Ngaba usebenzisa amayeza okwehlisa i-cholesterol yakho? Ukuba kunjalo, mhlawumbi usebenzisa udidi lwamayeza abizwa ngokuba yi-'statins'. Emva kokuqala eli yeza, ngaba ngamanye amaxesha uziva unesizungu, ulibale izinto, okanye unesi-'brain fog'? Le yingxaki abantu abaninzi abanayo. Ke namhlanje, masifumanise ukuba yintoni kanye kanye.

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Okokuqala, masibone, yintoni le statin?

Ngamafutshane, i-cholesterol yinto efana ne-wax, enamafutha egazini lethu. Imizimba yethu iyayidinga le cholesterol ukuze yakhe iiseli kwaye ivelise iihomoni, kodwa ukuba ininzi kakhulu ayilunganga. Ingakumbi xa i-cholesterol "embi", okanye i-LDL (Low-Density Lipoprotein) cholesterol iphezulu, inokwakhela eludongeni lwemithambo yegazi yethu ize iyivale. Le yimbangela enkulu yeemeko eziyingozi ezifana nokuhlaselwa yintliziyo kunye nokubetha.

Amayeza e-statin asebenza ngokunciphisa inani le-cholesterol embi ye-LDL eveliswa sisibindi. Ke ngoko, bekungayi kuba yinto ephosakeleyo ukubiza la mayeza njengamayeza ayimfuneko nasindisa ubomi kwabo basengozini yesifo sentliziyo.

Ngaba ke le 'ngxolo yengqondo' iyinyani?

Nangona ii-statins zithathwa njengezikhuselekileyo kubantu abaninzi, njengayo nayiphi na imithi, zinokubangela iziphumo ebezingalindelekanga ezincinci. Umzekelo, iintlungu zemisipha, umonakalo wesibindi, kunye 'nenkungu yobuchopho', okanye iingxaki zokukhumbula nokukhathalela, zezinye zazo.

'Ubuchopho obuneNkungu' yimeko yokudideka okukhulu. Khawuthelekelele, uyalibala apho uzibeke khona izitshixo zakho, mhlawumbi uvula ifriji uze ushiye isitshixo kuyo uze usikhangele kamva. Ezi zizinto ezenzekayo xa ukwimeko enjalo.

Kwane-FDA e-US ibandakanye ukulahlekelwa yinkumbulo kunye nokudideka njengemiphumo emibi "engeyongozi kwaye enokuguqulelwa" kwiilebhile ze-statin. I-cholesterol ibalulekile ekusebenzeni kwengqondo yethu. Enyanisweni, i-25% ye-cholesterol yethu iyonke isebuchotsheni. Ngoko ke kusengqiqweni ukucinga ukuba ukunciphisa i-cholesterol ngee-statins kunokuba nefuthe elithile ebuchotsheni.

Nangona kunjalo, iingcali zithi akukho mfuneko yokukhathazeka kakhulu ngale nto. Uphando olunzulu alukabonakalisi unxibelelwano oluthe ngqo phakathi kwale mithi kunye nokulahlekelwa yinkumbulo.

Amaxesha amaninzi, ezi mpawu zinokuba luphawu lwenye imeko yezonyango engabonakaliyo. Ingakumbi xa iingxaki zokukhumbula ezinje zisenzeka kubantu abakwiminyaka ephakathi okanye abadala, isenokuba luphawu lokuqala lwesifo sika-Alzheimer.

Ngoko ke into yokuqala ugqirha ayicingayo kukuba, "Ngaba oku kungenxa yamayeza? Okanye kukho enye ingxaki?" Ngenxa yoko, banokukuthumela kwingcali ye-neuropsychiatric ukuze ikuxilonge.

Kuyamangalisa!

Kwelinye icala, uphando oluthile lubonisa ukuba ukusetyenziswa kwe-statin kunokunciphisa umngcipheko we-dementia, okanye ukwehla kwengqondo kunye nenkumbulo okwenzeka xa umntu ekhula. Olunye uphando olwenziwe kwiminyaka eli-12 lufumanise ukuba abantu abathatha iidosi eziphezulu ze-statins banomngcipheko omncinci we-dementia. Ngoko ke uphando oluthe kratya lwenziwa ngale nto.

Yintoni omele uyenze ukuba ufumana ezi ziphumo ebezingalindelekanga?

Ukuba uthatha i-statin kwaye ufumana 'ingqondo ebuhlungu', iintlungu zemisipha, okanye naziphi na ezinye iimpawu ezingaqhelekanga, eyona nto ibalulekileyo nekuphela kwayo ekufuneka uyenze kukwazisa ugqirha wakho.

Ungaze uyeke ukuthatha amayeza akho ngequbuliso ngaphandle kokuthetha nogqirha wakho. Khumbula, la mayeza akukhusela kwiingozi ezinkulu ezifana nokuhlaselwa yintliziyo kunye nokubetha kwentliziyo.

Ugqirha wakho uza kuvavanya imeko yakho aze atshintshe isicwangciso sakho sonyango ukuba kuyimfuneko. Angenza oku kulandelayo:

Ukuyeka okwethutyana amayeza e-statin owasebenzisayo okwangoku.
Ukutshintshela kolunye uhlobo lwe-statin.
Ukunciphisa umthamo wamayeza.

Ziziphi ezinye iindlela zokuthatha indawo ye-statins?

Kwezinye iimeko, ukuba ii-statins ziyaqhubeka nokuba nemiphumo emibi, ugqirha wakho unokucebisa amayeza angezinye iindlela. Ezinye zezi zidweliswe ngezantsi.

Udidi lweziyobisi	Ukusebenza kakuhle	Imizekelo (amagama eebhrendi)
Izithinteli ze-ACL	Iyanciphisa ukuveliswa kwe-cholesterol sisibindi. Amanye amayeza akwathintela ukufunxwa kwe-cholesterol emathunjini amancinci.	I-Nexletol (i-bempedoic acid), i-Nexlizet (i-bempedoic acid kunye ne-ezetimibe)
Izithinteli ze-PCSK9	Ezi zi-injection. Azingeni engqondweni. Ziqhekeza i-cholesterol embi ye-LDL egazini kwaye zikhawulezise ukususwa kwayo.	I-Alirocumab (Praluent), i-Evolocumab (iRepatha)

La mayeza anokubiza kakhulu kunee-statins kwaye asenokungafaneleki kuye wonke umntu, ngoko ke esi sisigqibo esiza kwenziwa ngugqirha wakho.

Yintoni enye ekufuneka uyiqaphele xa uthatha ii-statins?

Ukuze unciphise iziphumo ebezingalindelekanga, qaphela la manqaku:

Lumka nge-grapefruit: Amanye amakhemikhali akwijusi ye-grapefruit anokuphazamisana nokukwazi komzimba ukuqhekeza amayeza e-statin. Akunyanzelekanga ukuba uyeke ngokupheleleyo i-grapefruit, kodwa buza ugqirha wakho ukuba ungatya/usela kangakanani.
Xelela ugqirha wakho ngazo zonke ezinye iziyobisi ozithathayo: Amanye amayeza anokusebenzisana ne-statins aze abangele iziphumo ebezingalindelekanga. Imizekelo:
Amayeza okuphazamiseka kwesantya sentliziyo (umz. i-Amiodarone)
Amanye amayeza e-cholesterol (umz., iGemfibrozil)
Amayeza asetyenziswa ukunyanga i-HIV
Amanye amayeza okubulala iintsholongwane kunye ne-antifungal (umz. iClarithromycin, i-Itraconazole)
Amayeza okuthintela amajoni omzimba (umz. iCyclosporine)
Isilumkiso: Isiphumo esiqhelekileyo se-statins ziintlungu zemisipha. Ukuba ngequbuliso uqala ukwenza umthambo onzima ngelixa usela wona, unokunyusa umngcipheko wokonakala kwemisipha. Ukuba usandul' ukuwenza umthambo, yandisa amandla kancinci kancinci.

Umyalezo Wokuya Ekhaya

Iistatins ziziyobisi ezibaluleke kakhulu nezisindisa ubomi ezinciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nesifo sohlangothi.
'I-Brain fog' sisiphumo esingaqhelekanga kakhulu. Ngokuqhelekileyo asibi yingozi kwaye siyaphela xa iyeza liyekisiwe okanye litshintshiwe.
Iingxaki zokukhumbula ozifumanayo zinokwenzeka ukuba zibangelwa zezinye izinto (ubudala, ezinye iimeko zempilo) kunokuba zibangelwa ngamayeza e-statin.
Ukuba ufumana naziphi na iziphumo ebezingalindelekanga, eyona nto ingcono onokuyenza kukuthetha nogqirha wakho.
Musa ukuyeka ukuthatha ii-statins nangasiphi na isizathu ngaphandle kwengcebiso kagqirha. Iingenelo zingaphezulu kakhulu kuneengozi.