Wake wazizwa sengathi umphimbo wakho uyavaleka futhi waba nenkinga yokugwinya ukudla? Mhlawumbe wena noma othile omaziyo unesifo esibizwa ngokuthi i-Eosinophilic Esophagitis. Kungaba igama elide, kodwa kungaba nomthelela omkhulu empilweni yakho yansuku zonke. Kodwa kunezindaba ezinhle! I-Dupixent umuthi omusha ovunyelwe ukwelapha lesi simo. Ake sixoxe ngakho kalula nangokucacile namuhla.
Kalula nje, iyini i-Eosinophilic Esophagitis?
Lesi yisimo esingamahlalakhona esithinta amasosha omzimba ethu. Cabanga ngakho, kunezinhlobo ezahlukene zamaseli emzimbeni wethu asivikela ezifweni, akunjalo? Olunye uhlobo olunjalo lwamaseli amhlophe egazi lubizwa ngokuthi i-eosinophil . Nakuba ngokuvamile esisiza, kumuntu one-Eosinophilic Esophagitis, la maseli aqoqana ngokweqile futhi abangele ukuvuvukala emhubheni , ipayipi esigwinya ngalo ukudla.
Lokhu kuvuvukala kubangela ukuthi umphimbo uvuvuke futhi unciphe. Kwenzekani-ke? Kuba nzima ukuthi ukudla kudlulele esiswini. Lokhu...
- Kuba nzima ukugwinya ukudla.
- Ukudla kubhajwa emphinjeni.
- Ubuhlungu noma ukusha kwesifuba kungase kwenzeke.
- Kungase kube nokuhlanza.
Ngokuvamile lesi simo sihlobene nokungezwani komzimba nokudla okuthile.
I-Dupixent isebenza kanjani kulesi sifo?
Ngokuvamile, odokotela baqala ngokunikeza imithi enciphisa i-asidi yesisu (Proton Pump Inhibitors). Isibonelo, kungenzeka ukuthi uke wezwa ngemithi efana ne-"omeprazole" kanye ne-"lansoprazole". Ngezinye izikhathi, banikeza nama-steroid (corticosteroids) ukunciphisa ukuvuvukala.
Kodwa i-Dupixent isebenza ngendlela ehluke ngokuphelele.
I-Dupixent iwumuthi wokugomela othinta ngqo amasosha omzimba wethu futhi ulawula ukuvuvukala okubangela lesi sifo.
Isithako esisebenzayo ku-Dupixent yi -dupilumab . Kalula nje, isebenza ngokuvimbela umsebenzi wamaprotheni amabili abizwa ngokuthi i-interleukin-4 kanye ne-interleukin-13, okuyizimpawu ezivela ohlelweni lwethu lokuzivikela komzimba ezibangela ukuvuvukala. Uma lezi zimpawu zivinjiwe, inani lama-eosinophil aqongelela emgudwini liyancipha, kunciphisa ukuvuvukala nokuvuvukala. Lokhu kunciphisa nobunzima bokugwinya.
Ucwaningo ngalesi sidakamizwa lwembule ini?
Kuye kwenziwa izifundo ezimbili ezinkulu zezokwelapha ukuze kubonwe ukuthi lo muthi usebenza kahle futhi uphephile kangakanani. Bonke abahlanganyeli kulezi zifundo kwakungabantu ababesebenzise i-proton pump inhibitor ngaphambilini cishe izinyanga ezimbili kodwa izimpawu zabo zingakathuthuki.
- Ucwaningo lokuqala: Abahlanganyeli babeneminyaka eyi-12 nangaphezulu.
- Ucwaningo lwesibili: Izingane ezincane eziphakathi kweminyaka eyi-1-11 zahlanganyela.
Kulezi zifundo, iqembu elilodwa lanikezwa umuthi wokugomela i-Dupixent. Elinye iqembu lanikwa i-placebo. Lokhu sikubiza ngokuthi i-placebo . Kodwa akekho owatshelwa ukuthi wayethola umuthi wangempela noma i-placebo.
Injani imiphumela?
Uma ngibheka emuva ngemva kwezinyanga ezingu-4-6, imiphumela iyakhuthaza ngempela.
1. Inani lama-Eosinophil: Abantu abangaphezu kuka-60% abathatha i-Dupixent babenciphise kakhulu inani lamaseli e-eosinophil emgudwini wabo, okwaholela ekukhululweni. Lokhu kwaba njalo cishe ku-5% kuphela walabo abathatha i-placebo.
2. Ubunzima bokugwinya: Ocwaningweni lwabantu abaneminyaka engaphezu kwengu-12 ubudala, labo abathatha i-Dupixent babenobunzima obuncane kakhulu bokugwinya kunalabo abathatha i-placebo.
Ngingawusebenzisa kanjani lo muthi?
I-Dupixent iwuketshezi. Inikezwa njengomjovo ongaphansi kwesikhumba . Udokotela wakho uzonquma ukuthi uzoyinika kanye ngesonto noma njalo emavikini amabili, kuye ngeminyaka yakho nesisindo sakho. Ivame ukunikezwa ethangeni, esiswini, noma engalweni engenhla.
Lomuthi uza ngezindlela ezimbili:
- Ipeni eligcwaliswe kusengaphambili: Kulula kakhulu ukulisebenzisa. Akudingeki ukhathazeke ngesirinji.
- Isirinji esigcwaliswe kusengaphambili: Lokhu kuvame ukusetshenziselwa izingane ezincane.
Into ebaluleke kakhulu ukuthi ngaphambi kokuba uyisebenzise okokuqala, udokotela wakho noma umhlengikazi oqeqeshiwe uzokukhombisa ukuthi ungayijova kanjani ngqo. Kubaluleke kakhulu futhi ukufunda nokuqonda incwajana yemiyalelo ehambisana nomuthi.
Imiphumela emibi nokuthi ungayiphatha kanjani?
Njenganoma yimuphi umuthi, i-Dupixent ingabangela imiphumela emibi emincane. Kodwa ungakhathazeki, eminingi yayo iyalawuleka.
| Imiphumela emibi evamile | Indlela yokuphatha |
|---|---|
| Ukusabela kwesikhumba endaweni yokujova(Ubomvu, ubuhlungu, ukuvuvukala, ukudumba) | Indlela engcono kakhulu yokwenza lokhu ukushintshanisa izindawo zokujova . Isibonelo, uma ujova ethangeni lakho lesokudla kanye, faka ethangeni lakho lesobunxele ngesikhathi esilandelayo. Gwema ukujova ezindaweni ezilimele, eziphukile, noma ezibuhlungu. |
| Izifo zokuphefumula (umkhuhlane, umphimbo obuhlungu) | Landela imikhuba emihle kakhulu yokuzivikela ezifweni. Geza izandla zakho njalo. Hlala kude nabantu abagulayo. Thola umjovo wakho womkhuhlane waminyaka yonke ngokushesha okukhulu. |
Lena imiphumela emibi eyinhloko engabonakala. Kodwa uma uzizwa ngenye indlela noma ungakhululeki, qiniseka ukuthi utshela udokotela wakho .
Ingabe kungaba nezinkinga ngeminye imithi?
Yebo, ngakho-ke lolu daba lubaluleke kakhulu.
- Tshela udokotela wakho ngayo yonke imithi oyithathayo: Ngaphambi kokuthi uqale i-Dupixent, kufanele utshele udokotela wakho ngayo yonke imithi oyithathayo (kufaka phakathi amavithamini, amakhambi, kanye nezithasiselo). Lokhu kubaluleke kakhulu uma uthatha imithi ye-asthma.
- Qaphela ngemithi yokugoma: Eminye imithi yokugoma ephilayo ayinconywa ngesikhathi uthatha lo muthi. Ngakho-ke uma kufanele uthole umuthi wokugoma, khuluma nodokotela wakho ngakho ngaphambi kokuqala umuthi.
Ungalokothi uyeke ukuthatha umuthi ngaphandle kokubonisana nodokotela wakho, noma ngabe umuthi usuqalile ukusebenza futhi izimpawu zakho sezithuthukile. Ukwenza kanjalo kungabangela izimpawu zakho ukuba ziphinde zibe zimbi kakhulu.
Umlayezo Wokuya Nawe Ekhaya
- I-Eosinophilic Esophagitis yisimo sesikhathi eside esihlobene nesimiso somzimba sokuzivikela esibangela ubunzima bokugwinya.
- I-Dupixent iwumjovo omusha ongaphansi kwesikhumba ovunyelwe ukwelapha lesi sifo.
- Lokhu kuvimbela izimpawu zomzimba ezibangela ukuvuvukala, okuyimbangela yesifo, futhi kulawula izimpawu.
- Imiphumela emibi emincane efana nokubomvu nokuvuvukala endaweni yomjovo ingase ivele, kodwa ingalawulwa.
- Kubalulekile ukwazisa udokotela wakho ngayo yonke eminye imithi oyithathayo kanye nanoma yimiphi imijovo ohlela ukuyithola.
- Ungalokothi uyeke ukwelashwa noma ushintshe umthamo ngaphandle kweseluleko sikadokotela.
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