Iyeza elitsha lokudakumba: Oko kufuneka ukwazi malunga ne-Auvelity

Uxinzelelo yimeko eyenza ubomi bube mnyama kakhulu kwaye bube nzima. Ukuba ulwa nale meko, usenokungafumani kuphumla njengoko ucinga ngamayeza owasebenzisayo ngoku. Ngoko ke, ngoku, iintlobo ezintsha zamayeza ziye zavela ukunyanga uxinezeleko. Namhlanje sithetha ngeyeza elibizwa ngokuba yi-'Auvelity' elizise ithemba elitsha. Eli liyeza elavunywa eMelika ngo-2022 kwaye lisetyenziselwa iMajor Depression Disorder.

Yintoni i-Auvelity? Isebenza njani?

Ngamafutshane, i-'Auvelity' yindibaniselwano yamayeza amabini. Oko kuthetha ukuba kukho iintlobo ezimbini zamayeza kwipilisi enye. Ziyi-'dextromethorphan' kunye ne-'bupropion'. Cinga ngayo njengokusebenza njengeqela. Abantu ababini abasebenza kunye benza amayeza angaphezu kwesinye bodwa.

• I-Bupropion : Eli sele liyiyeza elisetyenziselwa ukunyanga ukudakumba . Lisebenza ngokunyusa amanqanaba eekhemikhali ezikwingqondo yethu ezibizwa ngokuba yi-'dopamine' kunye ne-'norepinephrine', ezichaphazela indlela esivakalelwa ngayo.
• I-Dextromethorphan : Usenokuba uyayazi le. Ezinye iziraphu zokukhwehlela ziqulathe eli yeza. Nangona kunjalo, eli yeza likwafunyenwe ukuba lichaphazela iikhemikhali ezikwingqondo ezinxulumene neemvakalelo.

Ngoko ke, xa la mayeza mabini edityanisiwe , anceda kakhulu ekunciphiseni iimpawu zokudakumba kune-bupropion yodwa.

Impumelelo yale mayeza yavavanywa njani?

Ngaphambi kokuba banike abantu naliphi na iyeza, bavavanya ukuba likhuselekile kwaye lisebenza kangakanani na. Izifundo ezimbini ezifanayo zeklinikhi zenziwe kwi-'Auvelity'. Kule nto, indlela ekhethekileyo yasetyenziswa ukulinganisa ubukhali bokudakumba. Ibizwa ngokuba yi-"Montgomery-Asberg Depression Rating Scale (MADRS).`` Ifana nemibuzo. Ubuzwa imibuzo eli-10 malunga nezinto ezinje ngosizi, iingxaki zokulala, kunye neemvakalelo zokuba netyala kwaye unikwa amanqaku. Unganika amanqaku ukusuka ku-0 ukuya kuma-60. Okukhona amanqaku ephezulu, kokukhona udandatheka ngakumbi. Ukwehla kwamanqaku emva kokusela amayeza kuthetha ukuba isifo siya siphucuka. Ezi zifundo ziquka abantu abaneminyaka eli-18-65 abanesifo soxinzelelo olukhulu. Nangona kunjalo, abantu abanezinye izifo zengqondo (ezifana 'nesifo sengqondo esibi', 'isifo sengqondo'), abantu abasengozini enkulu yokuzibulala, kunye nabantu abanesifo sokuwa abazange bafakwe.

Zithini iziphumo zezifundo?

Iziphumo ziyakhuthaza ngokwenene. Eli yeza elithi `Auvelity` lalisebenza ngcono ekunciphiseni iimpawu zokudakumba kune-placebo kunye ne-`bupropion` yodwa. Oku kuthetha ukuba amanqaku e-`MADRS` ayephantsi kwabo bathathe i-`Auvelity` kunabo bathathe amanye amayeza.

Ngaba i-Auvelity inokunxibelelana namanye amayeza? (Ukusebenzisana kwamayeza)

Le yinxalenye ebaluleke kakhulu . Ewe, i-Auvelity inokunxibelelana namanye amayeza owasebenzisayo. Ngoko ke, kufuneka uxelele ugqirha wakho ngawo onke amayeza owasebenzisayo, kuquka amayeza athengiswa ngaphandle kwemvume kagqirha, iivithamini, kwanamayeza e-Ayurvedic.

Imeko eyingozi ebizwa ngokuba yiSerotonin Syndrome

Xa i-Auvelity ithathwa kunye nezinye izidambisi-ntlungu ezonyusa amanqanaba e-serotonin, inokubangela ukwanda okungafunekiyo kwe-serotonin yekhemikhali yobuchopho. Oku kubizwa ngokuba yi-Serotonin Syndrome. Le yimeko engxamisekileyo esongela ubomi. Ukuba ufumana ezi mpawu, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) elikufutshane nawe ngoko nangoko. Kufuneka kubekho isithuba seentsuku ezili-14 phakathi kokuthatha amayeza okudakumba e-MAOI kunye nokuthatha i-Auvelity.

Ezinye iziphumo

• Ngamayeza okunyusa i-dopamine: `Auvelity` yonyusa i-dopamine engqondweni. Ngoko ke xa ithathwa kunye namanye amayeza okunyusa i-dopamine (njengamanye amayeza esifo sikaParkinson), amanqanaba e-dopamine anokunyuka kakhulu, okubangela ukungazinzi, ukungcangcazela,Ukuhamba ngeenyawo kunokuba nzima.
• Ngotywala: Ukusela utywala kufuneka kuphetshwe okanye kuncitshiswe kakhulu xa usebenzisa i-'Auvelity'. Ukusela zombini ezi zinto kunye kwandisa umngcipheko wokuxhuzula .
• Amayeza entliziyo: Ukusebenza kakuhle kwamayeza entliziyo afana ne-digoxin kunokutshintshwa yi-Auvelity. Kubalulekile ukwazisa ugqirha wakho ngale nto.
• Amanye amayeza aphulwa sisibindi: Isibindi sethu sifana nomzi-mveliso ophula amayeza. Ukuqina komzimba kuchaphazela inkqubo ye-enzyme ebizwa ngokuba yi-``cytochrome P450 (CYP450)`` kule nkqubo. Oku kunokutshintsha indlela amanye amayeza owasebenzisayo asebenza ngayo.

Lisetyenziswa njani eli yeza kwaye zithini iziphumo ebezingalindelekanga?

I-'Auvelity' liyeza elinikwa ngugqirha kuphela. Umlinganiselo oqhelekileyo yipilisi enye ngosuku kwiintsuku ezintathu zokuqala, uze emva koko ipilisi enye kabini ngosuku (ukwahlukana ngeeyure ezisi-8).

Iziphumo ebezingalindelekanga kunye nezinto ekufuneka uziqaphele

• Uxinzelelo lwegazi oluphezulu: Ugqirha wakho angakuxelela ukuba ujonge uxinzelelo lwegazi lakho rhoqo.
• Ukudinwa: Eli yeza linokubangela isiyezi. Ngoko ke, lumka xa uqhuba, usebenzisa oomatshini, kwaye usenza imisebenzi enokuquka ukuwa.
• Iziphumo emehlweni: Xelela ugqirha wakho ukuba ubona iintlungu zamehlo, ukuba bomvu, okanye utshintsho kwindlela obona ngayo.
• Utshintsho kwindlela yokuziphatha: Abanye abantu banokuba nokudideka kwengqondo, ukubona okanye ukuva izinto ezingekhoyo (imibono), kunye nobunzima bokubona inyani.
• Ukuxhuzula: Le ngozi iyanda xa ithathwa notywala. Ukuba ufumana ukuxhuzula ngelixa usebenzisa amayeza, yeka ukuwasebenzisa ngoko nangoko uze uxelele ugqirha wakho.
• Oomama abakhulelweyo nabancancisayo: Eli yeza alikhuselekanga ngexesha lokukhulelwa okanye lokuncancisa. Ukuba uceba ukukhulelwa, ukhulelwe, okanye uncancisa, yazisa ugqirha wakho ngoko nangoko.

Ukuqonda okukhethekileyo malunga neengcinga zokuzibulala

Njengamanye amayeza okudakumba, i-Auvelity inokunyusa kancinci umngcipheko weengcinga okanye izenzo zokuzibulala kwabanye abantu, ingakumbi kwangethuba kunyango.Oku kuqheleke kakhulu kubantu abaselula. Ukuba wena okanye umntu osapho lwakho unezi ngcinga, musa ukuba wedwa.

• Fowunela u-1926 (uNcedo lwezeMpilo yeNgqondo yeSizwe) ngoko nangoko.
• Kungenjalo, yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
• Yazisa ugqirha wakho ngale nto ngoko nangoko.

Asinto yokuyifihla le. Kubaluleke kakhulu ukufumana uncedo ngokukhawuleza. Ukungabi naxhala, ukudakumba, impilo yengqondo, uxinezeleko, i-dextromethorphan, i-bupropion, i-serotonin syndrome, amayeza okunciphisa uxinzelelo, iziphumo ebezingalindelekanga