Ngaba wena okanye umntu omaziyo unikwe amayeza ngugqirha ngenxa yesifo esifana nokudakumba? Ukuba kunjalo, mhlawumbi ukhe weva igama elithi SNRI. Kuqhelekile ukuba imibuzo emininzi ifike engqondweni xa usiva eli gama. "Zithini ii-SNRI? Zisebenza njani ngokwenene? Ngaba zikhona iziphumo ebezingalindelekanga?" Mhlawumbi unemibuzo efana nale. Ungakhathazeki, kulungile ke, masithethe ngazo zonke ezi zinto ngendlela elula neyobuhlobo namhlanje.
Masiqale sibone, zithini ezi SNRI?
Ngamafutshane, ii-SNRI (i-Serotonin kunye ne-Norepinephrine Reuptake Inhibitors) ziindidi zamayeza asetyenziselwa ukulawula iimpawu zeemeko zempilo yengqondo ezifana nokudakumba. Nangona kunjalo, oogqirha banika eli yeza kwezinye iimeko ezininzi, kungekuphela nje kokudakumba.
ESri Lanka, amayeza amaninzi akweli candelo anikwa oogqirha. Umzekelo, amayeza afana neVenlafaxine, iDuloxetine, kunye neDesvenlafaxine awela kweli candelo. Nangona kunjalo , ngugqirha wakho kuphela onokugqiba ukuba loluphi unyango olufanelekileyo kuwe kunye nedosi.
Eli yeza lisebenza njani emzimbeni?
Ukuze siqonde oku, kufuneka siqale sazi kancinci ngeengqondo zethu. Iingqondo zethu zinezithunywa zeekhemikhali ezikhethekileyo ezibizwa ngokuba zii-neurotransmitters , ezifana namadoda athumela imiyalezo phakathi kwamalungu ahlukeneyo emizimba yethu.
Phakathi kwezi , iSerotonin kunye neNorepinephrine zezona zithunywa ziphambili ezilawula izinto ezininzi ezibalulekileyo, ezifana neemvakalelo zethu, ukulala, inkumbulo, kunye nengqalelo.
Kwiimeko ezinje ngokudakumba, umsebenzi waba bathunywa uyancipha. Oko kukuthi, babuyela ngokukhawuleza kwiiseli zemithambo-luvo emva kokuba bedlulise umyalezo (oku kubizwa ngokuba yi-reuptake). Emva koko umphumo wabo engqondweni uyancipha.
Ii-SNRI zisebenza ngokuthintela ukuphinda kuthathwe i-serotonin kunye ne-norepinephrine. Oku kuthetha ukuba ezi zithunywa zimbini zihlala zisebenza engqondweni ixesha elide. Ngenxa yoko, isimo sethu sengqondo siyaphucuka kwaye iimpawu zokudakumba ziqala ukwehla kancinci kancinci.
Ngoko ke yintoni umahluko phakathi kwe-SSRI kunye ne-SNRI?
Usenokuba ukhe weva ngee-SSRI. Ii-SSRI (Selective Serotonin Reuptake Inhibitors) zijolise kuphela kwi-neurotransmitter serotonin, ngelixa ii-SNRI zichaphazela zombini i-serotonin kunye ne-norepinephrine.
Oku akuthethi ukuba ii-SNRI "zingcono" kunee-SSRI. Abanye abantu banokufumanisa ukuba ii-SSRI zisebenza ngcono, ngelixa abanye banokufumanisa ukuba ii-SNRI zisebenza ngcono. Ugqirha wakho uya kugqiba ukuba yeyiphi efanelekileyo kuwe ngokusekelwe kwimeko yakho, iimpawu, kunye nendlela umzimba wakho osabela ngayo kuzo.
Zeziphi izifo ezisetyenziselwa amayeza e-SNRI?
Olu hlobo lweyeza lusetyenziselwa ukunyanga iimeko ezahlukeneyo zonyango. Makhe sijonge ukuba zeziphi.
| Imeko yezonyango | Ingcaciso elula |
|---|---|
| Ingxaki Enkulu Yokudakumba | Usizi olude kunye nokulahlekelwa ngumdla okuchaphazela imisebenzi yemihla ngemihla. |
| Ingxaki Yokuxhalaba Okuqhelekileyo (i-GAD) | Ukuxhalaba okungalawulekiyo ngezinto zemihla ngemihla ngaphandle kwesizathu esithile. |
| I-Fibromyalgia | Iintlungu ezingapheliyo emzimbeni wonke, ukudinwa, kunye neengxaki zokulala. |
| I-Diabetic Neuropathy | Intlungu, efana nokudumba kunye nokuba ndindisholo, okubangelwa kukonakala kwemithambo-luvo ngenxa yesifo seswekile. |
| Intlungu Yemisipha Engapheliyo | Iintlungu ezihlala ixesha elide, njengentlungu yomqolo. |
| Ingxaki Yokukhathazeka Kwentlalo | Uloyiko olugqithisileyo kunye nokuxhalaba kwiimeko zoluntu. |
Ukongeza, kuxhomekeke kumava kagqirha kunye nesigqibo sakhe sezonyango, eli yeza lingacetyiswa nakwizibilini zasebusuku ezinxulumene nokuya exesheni, ukuthintela i-migraine, kunye nezinye iimeko zokuxhalaba.
Zithini iziphumo ebezingalindelekanga eziqhelekileyo zala mayeza?
Njengayo nayiphi na imithi, ii-SNRI zinokubangela ukuba abanye abantu babe nemiphumo emibi emincinci. Nangona kunjalo, le miphumo idla ngokuba yeyokwexeshana . Uninzi lwayo luya kuphela kwiiveki ezimbalwa zokuqala njengoko umzimba wakho uqhelana namayeza.
- Isicaphucaphu nokuhlanza
- Umlomo owomileyo
- Ukuqhinwa
- Ukudinwa kunye nokozela
- Isiyezi
- Ukubila okugqithisileyo
- Iingxaki zokusebenza ngokwesondo (umz., ukuncipha komnqweno)
Eyona nto ibalulekileyo kukuba ukuba ukhathazwa zezi ziphumo ebezingalindelekanga, ungazihoyi kwaye uthethe nogqirha wakho. Usenokukwazi ukulungisa umthamo wakho okanye akunike elinye iyeza.
Iimeko eziyingozi ezifuna ingqalelo ekhethekileyo
Nangona ii-SNRIs ziyindlela esebenzayo kakhulu yonyango, kukho iimeko ezinqabileyo kodwa ezinokuba yingozi ekufuneka siziqaphele.
1. Umngcipheko okhulayo weengcinga zokuzibulala
Izifundo zibonise ukuba kusenokubakho ukwanda kweengcinga zokuzibulala, ingakumbi kubantu abancinci abangaphantsi kweminyaka engama-25 ubudala, xa eli yeza liqalwa okokuqala okanye xa kutshintshwa umthamo. Ukuba wena okanye umntwana wakho nineengcinga ezinjalo ngelixa nisela eli yeza, ungathandabuzi ukuqhagamshelana nogqirha wakho ngoko nangoko.
2. Isifo seSerotonin
Le yimeko engaqhelekanga kakhulu, kodwa enokuba yingozi ebomini. Yenzeka xa amanqanaba e-serotonin emzimbeni ephakama kakhulu. Lo mngcipheko uphezulu ngakumbi xa ii-SNRI zithathwa kunye namanye amayeza anyusa amanqanaba e-serotonin (afana nee-MAOIs). Ngoko ke, kubaluleke kakhulu ukwazisa ugqirha wakho malunga nawo onke amayeza owasebenzisayo, kuquka neevithamini.
| Iimpawu zeSerotonin Syndrome | |
|---|---|
| Iimpawu ngokubanzi | Ukungazoli, isicaphucaphu, urhudo, amehlo avuleke kakhulu , ukungcangcazela kwemisipha, ukubila, kunye nokubanda. |
| Iimpawu eziyingozi | Ukudideka, i-tachycardia, uxinzelelo lwegazi oluphezulu, umkhuhlane ophezulu, ukuxhuzula, ukungazi nto. |
| Ukuba unayo nayiphi na kwezi mpawu ziyingozi, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) elikufutshane nawe ngoko nangoko! | |
3. Ukuyeka amayeza ngequbuliso
Ukuba uyeka ukuthatha i-SNRI kangangeeveki ezingaphezu kwezi-6, unokufumana iimpawu ezingathandekiyo. Oku kubizwa ngokuba yi-Antidepressant Discontinuation Syndrome. Oku akusiyo "ingxaki yeziyobisi." Oku kuzama nje umzimba ukuziqhelanisa namayeza xa eyeka ngequbuliso. Iimpawu zingabandakanya iintlungu zomzimba ezifana nomkhuhlane, iintloko ezibuhlungu, isicaphucaphu, isiyezi, kunye nokuziva unomsindo.
Ngoko ke , ungaze, nangasiphi na isizathu, uyeke ukuthatha eli yeza ngequbuliso ngaphandle kokubonisana nogqirha wakho. Ukuba kufuneka uyeke ukulisebenzisa, yenza njalo ngokwemiyalelo kagqirha wakho, unciphise kancinci umthamo.
Kuthatha ixesha elingakanani ukubona iziphumo zeyeza?
Lo ngumbuzo abantu abaninzi abawubuzayo. Ngokuqhelekileyo kuthatha malunga neeveki ezi-6 ukuya kwezi-8 ukuba iziphumo ezipheleleyo zamayeza e-SNRI zibonakale. Uza kuqala ukuziva uphucukile emva kweeveki ezimbini ukuya kwezintathu zokuqala. Ngoko ke, kubalulekile ukuba nomonde kwaye usebenzise amayeza ngokuchanekileyo. Ukuba awuva mahluko emva kweli xesha, thetha nogqirha wakho ngaloo nto.
Umyalezo Wokuya Ekhaya
- Ii-SNRI ziluhlobo olusebenzayo kakhulu lwamayeza anyanga iimeko ezinje ngokudakumba, ixhala, kunye nentlungu engapheliyo.
- Eli yeza lisebenza ngokulinganisela amanqanaba eekhemikhali ezibizwa ngokuba yi-serotonin kunye ne-norepinephrine engqondweni.
- Iziphumo ebezingalindelekanga zokuqala zihlala zizezexeshana, kodwa ukuba ziyakhathaza, qiniseka ukuba uxelele ugqirha wakho.
- Ungaze uyeke ukuthatha eli yeza ngequbuliso ngaphandle kwengcebiso kagqirha wakho.
- Qaphela iimpawu eziyingozi ze-serotonin syndrome (umkhuhlane ophezulu, ukudideka, ukuxhuzula). Ukuba oku kuyenzeka, yiya kwigumbi longxamiseko (ETU) ngokukhawuleza.
- Kungathatha ixesha ukufumana amayeza afanelekileyo kuwe. Ngoko ke yiba nomonde kwaye uhlale unxibelelana rhoqo nogqirha wakho. Ugqirha wakho uhlala ekulungele ukukunceda.
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