Ngaba wena okanye umntu ohlala kusapho lwakho, ingakumbi umntwana, uneentlungu zesisu rhoqo? Ngaba wakha waphawula igazi elincinci esitulweni sakho? Okanye uzive udiniwe kwaye udiniwe? Sihlala sizithatha ezi mpawu njengentlungu yesisu okanye ukunganyamezelani nokutya. Nangona kunjalo, ngamanye amaxesha ezi mpawu zinokubangelwa yimeko esingazivanga kangako ngayo, kodwa ngokuqinisekileyo kufuneka siyiqaphele. Namhlanje siza kuthetha ngenye yeemeko ezinjalo, iJuvenile Polyposis Syndrome (JPS).
Yintoni kanye kanye iJPS?
Ngamafutshane, iJuvenile Polyposis Syndrome (JPS) yimeko yemfuza apho ukukhula okungaqhelekanga kwakheka khona eludongeni lwangaphakathi lwenkqubo yethu yokugaya ukutya (isisu - indlela ye-GI). Ngokwezonyango sibiza oku kukhula ngokuthi zii-polyps . Khawucinge ngeqhubu elincinci elifana nediliya elixhonywe kwisiqu ngaphakathi kwamathumbu ethu. Le yindlela ezi polyps ezenzeka ngayo.
Ezi polyps zinokwakheka naphi na kwinkqubo yethu yokugaya ukutya.
- Isisu
- Emathunjini amancinci
- Kwithumbu elikhulu (ikholoni)
- Ingxolo
Kodwa zifumaneka kakhulu emathunjini amakhulu nakwi-rectum. Umntu one-JPS unokuba namaqela ambalwa ukuya kwamakhulu ezi polyps.
Ngoku ungacinga ukuba kuba inegama elithi "ubutsha" kuyo, esi sisifo esichaphazela abantwana abancinci kuphela. Akunjalo ngokwenene. Igama elithi "ubutsha" apha alibhekiseli kwiminyaka esi sifo sikhula ngayo. Libhekisa kuhlobo lweeseli ezibonwayo xa i-polyp ithathwa kwaye ihlolwa phantsi kwe-microscope. Nangona kunjalo, uninzi lwexesha, iimpawu zesi sifo ziqala ukubonakala ebuntwaneni okanye ebusheni , ngesiqhelo ngaphambi kweminyaka engama-20.
Ngaba kukho iintlobo eziphambili zeJPS?
Ewe, i-JPS inokwahlulwa ibe ziintlobo ezintathu eziphambili. Olu hlulo lusekelwe kubungakanani bee-polyps ezakhayo kunye nendawo ezikuyo.
| Uhlobo lweJPS | Ingcaciso elula |
|---|---|
| Ulutsha olunepolyposis yobuntwana (JPI) | Olu lolona hlobo lwe-JPS lunzima kwaye lunzima. Luvela kwiintsana nakubantwana abancinci. Iimpawu zinokubonakala ngokukhawuleza kakhulu. |
| Iipolyposis zolutsha eziqhelekileyo | Olu lolona hlobo luqhelekileyo lwe-JPS. Iipolyps zinokukhula naphi na kwindlela yokugaya ukutya, kuquka isisu, amathumbu amancinci, kunye namathumbu amakhulu. |
| I-polyposis coli yabantwana abancinci | Kolu hlobo, iipolyps zenzeka kuphela kumathumbu amakhulu. Oku kuncinci kancinci xa kuthelekiswa nezinye iintlobo ezimbini. |
Ngubani ofumana le meko? Ingaba yimfuza?
I-JPS ibangelwa kukuguquka kwezakhi zofuzo, ngoko ke nabani na angayihlakulela. Yimeko engaqhelekanga kakhulu. Kwihlabathi liphela, ukwenzeka kwayo kumalunga ne -1 kwi-1000 lamawaka .
Ewe, esi sifo sinokufunyanwa njengelifa . I-JPS yinto esiyibiza ngokwezonyango ngokuba yimeko "elawulayo ye-autosomal". Oku kuthetha ukuba nokuba umntwana ufumana ikopi enye yejini eguquliweyo yesi sifo kumama okanye kutata, kwanele ukuba umntwana afumane esi sifo.
- Malunga nama-75% ezigulane ze-JPS zizuza esi sifo kubazali bazo.
- Kwi- 25% eseleyo yamatyala, esi sifo sinokubangelwa kukuguquka okuzenzekelayo emzimbeni womntwana, nangona abazali bengenalo olu tshintsho lwezakhi zofuzo.
Zithini iimpawu ze-JPS?
Uphawu oluphambili lwesi sifo kukwakheka kwee-polyps, ebesithethe ngazo ngaphambili, emathunjini. Ekubeni ezi zidalwa ngaphakathi emzimbeni, asinakuzibona ngaphandle. Kwiimeko ezininzi, ii-polyps zisenokungabonakalisi zimpawu de zibe nkulu kancinci okanye inani lazo linyuke. Kodwa xa iimpawu ziqala ukubonakala, zinokubonakala ngolu hlobo.
| Uphawu | Inkcazo |
|---|---|
| Ukopha emqolo | Olu lolona phawu luqhelekileyo nolokuqala ukubonakala. Usenokubona igazi elibomvu elikhanyayo kwindle yakho. |
| Intlungu yesisu okanye isisu | Usenokuba nentlungu engaqhelekanga efana nentlungu esiswini sakho. |
| Urhudo | Urhudo oluhlala ixesha elide lunokwenzeka. |
| Ukuqhinwa | Abanye abantu banokuba nokuqunjelwa endaweni yorhudo. |
| I-anemia | Njengoko igazi liqhubeka lihamba, ubungakanani begazi emzimbeni bunokuncipha, nto leyo ekhokelela kwi-anemia. Oku kunokubangela ukuba uzive udiniwe, uphaphathekile, kwaye ubuthathaka ngalo lonke ixesha. |
| Ukuhla ukusinda | Ukuba uqhubeka nokunciphisa umzimba ngaphandle kwesizathu, oko kungaba luphawu. |
Ezinye iimpawu ezinokubonwa ekuzalweni
Malunga ne-15% yezigulana ze-JPS zinezinye iziphene zomzimba ekuzalweni ukongeza kwi-intestinal polyps.
- Umlomo oqhekekileyo kunye nenkalakahla
- Ukuba neminwe okanye iinzwane ezingaphezulu (i-Polydactyly)
- Ukuphazamiseka kophuhliso lwengqondo, intliziyo, okanye inkqubo yomchamo
- Ukujija amathumbu (iMalrotation)
Ngaba kukho unxibelelwano phakathi kweJPS kunye nomngcipheko womhlaza?
Le yeyona nto ibalulekileyo ekufuneka uyazi ngesi sifo. Iipolyps ezikhula ngenxa ye-JPS azinazo umhlaza ekuqaleni (ezingenobungozi). Zii-tumor eziqhelekileyo. Nangona kunjalo, ngokuhamba kwexesha, kukho umngcipheko omkhulu wokuba ezi polyps ziguquke zibe ngumhlaza.
Umntu one-JPS usengozini yobomi bakhe bonke yokuba nomhlaza wenkqubo yokugaya ukutya ophakathi kwe-30% kunye ne-50%.
Ngoko ke, umntu one-JPS usengozini enkulu yokuphuhlisa ezi ntlobo zilandelayo zomhlaza:
- Umhlaza weColoral
- Umhlaza wesisu
- Umhlaza wamathumbu amancinci
- Umhlaza wePancreatic
Musa ukoyika oku. Oku akuthethi ukuba wonke umntu uza kufumana umhlaza. Kodwa kuthetha ukuba umngcipheko uphezulu. Yiyo loo nto kubaluleke kakhulu ukufumanisa isifo ngexesha elifanelekileyo kwaye uhlolwe ngamaxesha afanelekileyo njengoko kucetyisiwe ngugqirha wakho.
Yintoni unobangela othile weJPS?
Njengoko besitshilo ngaphambili, le yimeko yemfuza. I-JPS ibangelwa ikakhulu kukuguquka kwezakhi zofuzo emizimbeni yethu ekuthiwa yi -BMPR1A kunye ne -SMAD4 .
Ukuze siqonde oku, masisebenzise umzekelo olula. Khawuthelekelele ukuba iiseli emzimbeni wethu zifana neemoto ezisendleleni. Iijini ezimbini ezibizwa ngokuba yi-BMPR1A kunye ne-SMAD4 zifana namapolisa endlela. Zilawula ukukhula nokwahlukana kweeseli, zinika imiqondiso ethi "Kulungile, yahlula ngoku" kunye "Kulungile, yeka ngoku."
Xa ezi jini zimbini zitshintshatshintsha, njengaxa ezo mapolisa ezithuthi zingasekho, iiseli zilahlekelwa lulawulo. Ziqala ukwahlukana nangayiphi na indlela eziyifunayo, nangesantya esiphezulu. Yiyo le ndlela ezi seli zingalawulekiyo zokwahlulahlula zidibana ngayo zenze ezi thumba zibizwa ngokuba zii-polyps.
Ukongeza kwi-JPS, abantu abaneenguqu kwi-SMAD4 gene basengozini yokuphuhlisa enye imeko yemfuza ebizwa ngokuba yi-hereditary hemorrhagic telangiectasia (HHT).
Indlela yokuxilonga esi sifo?
Xa uxelela ugqirha wakho ngeempawu zakho, uza kukuhlola aze akubuze ngembali yezonyango yosapho lwakho. Ukuze uxilonge i-JPS, kufuneka ubuncinane ube nenye yezi zinto zilandelayo:
- Ukuba neepolyps ezintlanu nangaphezulu emathunjini amakhulu kunye/okanye emqolo.
- Ukubakho kwee-polyps kwenye indawo kwinkqubo yokugaya ukutya.
- Ukuba ne-polyp enye ubuncinane kunye nembali yosapho ene-JPS.
Kukho iimvavanyo ezimbini eziphambili zokuqinisekisa esi sifo.
1. Uvavanyo lwe-Endoscopic / Colonoscopy: Oku kuquka ukufaka ityhubhu encinci, eguquguqukayo enekhamera kunye nokukhanya ngaphakathi kwimpundu ukuze kuhlolwe yonke ingaphakathi lesisu esikhulu kunye nomgudu wokugaya ukutya. Oku kunokunceda ekuboneni ukuba kukho ii-polyps, zingaphi, kwaye ziphi. Ngexesha lovavanyo, ii-polyps ezincinci zinokususwa kwaye kuthathwe isampuli yethishu (i-biopsy) ukuze ivavanywe.
2. Uvavanyo lwegazi oluvela kwimfuza: Kuthathwa isampulu yegazi ize ivavanywe i-BMPR1A okanye i-SMAD4 gene mutations ezibangela i-JPS. Oku kunokuqinisekisa isifo i-100% yexesha.
Ziziphi iindlela zonyango ze-JPS?
Injongo ephambili yokunyanga i-JPS kukususa ii-polyps.Oku kunokulawula iimpawu kwaye kunciphise umngcipheko wokuba nomhlaza kwixesha elizayo. Ugqirha wakho uya kukumisela unyango olungcono ngokusekwe kwiminyaka yakho, impilo, inani lee-polyps, kunye nendawo ezikuyo.
Kukho iindlela ezininzi zonyango:
- Ukususa iipolyps ngexesha le-colonoscopy: Ukuba iipolyps zimbalwa kwaye zincinci ngobukhulu, zinokunqunyulwa zisuswe ngesixhobo esifanayo esisetyenziselwa ukwenza uviwo.
- Ukususwa kweepolyps ngotyando: Ukuba iipolyps zikhulu okanye zikwindawo ekunzima ukuyifikelela nge-colonoscope, utyando lunokufuneka.
- Ukususwa kwecandelo lekholoni ngotyando: Ukuba inani elikhulu lee-polyps lisasazeke kwindawo enye, oogqirha banokugqiba ekubeni basuse lonke elo candelo lekholoni ngotyando.
Ukuba abantwana abancinci bane-polyp enye kuphela, idla ngokususwa ngexesha le-colonoscopy. Utyando alufane lwenziwe ebantwaneni.
Indlela yokulawula esi sifo emva kokuxilongwa?
I-JPS yimeko ekufuneka ilawulwe ixesha elide. Emva konyango nokususwa kwee-polyps, kufuneka sihlale sijongiwe ukuze sibone ukuba ziyakhula kwakhona na okanye ziyavela ezintsha. Yiyo loo nto senza uvavanyo .
Ugqirha wakho uza kukuxelela ukuba wenze ezi mvavanyo kwishedyuli ecwangcisiweyo.
- Uvavanyo lwegazi
- I-Colonoscopy
- I-endoscopy ephezulu
Uvavanyo lokuqala ludla ngokwenziwa kwangoko nje xa kuvela iimpawu okanye ngaphambi kokuba ube neminyaka eli-15 ubudala. Ukuba iziphumo zovavanyo zilungile, uya kucelwa ukuba uphinde uvavanyo rhoqo emva kweminyaka emi-3. Nangona kunjalo, ukuba unee-polyps kwaye zisusiwe, unokufuna uvavanyo rhoqo ngonyaka . Ukuba ii-polyps azibuyi, ixesha eliphakathi kovavanyo linokwandiswa liye kwiminyaka emi-3.
Ukulandela olu cwangciso kubaluleke kakhulu kwimpilo yakho nakubomi bakho. Kunokukunceda ubone kwaye uthintele iingozi zomhlaza kwangethuba.
Udinga nini ukubona ugqirha?
Ukuba unayo nayiphi na kwezi mpawu sizikhankanyileyo, ingakumbi igazi elikwisitulo sakho , ungaze uyityeshele loo nto. Isenokuba yi-hemorrhoid nje, okanye ingaba luphawu lwemeko embi kakhulu efana ne-JPS. Ngoko ke, bonana nogqirha wakho ngoko nangoko.
Kwakhona, ukuba kukho umntu kusapho lwakho okhe waba ne-JPS ngaphambili, okanye ukuba ukhe waba nomhlaza wamathumbu usemncinci, kububulumko ukuthetha nogqirha wakho ngayo kwaye ufumane uvavanyo lwemfuza ukuba kuyimfuneko, nokuba awunazo iimpawu.
Umyalezo Wokuya Ekhaya
- I-Juvenile Polyposis Syndrome (JPS) sisifo semfuza esibangela ukukhula okungaqhelekanga (ii-polyps) emathunjini. Igama elithi 'Juvenile' libhekisa kuhlobo lwe-polyp, hayi ubudala.
- Ungaze ungazihoyi iimpawu ezifana negazi elisesitulweni, iintlungu zesisu ezinde, okanye ukwehla kobunzima. Funa ingcebiso kagqirha ngoko nangoko.
- I-JPS inyusa umngcipheko wokuba nomhlaza kwixesha elizayo. Ke ngoko, kubalulekile ukuba uhlolwe ngugqirha wakho ngexesha elifanelekileyo.
- Nangona kungekho nyango lupheleleyo lwesi sifo, sinokulawulwa ngempumelelo kwaye ubomi obusempilweni bunokuphilwa ngokususa ii-polyps kunye nokuhlolwa rhoqo.
- Ukuba unembali yosapho lwakho ye-JPS okanye umhlaza wamathumbu, thetha nogqirha wakho ngayo kwaye ucinge ngeengcebiso kunye novavanyo lwemfuza.
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