzimba ezibangela ukudumba, okubangela isifo, kwaye kulawula iimpawu.
- Iziphumo ezincinci ezinje ngokuba bomvu kunye nokudumba kwindawo efakwe kuyo inaliti zinokubakho, kodwa zinokulawulwa.
- Kubalulekile ukwazisa ugqirha wakho malunga nazo zonke ezinye iziyobisi ozithathayo kunye naluphi na ugonyo ocwangciselwe ukulufumana.
- Ungaze uyeke unyango okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha.
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