Ngaba wakha wazibuza ukuba uziva njani xa uzele? Xa sisitya, emva kwexesha elithile siziva "Kulungile, kwanele." Yintoni edala olu vakalelo? Kutheni ke abanye abantu bengaziva bezele kungakhathaliseki ukuba batya kangakanani na? I-Leptin ngumdlali ophambili kuyo yonke le nto. Le yi-hormone ebaluleke kakhulu ekulawuleni ubunzima bomzimba wethu. Makhe sithethe ngayo ngokulula nangokuchanekileyo namhlanje.
Ngokulula nje, yintoni iLeptin?
Ngamafutshane, i-leptin yi-hormone eveliswa ziiseli zamafutha emzimbeni wakho (iithishu zamafutha). Ikwaziwa ngokuba yi-"satiety hormone." Umsebenzi wayo ophambili kukuthumela umyalezo engqondweni yakho othi, "Kulungile, unamandla aneleyo, yeka ukutya." Le yindlela i-leptin enceda ngayo ukugcina ubunzima bomzimba buzinzile kwixesha elide.
Izazinzulu zafumanisa i-leptin hormone ngo-1994, nto leyo ethetha ukuba kusekho uphando oluninzi oluqhubekayo ngayo. Unxibelelwano lwe-Leptin kungekuphela nje ekulawuleni ubunzima, kodwa nakwizifo ezifana nesifo sika-Alzheimer, impilo yokuzala, kunye nokungazali lusaphandwa okwangoku.
Xa usiva igama elithi "ukulawula ubunzima," unokucinga, "Owu... ukuze sikwazi ukulawula i-leptin size sinciphise ubunzima." Kodwa inyani yile, ukulawula le hormone ngendlela esiyifunayo akulula njengoko sicinga.
I-leptin isebenza njani emizimbeni yethu?
Umsebenzi ophambili weLeptin kukunceda ukugcina ubunzima bomzimba wethu buphilile. Oko kukuthi, ukudala ulungelelwaniso oluhlala ixesha elide phakathi kobungakanani bokutya esikutyayo kunye namandla umzimba wethu owasebenzisayo. ILeptin iyasithintela ekubeni silambe ngokungeyomfuneko. Inceda ekuthinteleni umzimba ekuboniseni indlala xa ungadingi mandla (iikhalori).
I-Leptin isebenza kakhulu ngokuchaphazela inxalenye yengqondo yethu ebizwa ngokuba yi-hypothalamus. Nangona kunjalo, kukho ii-receptors kwezinye iindawo zomzimba ezisabela kwi-leptin.
Okubaluleke kakhulu, i-leptin ayilawuli indlala yethu ukusuka kwesinye isidlo ukuya kwesinye. Endaweni yoko, isebenza ukulawula ukutya kunye nokusetyenziswa kwamandla ixesha elide, ukugcina ubunzima bomzimba buzinzile.
Khawuthelekelele uzama ukunciphisa umzimba. Njengoko amafutha omzimba wakho ehla, amanqanaba akho e-leptin nawo ayancipha. Oku kuthumela umyalezo engqondweni yakho wokuba ulambile. Oku kukwenza uzive ulambile kakhulu kwaye unqwenela ukutya. Oku kunokukhokelela ekubeni utye kakhulu ngaphandle kokuqaphela. Esi sesinye sezizathu zokuba kube nzima kangaka ukunciphisa umzimba.
Amanqanaba e-leptin alawulwa njani?
I-Leptin iveliswa kwaye ikhutshwe egazini yi-white adipose tissue emizimbeni yethu. Ke ngoko, ubungakanani be-leptin egazini lakho bunxulumene ngokuthe ngqo nobungakanani bamafutha emzimbeni wakho.
- Ukuba unamafutha amaninzi emzimbeni:Amanqanaba eLeptin aphezulu.
- Ukuba amafutha omzimba aphantsi: amanqanaba e-leptin aphantsi.
Ekuhambeni kwexesha, ukuba amafutha omzimba wakho ayanda, amanqanaba e-leptin ayanda, kwaye ukuba amafutha omzimba wakho ayancipha, amanqanaba e-leptin ayancipha.
Kuthekani ukuba amanqanaba e-leptin aphezulu kakhulu? - Ukumelana ne-Leptin
Umntu otyebileyo unamafutha amaninzi emzimbeni wakhe. Ngenxa yoko, amanqanaba e-leptin egazini lakhe nawo aphezulu kakhulu. Le meko siyibiza ngokuba yi-hyperleptinemia .
Ngoku usenokuba ucinga, "Ukuba i-leptin iphezulu, kufuneka uzive uhluthi, ngoko ke kufuneka ulawule ukutya kwakho?" Kodwa okuchaseneyo kuyinyani. Xa amanqanaba e-leptin emzimbeni ephezulu ixesha elide, ingqondo iqala ukungaphenduli kuloo mqondiso we-leptin. Kufana nomntu ohlala esikhwaza kwaye siba nexhala emva kwexesha elithile. Oku kubizwa ngokuba yi-leptin resistance .
Ngamafutshane, ukuxhathisa i-leptin kuthetha ukuba nangona kukho i-leptin eyaneleyo emzimbeni, ingqondo ayifumani mqondiso "opheleleyo".
Kwenzeka ntoni ngenxa yoku?
1. Ukungaziva ugcwele: Nangona unamafutha aneleyo emzimbeni wakho, ingqondo yakho icinga ukuba usalambile. Ngoko ke uyaqhubeka nokutya.
2. Umzimba ungena "kwimo yokulamba": Ngenxa yokuba ingqondo ayifumani i-leptin signal, ingqondo icinga ukuba umzimba awunawo amandla aneleyo kwaye siyalamba. Ngoko ke, ukuze kongiwe amandla, izinga lomzimba elisisiseko (i-BMR) liyancipha. Oku kuthetha ukuba inani leekhalori ozitshisayo ngelixa uhleli nje uthule liyancipha.
Ngale ndlela, ukumelana ne-leptin, kwelinye icala, kwandisa indlala kwaye kwandisa ubungakanani bokutya okutyiwayo, kwaye kwelinye icala, izinga lokutshisa umzimba iikhalori liyancipha. Xa ezi zinto zimbini zidibana, isiphumo sikhula ngakumbi.
| Iimpawu eziphambili zeLeptin Resistance |
|---|
| Ukuhlala ulambile kakhulu (hyperphagia) nangona unamafutha omzimba amancinci okanye ungenawo kwaphela. |
| Ubunzima bokulawula ukutya okutyiwayo kunye nokutya okwandisiweyo. |
Ezi mpawu zinokubangelwa zezinye izinto, ngoko ke ukuba uhlangabezana nezi mpawu, kungcono ukuthetha nogqirha wakho.
Kuthekani ukuba amanqanaba e-leptin ehla?
Ukunqongophala kweLeptin yimeko engaqhelekanga kakhulu . Idla ngokuvela kwimeko yemfuza ebizwa ngokuba yi-congenital leptin deficiency . Umntu onesi sifo unesifo apho iiseli zakhe zamafutha zingakwazi ukuvelisa i-leptin.
Xa i-leptin ingekho, umzimba ucinga ukuba akukho mafutha emzimbeni. Oku kubonisa ukuba ingqondo ilambile kwaye ayikwazi ukuyilawula. Ngenxa yoko, abantwana abancinci abanale meko banomnqweno ongalawulekiyo wokutya. Ngenxa yoko, batyeba kakhulu (ubunzima beklasi yesi-3) besebancinci kakhulu kwaye bafikelele kwixesha lokufikisa elibazisekileyo.
| Iimeko ezinokunxulunyaniswa namanqanaba aphezulu e-leptin (i-Hyperleptinemia) | Iimeko ezinokunxulunyaniswa namanqanaba aphantsi e-leptin (i-Hypoleptinemia) |
|---|---|
| Uxinzelelo | Amanqanaba aphezulu e-insulin (i-Hyperiinsulinemia) |
| Ukuxhomekeka ekutyeni | Ukungalingani kwamafutha egazini (iDyslipidemia), umz. i-cholesterol, i-triglycerides |
| Isifo sesibindi esinamafutha esinganxilisiyo | Isifo sesibindi esinamafutha |
| Iingxaki ze-Neurodegenerative | Usulelo oluqhelekileyo lweebhaktheriya |
Ngaba amanqanaba e-leptin anokulinganiswa egazini?
Ewe, uvavanyo olulula lwegazi lunokulinganisa amanqanaba e-leptin. Nangona kunjalo, olu ayilovavanyo oluqhele ukucelwa ngoogqirha. Lwenziwa kuphela kwiimeko ezikhethekileyo. Umzekelo:
- Ukuba umntwana omncinci kakhulu utyebe kakhulu.
- Ukuba umntu otyebileyo uyaqhubeka elambile ngendlela engalawulekiyo.
Ngokwesiqhelo, amanqanaba e-leptin asempilweni anokuhluka ukusuka ku:
- Abasetyhini: 0.5 - 15.2 ng/mL (i-nanograms ngemililitha)
- Inkunzi: 0.5 - 12.5 ng/mL
La maxabiso anokwahluka kancinci kwilabhoratri nganye, ngoko ke ukuba unamathandabuzo malunga namaxabiso akwingxelo yakho, buza ugqirha wakho.
Singayilungisa njani imigangatho ye-leptin?
Akukho ndlela yokunyusa amanqanaba e-leptin ngokungekho mthethweni ukunciphisa indlala, kuba amanqanaba e-leptin anxulumene ngokuthe ngqo nobungakanani bamafutha emzimbeni wakho.
Nangona kunjalo, kukho izinto ezininzi ezinokunceda ekusebenzeni kwe-leptin kunye nokulinganisela kwamahomoni:
1. Lala ngokwaneleyo: Olunye uphando lufumanise ukuba ukungalali ngokwaneleyo kwandisa i-hormone yendlala i-ghrelin kwaye kunciphisa i-hormone ye-satiety leptin. Ke ngoko, ukulala ngokwaneleyo yonke imihla kubaluleke kakhulu kwi-hormone balance.
2. Yitya ukutya okunempilo: Ezinye izifundo zibonisa ukuba amanqanaba aphezulu e-triglycerides, uhlobo lwamafutha egazini, anokuphazamisana nokufikelela kwe-leptin engqondweni. Nangona kusenezimvo ezahlukeneyo ngale nto, kungcono ukutya ukutya okunesondlo okuquka imifuno, iziqhamo, ifayibha, iproteni elungileyo, kunye namafutha asempilweni, ngelixa unciphisa iswekile, umgubo, kunye nokutya okucutshungulweyo .
3. Yenza umthambo rhoqo: Uphando lubonise ukuba umthambo unokunceda ekunciphiseni ukuxhathisa i-leptin. Oko kukuthi, umthambo unokuphucula uvakalelo lwe-leptin engqondweni.
Into ebalulekileyo kukuba, i-leptin ayiyonto ifumaneka ekutyeni. Yi-hormone eveliswa yimizimba yethu. Ngoko ke akukho nto ifana "nokutya i-leptin eninzi."
Ukuba ukhathazekile ngobunzima bakho, okanye ufuna isikhokelo sendlela yokunciphisa umzimba ngendlela enempilo, kungcono ukuthetha nogqirha wakho. Ukuba kuyimfuneko, angakuthumela kwi-endocrinologist.
Umyalezo Wokuya Ekhaya
- I-Leptin yi-hormone "yokugcwala" eveliswa ziiseli zamafutha emzimbeni wethu. Ibonisa ingqondo ukuba sitye ukutya okwaneleyo.
- Njengoko amafutha omzimba wakho esanda, amanqanaba e-leptin nawo ayanda.
- Ingxaki ephambili ngokutyeba kakhulu ayikokunqongophala kwe-leptin, kodwa yimeko ebizwa ngokuba yi-"leptin resistance," apho ingqondo ingaphenduli kwi-leptin.
- Ukuxhathisa i-leptin kwandisa indlala kwaye kunciphisa ukutsha kweekhalori emzimbeni, nto leyo enokukhokelela ekutyebeni ngakumbi.
- Ukulala ngokwaneleyo, ukutya okunempilo, kunye nokuzilolonga kunceda ukugcina ukusebenza kwe-leptin kunye nokulinganisela kwamahomoni ngokubanzi.
- Ukuba unenkxalabo malunga nobunzima bakho okanye iindlela zokutya, soloko uqhagamshelana nogqirha wakho ukuze akunike icebiso.
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