Ngaba wakha wazibuza ukuba yeyiphi indlela emangalisayo esebenza ngaphakathi emzimbeni wakho ukugcina uxinzelelo lwegazi lwakho, oko kukuthi, uxinzelelo lwegazi, kwinqanaba elifanelekileyo? Ifana newotshi engabonakaliyo esebenza ngononophelo. Ngoko ke, omnye wabalinganiswa abaphambili kule nkqubo ibalulekileyo ngu-'Renin'. Usenokuba awuzange uve ngeli gama, kodwa inkonzo eliyinika impilo yakho intle kakhulu. Makhe sithethe ngale renin ngamazwi alula namhlanje.
Ngamafutshane, yintoni uRenin?
Kulungile, masiqale ekuqaleni. I-Renin yi-enzyme eveliswa luhlobo oluthile lweseli kwizintso zakho. I-enzyme yiproteni ekhawulezisa iinkqubo zeekhemikhali emizimbeni yethu.
Le renin ayilonto inye. Iyinxalenye yenkqubo ebaluleke kakhulu. Siyibiza ngokuba yi-'renin-angiotensin-aldosterone system'. Ungakhathazeki, igama lisenokuvakala lide kancinci. Luluhlu lweenkqubo ezidibeneyo. Injongo ephambili yale nkqubo yonke kukugcina uxinzelelo lwegazi lwakho luphantsi kolawulo.
Isebenza njani i-renin emzimbeni? Le yindlela eyenzeka ngayo le nkqubo!
Ukuze siqonde oku, masithathe umzekelo omncinci. Khawucinge ukuba umzimba wakho sisixeko, imithambo yegazi yimibhobho yamanzi kuloo dolophu, kwaye igazi ngamanzi ahamba kuloo mibhobho. Emva koko uxinzelelo lwegazi luxinzelelo olungaphakathi kuloo mibhobho yamanzi.
Ngoku khawucinge ukuba ngesizathu esithile olu xinzelelo lwamanzi (uxinzelelo lwegazi) luyehla. Kwenzeka ntoni ke ngoko? Isebe lamanzi lesixeko (oko kukuthi, izintso zakho) liyakuva oku. Ngoko nangoko, izintso zikhulula isithunywa. Loo sithunywa sibizwa ngokuba yi-renin.
Nje ukuba i-renin yongezwe egazini, nantsi into eyenzekayo:
1. Inyathelo lokuqala: URenin uqala ngokufumana iproteni engasebenziyo ebizwa ngokuba yi-angiotensinogen, eyenziwa esibindini. URenin uvuselela le proteni aze ayiguqule ibe yi-angiotensin I.
2. Inyathelo lesi-2: Le 'angiotensin I' ayikasebenzi ngokupheleleyo. Xa ihamba ngegazi ukuya emiphungeni, iguqulwa yenye i-enzyme apho ibe yi-'angiotensin II' enamandla ngakumbi.
3. Inyathelo Lesithathu: Ngoku umsebenzi wokwenyani uyenzeka. Le arhente inamandla ebizwa ngokuba yi-'angiotensin II' yenza izinto ezimbini.
- Enye kukuba, iyahamba ize ivalwe imithambo yegazi yethu (loo mibhobho yamanzi). Kwenzeka ntoni ke ngoko? Xa imibhobho ivalwe, uxinzelelo luyanda, kwaye uxinzelelo lwegazi luyanda.
- Okwesibini, inika imiqondiso kumadlala e-adrenal (amadlala amabini amancinci akwindawo engaphezulu kwezintso) ukuba avelise i-hormone ebizwa ngokuba yi-aldosterone.
4. Inyathelo lokugqibela:Le hormone, i-aldosterone, ixelela izintso ukuba "ziyeke ukukhupha ityuwa (isodium) namanzi emzimbeni okwethutyana." Oku kwandisa ubungakanani bolwelo emzimbeni. Oku kwandisa noxinzelelo lwegazi.
Ngamafutshane, xa uxinzelelo lwegazi lusehla, kufika isithunywa esibizwa ngokuba yi-renin size siqalise olu tshintsho lwe-chain reaction oluthi ekugqibeleni lubuyisele uxinzelelo lwegazi esiqhelweni. Uyayazi?
Ikhutshwa nini i-renin emzimbeni?
Kukho izizathu ezininzi eziphambili zokuba izintso zikhuphe i-renin. Oko kukuthi, umzimba wethu uzijonga ngobuchule ezi zinto.
- Uxinzelelo lwegazi oluphantsi: Xa izinzwa zoxinzelelo (ii-baroreceptors) kwimithambo yegazi zibona ukuba uxinzelelo lwegazi luyehla, zithumela imiyalezo kwizintso.
- Amanqanaba aphantsi etyuwa (isodium) emzimbeni: Izintso zinokubona xa ubungakanani besodium egazini buhlile. Ukuba kunjalo, zikhupha i-renin.
- Umsebenzi wenkqubo yemithambo-luvo: Inkqubo yethu yemithambo-luvo iyavuseleleka xa sisoyika, sidiniwe, okanye sizilolonga. Ukukhululwa kwe-renin nako kunokwenzeka ngala maxesha.
Ngaba kukho uvavanyo lokujonga amanqanaba e-renin?
Ewe, ngokuqinisekileyo. Ukuba ugqirha wakho ufuna, angenza uvavanyo lwegazi ukulinganisa amanqanaba akho e-renin. Oku kudla ngokulinganiswa ngovavanyo olubizwa ngokuba yi-'Plasma Renin Activity' (PRA). Olu vavanyo ludla ngokulinganisa amanqanaba akho e-aldosterone.
Ngoku usenokuba uzibuza, "Kutheni ndilufuna olu vavanyo?" Isizathu esiphambili sokuba ugqirha acele olu vavanyo kukuba unoxinzelelo lwegazi oluphezulu olunzima ukululawula ngamayeza aqhelekileyo.
Ngamanye amaxesha, uxinzelelo lwegazi oluphezulu lunokubangelwa yimeko ebizwa ngokuba yi-'primary aldosteronism', ekwaziwa ngokuba yi-'Conn's syndrome'. Kule meko, umzimba uvelisa i-hormone aldosterone eninzi kakhulu. Ngoko ke, ukuvavanya amanqanaba akho e-renin kunye ne-aldosterone kunokunceda ugqirha wakho ukuba afumanise unobangela ochanekileyo woxinzelelo lwakho lwegazi oluphezulu.
Ibonisa ntoni inqanaba eliphezulu le-renin?
Ukuba ingxelo yakho ibonisa amanqanaba aphezulu e-renin, oko kungabonisa ezinye zeengxaki zempilo ezifihlakeleyo. Esi asisosifo, kodwa luphawu nje.
| Imeko enokwenzeka | Ingcaciso elula |
|---|---|
| Isifo sika-Addison | Amadlala e-adrenal awavelisi iihomoni ezaneleyo. |
| Ukuphelelwa ngamanzi emzimbeni | Ukungabikho kwamanzi aneleyo emzimbeni. |
| Ukopha igazi | Ukopha kakhulu emzimbeni. |
| I-potassium ephantsi egazini (i-Hypokalemia) | Amanqanaba e-potassium aphantsi ngokungaqhelekanga egazini. |
| Uxinzelelo lwegazi lwezintso | Uxinzelelo lwegazi oluphezulu olubangelwa kukuncitshiswa kwemithambo yegazi ehambisa igazi ezintso. |
| Isifo sesibindi | Ukonakala kwesibindi kunye nokusebenza kakubi. |
| Iithumba ezivelisa i-renin | Ezinye iintlobo zeethumba zezintso zivelisa i-renin eninzi. |
Zithini izizathu zokuba amanqanaba aphantsi e-renin abe sezantsi?
Kwakhona, amanqanaba aphantsi kakhulu e-renin anokubangelwa ziimeko ezithile.
| Imeko enokwenzeka | Ingcaciso elula |
|---|---|
| I-Aldosteronism ePhambili (PA) | Ukuveliswa kakhulu kwe-aldosterone yi-adrenal glands, nto leyo ebangela ukuba umzimba uyeke ukuvelisa i-renin. |
| Unyango lwe-steroid | Ezinye ii-steroids zinokubangela ukugcinwa kwetyuwa namanzi emzimbeni. |
| Uxinzelelo lwegazi oluphezulu olunovakalelo kwityuwa | Imeko apho uxinzelelo lwegazi lunyuka ngenxa yobungakanani betyuwa esetyenzisiweyo. |
Ungayigcina njani imigangatho ye-renin isempilweni?
Le yeyona nto ibalulekileyo. Awunakuze "uzive" inqanaba le-renin yakho yodwa. Amanqanaba aphezulu okanye aphantsi e-renin ayisosifo, kodwa luphawu lwesinye isifo esingaphantsi.
Ngoko ke, ugqirha wakho nguye omele anike isisombululo sale nto. Uza kuhlola ingxelo yakho, enze uvavanyo olongezelelweyo ukuba kuyimfuneko, aze afumanise unobangela ochanekileyo wenqanaba elingaqhelekanga le-renin. Unyango luya kusekelwa kuloo nto.
Umzekelo, ukuba une-high blood pressure kunye namanqanaba aphezulu e-renin, ugqirha wakho unokukunika amayeza okunciphisa uxinzelelo lwegazi, anjenge-beta-blockers. Ukuba unobangela kukuphelelwa ngamanzi emzimbeni, unokukucebisa ukuba usele amanzi amaninzi.
Khumbula, amanqanaba e-renin ayinkimbinkimbi. Musa ukukhathazeka ngezi zinto wedwa. Ukuba uneengxaki, qiniseka ukuba uthetha nogqirha wakho. Uya kukwazi ukukunika iingcebiso kunye nonyango olufanelekileyo.
Umyalezo Wokuya Ekhaya
- I-Renin yi-enzyme ebaluleke kakhulu eveliswa zizintso zakho elawula uxinzelelo lwegazi.
- Isebenza njengenxalenye yenkqubo ye-renin-angiotensin-aldosterone.
- Amanqanaba aphezulu okanye aphantsi e-renin ayisosifo, kodwa luphawu lwenye ingxaki emzimbeni.
- Ukuba unoxinzelelo lwegazi oluphezulu olunzima ukululawula ngamayeza aqhelekileyo, ugqirha wakho unokuyalela uvavanyo lwenqanaba le-renin.
- Ungaze wenze izigqibo okanye uzame ukuzinyanga ngokusekelwe kulwazi olufundileyo malunga namanqanaba e-renin kwi-intanethi. Soloko unxibelelana nogqirha wakho ukuze ufumane ingcebiso efanelekileyo.
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