Uma udokotela wakho ekutshela noma othile omaziyo ukuthi unomdlavuza webele, kungenzeka ukuthi ukhulume ngokwelashwa ngama-hormone njengendlela yokwelapha. Ungase ukhathazeke kancane uma uzwa lokhu. Kodwa ungakhathazeki. Namuhla sikhuluma ngohlobo lomuthi olusebenza kahle kakhulu olunikezwa abantu abanamangqamuzana omdlavuza azwela i-hormone i-estrogen (`Estrogen Receptor-Positive` noma `ER+`). Lawa abizwa ngokuthi ama-Aromatase Inhibitors.
Kalula nje, ziyini lezi zithiyo ze-Aromatase?
Kulungile, ake sichaze lokhu. Ama-Aromatase inhibitors, noma ama-AI ngamafuphi, ayizinhlobo zemithi evame ukusetshenziswa ekwelashweni kwama-hormone. Asetshenziswa ekwelapheni umdlavuza webele we-ER+, ikakhulukazi kwabesifazane asebekhulile .
Manje, bheka, i-estrogen iyi-hormone ebalulekile emizimbeni yethu, ikakhulukazi empilweni yokuzala yabesifazane. Kodwa-ke, kwamanye amangqamuzana omdlavuza webele, le hormone ye-estrogen ifana nokudla. Okusho ukuthi, uma i-estrogen ikhona, lawo maseli omdlavuza akhula ngokushesha.
Yilapho izidakamizwa ze-'AI' zingena khona. Lokho okwenziwa yile mithi ukuvimba i-enzyme ebizwa ngokuthi i-aromatase emzimbeni wethu. Le enzyme ye-aromatase iguqula amanye ama-hormone abe yi-estrogen. Ngakho-ke, lapho lo muthi uvimba i-enzyme ye-aromatase ukuthi isebenze, amazinga e-estrogen emzimbeni ayancipha. Khona-ke lawo maseli omdlavuza alahlekelwa "ukudla" kwawo, ayayeka ukukhula, futhi umdlavuza uyalawulwa. Uyaqonda?
Kalula nje, lokho okwenziwa yilo muthi ukuvimba amangqamuzana omdlavuza ekutholeni "uphethiloli" awudingayo.
Kukuziphi izimo lapho lo muthi unconywa khona?
Kunezimo eziningana lapho udokotela wakho angancoma khona lokhu kwelashwa "kwe-AI":
- Uma uke wahlinzwa umdlavuza webele we-ER+, lo muthi unikezwa ukunciphisa ingozi yokuthi umdlavuza uphinde ubuye .
- Uma umdlavuza ususakazekele kuma-lymph node aseduze.
- Uma umdlavuza ususakazekele kwezinye izingxenye zomzimba (isib. amaphaphu, amathambo, ubuchopho, isibindi), siwubiza ngokuthi umdlavuza osakazekile.
- Uma unalo mdlavuza we-`ER+` ngaphambi kokunqamuka kokuya esikhathini. Ngalesi sikhathi, ama-ovari akho asakhiqiza i-estrogen, ngakho-ke unganikezwa ezinye izindlela zokwelapha ukulawula leyo hormone ye-estrogen kanye nemithi ye-`AI`.
- Uma indoda iba nomdlavuza webele we-`ER+`. (Yebo, amadoda nawo athola umdlavuza webele, futhi anamazinga aphansi e-estrogen emizimbeni yawo).
- Ezinye izifundo zibonise ukuthi abantu abasengozini enkulu yokuba nomdlavuza webeleKuthiwa lo muthi uyasiza ekunciphiseni leyo ngozi, kodwa awukakayitholi imvume esemthethweni.
Izinhlobo ezisetshenziswa kakhulu ze-aromatase inhibitors
Kunezinhlobo eziningana zale mithi "ye-AI" emakethe. Udokotela wakho uzokhetha leyo efanelana kahle nesimo sakho.
| Igama Lomuthi |
|---|
| I-Letrozole |
| I-Anastrozole |
| I-Exemestane |
Ngiyithola kanjani le ndlela yokwelashwa futhi kuthatha isikhathi esingakanani?
Lo muthi "we-AI" uyiphilisi okufanele uliphuze nsuku zonke . Ngezinye izikhathi, ukwelashwa kuqala ngalo muthi. Ngezinye izikhathi, udokotela wakho angase akunike omunye umuthi we-hormone obizwa ngokuthi i-tamoxifen iminyaka embalwa bese ekushintshela kumuthi "we-AI".
Ngokuvamile, lokhu kwelashwa kuqhubeka iminyaka engaba mihlanu . Ngemva kweminyaka emihlanu, uma ungenazo izimpawu zomdlavuza futhi ukuhlolwa kujwayelekile, ungayeka ukwelashwa.
Kodwa-ke, ezinye izifundo zikhombisile ukuthi umdlavuza ungabuya eminyakeni engama-20 ngemuva kokwelashwa. Lokhu kubizwa ngokuthi 'ukuphinda ubuye sekwephuzile'. Ngakho-ke, kubaluleke kakhulu ukukhuluma ngokukhululekile nodokotela wakho ngezingozi eziqondene nesimo sakho.
Izinzuzo zokwelashwa kanye nemiphumela emibi engaba khona
Inzuzo enkulu yalokhu kwelashwa ukuthi kungalapha cishe ngokuphelele umdlavuza webele we-ER+. Izifundo zikhombisile ukuthi abantu abangu-95% abathola lokhu kwelashwa kwe-AI ngemuva kokuhlinzwa ngeke baphinde bahlaselwe umdlavuza wabo zingakapheli iminyaka emi-5 . Lezo izindaba ezinhle, akunjalo?
Kodwa, njengayo yonke imithi, lena ingaba nemiphumela emibi. Ngoba, njengoba sixoxile ngaphambili, i-estrogen iyi-hormone esiza futhi ukugcina amathambo nezinhliziyo zethu ziphilile. Ngakho-ke, uma wehlisa amazinga e-estrogen nge-'AI', eminye imiphumela emibi ingenzeka.
| Umphumela Ongemuhle | Kalula nje... |
|---|---|
| I-Osteoporosis kanye nokuqhekeka kwamathambo | Amathambo aba buthakathaka futhi ingozi yokuphuka iyanda kalula. |
| Ubuhlungu bemisipha (i-Myalgia) | Ubuhlungu bemisipha. |
| Ubuhlungu bamalunga | Ubuhlungu bamalunga, njengamadolo nezindololwane. Lona umphumela ovame kakhulu. |
| Ukushisa okukhulu | Kungazelelwe ngizizwe ngishisa kakhulu futhi ngijuluka. |
| Ukoma kwesitho sangasese sowesifazane | Ubuhlungu bungase buvele ngesikhathi socansi. |
| Ingozi yesifo senhliziyo | Ingozi yesifo senhliziyo yanda kancane. |
Ungabhekana kanjani nemiphumela emibi?
Ungakhathazeki ngale miphumela emibi. Into ebaluleke kakhulu ukukhuluma nodokotela wakho ngayo. Ikakhulukazi uma izinto ezifana nobuhlungu bamalunga zinzima, akudingeki ubekezelele. Udokotela wakho angakunika izixazululo. Isibonelo:
- Ama-painkiller, ikakhulukazi ama-NSAID (isib. i-ibuprofen), anganikezwa.
- Uma ukuthola kunzima ukubekezelela, ungashintshela kolunye uhlobo lwe-AI esikhundleni se-AI oyisebenzisayo njengamanje.
- Kwezinye izimo, i-tamoxifen ingafakwa esikhundleni se-AI.
Into ebaluleke kakhulu ukwazisa udokotela wakho nganoma yikuphi ukungakhululeki, kunokwenza izinqumo wedwa.
Kunini lapho udinga ukukhuluma nodokotela?
Ezimweni ezilandelayo, qiniseka ukuthi ukhuluma nodokotela wakho.
- Uma imiphumela emibi imbi kakhulu kunalokho obekulindele.
- Uma umuthi onikezwe udokotela unganikezi impumuzo emiphumeleni emibi.
- Uma ubona izimpawu zokubuyela komdlavuza (isib., amaqhubu amasha, ubuhlungu obuqhubekayo, ubunzima bokuphefumula) , buza udokotela wakho ukuthi yiziphi izimpawu okufanele uziqaphele.
Umlayezo Wokuya Nawe Ekhaya
- Ama-inhibitor e-Aromatase ayindlela yokwelapha yama-hormone ebaluleke kakhulu futhi ephumelelayo yomdlavuza webele ozwela i-estrogen (ER+).
- Le mithi isebenza ngokunciphisa amazinga e-estrogen emzimbeni kanye nokuvimba ukukhula kwamaseli omdlavuza.
- Lokhu kwelashwa kunciphisa kakhulu ingozi yokuphinda umdlavuza.
- Imiphumela emibi efana nobuhlungu bamalunga kanye nokuncipha kwamathambo ingenzeka, kodwa iningi lale miphumela ingalawulwa.
- Okubaluleke kakhulu: Ungalokothi uyeke ukuthatha imithi yakho noma ushintshe umthamo ngaphandle kweseluleko sikadokotela wakho. Khuluma naye ngokukhululekile nganoma yikuphi ukungakhululeki okuzwayo.
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