Ingabe ukhona emndenini wakho onesifo "seSickle Cell Disease"? Ake sithole ngokuqinisekile!

Namuhla sizokhuluma ngesimo esisha kubantu abaningi, kodwa esingaba sisondelene kakhulu neminye imindeni. Sibizwa ngokuthi iSickle Cell Disease (SCD). Kungenzeka ukuthi uke wezwa leli gama ngaphambili. Empeleni yisifo esihlobene negazi lethu, okungukuthi, esihlobene negazi, futhi esidluliselwa ngofuzo. Ake sibheke ukuthi siyini ngempela, kungani senzeka, nokuthi yini enye engenziwa ngaso.

Kuyini isifo se-Sickle Cell? Masiqonde kalula!

Kalula nje, isifo se-sickle cell (SCD) yisifo esithinta amangqamuzana abomvu egazi emzimbeni wethu, azuzwe kubazali kubantwana. Lesi ngesinye sezifo zegazi ezivame kakhulu emhlabeni. Manje bheka, ngaphakathi kwamangqamuzana ethu abomvu egazi kukhona iphrotheni ebizwa ngokuthi i-hemoglobin . Le hemoglobin ibaluleke kakhulu. Ngoba, yile phrotheni ethwala umoya-mpilo emzimbeni wethu wonke. Ifana netekisi ye-oxygen. Amangqamuzana abomvu egazi omuntu ophilile avame ukuba yindilinga futhi aguquguquke. Njengamabhola enjoloba amancane. Ngenxa yalokhu, angakhasa kalula emithanjeni yegazi emincane emzimbeni (esiwabiza ngokuthi ama-capillary) futhi anikeze umoya-mpilo kuzo zonke izitho zethu nezicubu. Kodwa-ke, okwenzeka kumuntu onesifo se-sickle cell ukuthi kukhona ushintsho oluncane kule hemoglobin. Le hemoglobin engavamile ibizwa ngokuthi i-hemoglobin S. Lokhu kubangela ukuthi amangqamuzana abomvu egazi abe sesimweni se-crescent, noma abe sesimweni se-half-moon, esikhundleni sokuba yindilinga futhi aguquguquke. Akukhona lokho kuphela, kodwa lawa maseli aqinile kakhulu, awagobi kalula, futhi anamathelane. Cabanga, kwenzekani lapho lawa maseli anjengesickle edlula kulawo mithambo yegazi emincane? Ayabhajwa! Bese ukugeleza kwegazi kuphazamiseka. Lokho kusho ukuthi, izitho zethu ezibaluleke kakhulu nezicubu azitholi umoya-mpilo owanele. Yingakho izinkinga ezinkulu ezifana nobuhlungu obukhulu, izifo ezahlukahlukene, ukulimala kwezitho, kanye nokungasebenzi kahle komzimba kungenzeka. Enye into ukuthi la maseli amise okwesikela awaphili isikhathi eside njengamaseli abomvu egazi ajwayelekile. Afa ngokushesha. Bese umzimba uhlala untula amaseli abomvu egazi. Yilokhu esikubiza ngokuthi i-anemia . Isifo se-sickle cell yisimo sokuphila konke. Kodwa ungakhathazeki, kunezindlela zokwelapha lokhu. Ngalezi zindlela zokwelapha, unganciphisa izimpawu futhi wandise impilo yakho.

Ingabe kunezinhlobo ezahlukene zesifo se-sickle cell?

Yebo, kunezinhlobo eziningana zesifo se-sickle cell. Lezi zinhlobo zinqunywa izakhi zofuzo umuntu azizuza kubazali bakhe.

I-Hemoglobin SS (HbSS)

Lolu uhlobo olubi kakhulu lwesifo se-sickle cell. Cishe abantu abangu-65% abane-SCD banalolu hlobo. Laba bantu bathola ifa le-hemoglobin S kubazali bobabili. Lokhu kusho ukuthi iningi noma lonke i-hemoglobin yabo ayijwayelekile. Lokhu kubangela ukuthi babe ne-anemia engapheli.

I-Hemoglobin SC (HbSC)

Lokhu kuncane noma kuphakathi.Uhlobo olusezingeni eliphezulu. Cishe abantu abangu-25% abane-SCD banalo lolu hlobo. Laba bantu bathola ifa le-hemoglobin S kumzali oyedwa kanye nefa lenye i-hemoglobin engavamile ebizwa ngokuthi i-hemoglobin C komunye umzali.

I-Hemoglobin (HbS) Beta Thalassemia

Laba bantu bathola ifa le-hemoglobin S kumzali oyedwa kanye ne-gene engavamile ebizwa ngokuthi i-beta thalassemia komunye umzali. Kukhona futhi izinhlobo ezimbili zalokhu:

• “Plus” (HbS beta +): Lolu uhlobo oluthinta cishe abantu abangu-8% abane- SCD futhi ngokuvamile lumnene.
• “Zero” (HbS beta 0): Lolu uhlobo oluthinta cishe abantu abangu-2% abane-SCD futhi lungaba nzima njengesifo se -hemoglobin SS (HbSS).

Ezinye izinhlobo ezingavamile

Ngaphezu kwalokhu, kunezinye izinhlobo ezingavamile njenge -hemoglobin SD (HbSD), i-hemoglobin SE (HbSE), kanye ne-hemoglobin SO (HbSO) . Laba bantu bazuza i-gene eyodwa ye-hemoglobin S kanye nenye i-gene engavamile ebizwa ngokuthi i-D, E, noma i-O.

Uyini umehluko phakathi kweSickle Cell Anemia kanye neSickle Cell Disease?

Yilapho abantu abaningi bedideka khona. Isifo Se-Sickle Cell (SCD) yigama elijwayelekile lazo zonke izinhlobo ezahlukene zesifo se-sickle cell okukhulunywe ngazo ngenhla. Sifana nesambulela. Zonke ezinye izinhlobo ziwela ngaphansi kwaleso sambulela. Odokotela basebenzisa igama elithi "Sickle Cell Anemia" kuphela ezinhlotsheni ezimbi kakhulu ze-SCD ezibangela i-anemia . Okusho ukuthi, izinhlobo ezibizwa ngokuthi i-hemoglobin SS (HbSS) kanye ne-hemoglobin beta zero thalassemia. Uyaqonda?

Uyini umehluko phakathi kweSickle Cell Charit kanye neSifo?

Abanye abantu banesici se-sickle cell kuphela. Lokhu kusho ukuthi bazuza i-hemoglobin S gene kumzali oyedwa kuphela . Omunye umzali uzuza i-gene enempilo. Ngokuvamile, abantu abanesici se-sickle cell ababonisi izimpawu zesifo se-sickle cell. Kodwa-ke, bangadlulisela lesi sici se-sickle cell ezinganeni zabo. Lokhu kusho ukuthi bangabathwali balesi sici se-sickle cell. Kodwa-ke, akuvamile kakhulu, ngisho nabantu abanesici se-sickle cell bangaba nezinkinga zempilo uma bephelelwa amanzi emzimbeni kakhulu noma uma behlanganyela ekuzivocavoceni okunzima . Ucwaningo lusaqhubeka ngalokhu.

Sivame kangakanani isifo se-sickle cell?

Abacwaningi balinganisela ukuthi abantu abangaba yi-100,000 e-United States kuphela banesifo se-sickle cell. Sivame kakhulu kubantu bomdabu wase-Afrika. Sitholakala nakwabaseMelika baseHispanic, kanye nabantu bomdabu waseMedithera, eMpumalanga Ephakathi, eNdiya, nase-Asia. Kukhona nabantu abanalesi simo eSri Lanka.

Yini ebangela isifo se-sickle cell?

Isifo se-sickle cell sibangelwa ukuguquka kwezakhi zofuzo esakhiweni esibizwa ngokuthi i-HBB gene . Lesi sakhi sofuzo se-HBB sinomthwalo wokwenza ingxenye eyodwa ye-hemoglobin. Abantu abane-SCD bathola izakhi zofuzo ezimbili ze-HBB eziguquliwe ezenza i-hemoglobin engavamile - eyodwa evela kumzali ngamunye. Lokhu kubizwa ngokuthi i-autosomal recessive inheritance. Lokhu kusho ukuthi bobabili abazali bengane ene-SCD baphethe ikhophi eyodwa yesakhi sofuzo esiguquliwe (okusho ukuthi bangaba nesici se-sickle cell). Kodwa-ke, labo bazali ngokuvamile ababonisi izimpawu.

Ubani osengozini enkulu yokuthola isifo se-sickle cell (SCD)?

Amanye amaqembu abantu anamathuba amaningi okuthola lesi sifo. Lawa:

• Abantu bomdabu base-Afrika (isib. abamnyama baseMelika).
• AmaHispanic aseMelika eNingizimu Melika naseMelika Ephakathi.
• Abantu bozalo lwaseMedithera, eMpumalanga Ephakathi, eNdiya, nase-Asia.

Ziyini izimpawu zesifo se-sickle cell?

Izimpawu zesifo se-sickle cell zivame ukuqala ukuvela lapho ingane ineminyaka engaba ngu-5 kuya kwengu-6 ubudala. Lezi zimpawu zingahluka kumuntu nomuntu. Abanye abantu banezimpawu ezincane, kanti abanye bangaba nezinkinga ezinkulu. Izimpawu eziyinhloko ezingabonakala yilezi:

• Iziqephu zobuhlungu ezivame ukwenzeka.
• I-anemia : Lokhu kungabangela ukukhathala okukhulu, ukuphaphatheka, kanye nobuthakathaka.
• I-Jaundice : Ukuphuzi kwesikhumba kanye nokumhlophe kwamehlo.
• Ukuvuvukala okubuhlungu kwezandla nezinyawo.

Yiziphi izinkinga zalesi simo?

Isifo se-sickle cell singathinta izingxenye eziningi zomzimba. Eminye imiphumela iqala ngokuzumayo (ngokushesha), kanti eminye ihlala isikhathi eside (engapheli). Lezi zinkinga zingaqala kusenesikhathi futhi zihlale impilo yonke.

Ubuhlungu

Lena inkinga evame kakhulu yesifo se-sickle cell. Ubuhlungu buvela lapho amangqamuzana amise okwesikela ebhajwa emithanjeni yegazi futhi evimba ukugeleza kwegazi. Ungase ube nobuhlungu obungazelelwe nobunzima. Lokhu kubizwa nangokuthi i-pain crisis, i-sickle cell crisis, i-vaso-occlusive crisis (VOC), noma i-vaso-occlusive episode (VOE) . Lezi zinkinga zobuhlungu zingaba zincane noma zibe zimbi, futhi zingaqala ngokuzumayo futhi zihlale isikhathi eside. Ubuhlungu buvame kakhulu esifubeni, emhlane, emilenzeni nasezingalweni. Abanye abantu bangase babe nobuhlungu obungapheli , okusho ubuhlungu obuhlala isikhathi esingaphezu kwezinyanga eziyisithupha.

I-anemia

Isifo se-sickle cell sibangela i-anemia ngoba amangqamuzana abomvu egazi afa ngokushesha kakhulu. I-anemia ukuntuleka kwamangqamuzana abomvu egazi aphilile angathwala umoya-mpilo emzimbeni wonke. YingakhoUkukhathala okukhulu, i-jaundice, ukungahlaliseki, isiyezi, kanye nokucasuka kungase kwenzeke.

Isifo Sesifuba Esibukhali

Lesi yisimo esiphuthumayo sezokwelapha esisongela ukuphila . Singalimaza amaphaphu, sibangele ubunzima bokuphefumula, futhi sinciphise ukutholakala komoya-mpilo kwezinye izingxenye zomzimba. Le nkinga yenzeka lapho amaseli esikela evimba ukugeleza kwegazi nomoya-mpilo emaphashini.

Amahlule egazi

I-sickle cell anemia yandisa ingozi yokuqhekeka kwegazi. Lokhu kwandisa ingozi yokuba nehlule legazi emthanjeni ojulile (i-deep vein thrombosis - DVT). I-DVT ingaqhekeka futhi ihlale emaphashini (pulmonary embolism - PE).

Isifo sohlangothi

Uma amaseli esikela ebhajwa emthanjeni wegazi oholela ebuchosheni, ukugeleza kwegazi kuya ebuchosheni kuyavinjelwa. Ubuchopho abutholi umoya-mpilo owanele ukuze busebenze. Lokhu kungabangela isifo sohlangothi . Cishe abantu abayi-10% abane-SCD bazoba nesifo sohlangothi. Abantu abane-sickle cell anemia basengozini enkulu yesifo sohlangothi.

Izinkinga Zokubona

Amaseli esikela angavimba imithambo yegazi emehlweni. Lokhu kuvame ukwenzeka ku-retina . Ngezinye izikhathi azikho izimpawu bese umbono ungalahleka ngokuzumayo, futhi kungaholela ngisho nasekungabonini unomphela.

Ukuzikhethela

I-Priapism yisimo lapho amangqamuzana amise okwesikela epenis yendoda evaleka khona, okubangela ukuvuka okungapheli nokubuhlungu ( priapism ). Ngaphezu kobuhlungu, i-priapism ingabangela umonakalo ohlala njalo kanye nokungasebenzi kahle kwe-erection . I-Priapism ehlala amahora angaphezu kwamane iyisimo esiphuthumayo sezokwelapha.

Ukulimala kanye nokwehluleka kwezitho zomzimba

Abantu abanesifo se-sickle cell basengozini yokuba nezinkinga zenhliziyo, amaphaphu, izinso, nezinye izitho ngoba abatholi igazi ne-oxygen eyanele. I-SCD ingaholela ekuhlulekeni kwezitho eziningi .

Ingabe isici noma isifo se-sickle cell kuyathinta ukukhulelwa?

Abesifazane abaningi abanesifo se-sickle cell bakhulelwa kahle. Kodwa izingozi ziphezulu. I-SCD ingandisa ingozi yomfutho wegazi ophezulu, amahlule egazi, ukuphuphuma kwesisu, izingane ezizalwa zinesisindo esiphansi, kanye nokuzalwa ngaphambi kwesikhathi . Ngakho-ke kubalulekile ukulandela iseluleko sikadokotela wakho.

Isifo se-sickle cell sitholakala kanjani?

ESri Lanka, njengasemazweni amaningi emhlabeni jikelele, zonke izingane ezisanda kuzalwa zihlolwa isifo se-sickle cell njengengxenye yokuhlolwa kwezinsana . Lokhu kuhilela ukuthatha isampula encane yegazi esithendeni somntwana bese kulihlola. Lokhu kuphinde kuhlole nezinye izifo eziningi. Ukuqinisekisa ukuxilongwa, udokotela wengane uzokwenza ukuhlolwa kwe -hemoglobin electrophoresis . Futhi, isifo se-sickle cell singatholakala ngaphambi kokuba ingane izalwe ngokuhlolwa kokukhulelwa . Lezi zivivinyo zifaka:Lokhu kufaka phakathi i-chorionic villus sampling kanye ne-amniocentesis .

Ingabe ikhona ikhambi eliphelele lesifo se-sickle cell?

Yebo, ukufakelwa umnkantsha wethambo , okwaziwa nangokuthi ukufakelwa i-stem cell, kungelapha isifo se-sickle cell. Lokhu kuhilela ukuthatha umnkantsha wethambo onempilo kumuntu onikelayo onempilo, ohambisana nezakhi zofuzo (njengomfowabo noma udadewabo) bese uwufaka esigulini. Kodwa-ke, cishe abantu abayi-18% abane-SCD kuphela abangathola okufanayo. Kukhona futhi izingozi nezinkinga kulokhu kufakelwa. Udokotela wakho uzoxoxa nawe ngalokhu.

Yiziphi izindlela zokwelapha isifo se-sickle cell?

Ukwelashwa kwesifo se-sickle cell kufaka phakathi imithi, ukumpontshelwa igazi, ukufakelwa umnkantsha, kanye nokwelashwa ngezakhi zofuzo . Ukwelashwa kungaqala ngama -antibiotic . Izinsana ezine-SCD enzima zinikezwa ama-antibiotic kabili ngosuku kuze kube yiminyaka emi-5 ukuvimbela ukutheleleka.

Eminye imithi

Abantu abaningi abane-SCD basebenzisa imithi yokunciphisa ubukhali besifo sabo nokwelapha izimpawu. Ezinye zalezi zifo zifaka:

• I-Voxeletor: Lokhu kungavimbela amangqamuzana abomvu egazi ukuthi angabi sesimweni se-sickle futhi anamathele ndawonye. Lokhu kunganciphisa ukubhujiswa kwamanye amangqamuzana abomvu egazi, kuthuthukise ukugeleza kwegazi ezithweni zomzimba, futhi kunciphise ingozi ye-anemia.
• I-Crizanlizumab: Lo muthi usiza ukuvimbela amaseli abomvu egazi anomumo we-sickle ukuthi anganamatheli ezindongeni zemithambo yegazi . Lokhu kungathuthukisa ukugeleza kwegazi futhi kunciphise ukuvuvukala nobuhlungu.
• I-Hydroxyurea : Lokhu kunganciphisa noma kuvimbele izinkinga eziningana ze-SCD, njengezinkinga ezivamile zobuhlungu, i-acute chest syndrome, kanye ne-anemia enzima.
• I-L-glutamine: Lona umuthi wokuqeda izinhlungu. Ungasiza ekunciphiseni inani lokuhlaselwa ubuhlungu onabo. Ezinye izindlela zokwelapha izinhlungu zifaka phakathi izidakamizwa ezingezona eze-steroidal ezilwa nokuvuvukala (ama-NSAID) kanye nama-opiate .

Ukumpontshelwa igazi

Udokotela wakho angase ancome ukumpontshelwa igazi ukuze elaphe futhi avimbele izinkinga ze-SCD.

• Ukumpontshelwa igazi okuphuthumayo:Lokhu kusiza ekwelapheni izinkinga ezibangela ukuntuleka kwegazi okukhulu. Odokotela bangazisebenzisa futhi ezinkingeni ezifana nesifo sohlangothi, isifo sesifuba esibuhlungu, kanye nokwehluleka kwezitho zomzimba.
• Ukumpontshelwa amangqamuzana abomvu egazi: Lokhu kungandisa inani lamangqamuzana abomvu egazi emzimbeni futhi kunikeze amangqamuzana abomvu egazi ajwayelekile angabunjwa njengesikela.

Ukufakelwa kwamaseli e-stem (okubizwa nangokuthi ukufakelwa komnkantsha)

I-SCD ingelapheka ngokufakelwa i-stem cell. Lokhu kudinga umnikeli ohambisana kahle (njengomfowabo noma udadewabo). Ucwaningo luyaqhubeka nokuthuthukisa ukufakelwa okuvela kubazali noma kubafowabo noma kubafowabo noma kubafowabo abahambisana kancane. Udokotela wakho uzoxoxa ngezingozi nezinzuzo zalokhu kwelashwa ngokusekelwe esimweni sakho esithile.

Ukwelashwa Ngezakhi Zofuzo

Abacwaningi okwamanje baphenya ukwelashwa kwezakhi zofuzo ukuze baphathe i-SCD. Lokhu kuhilela ukulungisa i-hemoglobin gene engavamile noma ukufaka i-hemoglobin gene enempilo kumaseli okuqala omuntu. Imininingwane yokuqala ngalokhu iyathembisa kakhulu. Ithemba liwukuthi ukwelashwa kwezakhi zofuzo ngolunye usuku kuzoba ukwelashwa okuvamile kwe-SCD.

Ingabe lokhu kungavinjelwa?

Isifo se-sickle cell siyisimo sofuzo, ngakho-ke asinakuvinjelwa . Uma ukhulelwe, kungumqondo omuhle ukukhuluma nodokotela wakho mayelana nokuhlolwa kofuzo noma ukwelulekwa ngofuzo . Lokhu kuzokusiza wena nomlingani wakho nazi ukuthi ninayo yini i-gene nokuthi iyini ingozi yokuyidlulisela ezinganeni zenu.

Yini umuntu onesifo se-sickle cell angayilindela?

Abantu abanesifo se-sickle cell bangase babe nesikhathi sokuphila esifushane kancane kunesomphakathi jikelele. Kodwa-ke, ukwelashwa okusha kwe-SCD kuthuthukise kakhulu isikhathi sokuphila kanye nekhwalithi yokuphila . Uma lesi sifo silawulwa kahle, abantu abanesifo se-sickle cell bangaphila baze bafike eminyakeni engu-50.

Ngingamnakekela kanjani umntwana wami uma enesifo se-sickle cell?

Uma ingane yakho inesifo se-sickle cell, kunezinto eziningi ongazenza ukuze uphathe isimo sayo:

• Njalo yisa ingane yakho kudokotela.
• Nikeza ingane yakho yonke imijovo enconywayo ngesikhathi.
• Siza ingane yakho ukuthi izivocavoce njalo futhi idle ukudla okunempilo kwenhliziyo .
• Uma kuvela inkinga yobuhlungu, nikeza ingane yakho uketshezi oluningi kanye nomuthi ongewona owe-steroidal wokulwa nokuvuvukala (NSAID) . Uma ubuhlungu bungenakulawuleka ekhaya, yiyise esibhedlela ukuze uthole imithi enamandla yokudambisa izinhlungu.

Kunini lapho kudingeka uye e-Emergency Treatment Unit (ETU) ?

Isifo se-sickle cell singabangela izinkinga ezahlukahlukene ezisongela impilo. Uma wena noma ingane yakho nihlangabezana nanoma yiziphi izimpawu ezilandelayo, shayela u-911 noma uye ekamelweni lezimo eziphuthumayo eliseduze (ER) ngokushesha:

• Ubuhlungu obukhulu.
• Izimpawu ze-anemia enzima: ukukhathala okukhulu, isiyezi, kanye nokuphelelwa umoya.
• Umkhuhlane ongaphezu kwama-degrees Fahrenheit angu-101.3 (ama-degrees Celsius angu-38.5).
• Izinkinga zokubona.
• Ubunzima bokuphefumula.
• Ukuma kwenduku okuhlala amahora amane noma ngaphezulu (priapism).
• Izimpawu ze-acute chest syndrome: ubuhlungu besifuba, ukukhwehlela, umkhuhlane.
• Izimpawu zesifo sohlangothi: Ubuthakathaka obungazelelwe ohlangothini olulodwa lomzimba, ukungazweli, noma ukulahlekelwa ukwazi.

Kungani isifo se-sickle cell sibangela ubuhlungu?

Kalula nje, amangqamuzana egazi abomvu amise okwesikela abukeka njengohlamvu C, noma inyanga ecwebezelayo. Njengoba ehamba emithanjeni yakho yegazi, ayabhajwa futhi avimbe ukugeleza kwegazi. Yilapho-ke ubuhlungu buqala khona. Cabanga ngakho njengokuminyana kwezimoto emgwaqweni.

Ingabe i-sickle cell iyisifo sokuzivikela komzimba?

Cha. Nakuba isifo se-sickle cell sinezinye zezici zezifo ezizimele , odokotela ababheki i-SCD njengesifo esizimele. Babheka i-SCD njengesimo sofuzo .

Isifo se-sickle cell siyisimo esihlala isikhathi eside. Ukufakelwa kwe-stem cell, okunganikeza ukwelashwa okuphelele, akwenzeki ngaso sonke isikhathi, futhi kuyingozi. Kodwa-ke, ukuxilongwa nokwelashwa kusenesikhathi kungasiza ekunciphiseni izimpawu futhi kunciphise ingozi yezinkinga. Ngokunakekelwa kwezokwelapha okuvamile, ungaphila impilo egcwele, esebenzayo.

Okokugcina, ezinye izinto ezibalulekile okudingeka uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, ngakho-ke sesikhulume kakhulu ngesifo se-sickle cell. Nazi izinto ezibalulekile okufanele uzikhumbule:

• Isifo se-Sickle cell (SCD) yisifo segazi esizuzwe njengefa lapho isimo samaseli abomvu egazi sishintsha khona, okubangela izinkinga ngokugeleza kwegazi.
• Isizathu esiyinhloko salokhu uhlobo olungavamile lwe-hemoglobin olubizwa ngokuthi i-hemoglobin S.
• Ubuhlungu, i-anemia, izifo, kanye nokulimala kwezitho zomzimba kuvamile.
• Ukutholwa kusenesikhathi kanye nokwelashwa okufanele kubaluleke kakhulu. Izinsana ezisanda kuzalwa ziyahlolwa ngalokhu.
• Nakuba ukufakelwa umnkantsha kungaba ikhambi, akufaneleki kuwo wonke umuntu. Kunezinye izindlela zokwelapha, njengemithi kanye nokumpontshelwa igazi.
• Ungaphila kahle nalesi sifo ngokwenza izinguquko endleleni yokuphila, ngokulandela iseluleko esifanele sezokwelapha, kanye nokuthatha isinyathelo ngokushesha esimweni esiphuthumayo .

Uma wena noma othile omaziyo enemibuzo mayelana nesifo se-sickle cell, qiniseka ukuthi ubona udokotela ukuze akunike iseluleko. Akukho okufanele ukwesabe noma ukuhlazeka ngakho. Into ebaluleke kakhulu ukwaziswa! Isifo se-sickle cell, i-hemoglobin, amangqamuzana abomvu egazi, i-anemia, izifo zofuzo, izinkinga zobuhlungu, ukwelashwa kwe-sickle cell