Lingakanani izinga lakho le-LDH? (LDH - Ukuhlolwa kwe-Lactate Dehydrogenase) Ake sithole ngalokhu kalula!

Namuhla sizokhuluma ngokuhlolwa okungasitshela ulwazi oluningi olubalulekile mayelana nempilo yomzimba wethu. Kungenzeka ukuthi uke wezwa ngokuhlolwa kwe-'LDH'. Mhlawumbe udokotela ukucele nokuthi wenze lokhu kuhlolwa. Ngakho-ke, ake sibone ukuthi iyini le 'LDH' nokuthi yini ongayifunda kulolu vivinyo kalula.

Kuyini i-lactate dehydrogenase (LDH)?

Ngakho-ke, ake siqale sibone ukuthi iyini i-'Lactate Dehydrogenase'. Siyibiza nangokuthi '(LDH)' ngamafuphi. Kalula nje, lena yi- enzyme ebaluleke kakhulu emzimbeni wethu. I-enzyme uhlobo lweprotheni olusheshisa futhi lusize ukusabela kwamakhemikhali emzimbeni wethu. Cabanga ngayo njengabasizi abancane abenza imizimba yethu isebenze kalula.

Le enzyme ethi `LDH` isiza ngqo ekuphefumuleni kwamaseli ethu. Okusho ukuthi, le `LDH` isiza ngenqubo ebaluleke kakhulu yokuthatha i-glucose (ngokumane nje, ushukela) ekudleni esikudlayo nokukhiqiza amandla adingwa amaseli ethu omzimba. Lokhu kufana nokusiza ekwenzeni uphethiloli wamaseli asebenza njengezitshalo zamandla ezincane emzimbeni wethu.

Ubuwazi ukuthi le enzyme ethi `LDH` ikhona cishe kuzo zonke izicubu zomzimba wethu? Kodwa itholakala kakhulu emisipheni, esibindini, ezinso, nakumaseli abomvu egazi . Lapho kwakheka amangqamuzana amasha emzimbeni wethu, kususwa amangqamuzana amadala noma "afile". Lokhu kuvamile. Lapho kususwa amangqamuzana amadala, amanye `LDH` kulawo maseli afakwa egazini lethu noma kolunye uketshezi lomzimba. Ngakho-ke, kuvamile ukuba ne-`LDH` ethile kusampula yegazi noma kolunye uketshezi lomzimba.

Ngakho-ke, luyini lolu vivinyo lwe-LDH (lactate dehydrogenase)?

Kulungile, manje usunomqondo omncane wokuthi iyini i-`LDH`. Ukuhlolwa kwe-`LDH` kulinganisa inani le-`LDH` egazini lakho noma kolunye uketshezi lomzimba. Lokhu kuhloswe kakhulu ukuhlola ukuthi kukhona yini umonakalo ezicutshini zomzimba wakho .

Njengoba sixoxile ngaphambili, kuvamile ukuba nenani elithile le-'LDH' egazini lakho. Kodwa-ke, uma noma yisiphi izicubu emzimbeni wakho sonakele noma silimele , i-'LDH' eningi evela kulezo zicubu ezonakele izokhishwa iye egazini lakho noma kolunye uketshezi lomzimba. Ngakho-ke, uma izinga lakho le-'LDH' liphakeme kunokuvamile, kungasho ukuthi ezinye izicubu emzimbeni wakho zonakaliswe yisifo esingamahlalakhona , isifo esibi, noma ukulimala .

Kodwa into eyodwa okufanele uyikhumbule ukuthi kunzima ukusho ngqo ukuthi yisiphi izicubu ezonakele ngokuhlolwa kwe-'LDH' kuphela. Ngoba i-'LDH' ikhona ezindaweni eziningi emzimbeni wethu. Ngakho-ke, odokotela bavame uku-oda ezinye izivivinyo eziningana kanye nokuhlolwa kwe-'LDH' ukuze baxilonge lesi sifo ngokunembile.

Lolu vivinyo lwe-`LDH` lubizwa nangamanye amagama amaningana:

• ukuhlolwa kwe-`LD`
• I-Lactic dehydrogenase
• I-lactic acid dehydrogenase

Ngidinga nini ukuhlolwa kwe-LDH?

Odokotela basebenzisa ukuhlolwa kwe-LDH ukuxilonga nokuqapha izimo ezahlukene zempilo. Izizathu eziyinhloko zokwenza lokhu kuhlolwa yilezi:

• Hlola ukuthi izicubu zomzimba wakho zonakele yini.
• Qaphela izifo ezifana ne -anemia , izifo zezitho zangaphakathi (isib. isibindi, izinso), kanye nezimo ezonakalisa izicubu, njengezifo ezithile .
• Hlola ubucayi bezinhlobo ezithile zomdlavuza .
• Bheka ukuthi ukwelashwa komdlavuza othile (isib. i-chemotherapy) kuyaphumelela yini noma cha.

Njengoba ukuhlolwa kwe-'LDH' kwenziwa ezimweni eziningi ezahlukene, uma uceliwe ukuthi wenze lokhu kuhlolwa, kuwumqondo omuhle ukubuza udokotela wakho ukuthi kungani uhlolwa.

Ubani owenza lolu vivinyo lwe-LDH?

Ngokuvamile, ukuhlolwa kwegazi kwe-LDH kwenziwa yi-phlebotomist eqeqeshwe ukudonsa igazi . Kodwa-ke, noma yimuphi uchwepheshe wezempilo oqeqeshwe ukudonsa igazi angakwenza lokhu. Isampula yegazi ithunyelwa elabhorethri. Lapho, usosayensi welabhorethri yezokwelapha uhlola isampula futhi asebenzise imishini ekhethekile (abahlaziyi) ukukala izinga le-LDH.

Ngezinye izikhathi odokotela kudingeka balinganise amazinga e-LDH kwezinye izinto eziwuketshezi emzimbeni, hhayi egazini kuphela. Isibonelo, uketshezi lwakho lomgogodla (i-Cerebrospinal Fluid noma i-CSF), uketshezi lwakho lwe-pleural ( uketshezi oluzungeze amaphaphu akho ), noma uketshezi lwakho lwe-peritoneal (uketshezi oluzungeze isisu sakho ). Kulezi zimo, udokotela oqeqeshwe ngokukhethekile uzothatha isampula.

Ngingakulungiselela kanjani ukuhlolwa kwe-LDH?

Ezimweni eziningi, awudingi ukulungiselela noma yini ekhethekile yokuhlolwa kwegazi le-LDH.

Kodwa-ke, uma kuthathwa isampula kolunye uketshezi lomzimba, njengoba kushiwo ngaphambili, kungadingeka ukulungiselela okuthile. Udokotela wakho uzokuchazela lokhu ngaleso sikhathi.

Kwenzekani ngesikhathi sokuhlolwa kwe-LDH?

Uma unikela ngegazi, nakhu okuvame ukwenzeka:

• Uzohlaliswa esihlalweni. Ngemuva kwalokho isisebenzi sezempilo sizofuna umthambo engalweni yakho okulula ukuwukhipha igazi. Ngokuvamile, igazi likhishwa ngaphakathi kwendololwane yakho.
• Uma sekutholakale umthambo, indawo iyahlanzwa kahle bese kufakwa umuthi wokubulala amagciwane.
• Ngemuva kwalokho, kufakwa inaliti encane emthanjeni bese kukhishwa igazi elincane. Kuleli qophelo, ungase uzizwe ulunywa kancane, njengokulunywa yizintuthwane .
• Ngemva kokufaka inaliti, inani elincane legazi liqoqwa epayipini lokuhlola.
• Ngemva kokuthathwa kwesampula yegazi, inaliti iyasuswa bese kufakwa ucezu lwekotini noma i-gauze endaweni bese kufakwa ingcindezi encane ukuze kumiswe ukopha.
• Bese kufakwa iplasta endaweni. Yilokho kuphela.

Lonke lolu hlelo luvame ukuthatha imizuzu engaphansi kwemihlanu . Luwumsebenzi osheshayo kakhulu.

Njengoba sixoxile ngaphambili, ngezinye izikhathi kungadingeka olunye uketshezi lomzimba ukuze kulinganiswe i-'LDH'. Amacala anjalo afaka:

• Uketshezi Lomgogodla (CSF)
• Uketshezi lwe -Pleural
• Uketshezi lwe -Peritoneal

Uma kufanele wenze lolu hlobo lokuhlolwa, ungakhathazeki. Udokotela wakho uzokuchazela ngokuningiliziwe ukuthi ukuhlolwa kwenziwa kanjani nokuthi yini okudingeka ukwazi.

Kwenzekani ngemva kokuhlolwa kwe-LDH?

Ngemva kokuthathwa kwesampula yegazi lakho noma olunye uketshezi lomzimba, luthunyelwa elabhorethri ukuze luhlolwe. Uma imiphumela yokuhlolwa isifikile, udokotela wakho uzoxoxa nawe ngemiphumela.

Ingabe zikhona izingozi zokuhlolwa kwe-LDH?

Ukunikela ngegazi kuyindlela evamile kakhulu ocwaningweni lwezokwelapha. Akunangozi enkulu . Kungase kube khona ukuklwebheka nobuhlungu lapho igazi likhishwe khona. Kodwa lokho kuzophela ngokushesha.

Kuzongithatha isikhathi esingakanani ukwazi imiphumela yokuhlolwa kwe-LDH?

Esikhathini esiningi, imiphumela yakho yokuhlolwa kwe-LDH kufanele itholakale zingakapheli usuku noma ezimbili , kodwa ngezinye izikhathi kungathatha isikhathi eside.

Uma lokhu kuhlolwa kwenziwa esibhedlela noma egumbini lezimo eziphuthumayo, ungathola imiphumela zingakapheli amahora ambalwa .

Iyini imiphumela yokuhlolwa kwe-LDH?

Umbiko wokuhlolwa kwegazi, okungukuthi, umbiko wokuhlolwa kwe-`LDH`, uvame ukuqukethe ulwazi olulandelayo:

• Igama lokuhlolwa kwegazi, noma lokho okulinganiswe egazini lakho.
• Inani (okungukuthi, inombolo) lomphumela wokuhlolwa kwegazi lakho.
• Ububanzi obujwayelekile balolo vivinyo.
• Ulwazi olukhombisa ukuthi umphumela wakho ujwayelekile, awujwayelekile, noma uphezulu noma uphansi.

Angakanani amazinga ajwayelekile e-LDH (lactate dehydrogenase)?

Ububanzi obujwayelekile be-'LDH' bungahluka kancane kusuka kwelinye ilabhorethri kuya kwelinye. Uma uthola umbiko wakho wokuhlolwa kwegazi, uzosho ngokucacile ukuthi ungakanani ububanzi obujwayelekile be-'LDH' kulelo labhorethri.

Kodwa-ke, ngokuvamile, amanani ajwayelekile okuhlolwa kwe-LDH angokulandelayo:

• Kwabesilisa : amayunithi angu-135 - 225 ngelitha (U/L).
• Kwabesifazane : Amayunithi ngelitha (U/L) 135 – 214.

Amazinga ajwayelekile e-LDH ezinganeni ezincane ngokuvamile aphezulu kunakwabantu abadala.

Uma unemibuzo mayelana nemiphumela yakho, qiniseka ukuthi ubuza udokotela wakho.

Kusho ukuthini uma izinga lami le-LDH liphezulu?

Uma izinga lakho le-LDH liphakeme kunejwayelekile, cishe kusho ukuthi kukhona umonakalo kwezinye izicubu emzimbeni wakho.Kusho ukuthi kukhona okwenzekile. Lowo monakalo ungabangelwa ukugula kwesikhathi eside (okungamahlalakhona), isimo esiphuthumayo (esibucayi), noma ukutheleleka.

Ezinye zezimo zezokwelapha ezingabangela amazinga aphezulu e-LDH yilezi:

• I-anemia
• Isifo sezinso
• Isifo samaphaphu
• Isifo sesibindi
• Ukulimala kwemisipha
• Ukuwohloka kwemisipha
• Ukuphuka kwethambo
• Isifo senhliziyo
• I-Pancreatitis
• Ezinye izifo , njenge -meningitis , i-encephalitis , i-mononucleosis (i-mono ), kanye ne-HIV .
• Ezinye izinhlobo zomdlavuza , isibonelo, i-metastatic melanoma , i-multiple myeloma, i-lymphoma , umdlavuza wamasende , kanye ne-leukemia .

Futhi, ukuba nezinga le-LDH eliphakeme kunelijwayelekile kungasho ukuthi ukwelashwa komdlavuza akusebenzi kahle .

Nakuba ukuhlolwa kwe-LDH kungabonisa ukuthi izicubu zomzimba wakho zonakele noma ukuthi unesifo, akukwazi ukukutshela ngqo ukuthi umonakalo ukuphi . Futhi, uma amangqamuzana abomvu egazi ephukile ngesikhathi sesampula yegazi (i-hemolysis), inani le-LDH ngezinye izikhathi lingaba phezulu ngokungeyikho . Ngakho-ke uma imiphumela yakho ikhombisa ukuthi izinga lakho le-LDH liphezulu, udokotela wakho cishe kuzodingeka enze ukuhlolwa okwengeziwe ukuze athole ukuxilongwa okunembile.

Ingabe kufanele ngikhathazeke uma izinga lami le-LDH liphezulu?

Ngisho noma imiphumela yakho yokuhlolwa kwe-LDH ikhombisa ukuthi izinga lakho le-LDH liphezulu, akusho ukuthi unesifo esibi kakhulu . Ungakhathazeki.

Kunezinye izici eziningana ezingabangela amazinga aphezulu e-LDH:

• Ukuzivocavoca ngamandla .
• Eminye imithi , isibonelo i-aspirin , imithi yokubulala izinzwa , imithi yezidakamizwa , kanye ne-procainamide .

Futhi, kungenzeka ukuthi kube nephutha ngesikhathi sokuqoqwa kwamasampula, ukuthuthwa, noma ukuhlolwa.

Lapho ethatha isinqumo ngemiphumela yakho, udokotela wakho uzocabangela izinto eziningi, njengemithi oyiphuzayo njengamanje, umlando wakho wezempilo, kanye nezimpawu ozizwayo.Uzokutshela nokuthi udinga ukuhlolwa okwengeziwe noma cha.

Uma unemibuzo mayelana nemiphumela yakho, ungesabi ukukhuluma nodokotela wakho.

Kusho ukuthini uma izinga lami le-LDH liphansi?

Akuvamile kakhulu ukuthi imiphumela yokuhlolwa kwe-`LDH` ibe ngaphansi kunejwayelekile .

Ukuba nezinga eliphansi kangaka le-LDH kungabonisa isimo esingavamile kakhulu sezakhi zofuzo esibizwa ngokuthi ukuntuleka kwe-Lactate Dehydrogenase A - i-Glycogen Storage Disease XI, noma ukuntuleka kwe -Lactate Dehydrogenase B.

Futhi, abantu abadla i-vitamin C eningi kakhulu bangase babe nemiphumela yokuhlolwa kwe-LDH ephansi ngokungeyikho .

Yimiphi imibuzo okufanele ngiyibuze udokotela wami?

Uma uke wahlolwa i-LDH, kungaba usizo ukubuza udokotela wakho imibuzo efana nale:

• Ucabanga ukuthi yini engaba yimbangela yezinga lami eliphezulu le-'LDH'?
• Ingabe ngidinga ukwenza izivivinyo ezengeziwe ukuze ngithole imbangela eqondile yamazinga ami aphezulu e-LDH?
• (Uma ungumuntu onomdlavuza) Izinga lami le-'LDH' lithini ngobunzima kanye nokubikezela komdlavuza wami?
• (Uma welashelwa isifo esithile) Izinga lami le-'LDH' lithini ngendlela isimo sami esisabela ngayo ekwelashweni?

Into ebaluleke kakhulu okufanele uyikhumbule (Umyalezo Wokuya Ekhaya)

Kuvamile ukuzizwa wesaba futhi ukhathazekile kancane uma ubona umphumela wokuhlolwa ongajwayelekile. Kodwa khumbula, ukuthi nje izinga lakho le-'LDH' (lactate dehydrogenase) liphezulu akusho ukuthi unesifo esingathi sína futhi udinga ukwelashwa.

Udokotela wakho uzokutshela nakanjani ukuthi udinga ukwenza izivivinyo ezengeziwe ukuthola imbangela yaleli zinga elingavamile noma cha. Ungesabi noma ungabaze ukubuza udokotela wakho imibuzo . Bakhona ukukusiza. Khuluma nabo nganoma yini onayo ngempilo yakho.

I- LDH, i-lactate dehydrogenase, i-enzyme, umonakalo wezicubu, ukuhlolwa kwegazi, impilo, ukuxilongwa