Ngaba uyayazi i-capsule yeSonidegib (Odomzo) yomhlaza wolusu?

Kuqhelekile ukuba uloyiko oluncinci kunye nexhala lifike engqondweni yakho xa usiva amagama athi umhlaza wolusu. Kodwa sinethamsanqa, kuba ngesayensi yezonyango ephucukileyo namhlanje, kukho unyango olusebenzayo kakhulu lwezifo ezinjalo. I-Sonidegib liyeza lanamhlanje elisetyenziselwa ukunyanga uhlobo olunjalo lomhlaza wolusu, ngakumbi i-'Basal Cell Carcinoma'. Ke namhlanje, masithethe ngeli yeza ngokulula, indlela yokulisebenzisa, into ekufuneka uyilumkele, kunye nazo zonke iziphumo ebezingalindelekanga.

Loluphi uhlobo lonyango iSonidegib?

Ngamafutshane, olu luhlobo lwamayeza olubizwa ngokuba yi-"targetted therapy." Oku kuthetha ukuba eli yeza lijolise kuphela kwiiseli zomhlaza kwaye liyayeka ukukhula kwazo, ngaphandle kokulimaza iiseli eziphilileyo. Ngokuqhelekileyo uya kuyifumana le nto kwimarike phantsi kwegama lophawu i-Odomzo. Isetyenziswa kakhulu ukulawula uhlobo lomhlaza wolusu olubizwa ngokuba yi-'Basal Cell Carcinoma.'

Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza

Ngaphambi kokuba uqale olu nyango, kubaluleke kakhulu ukwazisa ugqirha wakho ngokucacileyo ngale nto ilandelayo:

• Nokuba ukhe waba neengxaki zemisipha ngaphambili.
• Nokuba kukho i-allergy kwiyeza iSonidegib okanye nakweyiphi na enye iyeza, ukutya, okanye idayi.
• Ukuba uzama ukukhulelwa, okanye ukhulelwe okwangoku, le yinto ekufuneka uyikhankanye. Le yingongoma ebaluleke kakhulu.
• Ukuba ungumama oncancisayo, nceda usazise nathi.

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Ndingayisebenzisa njani kanye kanye le yeza?

Ukuze ufumane okuninzi kweli yeza, kubalulekile ukulisebenzisa njengoko kuyalelwe.

• Eli yeza lifanele liginywe liphelele ngeglasi yamanzi .
• Ungaze uyiqhekeze, uyityumze, okanye uyihlafune le capsule. Ukwenza njalo kunokuchaphazela ukusebenza kakuhle kweyeza.
• Oku kufanele kuthathwe ungenanto esiswini . Oko kukuthi, iyure enye ngaphambi kokutya okanye iiyure ezimbini emva kokutya. Musa ukukuthatha oku kunye nokutya.
• Enye into ebalulekileyo kukuphepha ukusebenzisa eli yeza kunye nejusi yegrapefruit.
• Sela amayeza akho yonke imihla, njengoko kuyalelwe ngugqirha wakho, ngexesha elichazwe ngugqirha wakho. Musa ukuyeka ukuwasela amayeza akho ngaphandle kwengcebiso kagqirha wakho.
• Xa unikwa eli yeza, uza kufumana incwadana yolwazi ekhethekileyo (iMedGuide) ngalo. Kubalulekile ukulifunda nokuliqonda ngononophelo ngalo lonke ixesha.

Ukuba ngequbuliso uphoswe yidosi yamayeza, ungoyiki. Libala ngedosi ephoswe yiyo uze uthathe idosi elandelayo njengesiqhelo ngosuku olulandelayo ngexesha elicwangcisiweyo. Ungaze uthathe idosi ezimbini ngaxeshanye kuba nje ulibele.

Kuthekani ukuba ndisela kakhulu?

Ukuba ucinga ukuba uthathe amayeza amaninzi kakhulu, fowunela iZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko, okanye uye kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.

Izinto ekufuneka uzilumkele ngakumbi xa usebenzisa amayeza

Nika ingqalelo ekhethekileyo kwezi ngongoma ngenxa yokhuseleko lwakho kunye nempumelelo yonyango lwakho ngelixa usebenzisa eli yeza.

• Ukukhulelwa nokuncancisa (kwabasetyhini): Le yeyona nto ibalulekileyo. Musa ukukhulelwa nangasiphi na isizathu ngelixa usebenzisa eli yeza. Kwakhona, kufuneka uphephe ukukhulelwa iinyanga ezingama-20 emva kokuyeka iyeza. Eli yeza linokubangela iziphene ezinzulu zokuzalwa okanye nokufa kusana olungekazalwa. Kufuneka wenze uvavanyo ukuqinisekisa ukuba awukhulelwanga ngaphambi kokuba uqale iyeza. Ukuba ungumama oncancisayo, musa ukuncancisa ngelixa usebenzisa eli yeza kwaye iinyanga ezingama-20 emva kokuyeka iyeza.

• Kwamadoda afuna ukuba nguyise womntwana: Kuphephe ukuba nguyise womntwana ngelixa usela eli yeza kwaye kangangeenyanga ezisi-8 emva kokuliyeka. Ukuba ulala nomntu ngeli xesha , kufuneka usebenzise ikhondom yelatex. Oku kuyimfuneko nokuba sele wenze i-vasectomy. Ukuba iqabane lakho liyakhulelwa, xelela ugqirha wakho ngoko nangoko. Kwakhona, kuphephe ukunikela ngesidoda ngelixa usela eli yeza kwaye kangangeenyanga ezisi-8 emva kokuliyeka.

• Ukunikela ngegazi: Musa ukunikela ngegazi ngelixa usela amayeza kwaye kangangeenyanga ezingama-20 emva kokugqiba unyango. Ukuba igazi linikwe umfazi okhulelweyo, usenokuba sesichengeni sokufumana eli yeza.

• Uvavanyo lwezonyango: Ugqirha wakho uhlala eyalela umsebenzi wegazi ukuze abone ukuba iyeza lichaphazela njani umzimba wakho ngelixa usela eli yeza. Qiniseka ukuba ulwenza rhoqo olu vavanyo.

Iziphumo ebezingalindelekanga ezinokubakho ngenxa yamayeza

Njengayo nayiphi na iyeza, iSonidegib inokubangela ezinye iziphumo ebezingalindelekanga. Ezinye zezi zinokuba yingozi, ngoko ke kubalulekile ukuba uzazi.

Ukuba ufumana naziphi na ezinye iimpawu ezingaqhelekanga ezingakhankanywanga kolu luhlu, thetha nogqirha wakho ngazo.

Amanye amayeza anokusebenzisana nalo mayeza (Ukusebenzisana kwamayeza)

'Ukusebenzisana kwamayeza' kuxa elinye iyeza esilisebenzisayo lichaphazela ukusebenza kwelinye iyeza esilisebenzisayo. Kungoko ke, kubaluleke kakhulu ukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo. Amanye amayeza anokusebenzisana neSonidegib adweliswe apha ngezantsi.

• Amanye amayeza osulelo lwefungus (umz. i-ketoconazole, i-itraconazole, i-fluconazole)
• Amanye amayeza okuxhuzula (umz. i-carbamazepine, i-phenytoin)
• Amayeza afana ne-atazanavir kunye ne-saquinavir
• Ii-antibiotics ezifana ne-erythromycin kunye ne-telithromycin
• I-Rifampin, i-rifabutin
• Amayeza okulawula i-asidi yesisu (umz. i-omeprazole, i-famotidine)
• Iimveliso zezityalo ezifana neSt. John's Wort

Olu luhlu aluphelelanga. Ngoko ke, xelela ugqirha wakho malunga namayeza, iivithamini, okanye amayeza esintu owasebenzisayo. Kwakhona, ungalibali ukuxelela ugqirha wakho ukuba uyatshaya okanye usela utywala.