Ingabe unezindawo noma amaqhubu angajwayelekile esikhumbeni sakho? Ingabe lokhu kungaba yi-Cutaneous B-Cell Lymphoma?

Isikhumba sethu siyinto enhle kakhulu, akunjalo? Ngezinye izikhathi amaqhubu amancane namabala ayafika aphinde aphele. Kodwa ngezinye izikhathi ungase usole kancane ngebala elisha noma iqhubu esikhumbeni sakho, noma elidala elingapholi. Ngezikhathi ezinjalo, kudingeka siqaphele kancane. Ngoba, nakuba lingavamile kakhulu, izinguquko ezinjalo zesikhumba zingaba uphawu lwesimo esibucayi. Namuhla sizokhuluma ngesifo sesikhumba esingavamile, kodwa esibaluleke kakhulu okufanele siqashelwe. Leso yisimo esibizwa ngokuthi i-cutaneous B-cell lymphoma, noma `(Cutaneous B-Cell Lymphoma)`.

Kuyini i-Cutaneous B-Cell Lymphoma?

Kalula nje, i-Cutaneous B-Cell Lymphoma (CBCL) uhlobo lomdlavuza oluqala esikhumbeni sakho. Luyivelakancane. Lungolweqembu lomdlavuza olubizwa ngokuthi i-lymphoma. Kodwa into ekhethekile ukuthi luqala ngaphandle kwama-lymph node ethu, esikhumbeni. Yingakho lubizwa ngokuthi i-extranodal lymphoma.

Ngokuvamile, lokhu `(CBCL)` kuvela njengebala, ukuqubuka, noma iqhubu esikhumbeni. Lokhu kukhula kancane kakhulu. Kungathatha izinyanga, ngisho neminyaka, ukuthi kukhule. Futhi, akuvamile ukusabalala kwezinye izingxenye zomzimba. Abanye abantu bakubiza nangokuthi `(B-cell skin lymphoma)`. Ngakho-ke, uma ubona okuthile okusha noma okuhlukile esikhumbeni sakho, kungumqondo omuhle ukukunaka.

Ikhula kanjani le lymphoma? Ayini ama-B-cell?

Manje ungase uzibuze ukuthi kungani kwenzeka into efana nale. Uma ngikhuluma iqiniso, ososayensi abakayitholi imbangela eqondile yalokhu '(CBCL)'. Kodwa into eyodwa icacile: akuyona into edluliselwa ngofuzo noma ethelelanayo.

Kuqala ngamangqamuzana amhlophe egazi abizwa ngokuthi ama-lymphocyte. Lawa ma-lymphocyte angamalungu abaluleke kakhulu ohlelweni lwethu lokuzivikela komzimba. Afana nebutho elivikela izwe lethu. Kunezinhlobo ezimbili eziyinhloko zama-lymphocyte: ama-T-cell nama-B-cell. Lapho ama-B-cell eqala ukukhula kakhulu ngaphandle kokulawulwa, lesi simo esibizwa ngokuthi i-B-cell lymphoma siyenzeka. Kalula nje, amangqamuzana ethu ayahlanya kancane abe amangqamuzana omdlavuza.

Yiziphi izinhlobo eziyinhloko ze-cutaneous B-cell lymphoma?

Kunezinhlobo ezine eziyinhloko zalokhu ``(CBCL)``. Lezi zihlukaniswa ngokusekelwe endleleni amaseli abukeka ngayo ngaphansi kwesibonakhulu. Uhlobo ngalunye lungabonakala luhlukile esikhumbeni futhi lungadinga ukwelashwa okuhlukile.

1. I-lymphoma yesikhumba eyinhloko ye-follicle centre:

• Lolu uhlobo oluvame kakhulu lwe-`(CBCL)`.
• Ngokuvamile, zenzeka ekhanda, entanyeni, noma esifubeni/esithweni somzimba.
• Kubonakala sengathi kubomvu ngokunsundu, amaqhubu aphakanyisiwe noma ukuqubuka esikhumbeni .
• Lokhu kubi kakhulu, kukhula ngokuhamba kwezinyanga, mhlawumbe iminyaka.

2. I-B-cell lymphoma yesikhumba esiyinhloko:

• Lolu futhi uhlobo olukhula kahle.
• Ngokuvamile kubonakala njengezilonda ezibomvu ngokupinki, amaqhubu, noma izimila .
• Ngokuvamile kwenzeka emzimbeni noma ezingalweni.

3. I-lymphoma enkulu ye-B-cell diffuse eyinhloko, uhlobo lomlenze:

• Lokhu kuncane kancane kunezinye izinhlobo ezimbili, kodwa kunolaka kakhulu. Lokho kusho ukuthi kukhula ngokushesha, emavikini noma ezinyangeni ezimbalwa.
• Ngokuvamile kubonakala njengesimila esisodwa noma ngaphezulu noma amaqhubu emilenzeni, ezingalweni, noma esifubeni/esithweni somzimba.

4. I-lymphoma enkulu ye-B-cell esakazeka ngesikhumba, okunye:

• Lolu uhlobo olungavamile kakhulu futhi olunolaka.
• Ukubukeka kungahlukahluka, kodwa ngokuvamile kuqala ekhanda, esifubeni, nasemaphethelweni.

Ubani onamathuba amaningi okuthola lesi sifo? Sivame kangakanani?

Empeleni, lesi simo esibizwa ngokuthi ``(CBCL)`` singakhula kunoma ubani. Akukho mehluko wobulili, akukho mehluko wobudala, futhi kutholakale ukuthi sikhula ezizweni ezahlukene. Ngakho-ke, kunzima ukucabanga ukuthi, "Lokhu ngeke kwenzeke kimi."

Kodwa, ungesabi. Lesi yisimo esingavamile kakhulu. Cabanga ngakho, uma uthatha isilinganiso sabantu abayisigidi, abane kuphela kubo abazobhekana nalesi simo. Ngakho-ke, akudingeki wesabe futhi ucabange ukuthi lokhu "(CBCL)" lapho ubona okuthile okungajwayelekile esikhumbeni sakho. Kodwa-ke, uma unokungabaza, kuwukuhlakanipha ukufuna iseluleko sezokwelapha.

Ziyini izimpawu? Bheka ukuthi unazo yini lezi zimpawu

Uphawu oluyinhloko lwe-`(CBCL)` izinguquko esikhumbeni. Lokhu kungavela ngezindlela ezahlukene:

• Ukuqubuka
• Iqhubu noma iqhubu esikhumbeni
• Iqhubu elincane (iqhubu noma isimila)

Lezi zingaba bomvu, onsomi, noma onsundu. Ezinye ziphakanyisiwe futhi ziqinile, kodwa zibushelelezi. Lezi zibizwa ngokuthi ama-papules. Ezinye ziyisicaba, njengeziqephu zesikhumba esijiyile. Lezi zibizwa ngokuthi ama-plaque. Amaqhubu amakhulu abizwa nangokuthi amaqhubu noma amathumba.

Kungase kube nebala/iqhubu elilodwa nje, noma kungase kube neziningana. Futhi, zingase zivele endaweni eyodwa emzimbeni noma ezindaweni eziningana. Zingase zitholakale eduze komunye nomunye, noma ziqhelelene kakhulu.

Cabanga nje, uMalume uSunil wayenebala elibomvu elincane esandleni sakhe izinyanga eziningi. Wayecabanga ukuthi liwumkrwelo nje. Kodwa kancane kancane lakhula laba likhulu laba yiqhubu. Yilokho okungaba uphawu lokuqala lwalokhu.

Akuvamile kakhulu, abanye abantu bangase babe nezinye izimpawu. Lezi zibizwa nangokuthi "izimpawu ze-B". Lezi zifaka:

• Umkhuhlane oza ngaphandle kwesizathu.
• Ukujuluka ngokweqile ebusuku.
• Ukuvuvukala kwama-lymph node entanyeni, emakhwapheni, noma embotsheni.
• Ukwehlisa isisindo ngaphandle kwesizathu.

Ukuba khona kwalezi "zici ze-B" kusho ukuthi lesi sifo kungenzeka ukuthi sesisabalale kancane. Kodwa-ke, lezi azivamile kakhulu ku-`(CBCL)`.

Odokotela bakuthola kanjani lokhu?

Abantu abaningi bayalibala ukufuna iseluleko sezokwelapha ngoba amabala namaqhubu avela esikhumbeni ku-CBCL angabonakala njenge-acne evamile, ukulunywa yizinambuzane, ukungezwani komzimba, imihuzuko, noma ezinye izimo zesikhumba ezifana ne-eczema noma i-psoriasis. Kodwa-ke, uma unento engavamile esikhumbeni sakho engapholi, kufanele nakanjani ubone udokotela, ikakhulukazi udokotela wesikhumba.

Udokotela uzoqala ngokuhlolisisa isikhumba sakho. Uzobheka zonke izindawo zomzimba wakho futhi ahlole ukuthi azikho yini izinkinga.

Bese kuthi, ukuze kutholakale ukuthi lesi sifo sikhona ngempela, kudingeke "i-biopsy yesikhumba", okusho ukuthatha ingxenye encane yesikhumba endaweni engajwayelekile bese uyihlola. Le ngxenye encane yesikhumba ihlolwa ngaphansi kwe-microscope nguchwepheshe (``udokotela wezifo``) ukuze kubonakale ukuthi kukhona yini amangqamuzana omdlavuza, futhi uma kunjalo, ukuthi aluhlobo luni. I-``biopsy``` iyindlela kuphela yokubona kahle ukuthi ngabe iyi-``skin lymphoma`` nokuthi iyini uhlobo.

Ukuze abone ukuthi umdlavuza ususakazeke yini, udokotela wakho angase acele ukuhlolwa okwengeziwe (`ukuhlolwa kwesigaba`). Lokhu kungafaka:

• Ukuhlolwa kwegazi.
• Ukuhlolwa kwezithombe njenge-CT scan noma i-PET scan.
• I-biopsy yomnkantsha wamathambo.
• I-biopsy ye-lymph node.

Ake sifunde ngezigaba kanye nokusabalala kwalesi sifo.

Isigaba salesi sifo (CBCL) siyisilinganiso sokuthi umdlavuza ususakazeke yini nokuthi ususakazeke kangakanani. Lesi sigaba sibaluleke kakhulu ngoba sinquma ukwelashwa. Udokotela wakho uzochaza ukuthi lesi sifo sikusiphi isigaba nokuthi sizokuthinta kanjani.

• Isigaba 1E: Igama elithi "E" limelela elithi "extranodal," okusho ukuthi lingaphandle kwama-lymph node. Kulesi sigaba, umdlavuza ugcina esikhumbeni futhi awusakazekanga kwenye indawo. Uma kungekho zimpawu ezengeziwe ze-"B", njengomkhuhlane noma ukwehla kwesisindo, lokhu kubizwa nangokuthi "Isigaba 1AE."

Uma i-"CBCL" isisabalele, odokotela basebenzisa uhlelo olubizwa ngokuthi "uhlelo lokulinganisa lwe-TNM".

• Isimila (T): Uhlamvu "T" lubhekisela enanini lama-papules, ama-nodules, noma ama-tumors esikhumbeni, ukuthi makhulu kangakanani, nokuthi atholakala kuphi. Lokhu kubalwa kusukela ku-1 kuya ku-3 (kusukela kokuncane kuya kokubi kakhulu).
• Ama-Node (N):Uhlamvu "N" lubonisa ukuthi ama-lymph node athintekile yini, ukuthi mangaki, nokuthi akuphi. Lokhu futhi kunezinombolo kusukela ku-0 kuya ku-3.
• I-Metastasis (M): Uhlamvu "M" lubonisa ukuthi i-lymphoma isakazeke ngale kwesikhumba noma ama-lymph node (`M1`) noma cha (`M0`). `(Metastasis)` kusho ukuthi umdlavuza ususakazeke ezithweni ezikude.

Yiziphi izindlela zokwelapha? Ingabe ingelapheka?

Ukwelashwa kwe-`(CBCL)` kuncike kuhlobo lwesifo kanye nesigaba saso. Ngokuvamile singelapheka, ikakhulukazi ngezindlela ezithuthukile kakhulu. Kodwa-ke, ngezinye izikhathi lesi sifo singaphinde sibuye.

Kunezinketho eziningana zokwelapha:

• Ukuqapha okusebenzayo: Kwezinye izimo lapho isifo sikhula khona futhi singabangeli izinkinga ezinkulu, odokotela bangase basebenzise indlela "yokubuka nokulinda". Okusho ukuthi, baqapha lesi sifo kuze kube yilapho ukwelashwa sekuqalile.
• Ukwelashwa ngamakhemikhali: Ukunikeza imithi ebulala amangqamuzana omdlavuza. Lawa angathathwa njengamaphilisi noma anikezwe njengomjovo.
• Imithi yokwelapha noma ejovwayo: Imithi efana ne-corticosteroids ingasetshenziswa esikhumbeni noma ifakwe ngqo eqhubu.
• Ama-antibodies e-Monoclonal: Imithi efana ne-`(Rituximab)` ingeyaleli qembu. Lawa asebenza njengemithi yokwelapha eqondiwe futhi abhubhisa ama-B-cell.
• Ukwelashwa ngemisebe: Ukusetshenziswa kwemisebe enamandla amakhulu ukubhubhisa amangqamuzana omdlavuza. Lokhu kuvame ukusebenza kahle ezimila ezitholakala endaweni ethile.
• Ukususwa ngokuhlinzwa: Ngezinye izikhathi, uma kukhona iqhubu elilodwa, lingasuswa ngokuphelele ngokuhlinzwa.

Udokotela wakho uzoxoxa nawe ngendlela yokwelapha engcono kakhulu kuwe.

Ingabe ikhona indlela yokuvimbela lokhu ukuthi kungenzeki?

Ngeshwa, njengoba imbangela eqondile ye-`(CBCL)` ingakaziwa, azikho izindlela eziqinisekisiwe zokuyivimbela. Ngakho-ke, into engcono kakhulu esingayenza ukuqaphela noma yiziphi izinguquko ezingavamile esikhumbeni sethu futhi sifune iseluleko sezokwelapha ngokushesha uma sibona noma yini.

Iyini iphrojekthi? (Isibikezelo)

Ukubikezela, noma umbono, kuncike ezintweni eziningana, ikakhulukazi uhlobo lwe-lymphoma kanye nesigaba salesi sifo.

• Izinhlobo ezimbili ezivame kakhulu (`i-Primary cutaneous follicle center lymphoma` kanye ne-`Primary cutaneous marginal zone B-cell lymphoma`): Lezi zinesilinganiso sokusinda seminyaka emihlanu esingaba ngu-95%. Lokho kusho ukuthi eminyakeni emihlanu ngemva kokuxilongwa, iziguli ezingu-95 kwezingu-100 zisaphila. Lokhu kuwumkhuba omuhle kakhulu.
• Izinhlobo ezinolaka kakhulu (`I-primary cutaneous diffuse large B-cell lymphoma, uhlobo lomlenze` kanye `nokunye`): Lezi zinesilinganiso sokusinda seminyaka emihlanu esingaba ngu-60%.

Lezi zibalo zimane ziyisilinganiso. Isimo sakho singase sibe ngcono noma sibe sibi kakhulu, ngakho-ke kungcono ukukhuluma nodokotela wakho ngalokhu.

Ngingabuya yini ngemva kokwelashwa?

Yebo, i-cutaneous lymphoma ingaphinde ivele ngemva kokwelashwa. Amaqhubu angabuya endaweni efanayo noma endaweni entsha. Ngokuvamile, uhlobo olufanayo luyabuya. Kodwa-ke, akuvamile kakhulu, i-CBCL ephinde yabuya ingaba yisifo esijwayelekile noma olunye uhlobo lwe-lymphoma.

Ngakho-ke, kubaluleke kakhulu ukuhlola isikhumba sakho njalo ('ukuhlolwa kwesikhumba') futhi uhlolwe njalo nodokotela wesikhumba noma omunye uchwepheshe.

Uyinakekela kanjani impilo yakho njengomuntu one-CBCL?

Uma unayo (i-CBCL) noma uke waba nayo ngaphambilini walulama, kubaluleke kakhulu ukulandela imiyalelo kadokotela wakho. Kuzodingeka uqhubeke nokuhlolwa ukuqinisekisa ukuthi lesi sifo asiphindanga savela.

Ukuthi lezi zivivinyo zenziwa kangaki kuzohluka kuye ngohlobo lwe-CBCL nokuthi lunolaka kangakanani. Kungaba njalo emavikini ambalwa, njalo ezinyangeni ezimbalwa, noma kanye ngonyaka. Lokhu kuhlolwa okulandelayo kungafaka ukuhlolwa kwesikhumba, ukuhlolwa kwegazi, ama-x-ray, noma ama-biopsy.

Imibuzo okufanele uyibuze udokotela wakho nakanjani

Uma kutholakale ukuthi une-`(Cutaneous B-Cell Lymphoma)`, ungakhohlwa ukubuza udokotela wakho le mibuzo:

• Yiluphi uhlobo lwe-`(CBCL)` enginalo?
• Lokhu kusezingeni lini?
• Hlobo luni lokwelashwa olunconywayo?
• Yimiphi imiphumela emibi kanye nezingozi zalezo zindlela zokwelapha?
• Iyini iphrojekthi yami?
• Kuthatha isikhathi esingakanani ukwazi ukuthi ukwelashwa kuphumelele noma cha?
• Kufanele ngikubone kangaki ukuze ngiqinisekise ukuthi i-lymphoma ayibuyanga?

Izimpendulo zale mibuzo zizokusiza ukuthi uqonde kangcono lesi sifo kanye nezinyathelo ezilandelayo.

Umyalezo Wokuya Ekhaya Ovela Kulokho Ebesikhuluma Ngakho

I-Cutaneous B-Cell Lymphoma uhlobo lomdlavuza olungavamile oluqala emaseli abizwa ngokuthi ama-lymphocyte esikhumbeni.

• Iningi lamacala likhula kancane futhi alisabalali kwezinye izingxenye zomzimba. Kodwa-ke, ezinye izinhlobo zingaba nolaka futhi zisakazeke.
• Uma ubona iqhubu elisha, elingapholi, ibala, noma ukuqubuka esikhumbeni sakho, ungakushayi indiva . Bona udokotela, ikakhulukazi udokotela wesikhumba, ngokushesha.
• Izinhlobo eziningi ze-CBCL zingelapheka ngokutholwa kusenesikhathi kanye nokwelashwa okufanele.
• Ngenxa yokuthi lesi sifo singase sibuye ngemva kokwelashwa,Kubalulekile ukuhlolwa ngezikhathi ezihleliwe njengoba kunqunywe udokotela.

Khumbula, lolu lwazi lungolwezinjongo zokunikeza ulwazi kuphela. Uma unenkinga yezempilo, kungcono ukufuna iseluleko sezokwelapha.

I- Lymphoma Yesisele Esinesikhumba, Umdlavuza Wesikhumba, I-Lymphoma, Iseli Esine-B, Amaqhubu Esikhumba, Isifo Sesikhumba